- S1PR1
- S1PR4
- S1PR5
- S1PR2
S1PR1 选择性激动剂 | 调节剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S7952 | Ozanimod | Ozanimod is a selective oral S1P Receptor 1 modulator. Phase 3. | Selective | S1P1R, EC50: 0.41 nM |
| S8241 | Ponesimod | Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. | Selective | S1P1 receptor, EC50: 5.7 nM |
| S7179 | Siponimod (BAF312) | BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3. | Pan | S1P1 receptor, EC50: 0.39 nM |
