| S2419 |
Eprobemide |
Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia. |
Selective |
|
| S3868 |
Harmine |
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM. |
Selective |
MAO-A, Ki: 0.048 μM |
| S0160 |
Toloxatone (MD69276) |
Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of 0.93 µM. Toloxatone is an antidepressant agent. |
Selective |
MAO-A, IC50: 0.93 μM |
| S3212 |
Moclobemide (Ro 111163) |
Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM. |
Selective |
MAO-A (5-HT), IC50: 6.1 μM |
| S5795 |
Rasagiline |
Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively. |
Pan |
MAO-A, IC50: 412 nM |
| S2102 |
Rasagiline Mesylate |
Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. |
Pan |
MAO-A, IC50: 412 nM |
| S4246 |
Tranylcypromine (2-PCPA) HCl |
Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. |
Pan |
MAO-A, IC50: 11.5 μM |
| S3690 |
Pargyline hydrochloride |
Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey. |
Pan |
MAO-A, Ki: 13 μM |
| S2339 |
Paeonol |
Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM. |
Pan |
MAO-A, IC50: 54.6 μM |
| S4717 |
Isatin |
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A. |
Pan |
MAO-A, IC50: 58 μM |
