| S1544 |
AM1241 |
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. |
Selective |
CB2, Ki: 3.4 nM |
| S8033 |
6-Iodopravadoline (AM630) |
6-Iodopravadoline (AM630) is a selective cannabinoid CB2 receptor antagonist with Ki of 31.2 nM. |
Selective |
CB2 receptor, Ki: 31.2 nM |
| S2778 |
GW842166X |
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2. |
Selective |
CB2, EC50: 63 nM |
| S2854 |
BML-190 |
BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor. |
Selective |
CB2, Ki: 435 nM |
| S0412 |
Bay 59-3074 |
Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM, 48.3 nM and 45.5 nM at rat and human CB1 and human CB2 receptors, respectively. Bay 59-3074 displays analgesic properties. |
Pan |
human CB2 receptor, Ki: 45.5 nM |
| S3021 |
Rimonabant (SR141716) |
Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3. |
Pan |
hCB2, IC50: 1.64 μM |
