| S4527 |
Fenofibric acid |
Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides. |
Selective |
|
| S5121 |
Phytol |
Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα. |
Selective |
|
| S9674 |
Saroglitazar |
Saroglitazar (Lipaglyn, ZYH1) is an agonist of peroxisome proliferator-activated receptor (PPAR) with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively. |
Selective |
hPPARα, EC50: 0.65 pM |
| S8046 |
GW7647 |
GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively. |
Selective |
human PPARα, EC50: 6 nM |
| S0170 |
BMS-687453 |
BMS-687453 (compound 2) is a potent and selective agonist of PPARα with EC50 of 10 nM and IC50 of 260 nM for human PPARα. |
Selective |
PPARα, EC50: 10 nM; PPARα, IC50: 260 nM |
| S2798 |
GW6471 |
GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM. |
Selective |
PPARα, IC50: 0.24 μM |
| S8029 |
WY-14643 (Pirinixic Acid) |
WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM. |
Selective |
PPARα, EC50: 1.5 μM |
| S4708 |
Palmitoylethanolamide |
Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM. |
Selective |
PPARα, EC50: 3.1 μM |
| S1729 |
Gemfibrozil |
Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia. |
Selective |
|
| S1794 |
Fenofibrate |
Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy. |
Selective |
|
| S4207 |
Clofibric Acid |
Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent. |
Selective |
|
| S3720 |
Elafibranor |
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. |
Pan |
|
| S2915 |
GW9662 |
GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM in a cell-free assay, with at least 10- to 600-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. |
Pan |
PPARα, IC50: 32 nM |
| S9723 |
CDDO-Im |
CDDO-Im (CDDO-Imidazolide, RTA-403, TP-235) is an activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR). CDDO-Im binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. CDDO-Im inhibits inflammatory response and tumor growth in vivo. |
Pan |
PPARα, Ki: 232 nM |
| S3878 |
Bavachinin |
Bavachinin (7-O-Methylbavachin) is a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively). |
Pan |
PPARα, Ki: 7.881 μM |
