| S5894 |
Mirodenafil Dihydrochloride |
Mirodenafil Dihydrochloride(SK-3530 dihydrochloride) is an oral phosphodiesterase type 5 (PDE-5) inhibitor used to treat erectile dysfunction (ED). |
Selective |
|
| S4683 |
Sildenafil Mesylate |
Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. |
Selective |
|
| S5957 |
Vardenafil hydrochloride |
Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively. |
Selective |
PDE5, IC50: 0.7 nM |
| S2515 |
Vardenafil HCl Trihydrate |
Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
Selective |
PDE5, IC50: 0.7 nM |
| S4019 |
Avanafil |
Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. |
Selective |
PDE5, IC50: 1 nM |
| S1512 |
Tadalafil (IC351) |
Tadalafil (IC351) is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11 |
Selective |
PDE5, IC50: 1.8 nM |
| S4684 |
Sildenafil |
Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. |
Selective |
PDE5, IC50: 5.22 nM |
| S2312 |
Icariin |
Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4. |
Selective |
PDE5, IC50: 0.432 μM |
| S1431 |
Sildenafil Citrate |
Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction. |
Pan |
PDE5, IC50: 3.5 nM |
| S6433 |
Udenafil |
Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. |
Pan |
PDE5, IC50: 8.25 nM |
| S4837 |
Ibudilast |
Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities. |
Pan |
PDE5, IC50: 2.2 μM |
| S2320 |
Luteolin |
Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. |
Pan |
PDE5, Ki: 9.5 μM |
| S5836 |
IBMX |
IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist. |
Pan |
PDE5, IC50: 31.7 μM |
