| S8606 |
Siremadlin (HDM201) |
Siremadlin (HDM201) is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. |
Pan |
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| S7205 |
Idasanutlin (RG7388) |
Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity. |
Pan |
p53-MDM2 interaction, IC50: 6 nM |
| S7030 |
RG-7112 |
RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM. |
Pan |
p53-MDM2 interaction, IC50: 18 nM |
| S8059 |
Nutlin-3a |
Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner. |
Pan |
p53-MDM2 interaction, IC50: 90 nM |
| S7489 |
YH239-EE |
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
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Pan |
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