MG132
别名: (S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al
MG132 ((S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al)是一种有效的蛋白酶体(ChTL, TL和PGPH)抑制剂。MG132对calpain也有抑制作用(IC50=1.2 μM)。MG-132可用于诱导PD动物模型动物疾病模型。
MG132 Chemical Structure
CAS: 1211877-36-9
Selleck的MG-132蛋白酶体抑制效果显著高于Sigma同类产品，
正是因为采用了效果最好的(S,R,S)-(-)-2构型
p21蛋白可以被泛素化降解，MG-132通过抑制蛋白酶体活性导致了p21的累积，因此，MG-132抑制效果越强，p21蛋白累积越多。（检测蛋白：p21; 细胞种类：HeLa细胞系; 处理条件：终浓度5μM，处理时间6h）
产品质控
批次：
纯度：
99.52%
99.52
常与MG132一起在实验中被使用的化合物
Cycloheximide（放线菌酮）是一种蛋白质合成抑制剂。与MG132联用，以探讨蛋白质变化的原因是合成途径还是蛋白酶体降解途径。
Epoxomicin (B环氧酶素)是一种高度选择性和不可逆的蛋白酶体抑制剂，与MG132一起使用以比较不同蛋白酶抑制剂的效用区别。
Kisselev AF. Site-Specific Proteasome Inhibitors. Biomolecules. 2021 Dec 31;12(1):54.
MG132和Cycloheximide共处理可使DM1蛋白免于HEK293细胞的降解。
MG-132和Y-27632 2HCl处理可抑制卵母细胞突出并增加成熟促进因子(MPF)活性，而MAPK活性保持不变。
MG-132和Z-VAD-FMK对K562细胞进行预处理，确定三氧化二砷(ATO)/乙酸(EA)处理对Mcl-1的还原途径。
Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
MG132相关产品
| 相关靶点 | 20S proteasome | 点击展开 |
|---|---|---|
| 相关产品 | Epoxomicin (BU-4061T) Celastrol Oprozomib ONX-0914 (PR-957) Delanzomib VR23 Marizomib (Salinosporamide A) PI-1840 | 点击展开 |
| 相关化合物库 | FDA药物库 天然产物库 已知活性药物库-I 蛋白酶抑制剂库 泛素化化合物库 | 点击展开 |
相关信号通路图
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| SMMC-7721 | Cytotoxic Assay | 40 μM | 48 h | IC50=7.1 μM | 24697496 |
| HL-60 | Cytotoxic Assay | 40 μM | 48 h | IC50<10 μM | 24697496 |
| SW-480 | Cytotoxic Assay | 40 μM | 48 h | IC50=4 μM | 24697496 |
| MCF-7 | Cytotoxic Assay | 40 μM | 48 h | IC50=7.3 μM | 24697496 |
| A-549 | Cytotoxic Assay | 40 μM | 48 h | IC50<10 μM | 24697496 |
| NCI-H929 | Cytotoxic Assay | 1 μM | 72 h | IC50=0.17 μM | 24625088 |
| 293T | Function Assay | 10 μM | 24 h | Moderately induces heat-shock | 24625088 |
| 293T | Cytotoxic Assay | 10 μM | 72 h | IC50<2 μM | 24625088 |
| MDA-MB-231 | Growth Inhibition Assay | 1 μM | 72 h | IC50=0.18 μM | 24153206 |
| HeLa | Kinase Assay | 10 μM | 1 h | Induces PARP cleavage by inhibiting proseasome activity | 24321833 |
| MCF-7 | Growth Inhibition Assay | 1 μM | 72 h | IC50=0.13 μM | 24153206 |
| MCF10A | Growth Inhibition Assay | 1 μM | 72 h | IC50=0.29 μM | 24153206 |
| HEK-293 | Kinase Assay | 2 and 20 μM | 2 h | Inhibits ChT-L activity with IC50 of 9 nM | 23540790 |
| Calu6 | Function Assay | 10 μM | 18 h | Significantly accumulates frataxin precursor | 23506486 |
| IPC227F | Cytotoxic Assay | 1 μM | 48 h | IC50=0.077 μM | 21924528 |
| Hepa-1c1c7 | Function Assay | 25 μM | 6 h | Increases Nrf2 protein level | 20392544 |
| OCI-Ly3 | Function Assay | 10 μM | 4 h | Induces human IkappaBalpha stabilization with EC50 of 1 μM | 18024113 |
| PC12 | Function Assay | 100 μM | 24 h | Inhibits 6-OHDA- and H2O2-induced cytotoxicity | 17158454 |
| PC3 | Growth Inhibition Assay | 20 μM | 48 h | IC50=0.6 μM | 16686537 |
| LP-1 | Apoptosis Assay | 300 nM | 24 h | Induces apoptosis by increasing cleaved PARP level and reducing Mcl-1 protein level | 15958589 |
| LPS-stimulated RAW264.7 cells | Function Assay | 25 μM | Inhibits nitric oxide production with IC50 of 0.1 μM | 24697496 | |
| HuH-7 | Cytotoxic Assay | 10 μM | IC50<10 μM | 18088097 | |
| COS-7 | Cytotoxic Assay | 10 μM | IC50<10 μM | 18088097 | |
| LCL | Function assay | 12 h | IC50 = 1.077 μM | 20687609 | |
| HEK293 | Function assay | 2 h | IC50 = 0.6 μM | 23540790 | |
| RAW264.7 | Function assay | 18 h | IC50 = 0.35 μM | 21044847 | |
| RAW264.7 | Antiinflammatory activity assay | 1 h | IC50 = 0.2 μM | 29338260 | |
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.18 μM | 27203291 | |
| RAW264.7 | Function assay | 18 h | IC50 = 0.15 μM | 26757019 | |
| RAW264.7 | Function assay | 18 h | IC50 = 0.15 μM | 23327668 | |
| RAW264.7 | Function assay | 18 h | IC50 = 0.1 μM | 24219809 | |
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.1 μM | 23819871 | |
| RAW264.7 | Antiinflammatory activity assay | 18 h | IC50 = 0.08 μM | 22620677 | |
| IPC227F | Function assay | 1 h | IC50 = 0.077 μM | 16220988 | |
| LCL | Function assay | 12 h | IC50 = 0.002 μM | 20687609 | |
| A2780 cDDP | Apoptosis Assay | 24 h | Induces apoptosis by inhibiting PTEN degradation | 17684018 | |
| EHEB | Growth Inhibition Assay | IC50=21.6731 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=24.0201 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=24.6939 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=24.9012 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=25.1113 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=26.0623 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=26.7644 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=26.7922 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=28.0861 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=28.3446 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=28.2956 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=29.9281 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=30.7952 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=30.9503 μM | SANGER | ||
| NCI-H2107 | Growth Inhibition Assay | IC50=31.2338 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=31.3799 μM | SANGER | ||
| SNU-C1 | Growth Inhibition Assay | IC50=31.3126 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=32.2144 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=32.3474 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=33.6454 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=33.8969 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=34.2993 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=34.7536 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=34.4822 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=34.9057 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=36.9048 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=37.0864 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=38.1603 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=38.2083 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=39.4337 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=38.5653 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=39.7388 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=40.0948 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=40.8716 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=41.4405 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=41.7595 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=42.1806 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=42.9067 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=42.5875 μM | SANGER | ||
| EoL-1- | Growth Inhibition Assay | IC50=44.1568 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=44.8342 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=47.4128 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=45.7007 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=49.8061 μM | SANGER | ||
| TC-YIK | Growth Inhibition Assay | IC50=50.0363 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=54.8357 μM | SANGER | ||
| KP-N-RT-BM-1 | Growth Inhibition Assay | IC50=56.6638 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=58.8172 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=58.9526 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=60.9638 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=61.231 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=61.8266 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=62.1491 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=63.9892 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=68.5687 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=69.0047 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50=69.5209 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=70.06 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=70.3468 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=70.4447 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=71.032 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=71.9507 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=72.34 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=72.7456 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=74.505 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=74.7509 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=74.8732 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=74.9367 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=74.9514 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=75.0754 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=77.6122 μM | SANGER | ||
| NCI-H322M | Growth Inhibition Assay | IC50=78.3709 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=78.5877 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=79.4136 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=81.5884 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=82.2505 μM | SANGER | ||
| NCI-H716 | Growth Inhibition Assay | IC50=82.9075 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=83.1351 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=84.2107 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=91.6551 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=93.8269 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=94.9081 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=95.7786 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=98.4061 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=99.7588 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=104.242 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=106.19 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=108.728 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=109.671 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=109.69 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=113.352 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=117.382 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=118.009 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=121.745 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=127.32 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=134.044 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=139.736 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=143.708 μM | SANGER | ||
| EW-12 | Growth Inhibition Assay | IC50=144.699 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=147.082 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=148.268 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=156.279 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=167.87 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=180.331 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=181.571 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=188.866 μM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=190.064 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=192.728 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=198.304 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=199.739 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=236.626 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=239.121 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=264.738 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=271.456 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=283.847 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=345.338 μM | SANGER | ||
| HL-60 | Function assay | IC50 = 4.5 μM | 15780623 | ||
| HL-60 | Function assay | IC50 = 1.4 μM | 15780623 | ||
| lymphoblastoid | Function assay | IC50 = 1.077 μM | 17996987 | ||
| RAW264.7 | Toxicity assay | IC50 = 0.63 μM | 22858297 | ||
| RAW264.7 | Antiinflammatory activity assay | IC50 = 0.439 μM | 21561060 | ||
| MCF7 | Cytotoxicity assay | IC50 = 0.3 μM | 18598018 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 0.25 μM | 18598018 | ||
| RAW264.7 | Function assay | IC50 = 0.1 μM | 24597894 | ||
| HL-60 | Function assay | IC50 = 0.068 μM | 15780623 | ||
| lymphoblastoid | Function assay | IC50 = 0.002 μM | 17996987 | ||
| IFN-gamma-induced RAW264.7 | Function Assay | Inhibits nitric oxide production with IC50 of 0.077 μM | 22277277 | ||
| LPS-stimulated RAW264.7 cells | Function Assay | Inhibits NF-kappaB DNA binding | 17407277 | ||
| CHP-126 | Growth Inhibition Assay | IC50=21.6181 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=21.417 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=21.0643 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=21.3602 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=20.8821 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=21.0311 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=20.6224 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=20.4753 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=20.1965 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=19.6482 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=19.4066 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=18.8208 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=18.9231 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=17.9796 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=17.4755 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=17.6818 μM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50=15.9608 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=16.9617 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=14.7994 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=15.398 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=14.7448 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=14.7735 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=13.9885 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=14.4511 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=13.6994 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=13.736 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=13.8505 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=13.2902 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=13.6124 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=12.9783 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=13.195 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=12.9382 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=12.9462 μM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=12.7496 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=12.9026 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=12.0345 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=12.5633 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=12.7069 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=11.8061 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=11.9822 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=11.5186 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=11.4102 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=11.0965 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=11.0185 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=10.7031 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=10.6596 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=10.4969 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=10.361 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=10.2433 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=10.0979 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=9.74198 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=9.29317 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=9.09091 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=8.9794 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=8.91719 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=8.52191 μM | SANGER | ||
| RL95-2 | Growth Inhibition Assay | IC50=8.10842 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=7.99556 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=7.86558 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=7.72231 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=7.71089 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=7.24254 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=7.2243 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=7.00326 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=6.86754 μM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=6.84787 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=6.67099 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=6.71895 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=6.45854 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=6.51926 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=6.36897 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=6.45593 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=6.08118 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=6.23849 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=5.67087 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=5.63795 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=5.47236 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=5.622 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=5.30765 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=5.37541 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=5.23422 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=5.19352 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=5.23102 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=5.03041 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=5.17662 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=4.57034 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=4.72371 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=5.00447 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=4.56308 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=4.40255 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=4.32824 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=4.35424 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=4.15797 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=4.01166 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=3.94561 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=3.77378 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=3.75634 μM | SANGER | ||
| SKM-1 | Growth Inhibition Assay | IC50=3.71376 μM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=3.67723 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=3.60103 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=3.59888 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=3.5968 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=3.46937 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=3.44266 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=3.38748 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=3.10848 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=3.06111 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=2.88791 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=2.5148 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=2.50871 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=2.44883 μM | SANGER | ||
| ECC12 | Growth Inhibition Assay | IC50=2.3794 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=2.29043 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=2.2295 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=2.16762 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=2.03104 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=2.02552 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=2.02337 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=2.01252 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=1.93904 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=1.92373 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=1.72685 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=1.71281 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=1.69807 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=1.67317 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=1.67211 μM | SANGER | ||
| NCI-H2227 | Growth Inhibition Assay | IC50=1.61561 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=1.55198 μM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=1.55196 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=1.47131 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=1.44539 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=1.4185 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=1.40208 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=1.3817 μM | SANGER | ||
| NCI-H128 | Growth Inhibition Assay | IC50=1.35814 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=1.31347 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=1.30221 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=1.28659 μM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=1.27411 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=1.27016 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=1.24116 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=1.2041 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=1.17501 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=1.12753 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=1.12374 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=1.11839 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=1.07921 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=1.05045 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=1.04016 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=1.03442 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.98971 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.9643 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.93854 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.90658 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.8965 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.85466 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=0.79621 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.77955 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=0.72124 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.70739 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.69545 μM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=0.69388 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.68619 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=0.66751 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=0.65729 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.65641 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=0.62669 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=0.61033 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=0.59036 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.56811 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.53611 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=0.51762 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=0.49911 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=0.49096 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.48692 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.47972 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.47674 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.46584 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=0.45119 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=0.43607 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=0.4297 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.39837 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.38844 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.37103 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=0.35104 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.34279 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.32897 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=0.31783 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=0.31306 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=0.313 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=0.3112 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.30323 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=0.29524 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=0.2899 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=0.27907 μM | SANGER | ||
| CP67-MEL | Growth Inhibition Assay | IC50=0.2673 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.26374 μM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50=0.25456 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.25435 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=0.25015 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.24763 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.24257 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.24198 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=0.23303 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.2319 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.22638 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.22257 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.22049 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=0.21851 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=0.21047 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=0.20534 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=0.20094 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.19658 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.1934 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=0.19306 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.19303 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=0.19115 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=0.18517 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.17559 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=0.1706 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=0.16706 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=0.16128 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=0.16006 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=0.15482 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=0.15141 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.1479 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=0.14278 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.14247 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.13895 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.13278 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.12935 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.11995 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=0.11927 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.11806 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.10949 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.10938 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=0.10474 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=0.09065 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=0.08909 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=0.08036 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.075 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=0.07268 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=0.07209 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.07066 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=0.06947 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.06458 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=0.05957 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.05772 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=0.05289 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=0.04441 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.0431 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.0376 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=0.03737 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.03279 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.01306 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=0.1111 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.27009 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.30094 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.33014 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.33422 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.4231 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.42592 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.47349 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.47626 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=0.56207 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.57053 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=0.58379 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.60509 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=0.60813 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.62764 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.63942 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.68642 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.71274 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.7182 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=0.74747 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=0.75792 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=0.75837 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.83646 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.87076 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=0.87844 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.89904 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.93176 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.95567 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.97175 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=1.07025 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=1.07291 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=1.17566 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=1.18954 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=1.20033 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=1.25589 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=1.28397 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=1.30754 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=1.46531 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=1.46658 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=1.49911 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=1.55279 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=1.58368 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=1.5921 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=1.70043 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=1.83901 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=1.85897 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=1.95209 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=2.05459 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=2.07059 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=2.11804 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=2.15065 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=2.15677 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=2.18576 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=2.23667 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=2.25183 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=2.26226 μM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=2.30393 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.31255 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=2.38186 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=2.38967 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=2.45622 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=2.47955 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=2.60022 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=2.67382 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=2.67795 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=2.84394 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=2.86126 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=2.88421 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=2.98023 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=3.0086 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=3.14413 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=3.20254 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=3.21082 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=3.24287 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=3.59266 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=3.59326 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=3.62126 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=3.76302 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=3.82083 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=3.85926 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=3.96369 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=3.98406 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=3.9918 μM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=3.99677 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=4.04835 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=4.06592 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=4.19255 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=4.26164 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=4.3002 μM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=4.36265 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=4.39507 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=4.44812 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=4.5114 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=4.51454 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=4.63784 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=4.8413 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=4.90737 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=4.92582 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=5.04589 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=5.05273 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=5.16913 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=5.40415 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=5.40704 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=5.48599 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=5.63865 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=5.76359 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=5.85194 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=5.90945 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=5.99228 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=6.10875 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=6.3288 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=6.36816 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=6.55658 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=6.64033 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=6.674 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=6.92652 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=7.20588 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=7.21282 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=7.27563 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=7.32929 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=7.57964 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=7.85992 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=8.12437 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=8.13337 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=8.23226 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=8.27928 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=8.46677 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=8.5574 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=8.79201 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=8.84538 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=8.86801 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=8.88154 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=9.15716 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=9.27307 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=9.52951 μM | SANGER | ||
| SKM-1 | Growth Inhibition Assay | IC50=9.61824 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=9.83673 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=10.1011 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=10.2198 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=10.2432 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=10.5981 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=10.616 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=10.8222 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=11.7876 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=12.0629 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=12.1105 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=12.4485 μM | SANGER | ||
| SNU-C1 | Growth Inhibition Assay | IC50=12.6517 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=12.9298 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=13.0111 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=13.2394 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=13.3147 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=13.565 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=13.6084 μM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50=13.7564 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=13.8253 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=13.8349 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=14.0902 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=14.1004 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=14.1615 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=14.3226 μM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=14.5781 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=14.6373 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=15.0867 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=15.1938 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=15.3376 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=15.6556 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=15.8269 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=15.8866 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=16.566 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=17.0105 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=17.1644 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=17.6506 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=18.0735 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=18.3741 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=18.5752 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=18.6376 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=18.7023 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=18.944 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=18.9815 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=19.3517 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=19.46 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=19.5619 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=19.6307 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=19.7956 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=20.0459 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=20.8915 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=20.9557 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=21.0468 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=21.2129 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=21.4585 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=22.3294 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=22.4135 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=22.956 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=23.2708 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=23.8942 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=23.9489 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=24.239 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=24.9878 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=25.1851 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=25.5136 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=25.9507 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=26.5085 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=26.5486 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=26.6166 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=26.6901 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=26.8177 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=27.479 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=27.6883 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=27.8955 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=27.9353 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=28.9415 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=29.1543 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=29.2129 μM | SANGER | ||
| RL95-2 | Growth Inhibition Assay | IC50=29.5637 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=29.7428 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=29.9399 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=30.5434 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=30.9584 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=31.0823 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=32.3473 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=33.7814 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=34.065 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=34.4958 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=34.7578 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=35.1091 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=35.8459 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=36.8021 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=36.9848 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=36.9919 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=37.05 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=37.2234 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=37.3946 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=38.6705 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=38.6818 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=38.9944 μM | SANGER | ||
| NCI-H128 | Growth Inhibition Assay | IC50=39.5567 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=39.7722 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=40.0164 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=40.4441 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=40.7601 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=40.7771 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=40.8264 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=41.0485 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=41.4224 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=41.7115 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=43.4398 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=43.4687 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=44.6708 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=44.7331 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=45.9253 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=46.4915 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=46.5661 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=46.8105 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=47.7106 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=47.8793 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=49.101 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=51.0359 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=51.178 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=54.3092 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=56.4043 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=57.0315 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=58.6442 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=58.6841 μM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=58.8002 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=59.7717 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=60.4282 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=61.2697 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=61.2933 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=62.2931 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=65.0102 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=65.873 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=66.8299 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=67.97 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=69.6286 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=70.1607 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=71.6266 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=72.7372 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=75.1944 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=75.8461 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=78.0688 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=78.4739 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=79.7008 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=81.9603 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=82.9596 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=84.6867 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=85.9404 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=86.8607 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=88.1676 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=88.8718 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=89.0582 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=97.7609 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=99.7585 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=102.901 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=103.457 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=106.528 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=107.635 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=108.33 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=112.333 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=113.512 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=114.376 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=115.234 μM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=115.583 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=117.411 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=118.868 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=119.978 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=123.948 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=134.232 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=135.081 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=135.852 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=136.429 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=136.607 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=139.732 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=146.561 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=148.717 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=165.958 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=167.261 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=182.57 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=186.961 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=188.945 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=201.087 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=209.004 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=209.602 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=230.298 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=231.162 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=237.146 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=240.731 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=243.062 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=246.503 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=247.336 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=253.811 μM | SANGER | ||
| NCI-H716 | Growth Inhibition Assay | IC50=259.637 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=312.028 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=312.685 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=316.901 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=327.666 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=340.486 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=348.123 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=387.778 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=414.626 μM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=428.541 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=434.624 μM | SANGER | ||
| NCI-H322M | Growth Inhibition Assay | IC50=452.677 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=483.609 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=525.413 μM | SANGER | ||
| EW-12 | Growth Inhibition Assay | IC50=557.847 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=672.665 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | MG132 ((S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al)是一种有效的蛋白酶体(ChTL, TL和PGPH)抑制剂。MG132对calpain也有抑制作用(IC50=1.2 μM)。MG-132可用于诱导PD动物模型动物疾病模型。 | ||
|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | MG-132抑制20S 蛋白酶体ZLLL-MCA降解活性，IC50为100 nM，比ZLLal(IC50为110 μM)有效1000多倍。MG-132也会抑制钙蛋白酶，IC50 为1.2 μM。MG-132在20 nM的最佳浓度下诱导PC12细胞中神经突增生，表现出高于ZLLal 500倍的效能。[1] MG-132 (10 μM) 通过抑制蛋白酶体介导的IκBα降解，有效抑制A549细胞中TNF-α诱导的NF-κB活化，白介素-8 (IL-8)基因转录，和IL-8蛋白质释放。[2] MG-132处理通过抑制26S蛋白酶体，有效诱导p53依赖性KIM-2细胞凋亡。[3]不同于BzLLLCOCHO或PS-341，MG-132处理对26S蛋白酶体的糜蛋白样(CT-L)和肽谷氨酰基肽水解(PGPH)活性抑制较弱，而相对于BzLLLCOCHO，MG-132能够更有效诱导多发性骨髓瘤细胞(U266 和OPM-2)的细胞凋亡。[4] MG-132 (1 μM)通过激活AP-1家族成员c-Fos和 c-Jun，使TRAIL抗性前列腺癌细胞敏感，这反过来抑制抗凋亡分子c-FLIP(L)。[5] MG-132显著增强肌醇六磷酸(IP6) 的作用以降低PC3 和DU145雄激素非依赖性前列腺癌(AIPCa)细胞系的细胞代谢活性。[6] |
|||
|---|---|---|---|---|
| 激酶实验 | MG-132对20S蛋白酶体抑制活性的测定 | |||
| 20S蛋白酶体抑制试验的反应混合物包含0.1 M Tris-乙酸，pH 7.0，20S 蛋白酶体，MG-132，和25 μM底物，溶解于二甲基亚砜，终体积为1 mL。在37 °C下培养15分钟后，加入pH 9.0的0.1 mL 10% SDS 和0.9 mL 0.1M Tris 乙酸盐停止反应。测量反应产物的荧光。为测定对20S蛋白酶体的IC50，试验混合物中包含不同浓度的MG-132。 | ||||
| 细胞实验 | 细胞系 | KIM-2，HC11，和 ES | ||
| 浓度 | 溶解于DMSO，终浓度为~25 μM | |||
| 孵育时间 | 24 和 48小时 | |||
| 方法 | 细胞在不同浓度的MG-132下暴露24，和48小时。上清液和单层细胞通过离心采集，并固定在含70%乙醇的PBS中，用吖啶橙着色。等体积细胞和吖啶橙(5 mg/mL的PBS溶液)在显微镜载玻片上固定，并通过荧光显微镜检测。对于膜联蛋白V分析，细胞通过离心采集，并用膜联蛋白V和碘化丙啶着色。对于细胞分析，细胞在PBS中于室温下再水化10分钟，随后用碘化丙啶(5 mg/mL)着色。所有样品使用Coulter Epics XL流式细胞分析仪分析。 |
|||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western Blot | Bcr-Abl Ac-histone H3 Cleaved-caspase3 Cleaved-PARP ASCL1 CgA Nrf2 HO-1 |
|
26722260 | |
| Immunofluorescence | C2GnT-M / NMIIA AGS3 / Vimentin Bak |
|
22525330 | |
| Growth inhibition assay | Apoptosis assay Cell viability cell proliferation |
|
20557369 | |
| ELISA | IL-8 IL-1beta |
|
11160671 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | MG-132给药有效恢复mdx小鼠骨骼肌纤维中肌萎缩蛋白，β-营养不良聚糖蛋白，α-营养不良聚糖蛋白，和α-肌聚糖蛋白的表达水平和血浆膜定位，减少肌肉膜损伤，并改善肌肉萎缩症的组织病理学信号。[7] MG-132治疗通过下调肌肉特异性泛素连接酶atrogin-1/MAFbx 和MuRF-1 mRNA，显著减少小鼠体内固定化诱导的骨骼肌萎缩。[8] |
|
|---|---|---|
| 动物实验 | Animal Models | 雄性 mdx (C57BL/10ScSn DMD mdx) 小鼠 |
| Dosages | ~10 μg/kg/day | |
| Administration | 注射 | |
化学信息&溶解度
| 分子量 | 475.62 | 分子式 | C26H41N3O5 |
| CAS号 | 1211877-36-9 | SDF | Download MG132 SDF |
| Smiles | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 95 mg/mL ( (199.73 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 95 mg/mL (199.73 mM) Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
如果有其他问题，请给我们留言。
* 必填项
常见问题及建议解决方法
问题 1:
I want to know whether it contains EDTA or other chelating agent in this product(S2619)?
回答：
Our S2619 MG-132 doesn't contain EDTA or other chelating agent.
Tags: buy MG132 | MG132 supplier | purchase MG132 | MG132 cost | MG132 manufacturer | order MG132 | MG132 distributor
