| S2480 |
Loperamide HCl |
Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. |
Selective |
μ-opioid receptor, Ki: 3.3 nM |
| S2103 |
Naltrexone HCl |
Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. |
Selective |
opioid receptor, IC50: 8 nM |
| S3066 |
Naloxone HCl |
Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose. |
Selective |
|
| S2503 |
Racecadotril |
Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM. |
Selective |
|
| S5701 |
Alvimopan dihydrate (LY246736 dihydrate) |
Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
μ-opioid receptor, Ki: 0.77 nM |
| S5935 |
Alvimopan |
Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
μ-opioid receptor, Ki: 0.77 nM |
