| S2176 |
Tenovin-3 |
Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells. |
Selective |
|
| S8245 |
Thiomyristoyl |
Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM. |
Selective |
SIRT2, IC50: 28 nM |
| S7845 |
SirReal2 |
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
|
Selective |
SIRT2, IC50: 140 nM |
| S7577 |
AGK2 |
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. |
Selective |
SIRT2, IC50: 3.5 μM |
| S5914 |
AK 7 |
AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM. |
Selective |
SIRT2, IC50: 15.5 μM |
| S8628 |
3-TYP |
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
|
Pan |
SIRT2, IC50: 92 nM |
| S8942 |
Suramin sodium salt |
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). |
Pan |
SirT2, IC50: 1.15 μM |
| S4900 |
Tenovin-6 |
Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2. |
Pan |
SIRT2, IC50: 10 μM |
| S2804 |
Sirtinol |
Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. |
Pan |
SIRT2, IC50: 38 μM |
| S8627 |
OSS_128167 |
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication. |
Pan |
SIRT2, IC50: 751 μM |
| S1396 |
Resveratrol |
Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis. |
Pan |
|
| S8460 |
Salermide |
Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2. |
Pan |
|
