| S1413 |
Bafilomycin A1 (Baf-A1)
|
Bafilomycin A1 (Baf-A1)是一种液泡H+-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。 |
-
Nature, 2025, 10.1038/s41586-025-09745-x
-
Cell Res, 2025, 10.1038/s41422-025-01085-9
-
Signal Transduct Target Ther, 2025, 10(1):81
|
|
| S1389 |
Omeprazole
|
Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。 |
-
Cells, 2025 Sep 24, 1489
-
Gut, 2025, nan
-
Cells, 2025, 1489
|
|
| S1354 |
Lansoprazole
|
Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。 |
-
Journal of Virology, May 10, 2021, e00190-21
-
Frontiers in Cell and Developmental Biology, 2021, 655559
-
Frontiers in Cell and Developmental Biology, 2021, 655559
|
|
| S4845 |
Rabeprazole
|
Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach. |
-
J Extracell Vesicles, 2024, 13(4):e12426
-
Sci Rep, 2024, 14(1):28163
-
Med Oncol, 2024, 41(8):188
|
|
| S3666 |
Ilaprazole
|
Ilaprazole (IY-81149)是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。 |
-
bioRxiv, May 19, 2025, 2025.05.19.654850
-
Journal of Virology, May 10, 2021, 95(11):e00190-21
-
Journal of Virology, June 10, 2021, 95(13):e02466-20
|
|
| S2105 |
Pantoprazole
|
Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。 |
-
Journal of Virology, May 10, 2021, e00190-21
-
Med Oncol, 2024, 41(8):188
-
Int J Mol Sci, 2022, 23-158572
|
|
| S4099 |
Dexlansoprazole
|
Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。 |
-
Food Chem Toxicol, 2025, 197:115262
-
J Immunother Cancer, 2024, 12(11)e009805
-
Journal of Virology, 2021, e00190-21
|
|
| S5608 |
Pantoprazole sodium hydrate
|
Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) 是一种 H+/K(+)-ATPase 的有效抑制剂，其IC50值为6.8 μM。 |
-
Molecular Therapy, 2025, 336-355
-
Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
-
Journal of Virology, 2021, e00190-21
|
|
| S4075 |
Zinc Pyrithione
|
Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。 |
-
Cell Chem Biol, 2021, S2451-9456(21)00213-0
-
Biol Reprod, 2019, 100(2):468-478
-
Biology of Reproduction, 2019, 468–478
|
|
| S5658 |
Omeprazole Sodium
|
Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19. |
-
Theranostics, 2021, 11(5):2364-2380
-
J Virol, 2021, JVI.00190-21
-
Biosci Rep, 2021, BSR20200842
|
|
| S4665 |
Rabeprazole sodium
|
Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole)是一种抗溃疡药物，是质子泵的抑制剂。 |
-
Journal of Virology, 2021 May 10, e00190-21
-
J Virol, 2021, JVI.00190-21
-
Journal of Virology, 2021, e00190-21
|
|
| S4538 |
Pantoprazole sodium
|
Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。 |
-
Journal of Virology, May 10, 2021, e00190-21
-
Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
-
J Virol, 2021, JVI.00190-21
|
|
| S4212 |
Tenatoprazole
|
Tenatoprazole (TU-199,STU-Na)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。
|
-
Advanced Science, 2024, e2308312
-
Viruses, 2024, 16(10)1566
-
J Virol, 2021, JVI.00190-21
|
|
| S1743 |
Esomeprazole magnesium
|
Esomeprazole Magnesium(NEXIUM)通过抑制胃壁细胞中 H(+)/K(+)-ATPase (一种质子泵( proton pump))，减少胃酸分泌。 |
-
Scientific Reports, August 17, 2017, 8491
-
Scientific Reports, 2017, 8491
|
|
| S5885 |
Rabeprazole Related Compound E
|
Rabeprazole Related Compound E (Rabeprazole thioether)是rabeprazole的活性代谢物。Rabeprazole是proton pump抑制剂。 |
-
Stem Cells Int, 2022, 2022:1396735
|
|
| S5502 |
Ilaprazole sodium
|
Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation. |
-
J Virol, 2021, JVI.00190-21
|
|
| E6009 |
Esomeprazole
|
Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) 是一种强效的 质子泵 抑制剂。它通过抑制胃壁细胞中的 H+、K+-ATPase 酶来减少酸的产生。Esomeprazole 的药代动力学特性使其比 omeprazole 更有效，并有可能用于有症状的胃食管反流病的研究。 |
-
Scientific Reports, August 17, 2017, 8491
|
|
| S5058 |
Revaprazan Hydrochloride
|
Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。 |
-
ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
|
|
| S2222 |
PF-3716556
|
PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H+，K+-ATPase活性，抑制胃酸分泌，对Na+，K+-ATPas没有作用活性，用于治疗胃食管返流疾病。 |
|
|
| E4878 |
Lansoprazole sodium
|
Lansoprazole Sodium是Lansoprazole的钠盐形式，是一种口服的质子泵抑制剂，可防止胃产生酸。兰索拉唑可增强runt相关转录因子2 (Runx2)的表达和转录效率，刺激骨祖细胞向其谱系的定向分化和成熟。 |
|
|
| S5847 |
Ethacrynate Sodium
|
Ethacrynate Sodium (ethacrynic acid sodium)是ethacrynic acid的钠盐形式。Ethacrynic acid可抑制钠离子、钾离子和氯离子的同乡转移，主要是在髓袢薄壁段升支，也作用于远端和近端小管。 |
|
|
| S6438 |
Ufiprazole
|
Ufiprazole (Omeprazole sulfide)是生产胃质子泵抑制剂omeprazole和esomeprazole的中间物。 |
|
|
| S1413 |
Bafilomycin A1 (Baf-A1)
|
Bafilomycin A1 (Baf-A1)是一种液泡H+-ATPase抑制剂，IC50为0.44 nM。研究发现 Bafilomycin A1 可以抑制自噬，但是诱导凋亡。 |
- Nature, 2025, 10.1038/s41586-025-09745-x
- Cell Res, 2025, 10.1038/s41422-025-01085-9
- Signal Transduct Target Ther, 2025, 10(1):81
|
|
| S1389 |
Omeprazole
|
Omeprazole 是一种可阻滞 H(+)-K(+)-ATPase 的质子泵抑制剂，用于治疗消化不良，消化性溃疡，胃食管逆流，咽喉逆流。 |
- Cells, 2025 Sep 24, 1489
- Gut, 2025, nan
- Cells, 2025, 1489
|
|
| S1354 |
Lansoprazole
|
Lansoprazole (A-65006, AG-1749)是一种质子泵抑制剂（PPI）可共价结合壁细胞的 H(+),K(+)-ATPase，防止胃产生胃酸。 |
- Journal of Virology, May 10, 2021, e00190-21
- Frontiers in Cell and Developmental Biology, 2021, 655559
- Frontiers in Cell and Developmental Biology, 2021, 655559
|
|
| S4845 |
Rabeprazole
|
Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach. |
- J Extracell Vesicles, 2024, 13(4):e12426
- Sci Rep, 2024, 14(1):28163
- Med Oncol, 2024, 41(8):188
|
|
| S3666 |
Ilaprazole
|
Ilaprazole (IY-81149)是新型的质子泵 (proton pump)抑制剂，用于治疗消化不良、消化性溃疡、胃食管返流疾病和十二指肠溃疡。它能抑制H+/K+-ATPase，IC50为6 μM。 |
- bioRxiv, May 19, 2025, 2025.05.19.654850
- Journal of Virology, May 10, 2021, 95(11):e00190-21
- Journal of Virology, June 10, 2021, 95(13):e02466-20
|
|
| S2105 |
Pantoprazole
|
Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。 |
- Journal of Virology, May 10, 2021, e00190-21
- Med Oncol, 2024, 41(8):188
- Int J Mol Sci, 2022, 23-158572
|
|
| S4099 |
Dexlansoprazole
|
Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole)是Lansoprazole的右旋对映体，是质子泵抑制剂（PPI），具有双重缓释性能。Dexlansoprazole 作用于胃壁细胞，通过直接抑制 H(+),K(+)-ATPase 质子泵选择性地抑制胃酸分泌。 |
- Food Chem Toxicol, 2025, 197:115262
- J Immunother Cancer, 2024, 12(11)e009805
- Journal of Virology, 2021, e00190-21
|
|
| S5608 |
Pantoprazole sodium hydrate
|
Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) 是一种 H+/K(+)-ATPase 的有效抑制剂，其IC50值为6.8 μM。 |
- Molecular Therapy, 2025, 336-355
- Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
- Journal of Virology, 2021, e00190-21
|
|
| S4075 |
Zinc Pyrithione
|
Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物，可以通过阻断质子泵破坏膜转运。 |
- Cell Chem Biol, 2021, S2451-9456(21)00213-0
- Biol Reprod, 2019, 100(2):468-478
- Biology of Reproduction, 2019, 468–478
|
|
| S5658 |
Omeprazole Sodium
|
Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19. |
- Theranostics, 2021, 11(5):2364-2380
- J Virol, 2021, JVI.00190-21
- Biosci Rep, 2021, BSR20200842
|
|
| S4665 |
Rabeprazole sodium
|
Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole)是一种抗溃疡药物，是质子泵的抑制剂。 |
- Journal of Virology, 2021 May 10, e00190-21
- J Virol, 2021, JVI.00190-21
- Journal of Virology, 2021, e00190-21
|
|
| S4538 |
Pantoprazole sodium
|
Pantoprazole (SKF96022, BY-1023) 是质子泵抑制剂，抑制胃酸分泌。它作用于胃黏膜壁细胞，可逆性抑制(H+/K+)-ATPase功能以及抑制胃酸的产生。 |
- Journal of Virology, May 10, 2021, e00190-21
- Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
- J Virol, 2021, JVI.00190-21
|
|
| S4212 |
Tenatoprazole
|
Tenatoprazole (TU-199,STU-Na)是proton pump 抑制剂类前药, 抑制质子的运输，IC50为3.2 μM。Tenatoprazole 仅标记胃部 H(+),K(+)-ATPase 的α-亚基，约2.6 nM/mg 结合于 H(+),K(+)-ATPase。
|
- Advanced Science, 2024, e2308312
- Viruses, 2024, 16(10)1566
- J Virol, 2021, JVI.00190-21
|
|
| S1743 |
Esomeprazole magnesium
|
Esomeprazole Magnesium(NEXIUM)通过抑制胃壁细胞中 H(+)/K(+)-ATPase (一种质子泵( proton pump))，减少胃酸分泌。 |
- Scientific Reports, August 17, 2017, 8491
- Scientific Reports, 2017, 8491
|
|
| S5885 |
Rabeprazole Related Compound E
|
Rabeprazole Related Compound E (Rabeprazole thioether)是rabeprazole的活性代谢物。Rabeprazole是proton pump抑制剂。 |
- Stem Cells Int, 2022, 2022:1396735
|
|
| S5502 |
Ilaprazole sodium
|
Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation. |
- J Virol, 2021, JVI.00190-21
|
|
| E6009 |
Esomeprazole
|
Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) 是一种强效的 质子泵 抑制剂。它通过抑制胃壁细胞中的 H+、K+-ATPase 酶来减少酸的产生。Esomeprazole 的药代动力学特性使其比 omeprazole 更有效，并有可能用于有症状的胃食管反流病的研究。 |
- Scientific Reports, August 17, 2017, 8491
|
|
| S5058 |
Revaprazan Hydrochloride
|
Revaprazan Hydrochloride (YH1885) 是一种新型可逆的proton pump抑制剂，具有长效抑酸活性。Revaprazan Hydrochloride 通过结合泵上K+结合位点来可逆性地抑制 H(+)/K(+)-ATPase。 |
- ACS Infect Dis, 2021, 10.1021/acsinfecdis.0c00754
|
|
| S2222 |
PF-3716556
|
PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H+，K+-ATPase活性，抑制胃酸分泌，对Na+，K+-ATPas没有作用活性，用于治疗胃食管返流疾病。 |
|
|
| E4878 |
Lansoprazole sodium
|
Lansoprazole Sodium是Lansoprazole的钠盐形式，是一种口服的质子泵抑制剂，可防止胃产生酸。兰索拉唑可增强runt相关转录因子2 (Runx2)的表达和转录效率，刺激骨祖细胞向其谱系的定向分化和成熟。 |
|
|
| S5847 |
Ethacrynate Sodium
|
Ethacrynate Sodium (ethacrynic acid sodium)是ethacrynic acid的钠盐形式。Ethacrynic acid可抑制钠离子、钾离子和氯离子的同乡转移，主要是在髓袢薄壁段升支，也作用于远端和近端小管。 |
|
|
| S6438 |
Ufiprazole
|
Ufiprazole (Omeprazole sulfide)是生产胃质子泵抑制剂omeprazole和esomeprazole的中间物。 |
|
|
