Doxorubicin (DOX) HCl
别名: Adriamycin, NSC 123127, Hydroxydaunorubicin HCl 中文名称：盐酸多柔比星，盐酸阿霉素
Doxorubicin (DOX) HCl是一种抗生素类试剂，可抑制人类DNA topoisomerase I和topoisomerase II，IC50 分别为 0.8 μM 和 2.67 μM。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗，但是在免疫治疗中有将HBV重活化的风险。此产品溶解于PBS溶液可能会析出。推荐使用纯水配置母液，纯水或生理盐水稀释为工作液。
Doxorubicin (DOX) HCl Chemical Structure
CAS: 25316-40-9
产品质控
批次：
纯度：
99.82%
99.82
常与Doxorubicin (DOX) HCl一起在实验中被使用的化合物
5-氟尿嘧啶 (5-FU)、阿霉素以及丝裂霉素 (FAM) 通常被推荐用于原发灶不明的腺癌患者的经验性治疗。
聚乙二醇化脂质体阿霉素形式的阿霉素与奥拉帕尼一起用于治疗铂耐药性卵巢癌。
Doxorubicin (DOX) HCl相关产品
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| MFE-280 | Growth Inhibition Assay | IC50=1.66812 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=1.66343 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=1.65305 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=1.63084 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=1.61711 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=1.57026 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=1.53055 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=1.49429 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=1.47168 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=1.45942 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=1.43159 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=1.42066 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=1.37129 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=1.34337 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=1.32145 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=1.2748 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=1.26763 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=1.23742 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=1.23083 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.06036 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=1.04568 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=1.00076 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=989.42 nM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=981.31 nM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=957.22 nM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=914.35 nM | SANGER | ||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=901.35 nM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=900.87 nM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=898.11 nM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=873.52 nM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=871.87 nM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=861.48 nM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=856.34 nM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=855.26 nM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=840.67 nM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=804.65 nM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=790.9 nM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=778.81 nM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=725.12 nM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=703.94 nM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=698.15 nM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=689.95 nM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=678.08 nM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=665.83 nM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=662.55 nM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=639.4 nM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=556.49 nM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=548.01 nM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=540.83 nM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=527.24 nM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=521.83 nM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=513.16 nM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=501.81 nM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=499.01 nM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=493.21 nM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=479.92 nM | SANGER | ||
| C-4-II | Growth Inhibition Assay | IC50=472.56 nM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=469.81 nM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=469.69 nM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=460.97 nM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=425.05 nM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=418.06 nM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=405.15 nM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=405.05 nM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=395.92 nM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=394.87 nM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=392.94 nM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=391.41 nM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=384.51 nM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=381.86 nM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=375.48 nM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=372.72 nM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=370.04 nM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=363.23 nM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=362.05 nM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=361.52 nM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=359.81 nM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=359.59 nM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=354.27 nM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=353.87 nM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=346.4 nM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=346.04 nM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=344.92 nM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=341.56 nM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=335.43 nM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=334.64 nM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=323.35 nM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=315.11 nM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=313.44 nM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=311.14 nM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=305.52 nM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=300.73 nM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=294.55 nM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=290.7 nM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=290.5 nM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=283.92 nM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=281.52 nM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=279.89 nM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=277.12 nM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=266.61 nM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=260.77 nM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=258.44 nM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=257.47 nM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=250.77 nM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=248.71 nM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=248.5 nM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=238.31 nM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=236.12 nM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=236.08 nM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=235.11 nM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=234.1 nM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=222.83 nM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=220.22 nM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=219.79 nM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=218.4 nM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=217.61 nM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=215.79 nM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=215 nM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=213.49 nM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=212.73 nM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=201.9 nM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=200.26 nM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=200.18 nM | SANGER | ||
| IPC-298 | Growth Inhibition Assay | IC50=196.21 nM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=193.41 nM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=192.2 nM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=192.13 nM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=189.01 nM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=188.92 nM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=186.08 nM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=182.49 nM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=182.83 nM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=171.8 nM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=169.13 nM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=164.87 nM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=162.48 nM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=161.71 nM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=160.47 nM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=160.38 nM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=160.32 nM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=159.7 nM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=159.33 nM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=158.34 nM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=156.78 nM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=153.73 nM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=152.24 nM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=149.31 nM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=148.65 nM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=147.61 nM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=147.31 nM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=139.5 nM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=139.13 nM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=137.8 nM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=136.88 nM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=135.16 nM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=135.02 nM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=133.21 nM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=133.04 nM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=132.65 nM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=131.94 nM | SANGER | ||
| SK-CO-1 | Growth Inhibition Assay | IC50=129.21 nM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=127.7 nM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=126.76 nM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=126.42 nM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=122.22 nM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=122.08 nM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=121.72 nM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=120.81 nM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=118.48 nM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=116.81 nM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=117.95 nM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=116.26 nM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=115.84 nM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=115.26 nM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=114.45 nM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=112.68 nM | SANGER | ||
| EHEB | Growth Inhibition Assay | IC50=112.59 nM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50=110.87 nM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=109.99 nM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=109.92 nM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=109.34 nM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=109.24 nM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=108.01 nM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=107.95 nM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=106.48 nM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=104.58 nM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=104.51 nM | SANGER | ||
| NCI-H1618 | Growth Inhibition Assay | IC50=104.35 nM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=103.46 nM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=102.5 nM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=102.25 nM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=102.18 nM | SANGER | ||
| MES-SA | Growth Inhibition Assay | IC50=99.53 nM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=99.09 nM | SANGER | ||
| LS-441N | Growth Inhibition Assay | IC50=99.06 nM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=97.99 nM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=98.24 nM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=97.44 nM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=96.9 nM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=96.31 nM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=95.12 nM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=93.33 nM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=93.26 nM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=90.68 nM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=84.47 nM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=83.45 nM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=83.01 nM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=81.82 nM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=81.51 nM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=81.06 nM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=80.55 nM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=79.72 nM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=79.2 nM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=79.14 nM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=78.9 nM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=78.45 nM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=77.42 nM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=76.35 nM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=74.53 nM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=73.81 nM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=73.73 nM | SANGER | ||
| Calu-1 | Growth Inhibition Assay | IC50=73.6 nM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=72.93 nM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=72.54 nM | SANGER | ||
| MFE-296 | Growth Inhibition Assay | IC50=70.49 nM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=71.56 nM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=69.95 nM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=68.4 nM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=67.9 nM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=67.87 nM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=67.28 nM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=67.68 nM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=64.89 nM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=64.64 nM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=64019 nM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=63.95 nM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=63.54 nM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=55.98 nM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=53.86 nM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=53.22 nM | SANGER | ||
| NCI-H1734 | Growth Inhibition Assay | IC50=53 nM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=52.5 nM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=52.22 nM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=51.93 nM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=51.76 nM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=51.76 nM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=51.48 nM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=49.34 nM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=49.27 nM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=49.12 nM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=49.08 nM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=49.03 nM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=48.74 nM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=45.99 nM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=45.29 nM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=45.2 nM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=45.05 nM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=44.84 nM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=44.84 nM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=44.71 nM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=44.52 nM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=44.48 nM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=43.76 nM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=43.66 nM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=42.5 nM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=39.65 nM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=39.36 nM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=39.22 nM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=38.44 nM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=37.9 nM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=37.73 nM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=37.48 nM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=37.59 nM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=37.32 nM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=36.57 nM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=36.25 nM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=35.88 nM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=35.8 nM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=35.61 nM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=33.83 nM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=33.87 nM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=33.73 nM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=33.61 nM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=33.36 nM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=32.92 nM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=32.89 nM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=32.57 nM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=31.96 nM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=31.91 nM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=31.87 nM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=31.5 nM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=31.37 nM | SANGER | ||
| EW-7 | Growth Inhibition Assay | IC50=30.63 nM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=30.2 nM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=29.33 nM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=28.26 nM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=28.16 nM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=28.88 nM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=27.78 nM | SANGER | ||
| COLO-205 | Growth Inhibition Assay | IC50=26.99 nM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=26.9 nM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=26.78 nM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=26.63 nM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=25.86 nM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=25.72 nM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=25.69 nM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=24.41 nM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=24.14 nM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=23.81 nM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=22.86 nM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=22.28 nM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=22.12 nM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=22.12 nM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=21.58 nM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=21.07 nM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=20.87 nM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=20.76 nM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=20.74 nM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=20.72 nM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=20.65 nM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=20.13 nM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=19.99 nM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=19.56 nM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=19.14 nM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=19.09 nM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=18.91 nM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=18.81 nM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=18.77 nM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=18.76 nM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=18.63 nM | SANGER | ||
| SNG-M | Growth Inhibition Assay | IC50=18.32 nM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=18.46 nM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=3.44 nM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=2.12 nM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=1.91 nM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=1.37 nM | SANGER | ||
| IMR32 | Cytotoxic Assay | 250 μM | 48 h | IC50=0.0051 μM | 24996140 |
| Saos2 | Growth Inhibition Assay | 40 μM | 24 h | IC50=0.33 μM | 24941130 |
| KCL22 | Growth Inhibition Assay | 48 h | IC50=1.8 μM | 24941129 | |
| YOYO1 | Function Assay | Displacement of YOYO1 from phage lambda DNA with IC50 of 0.6 μM | 24900668 | ||
| DA-3 | Function Assay | 10 μM | 10 h | Cellular uptake in mouse DA-3 cell nucleus | 24900668 |
| DA-3 | Function Assay | 10 μM | 10 h | Cellular uptake in mouse DA-3 cell lysosome | 24900668 |
| NAR | Cytotoxic Assay | 100 μM | 24 h | Cytotoxicity against doxorubicin-resistant human NAR cells assessed as cell viability | 24900344 |
| NAR | Cytotoxic Assay | 10 μM | 24 h | Cytotoxicity assessed as induction of cell death | 24900344 |
| NAR | Function Assay | 5 μM | 2 h | Drug uptake in doxorubicin-resistant human NAR cell plasma membrane | 24900344 |
| HT-29 | Function Assay | 5 μM | 1 h | Induction of nitrite production in doxorubicin-resistant human HT-29 cells | 24900337 |
| HT-29 | Function Assay | 5 μM | 24 h | Inhibition of MRP3 in doxorubicin-resistant human HT-29 cells assessed as nitration of tyrosine residues | 24900337 |
| HT-29 | Function Assay | 25 μM | 24 h | Inhibition of MRP3-mediated drug resistance in doxorubicin-resistant human HT-29 cells assessed as increase in drug accumulation | 24900337 |
| A431 | Cytotoxic Assay | IC50=0.00135 μM | 24890652 | ||
| L1210 | Function Assay | Inhibition of RNA synthesis with ED50 of 0.58 μM | 490536 | ||
| N417 | Growth Inhibition Assay | IC50=0.23 μM | 1479585 | ||
| H9 | Growth Inhibition Assay | Inhibition of H9 cells chronically infected with the HIV-1 (H9/IIIB) with ID50 of 0.01 μM | 1548681 | ||
| T-C8166 | Growth Inhibition Assay | ID50=0.01 μM | 1548681 | ||
| T-H9 | Growth Inhibition Assay | ID50=0.01 μM | 1548681 | ||
| T-MT4 | Growth Inhibition Assay | ID50=0.01 μM | 1548681 | ||
| SKMEL-5 | Growth Inhibition Assay | ED50=3.2 μM | 1613753 | ||
| MLM | Cytotoxic Assay | ED50=0.13 μM | 1875350 | ||
| KBM-3 | Growth Inhibition Assay | IC50=0.026 μM | 1995877 | ||
| HT-29 | Growth Inhibition Assay | 0.01 μg | 48 h | Antiproliferative activity | 2778449 |
| EAC | Cytotoxic Assay | 72 h | IC50=0.35 μM | 8350087 | |
| SKVLB | Cytotoxic Assay | IC50=5.6 μM | 8576914 | ||
| AUC375 | Growth Inhibition Assay | IC50=0.112 μM | 8648600 | ||
| A2780-C25 | Cytotoxic Assay | Cytotoxicity against A2780-C25 with IC50 of 0.063 μM | 8831755 | ||
| A2780-CP3 | Cytotoxic Assay | Cytotoxicity against A2780-CP3 with IC50 of 0.056 μM | 8831755 | ||
| MXF7 | Cytotoxic Assay | Antitumor activity against sensitive MXF7 with IC50 of 0.028 μM | 8960558 | ||
| MXF7 | Cytotoxic Assay | Antitumor activity against MXF7 with IC50 of 0.028 μM | 8960558 | ||
| MXF7 | Cytotoxic Assay | Antitumor activity against doxorubicin-resistant MXF7 with IC50 of 1.172 μM | 8960558 | ||
| MCF | Function Assay | Reversal of P-gp-mediated multidrug resistance assessed as enhancement in cytotoxicity of adriamycin | 8984151 | ||
| C6 | Cytotoxic Assay | 2.5 mg/mL | 72 h | Cytotoxicity against rat C6 cells at 50 ug/mL to 2.5 mg/mL | 8988604 |
| C6 | Function Assay | 2.5 mg/mL | 4 h | Inhibition of tubulin polymerization | 8988604 |
| Panc02 | Growth Inhibition Assay | 10 μM | 6 d | IC50=0.065 μM | 9526570 |
| PC14 | Cytotoxic Assay | 4 d | IC50=0.29 μM | 9822542 | |
| HOP62 | Cytotoxic Assay | 72 h | IC50=0.004 μM | 9873661 | |
| SF-295 | Cytotoxic Assay | 72 h | IC50=0.035 μM | 9873661 | |
| MDA-MB-361 | Cytotoxic Assay | 1 h | Cytotoxicity against MDA-MB-361 expressing LacZ with IC50 of 0.012 μM | 10395490 | |
| MDA-MB-361 | Cytotoxic Assay | 1 h | Cytotoxicity against MDA MB 361 expressing carboxypeptidase stCPG2 with IC50 of 0.018 μM | 10395490 | |
| CCRF-SB | Growth Inhibition Assay | 4 d | IC50=0.01 μM | 10411476 | |
| CHO-K1 | Growth Inhibition Assay | 4 d | IC50=0.4 μM | 10411476 | |
| KB | Growth Inhibition Assay | 4 d | Antiproliferative activity against drug-resistant KBCampwith IC50 of 0.06 μM | 10411476 | |
| KB | Growth Inhibition Assay | 4 d | Antiproliferative activity against drug-resistant KBMDR with IC50 of 0.5 μM | 10411476 | |
| KB | Growth Inhibition Assay | 4 d | Antiproliferative activity against drug-resistant KBV20C with IC50 of 0.4 μM | 10411476 | |
| HTB-54 | Cytotoxic Assay | 100 μM | IC50=1.1 μM | 10476861 | |
| MEL-AC | Cytotoxic Assay | 100 μM | IC50=1.2 μM | 10476861 | |
| DU145 | Cytotoxic Assay | 72 h | IC50=0.0528 μM | 10479282 | |
| K562R | Cytotoxic Assay | 72 h | IC50=0.0156 μM | 10479282 | |
| PACA-2 | Cytotoxic Assay | 6 d | ED50=0.0063 μM | 10498214 | |
| 3Y1 | Cytotoxic Assay | 72 h | GI50=0.0038 μM | 10691710 | |
| P388 | Cytotoxic Assay | 72 h | GI50=0.012 μM | 10691710 | |
| HMV-1 | Growth Inhibition Assay | IC50=0.28 μM | 10698436 | ||
| MKN-1 | Growth Inhibition Assay | IC50=0.64 μM | 10698436 | ||
| PC14 | Growth Inhibition Assay | IC50=1.9 μM | 10698436 | ||
| T24 | Growth Inhibition Assay | IC50=0.64 μM | 10698436 | ||
| H460pv8/eto | Cytotoxic Assay | 100 μM | 48 h | IC50=0.02 μM | 10780913 |
| H460pv8 | Cytotoxic Assay | 100 μM | 48 h | IC50=0.004 μM | 10780913 |
| MDA-468 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against MDA-468 cell (ER-, amplified EGFR, mutant p53) with IC50 of 0.005 μM | 10780913 |
| NCI-H226 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against NCI-H226 cell (mutant p53) with IC50 of 0.008 μM | 10780913 |
| NCI-H322 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against NCI-H322 cell (mutant p53) with IC50 of 0.03 μM | 10780913 |
| NCI-H358 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against NCI-H358 cell (mutant p53) with IC50 of 0.13 μM | 10780913 |
| NCI-H647 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against NCI-H647 cell (mutant p53) with IC50 of 0.001 μM | 10780913 |
| SKBR-3 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against SKBR-3 cell (ER-amplified erB2,mutant p53) with IC50 of 0.02 μM | 10780913 |
| T47D | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against T47D cell (ER+,mutant p53) with IC50 of 0.007 μM | 10780913 |
| ZR-75-1 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against ZR-75-1 cell (ER+,pgr+,mutant p53) with IC50 of 0.009 μM | 10780913 |
| L1210 | Cytotoxic Assay | IC50=0.025 μM | 10890167 | ||
| D40 | Cytotoxic Assay | 24 h | IC50=1.172 μM | 10956214 | |
| OVCAR-3 | Cytotoxic Assay | 24 h | IC50=0.035 μM | 10956214 | |
| UA375 | Cytotoxic Assay | 24 h | IC50=0.112 μM | 10956214 | |
| CH1 | Cytotoxic Assay | 96 h | IC50=0.0063 μM | 11123989 | |
| RENCA | Growth Inhibition Assay | 48 h | IC50<0.01 μM | 11454467 | |
| CNS | Growth Inhibition Assay | 48 h | GI50=0.064 μM | 11473418 | |
| LoVo | Cytotoxic Assay | 10 μM | Cytotoxicity against LoVo sensitive cell with IC50 of 0.008 μM | 11606141 | |
| T24 | Cytotoxic Assay | 10 μM | Cytotoxicity against T24 sensitive cell with IC50 of 0.02 μM | 11606141 | |
| U373 | Cytotoxic Assay | 10 μM | Cytotoxicity against U373 sensitive cell with IC50 of 0.01 μM | 11606141 | |
| U87 | Cytotoxic Assay | 10 μM | Cytotoxicity against U87 sensitive cell with IC50 of 0.06 μM | 11606141 | |
| U87 | Cytotoxic Assay | 10 μM | Cytotoxicity against U87 resistant cell with IC50 of 0.14 μM | 11606141 | |
| UACC62 | Cytotoxic Assay | 3-5 m | GI50=0.094 μM | 11678649 | |
| COR-L23 | Cytotoxic Assay | 5-6 d | IC50=0.0201 μM | 11806724 | |
| H69P | Cytotoxic Assay | 5-6 d | IC50=0.0273 μM | 11806724 | |
| SK-MES-1 | Cytotoxic Assay | 6 d | IC50=0.03 μM | 12431048 | |
| Hep-2 | Growth Inhibition Assay | 96 h | IC50=0.04 μM | 12431049 | |
| Raji | Growth Inhibition Assay | 96 h | IC50=0.03 μM | 12431049 | |
| Wil-NS | Growth Inhibition Assay | 96 h | IC50=0.02 μM | 12431049 | |
| 2SC/20 | Growth Inhibition Assay | 72 h | IC50=0.62 μM | 12431060 | |
| HET-SR-2SC-LNM | Growth Inhibition Assay | 72 h | IC50=0.052 μM | 12431060 | |
| L1210 | Cytotoxic Assay | 48 h | IC50=0.025 μM | 12443763 | |
| LXFL529 | Growth Inhibition Assay | 36 h | IC50=0.04 μM | 12459020 | |
| 8226/S | Cytotoxic Assay | 72 h | Cytotoxity against 8226/S | 12570378 | |
| Jurkat | Growth Inhibition Assay | 72 h | IC50=0.0096 μM | 12620081 | |
| P388 | Growth Inhibition Assay | 72 h | IC50=0.015 μM | 12620081 | |
| L2987 | Cytotoxic Assay | IC50=0.3 μM | 12798317 | ||
| 401NL | Growth Inhibition Assay | 72 h | IC50=0.01 μM | 12852768 | |
| LXF529L | Growth Inhibition Assay | 72 h | IC50=0.03 μM | 12852768 | |
| LXF629L | Growth Inhibition Assay | 72 h | IC50=0.07 μM | 12852768 | |
| RXF944L | Growth Inhibition Assay | 72 h | IC50=0.06 μM | 12852768 | |
| MEL-28 | Cytotoxic Assay | IC50=0.03 μM | 15225700 | ||
| MES-SA | Cytotoxic Assay | IC50=0.016 μM | 16169719 | ||
| MESSA/DX5 | Cytotoxic Assay | Cytotoxicity against multidrug-resistant MES-SA/Dx5 cells with IC50 of 1.56 μM | 16169719 | ||
| VA13 | Growth Inhibition Assay | 48 h | IC50=0.22 μM | 16499322 | |
| C8166 | Growth Inhibition Assay | 96 h | IC50=0.02 μM | 16913700 | |
| G361 | Growth Inhibition Assay | 96 h | IC50=0.09 μM | 16913700 | |
| Wil2-NS | Growth Inhibition Assay | 96 h | IC50=0.02 μM | 16913700 | |
| BC | Cytotoxic Assay | IC50=0.288 μM | 16933890 | ||
| H9c2 | Growth Inhibition Assay | 24 h | IC50=0.01995 μM | 17125253 | |
| SK-HEP-1 | Growth Inhibition Assay | 24 h | IC50=0.05012 μM | 17125253 | |
| Vero | Cytotoxic Assay | 24 h | IC50=0.50119 μM | 17125253 | |
| A2780 | Growth Inhibition Assay | 1 μM | 4 d | Inhibition of A2780 cell growth with IC50 of 0.003 μM | 17125254 |
| MDA-MB-231 | Cytotoxic Assay | 72 h | IC50=0.03 μM | 17141923 | |
| 2780AD | Cytotoxic Assay | 10 μM | Cytotoxicity againt multidrug-resistant human 2780AD cells with IC50 of 0.909 μM | 17239597 | |
| CEM/VLB100 | Cytotoxic Assay | 72 h | Cytotoxicity against CEM/VLB100 cells with IC50 of 3.71 μM | 17323939 | |
| KB-VIN | Cytotoxic Assay | 72 h | Cytotoxicity against human multidrug-resistant KB-VIN cells with EC50 of 1.7 μM | 17378530 | |
| PC3 | Function Assay | 20 nM | 72 h | Induction of senescence in human PC3 cells | 17658777 |
| BxPc3 | Growth Inhibition Assay | 3 h | IC50=0.31623 μM | 17696516 | |
| IGROVI | Growth Inhibition Assay | 48 h | IC50=0.10965 μM | 17696516 | |
| RXF393 | Growth Inhibition Assay | 48 h | IC50=0.17783 μM | 17696516 | |
| UACC257 | Growth Inhibition Assay | 48 h | IC50=0.20893 μM | 17696516 | |
| MIAPaCa2 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.024 μM | 17935309 |
| WI38 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.1 μM | 17935309 |
| KB3.1 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.0004 μM | 17949859 |
| 2780.9S | Cytotoxic Assay | 100 μM | 96 h | Cytotoxicity against human 2780.9S cells under deem light with IC50 of 15 μM | 17993275 |
| Daudi | Cytotoxic Assay | 100 μM | 96 h | Cytotoxicity against human Daudi cells under deem light with IC50 of 0.3 μM | 17993275 |
| W301 | Growth Inhibition Assay | 50 mM | 48 h | Growth inhibition of Saccharomyces cerevisiae W301 with IC50 of 10 μM | 18040043 |
| SF268 | Growth Inhibition Assay | 72 h | IC50=0.04 μM | 18052326 | |
| SNU638 | Growth Inhibition Assay | 72 h | IC50=0.07 μM | 18063366 | |
| U373MG | Growth Inhibition Assay | 24 h | Growth inhibition of human U373MG cells containing U373IRES plasmid with IC50 of 0.15849 μM | 18173233 | |
| U373MG | Growth Inhibition Assay | 24 h | Growth inhibition of human U373MG cells containing UhCE1 expressing plasmid with IC50 of 0.15849 μM | 18173233 | |
| SJSA1 | Cytotoxic Assay | 1 μM | 6 h | Cytotoxicity against human SJSA1 cells expressing GRP78 with IC50 of 0.0062 μM | 18243696 |
| PC3M | Growth Inhibition Assay | 72 h | IC50=1.11 μM | 18247573 | |
| SNU638 | Cytotoxic Assay | 72 h | IC50=0.052 μM | 18321715 | |
| MCF7/DX | Cytotoxic Assay | 24 h | Cytotoxicity against human doxorubicin-resistant MCF7/Dx cells with IC50 of 5.3 μM | 18429610 | |
| Colon 26-L5 | Cytotoxic Assay | 72 h | IC50=0.01 μM | 18440233 | |
| LLC | Cytotoxic Assay | 72 h | IC50=0.01 μM | 18440233 | |
| AW8507 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.17 μM | 18657979 |
| Jurkat | Cytotoxic Assay | 72 h | IC50=0.03 μM | 18783950 | |
| MRC5 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 18783950 | |
| DU145 | Cytotoxic Assay | 25 μg/mL | 72 h | IC50=0.0039 μM | 18829316 |
| Bel7402 | Cytotoxic Assay | 72 h | IC50=0.021 μM | 19028425 | |
| HT-29 | Cytotoxic Assay | 72 h | IC50=0.018 μM | 19028425 | |
| HT-29 | Growth Inhibition Assay | 96 h | IC50=0.002 μM | 19053767 | |
| MT4 | Growth Inhibition Assay | 96 h | IC50=0.003 μM | 19053767 | |
| XF498 | Growth Inhibition Assay | 96 h | IC50=0.16 μM | 19053767 | |
| A2780/DX3 | Function Assay | 10 μM | 2 h | Reversal of P-gp 170-mediated multidrug resistance assessed as increase in intracellular doxorubicin accumulation | 19093883 |
| HL60 | Cytotoxic Assay | 100 μM | 72 h | IC50=0.018 μM | 19136263 |
| Hs888Lu | Cytotoxic Assay | 72 h | IC50=1.4 μM | 19186946 | |
| MEF | Cytotoxic Assay | 72 h | IC50=3.4 μM | 19186946 | |
| SNU398 | Apoptosis Assay | 10 μM | 48 h | Induction of apoptosis assessed as caspase activation with EC50 of 0.39 μM | 19282188 |
| NH32 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in p53 deficient human NH32 cells assessed as increase in cleaved caspase 3 level | 19349174 |
| NH32 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in p53 deficient human NH32 cells assessed as increase in PARP cleavage | 19349174 |
| TK6 | Function Assay | 0.1 μM | 8 h | Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 | 19349174 |
| TK6 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in cleaved caspase 3 level | 19349174 |
| TK6 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as increase in PARP cleavage | 19349174 |
| TK6 | Function Assay | 25 μM | 8 h | Induction of p53 phosphorylation at Ser15 in human TK6 cells expressing wild type p53 | 19349174 |
| WTK1 | Function Assay | 0.1 μM | 8 h | Induction of p53 phosphorylation at Ser15 in human WTK1 cells expressing p53 M237I mutant | 19349174 |
| WTK1 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as decrease in pro-caspase 3 level | 19349174 |
| WTK1 | Function Assay | 0.1 μM | 8 h | Induction of p53 transcriptional activity in human WTK1 cells expressing p53 M237I mutant assessed as p21-Cip1/Waf1 expression | 19349174 |
| WTK1 | Function Assay | 25 μM | 8 h | Induction of p53 transcriptional activity in human WTK1 cells expressing p53 M237I mutant assessed as p21-Cip1/Waf1 expression | 19349174 |
| PA1 | Cytotoxic Assay | 10 μM | 72 h | IC50=0.63 μM | 19361894 |
| A431 | Growth Inhibition Assay | GI50=0.0012 μM | 19394218 | ||
| A549 | Growth Inhibition Assay | GI50=0.003 μM | 19394218 | ||
| MESSA | Growth Inhibition Assay | GI50=0.0051 μM | 19394218 | ||
| SKOV3 | Growth Inhibition Assay | GI50=0.021 μM | 19394218 | ||
| MDA-MB-231 | Growth Inhibition Assay | 200 μM | 48 h | Antitumor activity against human estrogen receptor deficient MDA-MB-231 cells with GI50 of 0.01086 μM | 19428155 |
| SNU1 | Cytotoxic Assay | IC50=4 μM | 19585998 | ||
| SK-N-SH | Apoptosis Assay | 5 μM | Induction of apoptosis at 0.5 to 5 uM | 19631549 | |
| IMR90 | Growth Inhibition Assay | 72 h | IC50=1 μM | 19632833 | |
| L78 | Growth Inhibition Assay | 72 h | IC50=2.4 μM | 19632833 | |
| IMR32 | Growth Inhibition Assay | 48 h | IC50=1.7 μM | 19939522 | |
| MCF10A | Cytotoxic Assay | 40 μM | 48 h | IC50=0.18 μM | 20064676 |
| MESSA | Function Assay | 50 μM | 2 h | Induction of DNA damage assessed as increase in comet-tail length | 20151639 |
| MESSA | Function Assay | 25 μM | 2 h | Cellular uptake | 20151639 |
| PCO3 | Cytotoxic Assay | 250 μg/mL | 48 h | GI50=0.17 μM | 20413188 |
| A2780/ADR | Cytotoxic Assay | IC50=0.194 μM | 21774499 | ||
| LAMA-84 | Cytotoxic Assay | 48 h | IC50=0.74 μM | 21797280 | |
| SH-SY5Y | Cytotoxic Assay | 48 h | IC50=0.5 μM | 21797280 | |
| Ca9-22 | Cytotoxic Assay | 72 h | IC50=0.26 μM | 21800859 | |
| K562/A02 | Cytotoxic Assay | 48 h | IC50=17.84 μM | 21843940 | |
| BT20 | Growth Inhibition Assay | 10 μM | 72 h | Antiproliferative activity | 21852023 |
| AGS | Growth Inhibition Assay | 48 h | GI50=0.01 μM | 21875046 | |
| PC3 | Growth Inhibition Assay | 48 h | GI50=0.09 μM | 21875046 | |
| Neuro2a | Cytotoxic Assay | 72 h | IC50=1.2 μM | 21996519 | |
| MCF7 | Function Assay | 50 μg/mL | 48 h | Reduction in CYP19 mRNA expression | 22000946 |
| MCF7 | Function Assay | 50 μg/mL | 48 h | Reduction in AP-2 gamma mRNA expression | 22000946 |
| HCT8 | Cytotoxic Assay | 5 μg/mL | 72 h | IC50=0.02 μM | 22000949 |
| BGC823 | Cytotoxic Assay | 96 h | IC50=0.98 μM | 22070654 | |
| PC3M | Cytotoxic Assay | 72 h | IC50=0.24 μM | 22264149 | |
| LNcaP | Apoptosis Assay | 20 μg/mL | 24 h | Induction of apoptosis assessed as increase in caspase 3/7 activation | 22264758 |
| SKOV3 | Function Assay | 5 μM | 1 h | Cellular uptake in doxorubicin-resistant human SKOV3 cells | 22276998 |
| B16 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 22330634 | |
| SiHa | Growth Inhibition Assay | GI50=0.14 μM | 22361684 | ||
| SK-N-SH | Cytotoxic Assay | 48 h | IC50=0.97 μM | 22386528 | |
| HuH7 | Growth Inhibition Assay | 25 ng/mL | 72 h | Antiproliferative activity assessed as inhibition of BrdU incorporation | 22409771 |
| LLC | Growth Inhibition Assay | 48 h | IC50=0.207 μM | 22515366 | |
| NCI-H290 | Growth Inhibition Assay | 2 μM | 48 h | IC50=0.32 μM | 22515366 |
| U87MG | Growth Inhibition Assay | 2 μM | 48 h | IC50=0.79 μM | 22515366 |
| KB/VCR | Cytotoxic Assay | 500 μM | 48 h | IC50=0.45 μM | 22537362 |
| SMMC7721 | Cytotoxic Assay | 500 μM | 48 h | IC50=0.37 μM | 22537362 |
| 786-0 | Growth Inhibition Assay | 25 μg/mL | 48 h | IC50=2.1 μM | 22537680 |
| NCI/ADR | Growth Inhibition Assay | 25 μg/mL | 48 h | IC50=13.5 μM | 22537680 |
| MKN45 | Cytotoxic Assay | 48 h | IC50=0.168 μM | 22647723 | |
| SKLU1 | Cytotoxic Assay | 48 h | IC50=0.0067 μM | 22858298 | |
| MESSA/DX5 | Growth Inhibition Assay | 100 μg/mL | 72 h | IC50=0.25 μM | 22944121 |
| A549 | Cytotoxic Assay | IC50=0.001 μM | 22951040 | ||
| HL60/A | Cytotoxic Assay | 18 h | IC50=6.7 μM | 22985027 | |
| MG63 | Cytotoxic Assay | IC50=2.7 μM | 23043498 | ||
| BALB/3T3 | Cytotoxic Assay | 100 μg/mL | 72 h | IC50=1.91 μM | 23079523 |
| A673 | Cytotoxic Assay | 72 h | Cytotoxicity against human A673 cells after 72 hrs by resazurin/resorufin-based fluorescence assay with IC50 of 0.17 μM | 23600925 | |
| U266 | Cytotoxic Assay | 72 h | IC50=0.67 μM | 23600925 | |
| MALME-3M | Cytotoxic Assay | 100 μM | 48 h | GI50=0.12 μM | 23871905 |
| NCI-H226 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.05 μM | 23871905 |
| SN12C | Cytotoxic Assay | 100 μM | 48 h | GI50=0.07 μM | 23871905 |
| SNB19 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.04 μM | 23871905 |
| SNB75 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.07 μM | 23871905 |
| SR | Cytotoxic Assay | 100 μM | 48 h | GI50=0.03 μM | 23871905 |
| TK10 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.18 μM | 23871905 |
| U251 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.04 μM | 23871905 |
| UACC257 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.14 μM | 23871905 |
| UO31 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.49 μM | 23871905 |
| HaCaT | Growth Inhibition Assay | 25 μg/mL | 48 h | TGI50=0.4 μM | 23876338 |
| H9c2 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intramitochondrial ROS level | 23973213 |
| H9c2 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intracellular malonyldialdehyde level | 23973213 |
| MCF7 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intramitochondrial ROS level | 23973213 |
| MCF7 | Function Assay | 5 μM | 24 h | Cellular uptake | 23973213 |
| MCF7 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intracellular malonyldialdehyde level | 23973213 |
| MCF7 | Function Assay | 5 μM | 24 h | Cellular uptake | 23973213 |
| MDA-MB-231 | Function Assay | 5 μM | 24 h | Cellular uptake | 23973213 |
| MDA-MB-231 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intracellular malonyldialdehyde level | 23973213 |
| MDA-MB-231 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intramitochondrial ROS level | 23973213 |
| KB/HeLa | Cytotoxic Assay | 45 h | EC50=0.25 μM | 23988351 | |
| HUVEC | Cytotoxic Assay | 48 h | IC50=0.0807 μM | 24012378 | |
| HepG2 | Function Assay | 40 μg/mL | 48 h | Inhibition of TRK with IC50 of 0.0025 μM | 24013411 |
| MRC5 | Growth Inhibition Assay | 72 h | IC50=0.1 μM | 24021462 | |
| HUVEC | Function Assay | 5 μM | 2 h | Cellular uptake | 24028446 |
| MDA-MB-435 | Cytotoxic Assay | 100 μM | 48 h | IC50=0.15 μM | 24028446 |
| AS49-RAW | Cytotoxic Assay | 100 μM | 48 h | IC50=32.78 μM | 24077528 |
| Caov3 | Growth Inhibition Assay | 72 h | IC50=0.1 μM | 24095089 | |
| LNcaP | Function Assay | 3 μM | 24 h | Increase of cleaved caspase-9 level | 24095089 |
| LNcaP | Function Assay | 3 μM | 24 h | Up-regulation of p53 expression | 24095089 |
| SGC7901 | Cytotoxic Assay | IC50=0.011 μM | 24195466 | ||
| Bel7402 | Growth Inhibition Assay | 96 h | IC50=0.5782 μM | 24211639 | |
| CHP100 | Cytotoxic Assay | 72 h | IC50=0.79 μM | 24251417 | |
| MGC803 | Cytotoxic Assay | 72 h | IC50=0.17 μM | 24370114 | |
| ME180 | Cytotoxic Assay | 48 h | IC50=0.39 μM | 24487188 | |
| L929 | Cytotoxic Assay | 1.10 μM | 72 h | IC50=0.16 μM | 24530030 |
| MX1 | Cytotoxic Assay | 1.10 μM | 72 h | IC50=0.5 μM | 24530030 |
| V79 | Cytotoxic Assay | 1.10 μM | 72 h | IC50=0.24 μM | 24530030 |
| CCRF-CEM | Cytotoxic Assay | IC50=0.009 μM | 24561670 | ||
| LC-1F | Growth Inhibition Assay | IC50=1.66203 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=1.47841 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=1.33771 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=1.019 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=1.01762 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=971.53 nM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=970.4 nM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=942.3 nM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=905.27 nM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=777.52 nM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=771.02 nM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=737.95 nM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=631.74 nM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=625.95 nM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=605.37 nM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=604.6 nM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=598.27 nM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=591.47 nM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=581.07 nM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=579.87 nM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=576.32 nM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=573.69 nM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=572.43 nM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=570.15 nM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=568.8 nM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=568.59 nM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=521.51 nM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=517.42 nM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=513.98 nM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=478.27 nM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=470.41 nM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=451.49 nM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=440.67 nM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=437.3 nM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=430.11 nM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=427.18 nM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=426.02 nM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=416.64 nM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=415.79 nM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=413.1 nM | SANGER | ||
| Caov-3 | Growth Inhibition Assay | IC50=406.19 nM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=396.31 nM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=389.19 nM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=385.8 nM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=361.85 nM | SANGER | ||
| MHH-CAL-2 | Growth Inhibition Assay | IC50=359.21 nM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=344.64 nM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=342.01 nM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=331.28 nM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=329.94 nM | SANGER | ||
| DV-90 | Growth Inhibition Assay | IC50=329.45 nM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=325.41 nM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=324.43 nM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=321.64 nM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=321.17 nM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=292.65 nM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=290.32 nM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=285.56 nM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=274.78 nM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=272.79 nM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=256.91 nM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=255.42 nM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=253.55 nM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=252.53 nM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=250.9 nM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=250.13 nM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=245.48 nM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=242.67 nM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=242.17 nM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=241.46 nM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=240.89 nM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=240.88 nM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=234.27 nM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=230.72 nM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=230.3 nM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=229.82 nM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=229.37 nM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=229.15 nM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=228.49 nM | SANGER | ||
| NCI-H838 | Growth Inhibition Assay | IC50=224.73 nM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=224.66 nM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=224.43 nM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=218.15 nM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=213.37 nM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=212.58 nM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=210.96 nM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=207.39 nM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=206.25 nM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=204.47 nM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=194.58 nM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=188.24 nM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=188.09 nM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=183.71 nM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=181.66 nM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=180.1 nM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=178.84 nM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=176.6 nM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=175.47 nM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=175.15 nM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=172.94 nM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=172.17 nM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=165.86 nM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=165.55 nM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=156.4 nM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=155.34 nM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=154.58 nM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=154.36 nM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=153.84 nM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=146.55 nM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=137.12 nM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=134.55 nM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=130.14 nM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=123.35 nM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=114.6 nM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=112.84 nM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=111.71 nM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=111.05 nM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=92.42 nM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=92.11 nM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=89.82 nM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=89.48 nM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=88.45 nM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=86.76 nM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=86.02 nM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=82.81 nM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=78.62 nM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=76.32 nM | SANGER | ||
| MDA-MB-468 | Growth Inhibition Assay | IC50=76.18 nM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=76 nM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=75.76 nM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=75.36 nM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=74.96 nM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=72.32 nM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=69.65 nM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=68.96 nM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=68.79 nM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=67.19 nM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=67.17 nM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=67.11 nM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=65.99 nM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=65.86 nM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=65.03 nM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=63.12 nM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=62.56 nM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=61.92 nM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=61.35 nM | SANGER | ||
| CAMG | Growth Inhibition Assay | IC50=59.96 nM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=59.75 nM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=59.24 nM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=57.57 nM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=57.06 nM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=56.95 nM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=53.46 nM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=51.43 nM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=51.4 nM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=51.02 nM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=50.42 nM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=50.12 nM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=50.07 nM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=49.96 nM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=49.72 nM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=49.42 nM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=48.73 nM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=46.12 nM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=41.08 nM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=40.77 nM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=40.14 nM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=35.97 nM | SANGER | ||
| CCF-STTG1 | Growth Inhibition Assay | IC50=35.5 nM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=34.96 nM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=34.68 nM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=34.24 nM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=33.92 nM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=33.31 nM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=33.24 nM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=32.79 nM | SANGER | ||
| CAN | Growth Inhibition Assay | IC50=31.12 nM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=29.85 nM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=29.47 nM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=28.88 nM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=28.46 nM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=28.42 nM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=27.78 nM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=24.52 nM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=22.91 nM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=22.79 nM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=22.6 nM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=22.08 nM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=21.34 nM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50=21.32 nM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=21.24 nM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=21.05 nM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=20.54 nM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=19.96 nM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=18.3 nM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=18.07 nM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=17.65 nM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=17.44 nM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=17.4 nM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=17.32 nM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=16.93 nM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=16.18 nM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=16.07 nM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=15.97 nM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=15.91 nM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=15.53 nM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=15.48 nM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=15.42 nM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=15.15 nM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=14.82 nM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=14.5 nM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=13.72 nM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=13.69 nM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=13.56 nM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=13.48 nM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=13.27 nM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=12.88 nM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=12.7 nM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=12.54 nM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=12.1 nM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=11.83 nM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=11.83 nM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=11.81 nM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=11.65 nM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=11.22 nM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=11.09 nM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=10.03 nM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=9.86 nM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=9.63 nM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=9.17 nM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=8.47 nM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=8.11 nM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=8.07 nM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=7.5 nM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=7.21 nM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=7.2 nM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=6.73 nM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=6.34 nM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=6.11 nM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=6.05 nM | SANGER | ||
| LC-2 | Growth Inhibition Assay | IC50=5.07 nM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=3.99 nM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=3.51 nM | SANGER | ||
| DA-3 | Function Assay | 10 μM | 10 h | Cellular uptake in mouse DA-3 cell mitochondria | 24900668 |
| DA-3 | Cytotoxic Assay | 60 μM | 24 h | IC50=4 μM | 24900668 |
| HT-29 | Function Assay | 5 μM | 1 h | Inhibition of MRP3-mediated drug resistance in doxorubicin-resistant human HT-29 cells assessed as increase in drug accumulation | 24900337 |
| Yoshida sarcoma | Function Assay | Inhibition of [3H]TdR incorporation with IC50 of 0.02 μM | 1322986 | ||
| CHO | Growth Inhibition Assay | IC50=0.06 μM | 1354750 | ||
| 8226 | Growth Inhibition Assay | IC50=0.033 μM | 1447730 | ||
| 8226/ADR | Growth Inhibition Assay | IC50=0.56 μM | 1447730 | ||
| MCF7/ADR | Growth Inhibition Assay | IC50=3.1 μM | 1447730 | ||
| H69 | Growth Inhibition Assay | IC50=0.87 μM | 1479585 | ||
| EMT6 | Growth Inhibition Assay | 0.5 μM | 1 h | Inhibition of proliferation by measuring for surviving fractions with ED50 of 0.0001 μM | 7452674 |
| H2981 | Cytotoxic Assay | IC50=0.5 μM | 7731023 | ||
| LOX | Cytotoxic Assay | IC50=0.042 μM | 7853331 | ||
| C38 | Cytotoxic Assay | IC50=0.01 μM | 8057291 | ||
| A2780-DX5 | Cytotoxic Assay | Cytotoxicity against doxorubicin-resistant A2780-DX5 with IC50 of 0.357 μM | 8831755 | ||
| WiDr | Cytotoxic Assay | Activity against sensitive WiDr cell with IC50 of 0.053 μM | 8960558 | ||
| C6 | Cytotoxic Assay | 2.5 mg/mL | 5 h | Cytotoxicity assessed as cell release | 8988604 |
| SKVLB | Cytotoxic Assay | 72 h | IC50=6.54 μM | 9003520 | |
| MCF7/VP16 | Cytotoxic Assay | 50 μg/mL | 72 h | IC50=14.2 μM | 9022792 |
| CA755 | Growth Inhibition Assay | 10 μM | 6 d | IC50=0.014 μM | 9526570 |
| CHO | Growth Inhibition Assay | 10 μM | 6 d | IC50=0.06 μM | 9526570 |
| KB | Growth Inhibition Assay | 4 d | Antiproliferative activity against drug-resistant KB7D with IC50 of 0.65 μM | 10411476 | |
| U937 | Function Assay | 24 h | Inhibits incorporation of [3H]thymidine with IC50 of 0.1 μM | 10780911 | |
| MDA-231 | Cytotoxic Assay | 100 μM | 48 h | Cytotoxicity against MDA-231 cell (ER-,EGFR+,mutant p53) with IC50 of 0.006 μM | 10780913 |
| J82 | Cytotoxic Assay | 10 μM | Cytotoxicity against J82 sensitive cell with IC50 of 0.03 μM | 11606141 | |
| SKVLB1 | Cytotoxic Assay | 72 h | Cytotoxicity against human multidrug-resistant SKVLB1 cell with IC50 of 2.2 μM | 11754602 | |
| HCT116 | Growth Inhibition Assay | GI50=0.023 μM | 11755363 | ||
| H69/LX4 | Growth Inhibition Assay | 4 d | Inhibitory activity against drug resistant H69/LX4 cell overexpressing P-glycoprotein with IC50 of 0.137 μM | 11806725 | |
| H69P | Growth Inhibition Assay | 4 d | IC50=0.027 μM | 11806725 | |
| U251 | Cytotoxic Assay | IC50=0.09 μM | 12039588 | ||
| UMUC3 | Cytotoxic Assay | IC50=0.0092 μM | 12392727 | ||
| CRL7065 | Cytotoxic Assay | 6 d | IC50=0.5 μM | 12431048 | |
| SKMEL-28 | Cytotoxic Assay | 6 d | IC50=0.06 μM | 12431048 | |
| 8226/DOX1V | Cytotoxic Assay | 72 h | Cytotoxity against 8226/DOX1V | 12570378 | |
| Neuro2A | Function Assay | 3 ug/mL | 24 h | Neuritogenic activity assessed as morphological changes | 14575440 |
| HT1080 | Growth Inhibition Assay | 72 h | IC50=0.059 μM | 14640513 | |
| H460 | Cytotoxic Assay | GI50=3.0 × 10-7 μg/mL | 14640532 | ||
| MCF7 | Cytotoxic Assay | GI50=8.0 × 10-7 μg/mL | 14640532 | ||
| SF268 | Cytotoxic Assay | GI50=8.5 × 10-7 μg/mL | 14640532 | ||
| DuPRO | Cytotoxic Assay | EC50=1.8 μM | 14667208 | ||
| DU145 | Growth Inhibition Assay | 72 h | GI50=0.02 μM | 14971893 | |
| HeLa | Growth Inhibition Assay | 72 h | GI50=0.01 μM | 14971893 | |
| IGROV | Growth Inhibition Assay | 72 h | GI50=4.4 μM | 14971893 | |
| LNcaP | Growth Inhibition Assay | 72 h | GI50=0.02 μM | 14971893 | |
| LOVO | Growth Inhibition Assay | 72 h | GI50=0.01 μM | 14971893 | |
| MEL-28 | Growth Inhibition Assay | 72 h | GI50=3.1 μM | 14971893 | |
| PANC-1 | Growth Inhibition Assay | 72 h | GI50=3.5 μM | 14971893 | |
| MDA-MB-435 | Growth Inhibition Assay | 4 h | IC50=0.15 μM | 14971899 | |
| TRAMP-C2D | Growth Inhibition Assay | 72 h | IC50=0.0465 μM | 14971910 | |
| TRAMP-C2G | Growth Inhibition Assay | 72 h | IC50=0.0287 μM | 14971910 | |
| MD-MB468 | Cytotoxic Assay | 72 h | IC50=0.007 μM | 14980672 | |
| T47D | Cytotoxic Assay | 72 h | IC50=0.007 μM | 14980672 | |
| RPMI8226 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 14987049 | |
| U937/GTB | Cytotoxic Assay | 72 h | IC50=0.1 μM | 14987049 | |
| Col2 | Cytotoxic Assay | 72 h | IC50=0.52 μM | 15177438 | |
| Rtx6 | Growth Inhibition Assay | 4 h | Growth inhibition of ER expressing Rtx6 cells | 15588086 | |
| WI38 | Cytotoxic Assay | 48 h | IC50=0.3 μM | 15620238 | |
| MeVo | Growth Inhibition Assay | 24 h | IC50=0.82 μM | 15715481 | |
| VA13 | Cytotoxic Assay | 48 h | IC50=0.38 μM | 15730243 | |
| NCI-H69 | Cytotoxic Assay | 6 d | IC50=0.0113 μM | 15743178 | |
| HSC-2 | Cytotoxic Assay | 24 h | CC50=0.68 μM | 15745812 | |
| HSG | Cytotoxic Assay | 24 h | CC50=1.9 μM | 15745812 | |
| MCF7 | Function Assay | 0.5 μg/mL | 24 h | Inhibition of p53-mediated transactivation | 16862141 |
| 5637 | Growth Inhibition Assay | 96 h | IC50=0.02 μM | 16913700 | |
| ACHN | Growth Inhibition Assay | 96 h | IC50=0.001 μM | 16913700 | |
| HL60/ADR | Cytotoxic Assay | 1 mM | 72 h | Cytotoxicity against adriamycin-resistant HL60/ADR cells expressing MRP1 with IC50 of 2 μM | 17069934 |
| HA22T | Cytotoxic Assay | 72 h | IC50=0.31 μM | 17107806 | |
| AGS | Cytotoxic Assay | IC50=0.31 μM | 17125240 | ||
| SHP77 | Growth Inhibition Assay | 24 h | IC50=0.12589 μM | 17125253 | |
| A2780 | Growth Inhibition Assay | 1 μM | 4 d | Inhibition of doxorubicin-resistant A2780 cell growth with IC50 of 0.061 μM | 17125254 |
| MDA435/LCC6 | Growth Inhibition Assay | 4 d | IC50=0.3 μM | 17154505 | |
| K562 | Growth Inhibition Assay | 48 h | IC50=0.01 μM | 17181164 | |
| TRAMP-C1A | Growth Inhibition Assay | 72 h | GI50=0.0204 μM | 17181166 | |
| TRAMP-C2H | Growth Inhibition Assay | 72 h | GI50=0.0158 μM | 17181166 | |
| K562I/S9 | Growth Inhibition Assay | 72 h | Antiproliferative activity against human multidrug-resistant K562i/S9 cells expressing Pgp with IC50 of 2 μM | 17276690 | |
| CEM/VM1 | Cytotoxic Assay | 72 h | Cytotoxicity against teniposide-resistant CEM/VM1 cells with IC50 of 0.55 μM | 17323939 | |
| MeVo | Cytotoxic Assay | 48 h | IC50=0.82 μM | 17375902 | |
| 2780AD | Growth Inhibition Assay | 10 μM | Growth inhibition of multidrug-resistant human 2780AD cells with IC50 of 0.298 μM | 17490878 | |
| BGC823 | Cytotoxic Assay | 48 h | IC50=0.35 μM | 17583953 | |
| ZR-751 | Cytotoxic Assay | 72 h | IC50=0.04 μM | 17585747 | |
| 1A9 | Cytotoxic Assay | ED50=0.02 μM | 17591444 | ||
| LNcaP | Cytotoxic Assay | ED50=0.04 μM | 17591444 | ||
| UACC62 | Growth Inhibition Assay | 48 h | GI50=0.094 μM | 17614292 | |
| DLD1 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 17656091 | |
| UO31 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 17656091 | |
| MCF7 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.0007 μM | 17949859 |
| U373MG | Growth Inhibition Assay | 24 h | Growth inhibition of human U373MG cells containing UhiCE expressing plasmid with IC50 of 0.19953 μM | 18173233 | |
| HepG2 | Cytotoxic Assay | 100 μM | 72 h | IC50=0.07 μM | 18181575 |
| K/VP.5 | Growth Inhibition Assay | 72 h | Growth inhibition of human K/VP.5 cells with IC50 of 0.41 μM | 18258442 | |
| A375 | Cytotoxic Assay | 24 h | IC50=0.01 μM | 18281125 | |
| Hep2 | Cytotoxic Assay | 24 h | IC50=0.42 μM | 18281125 | |
| HT1080 | Cytotoxic Assay | 72 h | IC50=0.022 μM | 18321715 | |
| Caco2 | Function Assay | 50 nM | 48 h | Decrease in cyclin A expression | 18429610 |
| L1210 | Function Assay | 0.5 μg/mL | 12 h | Cell cycle arrest in mouse L1210 cells by accumulation at G2/M phase | 18508273 |
| SK-MEL-2 | Growth Inhibition Assay | 72 h | GI50=0.11 μM | 18585035 | |
| AW13516 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.1 μM | 18657979 |
| T47D | Apoptosis Assay | 10 μM | 48 h | Induction of apoptosis assessed as caspase activation with EC50 of 0.57 μM | 19282188 |
| SMMC-7541 | Cytotoxic Assay | 72 h | IC50=0.0037 μM | 19285863 | |
| NH32 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in p53 deficient human NH32 cells assessed as decrease in pro-caspase 3 level | 19349174 |
| NH32 | Growth Inhibition Assay | 0.1 μM | 72 h | Cell cycle arrest in p53 deficient human NH32 cells assessed as accumulation at sub-G0/G1 phase | 19349174 |
| TK6 | Function Assay | 0.1 μM | 8 h | Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression | 19349174 |
| TK6 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human TK6 cells expressing wild type p53 assessed as decrease in pro-caspase 3 level | 19349174 |
| TK6 | Function Assay | 0.1 μM | 72 h | Cell cycle arrest in human TK6 cells expressing wild type p53 assessed as accumulation at sub-G0/G1 phase | 19349174 |
| TK6 | Function Assay | 25 μM | 8 h | Induction of p53 transcriptional activity in human TK6 cells expressing wild type p53 assessed as p21-Cip1/Waf1 expression | 19349174 |
| WTK1 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as increase in cleaved caspase 3 level | 19349174 |
| WTK1 | Apoptosis Assay | 0.1 μM | 8 h | Induction of apoptosis in human WTK1 cells expressing p53 M237I mutant assessed as increase in PARP cleavage | 19349174 |
| WTK1 | Function Assay | 25 μM | 8 h | Induction of p53 phosphorylation at Ser15 in human WTK1 cells expressing p53 M237I mutant | 19349174 |
| WTK1 | Function Assay | 0.1 μM | 72 h | Cell cycle arrest in human WTK1 cells expressing p53 M237I mutant assessed as accumulation at sub-G0/G1 phase | 19349174 |
| ECV304 | Cytotoxic Assay | 10 μM | 72 h | Cytotoxicity | 19361894 |
| HBL100 | Cytotoxic Assay | 10 μM | 72 h | IC50=0.24 μM | 19361894 |
| U251 | Function Assay | 1 μM | 16 h | Inhibition of HIF1 activation in human U251 cells stably transfected in pGL2-TK-HRE plasmid with EC50 of 0.12 μM | 19405508 |
| SK-N-SH | Apoptosis Assay | 5 μM | Induction of apoptosis assessed as caspase 3 activity | 19631549 | |
| MOLT4 | Growth Inhibition Assay | 72 h | IC50=0.002 μM | 19632833 | |
| OS-RC2 | Growth Inhibition Assay | 72 h | IC50=5.4 μM | 19632833 | |
| U251 | Growth Inhibition Assay | 72 h | IC50=0.6 μM | 19632833 | |
| HCT116 | Cytotoxic Assay | 72 h | IC50=0.006 μM | 19655762 | |
| KB | Cytotoxic Assay | 72 h | IC50=0.001 μM | 19655762 | |
| B16-BL6 | Cytotoxic Assay | 72 h | IC50=3.07 μM | 19689125 | |
| Colon 26-L5 | Cytotoxic Assay | 72 h | IC50=3.12 μM | 19689125 | |
| 2008/MRP1 | Cytotoxic Assay | 5 d | IC50=0.577 μM | 19725578 | |
| 2008/P | Cytotoxic Assay | 5 d | IC50=0.063 μM | 19725578 | |
| HL60/MX2 | Cytotoxic Assay | 48 h | IC50=8.046 μM | 19743858 | |
| MDA-MB-453 | Cytotoxic Assay | 0.58 μg/mL | 69 h | IC50=0.12 μM | 19788290 |
| HCT15 | Cytotoxic Assay | IC50=0.037 μM | 19819696 | ||
| HuCCa1 | Cytotoxic Assay | 4 d | IC50=0.64 μM | 19824618 | |
| MOLT3 | Cytotoxic Assay | IC50=0.04 μM | 19824618 | ||
| MESSA/DX5 | Function Assay | 50 μM | 2 h | Induction of DNA damage assessed as increase in comet-tail length | 20151639 |
| SKHep | Growth Inhibition Assay | 48 h | IC50=0.09 μM | 20171108 | |
| MIAPaCa2 | Cytotoxic Assay | 100 μM | 72 h | IC50=0.01 μM | 20207049 |
| SKHEP1 | Cytotoxic Assay | 48 h | IC50=0.01 μM | 20210346 | |
| U87MG | Cytotoxic Assay | 48 h | IC50=0.018 μM | 20210346 | |
| SK-N-MC | Cytotoxic Assay | 72 h | IC50=0.12 μM | 20303768 | |
| GOTO | Cytotoxic Assay | 72 h | IC50=0.00473 μM | 20356655 | |
| HL60 | Cytotoxic Assay | 72 h | IC50=0.00113 μM | 20356655 | |
| K562 | Cytotoxic Assay | 72 h | IC50=0.00612 μM | 20356655 | |
| NB-1 | Cytotoxic Assay | 72 h | IC50=0.00515 μM | 20356655 | |
| U937 | Cytotoxic Assay | 72 h | IC50=0.00445 μM | 20356655 | |
| HBI10A | Cytotoxic Assay | CC50<0.3 μM | 20363140 | ||
| 3T3 | Cytotoxic Assay | 10 μM | 48 h | IC50=3.7 μM | 20405844 |
| NCI/ADR | Cytotoxic Assay | 250 μg/mL | 48 h | GI50=5.99 μM | 20413188 |
| OVCAR-3 | Cytotoxic Assay | 250 μg/mL | 48 h | GI50=0.07 μM | 20413188 |
| CEM/ADR5000 | Apoptosis Assay | 1 μg/mL | 24 h | Induction of apoptosis | 20527917 |
| CEM/ADR5000 | Function Assay | 1 μg/mL | 6 h | Increase in ROS generation | 20527917 |
| GXF251L | Cytotoxic Assay | 10 μM | 24 h | IC50=0.052 μM | 20545334 |
| MAXF401NL | Cytotoxic Assay | 10 μM | 24 h | IC50=0.052 μM | 20545334 |
| MEXF462NL | Cytotoxic Assay | 10 μM | 24 h | IC50=0.052 μM | 20545334 |
| PAXF1657L | Cytotoxic Assay | 10 μM | 24 h | IC50=0.052 μM | 20545334 |
| HAEC | Cytotoxic Assay | 100 μM | 24 h | IC50=13 μM | 20547797 |
| CCRF-CEM | Growth Inhibition Assay | 48 h | GI50=0.02 μM | 20570145 | |
| NUGC3 | Cytotoxic Assay | GI50=0.202 μM | 20579876 | ||
| HCT-15 | Cytotoxic Assay | IC50=0.038 μM | 20594848 | ||
| COLO205 | Cytotoxic Assay | 48 h | GI50=0.1 μM | 20673627 | |
| Hep3B | Cytotoxic Assay | 11 d | IC50=0.14 μM | 20718475 | |
| SKOV3 | Cytotoxic Assay | IC50=0.001 μM | 20719504 | ||
| DWD | Cytotoxic Assay | 4 μM | 24 h | GI50=0.1 μM | 20732817 |
| SiHa | Cytotoxic Assay | 4 μM | 24 h | GI50=0.17 μM | 20732817 |
| THP1 | Cytotoxic Assay | 72 h | IC50=0.008 μM | 20833057 | |
| ARPE19 | Cytotoxic Assay | 48 h | IC50=0.76 μM | 20931970 | |
| BJ | Cytotoxic Assay | 48 h | IC50=2.33 μM | 20931970 | |
| KB8.5 | Cytotoxic Assay | 50 μM | 72 h | IC50=3.3 μM | 21035234 |
| H460 | Growth Inhibition Assay | 72 h | IC50=0.00038 μM | 21067930 | |
| KB | Growth Inhibition Assay | 72 h | IC50=0.00023 μM | 21067930 | |
| MKN45 | Growth Inhibition Assay | 72 h | IC50=0.00019 μM | 21067930 | |
| C33A | Cytotoxic Assay | 100 μg/mL | 48 h | IC50=0.82 μM | 21071221 |
| HL60R | Cytotoxic Assay | 10 μM | 72 h | IC50=0.99 μM | 21142180 |
| MDA231 | Cytotoxic Assay | 10 μM | 72 h | IC50=4.7x10-5 μM | 21142180 |
| MDA435 | Cytotoxic Assay | 10 μM | 72 h | IC50=0.0035 μM | 21142180 |
| CEM | Cytotoxic Assay | 72 h | IC50=0.06 μM | 21144624 | |
| Molt4/C8 | Cytotoxic Assay | 72 h | IC50=0.2 μM | 21144624 | |
| IMR90 | Cytotoxic Assay | 48 h | IC50=0.59 μM | 21215623 | |
| CCRF | Growth Inhibition Assay | 96 h | IC50=0.0375 μM | 21296467 | |
| HepG2 | Growth Inhibition Assay | 96 h | IC50=0.019 μM | 21296467 | |
| HUVEC | Growth Inhibition Assay | 96 h | IC50=0.0303 μM | 21296467 | |
| NCI-N87 | Growth Inhibition Assay | 96 h | IC50=0.4198 μM | 21296467 | |
| HCT8 | Cytotoxic Assay | 0.58 μg/mL | 69 h | IC50=0.02 μM | 21381705 |
| A375 | Growth Inhibition Assay | 72 h | IC50=0.13 μM | 21496972 | |
| SF295 | Growth Inhibition Assay | 25 nM | 24 h | IC50=4.4 μM | 21553829 |
| SK-MEL-28 | Growth Inhibition Assay | 25 nM | 24 h | IC50=0.6 μM | 21553829 |
| KATOIII | Growth Inhibition Assay | IC50=4.38 μM | 21570750 | ||
| P388D1 | Growth Inhibition Assay | IC50=0.338 μM | 21570750 | ||
| H22 | Growth Inhibition Assay | 48 h | IC50=36.51 μM | 21620529 | |
| S180 | Growth Inhibition Assay | 48 h | IC50=29.2 μM | 21620529 | |
| SW480 | Growth Inhibition Assay | 48 h | IC50=0.06 μM | 21641694 | |
| HOP62 | Cytotoxic Assay | 24 h | GI50=0.14 μM | 21676506 | |
| BT549 | Cytotoxic Assay | 160 μg/mL | 5 d | GI50=0.01 μM | 21711054 |
| Hs578 | Cytotoxic Assay | 160 μg/mL | 5 d | GI50=0.006 μM | 21711054 |
| NCI-H23 | Cytotoxic Assay | 160 μg/mL | 5 d | GI50=0.005 μM | 21711054 |
| PC3 | Cytotoxic Assay | 160 μg/mL | 5 d | GI50=0.021 μM | 21711054 |
| MG63 | Growth Inhibition Assay | 72 h | IC50=2.8 μM | 21721519 | |
| Ew36 | Cytotoxic Assay | 72 h | IC50=0.01 μM | 21721528 | |
| HEK293 | Cytotoxic Assay | 72 h | IC50=0.01 μM | 21721528 | |
| HEK293 | Cytotoxic Assay | 72 h | IC50=0.42 μM | 21721528 | |
| KB3-1 | Cytotoxic Assay | 72 h | IC50=0.02 μM | 21721528 | |
| KBV1 | Cytotoxic Assay | 72 h | IC50=4.7 μM | 21721528 | |
| LLC-PK1 | Cytotoxic Assay | 72 h | IC50=0.2 μM | 21721528 | |
| NCI/ADR-RES | Cytotoxic Assay | 72 h | IC50=9.3 μM | 21721528 | |
| NIH3T3 | Cytotoxic Assay | 72 h | IC50=0.05 μM | 21721528 | |
| SW620 | Cytotoxic Assay | 72 h | IC50=0.01 μM | 21721528 | |
| ZR-75B | Cytotoxic Assay | 72 h | IC50=0.04 μM | 21721528 | |
| ZR-75B | Cytotoxic Assay | 72 h | IC50=2.02 μM | 21721528 | |
| Gurav | Cytotoxic Assay | 100 μM | 48 h | GI50<0.1 μM | 21737288 |
| HFF | Cytotoxic Assay | 72 h | CC50=0.03 μM | 21741131 | |
| BT474 | Cytotoxic Assay | 72 h | IC50=0.07 μM | 21741833 | |
| ChaGo | Cytotoxic Assay | 72 h | IC50=0.83 μM | 21741833 | |
| KATO | Cytotoxic Assay | 72 h | IC50=0.33 μM | 21741833 | |
| NCI-H187 | Cytotoxic Assay | 72 h | IC50=0.03 μM | 21741833 | |
| A2780 | Cytotoxic Assay | IC50=0.0012 μM | 21774499 | ||
| MCF7 | Function Assay | 50 μg/mL | 48 h | Reduction in VEGF mRNA expression | 22000946 |
| SKOV3 | Growth Inhibition Assay | 50 μM | 72 h | Antiproliferative activity against human SKOV3 cells overexpressing c-Src | 22119472 |
| RAW264.7 | Cytotoxic Assay | 10 μM | 24 h | Cytotoxicity assessed as cell viability | 22129061 |
| A375-C5 | Growth Inhibition Assay | 48 h | GI50=0.0915 μM | 22177409 | |
| QGY7701 | Cytotoxic Assay | 24 h | IC50=8.65 μM | 22182926 | |
| SKOV3 | Function Assay | 5 μM | 1 h | Drug uptake in doxorubicin-resistant human SKOV3 cell nucleu | 22276998 |
| HuH7 | Function Assay | 25 ng/mL | 72 h | Induction of senescence assessed as increase in senescence associated beta-galactosidase activity | 22409771 |
| K562/A02 | Growth Inhibition Assay | 72 h | Antiproliferative activity against multidrug-resistant human K562/A02 cells overexpressing p-glycoprotein with IC50 of 46.69 μM | 22450134 | |
| SK-MEL-2 | Cytotoxic Assay | 48 h | IC50=0.002 μM | 22483395 | |
| XF498 | Cytotoxic Assay | 48 h | IC50=0.015 μM | 22483395 | |
| SW620 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.04 μM | 22555152 |
| WI38 | Growth Inhibition Assay | 100 μM | 72 h | IC50=0.04 μM | 22555152 |
| J774A.1 | Cytotoxic Assay | 72 h | IC50=0.02 μM | 22608675 | |
| BMDM | Cytotoxic Assay | 250 μg/mL | 72 h | IC50=4.6 μM | 22616554 |
| HMEC1 | Cytotoxic Assay | 250 μg/mL | 72 h | IC50=0.06 μM | 22616554 |
| B16 | 48 h | IC50=0.03 μM | 22668451 | ||
| U2OS | Cytotoxic Assay | 4 μM | 72 h | IC50=3.4 μM | 22749279 |
| HCT15 | Cytotoxic Assay | 48 h | IC50=0.005 μM | 22858298 | |
| HL60/Vinc | Cytotoxic Assay | 100 μg/mL | 72 h | Cytotoxicity against human HL60/Vinc cells with IC50 of 0.91 μM | 23079523 |
| Bcap37 | Growth Inhibition Assay | 20 μM | 72 h | IC50=1.28 μM | 23124210 |
| MGC803 | Growth Inhibition Assay | 20 μM | 72 h | IC50=0.7 μM | 23124210 |
| MOLT4 | Cytotoxic Assay | 48 h | IC50=0.02 μM | 23218718 | |
| WHCO1 | Cytotoxic Assay | 48 h | IC50=0.5 μM | 23353747 | |
| AT6-1 | Growth Inhibition Assay | 72 h | IC50=2 μM | 23360521 | |
| L929 | Growth Inhibition Assay | 72 h | IC50=0.161 μM | 23360521 | |
| OSRGA | Growth Inhibition Assay | 72 h | IC50=0.093 μM | 23360521 | |
| POS1 | Growth Inhibition Assay | 72 h | IC50=0.043 μM | 23360521 | |
| HeLa | Cytotoxic Assay | 1 μM | 72 h | IC50=0.01 μM | 23470139 |
| SK-MEL | Cytotoxic Assay | 48 h | IC50=1.5 μM | 23547843 | |
| MA9.3 | Cytotoxic Assay | 100 μM | 48 h | IC50=0.086 μM | 23578690 |
| A673 | Apoptosis Assay | 24 h | Induction of apoptosis assessed as caspase-3 activation with EC50 of 0.39 μM | 23600925 | |
| MDA-MB-436 | Cytotoxic Assay | 72 h | IC50=0.1 μM | 23600925 | |
| MNNG-HOS | Cytotoxic Assay | 72 h | IC50=0.59 μM | 23600925 | |
| NCI-H929 | Cytotoxic Assay | 72 h | IC50=0.065 μM | 23600925 | |
| SK-BR-3 | Cytotoxic Assay | 72 h | IC50=0.09 μM | 23600925 | |
| SK-ES-1 | Cytotoxic Assay | 72 h | IC50=0.042 μM | 23600925 | |
| SK-UT-1 | Cytotoxic Assay | 72 h | IC50=0.076 μM | 23600925 | |
| SW872 | Cytotoxic Assay | 72 h | IC50=0.14 μM | 23600925 | |
| JURKAT-TALL | Cytotoxic Assay | 48 h | IC50=0.0096 μM | 23673218 | |
| B16F10 | Cytotoxic Assay | 48 h | IC50=0.072 μM | 23777898 | |
| C643 | Cytotoxic Assay | 25 mM | 24 h | IC50=0.07 μM | 23802716 |
| HGF | Cytotoxic Assay | 25 mM | 24 h | IC50=0.5 μM | 23802716 |
| 786 | Cytotoxic Assay | 48 h | IC50=0.33 μM | 23810282 | |
| LS180 | Cytotoxic Assay | 72 h | IC50=0.04 μM | 23827179 | |
| COLO205 | Growth Inhibition Assay | 100 μM | 48 h | GI50=0.14 μM | 23849207 |
| DWD | Growth Inhibition Assay | 100 μM | 48 h | GI50=0.1 μM | 23849207 |
| Gurav | Growth Inhibition Assay | 100 μM | 48 h | GI50=0.17 μM | 23849207 |
| HOP62 | Growth Inhibition Assay | 100 μM | 48 h | GI50=0.14 μM | 23849207 |
| 786-0 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.13 μM | 23871905 |
| ACHN | Cytotoxic Assay | 100 μM | 48 h | GI50=0.08 μM | 23871905 |
| Caki1 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.95 μM | 23871905 |
| EKVX | Cytotoxic Assay | 100 μM | 48 h | GI50=0.41 μM | 23871905 |
| HCC2998 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.26 μM | 23871905 |
| HOP92 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.1 μM | 23871905 |
| IGROVI | Cytotoxic Assay | 100 μM | 48 h | GI50=0.17 μM | 23871905 |
| KM12 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.27 μM | 23871905 |
| LOXIMVI | Cytotoxic Assay | 100 μM | 48 h | GI50=0.07 μM | 23871905 |
| M14 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.18 μM | 23871905 |
| NCI-H322M | Cytotoxic Assay | 100 μM | 48 h | GI50=0.54 μM | 23871905 |
| NCI-H522 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.03 μM | 23871905 |
| OVCAR4 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.37 μM | 23871905 |
| OVCAR5 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.41 μM | 23871905 |
| OVCAR-8 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.1 μM | 23871905 |
| PRMI8226 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.08 μM | 23871905 |
| RXF393 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.1 μM | 23871905 |
| SF539 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.12 μM | 23871905 |
| SK-MEL-28 | Cytotoxic Assay | 100 μM | 48 h | GI50=0.21 μM | 23871905 |
| H9c2 | Function Assay | 5 μM | 24 h | Antioxidant activity assessed as intracellular ROS level | 23973213 |
| H9c2 | Function Assay | 5 μM | 24 h | Cellular uptake | 23973213 |
| OVCAR8 | Growth Inhibition Assay | 20 μM | 72 h | Antiproliferative activity | 24095089 |
| U2OS | Growth Inhibition Assay | 72 h | IC50=0.3 μM | 24095089 | |
| Caco2 | Cytotoxic Assay | 40 μM | 24 h | Cytotoxicity | 24099994 |
| MDA-MB-468 | Growth Inhibition Assay | 10 μM | 72 h | GI50=0.085 μM | 24163729 |
| Caco2 | Growth Inhibition Assay | 48 h | GI50=0.32 μM | 24184076 | |
| MKN28 | Growth Inhibition Assay | 48 h | GI50=0.24 μM | 24184076 | |
| CEM/ADR5000 | Cytotoxic Assay | Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells expressing p-glycoprotein with IC50 of 23.27 μM | 24561670 | ||
| 26-L5 | Function Assay | 6 h | Antiinvasive activity | 24592993 | |
| BALB/3T3 | Growth Inhibition Assay | IC50=0.5 μM | 24631190 | ||
| 16HBE | Growth Inhibition Assay | 10 μM | 72 h | GI50=0.18 μM | 24650643 |
| HLF | Growth Inhibition Assay | 10 μM | 72 h | GI50=0.33 μM | 24686011 |
| SGC7901 | Growth Inhibition Assay | 10 μM | 72 h | GI50=0.55 μM | 24686011 |
| S-117 | Growth Inhibition Assay | IC50=1.70504 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=1.71733 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=1.74068 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=1.74078 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=1.78324 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=1.80143 μM | SANGER | ||
| RT4 | Growth Inhibition Assay | IC50=1.84417 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=1.93886 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=1.95701 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=2.00624 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=2.01767 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=2.01782 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=2.05463 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=2.06931 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=2.185 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=2.26917 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=2.29135 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=2.30089 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=2.35466 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=2.36583 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=2.39738 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=2.41429 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=2.51328 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=2.56592 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=2.73015 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=2.80401 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=2.90988 μM | SANGER | ||
| SNU-475 | Growth Inhibition Assay | IC50=2.92572 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=3.0287 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=3.32832 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50=3.33738 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=3.46086 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=3.57378 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=3.91309 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=3.98703 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=4.01174 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=4.3958 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=4.49272 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=4.60618 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=4.76541 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=4.85134 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=5.22877 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=5.24262 μM | SANGER | ||
| NCI-H2227 | Growth Inhibition Assay | IC50=5.36231 μM | SANGER | ||
| DMS-53 | Growth Inhibition Assay | IC50=6.17106 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=6.46806 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=7.41791 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=7.57303 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=7.9688 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=8.15122 μM | SANGER | ||
| EFE-184 | Growth Inhibition Assay | IC50=8.37216 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=8.68686 μM | SANGER | ||
| TT | Growth Inhibition Assay | IC50=9.06966 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=9.81393 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=9.9029 μM | SANGER | ||
| HCC1143 | Growth Inhibition Assay | IC50=10.4797 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=18.2976 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=18.6093 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=21.4418 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=23.3371 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=30.0611 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=31.1836 μM | SANGER | ||
| SNU-C1 | Growth Inhibition Assay | IC50=32.4175 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=32.872 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=34.1561 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=35.5377 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=36.7547 μM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=41.9726 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=44.3284 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=48.8248 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Doxorubicin (DOX) HCl是一种抗生素类试剂，可抑制人类DNA topoisomerase I和topoisomerase II，IC50 分别为 0.8 μM 和 2.67 μM。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗，但是在免疫治疗中有将HBV重活化的风险。此产品溶解于PBS溶液可能会析出。推荐使用纯水配置母液，纯水或生理盐水稀释为工作液。 | ||
|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Adriamycin是抗菌的蒽环霉素，通常在两种水平发挥其抗肿瘤活性，改变DNA，和产生自由基，通过DNA损伤，触发癌细胞凋亡。Adriamycin 通过插入到 DNA链中而阻断DNA合成，且抑制DNA拓扑异构酶 II(TOP2)。Adriamycin 作用于快速增值和表达高水平TOP2的细胞最有效。此外, Adriamycin通过产生神经酰胺(通过激活p53 或其他下游通路如JNK而促进凋亡)而触发凋亡，通过丝苏氨酸蛋白酶而降解,线粒体中释放细胞色素 c,提高 FasL(死亡受体Fas/CD95 配体)mRNA产量, 且产生更多的自由基。[2] 使用GSNO(亚硝基谷胱甘肽)预处理，抑制抗Doxorubicin的乳腺癌细胞系MCF7/Dx,伴随着增强蛋白谷胱甘肽和核中Doxorubicin 的积累。[3] 在共济失调毛细血管扩张症突变(ATM)，及ATM 和 Rad3相关的(ATR)信号通路中，提高的 cyclin G2(CycG2)表达和蛋白磷酸化修饰导致Adriamycin诱导的G2/M 检查点停滞。[5] Adriamycin作用于小鼠胚胎成纤维细胞(MEFs)和心肌细胞，抑制AMP活化蛋白激酶(AMPK),导致SIRT1 功能障碍,p53 累积, 且促进细胞死亡。[6] Adriamycin产生明显的热休克反应，抑制热休克蛋白或使热休克蛋白沉默增强，Adriamycin增强促进神经母细胞瘤细胞凋亡的效果。在不可测量蛋白酶抑制的条件下，纳摩尔Adriamycin处理神经母细胞瘤细胞，使特定的一系列蛋白过泛素化，这种作用存在剂量依赖性，且引起泛素化酶，如乳酸脱氢酶和α-烯醇酶的缺失，α-enolase, 蛋白泛素化模式与蛋白酶抑制剂相似,说明Adriamycin也可通过损伤蛋白而发挥作用。[8] |
|||
|---|---|---|---|---|
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | POU5F1 / SOX2 / NANOG ATG5 / ATG7 / SQSTM1 / LC3A-II / LC3B-II / p-mTOR P62 / LC3II p-AKT(T308) / p-Akt(S473) / Akt / p-PRAS40(T246) / PRAS40 / p-H2A.X(S139) |
|
27929731 | |
| Growth inhibition assay | Cell viability |
|
25871400 | |
| Immunofluorescence | LC3 |
|
24970805 | |
| ELISA | OPN |
|
24963635 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | 虽然Adriamycin的使用价值受其慢性和急性毒副作用所限制，但是Although 在治疗乳腺癌和食道癌，儿童实体瘤，骨肉瘤，Kaposi’s 肉瘤,软组织肉瘤, 及Hodgkin和非-Hodgkin 淋巴癌方面仍然是必需的。 [2] 在体内, Adriamycin与腺病毒MnSOD (AdMnSOD) 及1,3 - 双（2 - 氯乙基）-1-亚硝基脲（BCNU）联用降低 MB231 肿瘤体积和延长小鼠寿命，具有最大作用效果。[1] |
|
|---|---|---|
| 动物实验 | Animal Models | 皮下注射MB231细胞的雌性无胸腺裸鼠 |
| Dosages | 3 mg/kg/day | |
| Administration | 瘤内处理 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06186700 | Active not recruiting | Breast Cancer Female |
Mansoura University |
December 25 2023 | Phase 2 |
| NCT05567601 | Not yet recruiting | Ovarian Cancer|AIDS-related Kaposi Sarcoma|Multiple Myeloma|Metastatic Breast Cancer |
Baxter Healthcare Corporation |
November 30 2023 | Phase 1 |
| NCT06088290 | Recruiting | Leiomyosarcoma |
PharmaMar |
September 21 2023 | Phase 2|Phase 3 |
| NCT05748834 | Recruiting | Breast Cancer |
SCRI Development Innovations LLC|Seagen Inc. |
July 24 2023 | Phase 2 |
| NCT05853120 | Recruiting | Sexually Transmitted Diseases |
Emory University|Centers for Disease Control and Prevention |
May 31 2023 | Phase 4 |
化学信息&溶解度
| 分子量 | 579.98 | 分子式 | C27H29NO11.HCl |
| CAS号 | 25316-40-9 | SDF | Download Doxorubicin (DOX) HCl SDF |
| Smiles | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 100 mg/mL ( (172.41 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : 100 mg/mL (172.41 mM) Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
如果有其他问题，请给我们留言。
* 必填项
常见问题及建议解决方法
问题 1:
Why the IC50 of the compound varied over time in our measurement?
回答：
Sometimes the IC50 value might vary between different batch of compounds due to the slight differences in purity. If different IC50 was seen in the same batch of compound, the problem may lies in the process of dissolvement. Make sure that you see no particles and the solution is clear with your stock solution.
Tags: buy Doxorubicin (DOX) HCl | Doxorubicin (DOX) HCl supplier | purchase Doxorubicin (DOX) HCl | Doxorubicin (DOX) HCl cost | Doxorubicin (DOX) HCl manufacturer | order Doxorubicin (DOX) HCl | Doxorubicin (DOX) HCl distributor
