HeLa |
Function Assay |
5 μg/ml |
3 h |
causes nuclear exclusion of the FoxO1 transcription factor and decreases transcription of FoxO1-regulated genes |
24843827 |
3T3-L1 |
Function Assay |
5 μg/ml |
1 h |
causes phosphorylation of the FoxO1 transcription factor |
24843827 |
3T3-L1 |
Function Assay |
5 μg/ml |
1 h |
causes redistribution of GLUT4 but not increase in glucose uptake |
24843827 |
3T3-L1 |
Function Assay |
5 μg/ml |
30 min |
causes reversible redistribution of GLUT4 |
24843827 |
3T3-L1 |
Function Assay |
5 μg/ml |
30 min |
recapitulates insulin action with respect to regulating Akt activity and AS160 phosphorylation |
24843827 |
3T3-L1 |
Function Assay |
5 μg/ml |
30 min |
mimics the effects of insulin and causes robust phosphorylation of Akt (Ser 473) and phosphorylation of AS160 (Thr 642 and Ser 588) |
24843827 |
H838-KDLKB1 |
Function Assay |
30 ng/ml |
12/18 h |
increases the levels of phosphorylated eIF2α (phospho-eIF2α) |
25011082 |
H838-KDLKB1 |
Function Assay |
30 ng/ml |
12/18 h |
increases the protein levels of BiP |
25011082 |
H838-LKB1 |
Function Assay |
30 ng/ml |
12/18 h |
increases the protein levels of BiP |
25011082 |
HepG2 |
Function Assay |
1μg/mL |
3–24 h |
increases the level of APE1 in a time-dependent manner |
25026174 |
Huh-7 |
Function Assay |
1μg/mL |
3–24 h |
increases the level of APE1 in a time-dependent manner |
25026174 |
RBE4 |
Function Assay |
2 μM |
3–24 h |
induces an overload of Ca2+ in the mitochondria in the first 6 h of incubation (p < 0.001) but Ca2+ levels in this organelle decreased after 12 h of incubation |
25128025 |
RBE4 |
Function Assay |
2 μM |
3–24 h |
induces a delayed depletion of the ER Ca2+ content at 6 h of incubation significantly |
25128025 |
RBE4 |
Function Assay |
2 μM |
3–24 h |
increases the levels of ROS time-dependently |
25128025 |
RBE4 |
Function Assay |
2 μM |
3–24 h |
increases active caspase-12 in a time-dependent manner |
25128025 |
RBE4 |
Function Assay |
2 μM |
3–24 h |
increases the XBP1 protein levels after 3 and 6 h of treatment |
25128025 |
RBE4 |
Apoptosis Assay |
2 μM |
3–24 h |
induces apoptosis time dependently |
25128025 |
HEK293/hERG |
Function Assay |
10 μM |
1 h |
results in a time-dependent reduction mature hERG protein |
25218469 |
MEC |
Function Assay |
1 μM |
1.5 h |
causes a dramatic decrease in the surface VEGFR2 |
25228815 |
KMS-6 |
Function Assay |
1 μM |
24 h |
exhibits half the secretion of galanin-LI as did the control |
25229126 |
A172 |
Function Assay |
10 μg/ml |
4 h |
results in the retrograde transport of fluorescent granules |
25239507 |
MDA-MB-231 |
Function Assay |
0–50 μg/mL |
24 h |
inhibits the formation of 3D and 2D colonies |
25356567 |
MDA-MB-231 |
Apoptosis Assay |
0.05–1 μg/mL |
24 h |
induces PARP (poly ADP-ribose polymerase-1) cleavage |
25356567 |
MDA-MB-231 |
Growth Inhibition Assay |
0.01/0.05 μg/mL |
24 h |
increases the fraction of sub-G1 cell debris |
25356567 |
MDA-MB-231 |
Apoptosis Assay |
0.1 μg/mL |
4 h |
induces apoptosis |
25356567 |
MDA-MB-231 |
Cell Viability Assay |
0–50 μg/mL |
48 h |
EC50 = 0.016 µg/mL |
25356567 |
H1299 |
Function Assay |
10 μg/ml |
24 h |
induces autophagy |
25388970 |
PEXEL-Nluc |
Function Assay |
5 mg/mL |
6 h |
causes an increase in reporter activity in the parasite |
25392998 |
SP-Nluc |
Function Assay |
5 mg/mL |
6 h |
causes an increase in reporter activity in the parasite |
25392998 |
iPSC-CMs |
Function Assay |
500 ng/ml |
48 h |
increases the intensity of the higher mobility LAMPs at the cost of the lower mobility species |
25488666 |
OB-6 |
Apoptosis Assay |
2.7 μM |
48 h |
induces apoptosis |
25532480 |
SMCs |
Function Assay |
1μg/mL |
3 h |
accumulates CNPY2 protein in the ER compartment and no longer co-localized with the Golgi marker |
25589425 |
HepG2 |
Function Assay |
1 µM |
24 h |
decreases the level of PXR mRNA |
25616597 |
FRT |
Function Assay |
5 μg/ml |
2 h |
prevents the increase in cleaved α subunits when [Na+]i was reduced |
25767115 |
FRT |
Function Assay |
5 μg/ml |
2 h |
blocks trafficking through the Golgi complex by inhibiting ER-to-Golgi transport |
25767115 |
nHDFs |
Function Assay |
1 μM |
2 h |
prevents the assembly of cytosolic coat proteins onto Golgi membranes |
25772616 |
DF1 |
Function Assay |
1 μM |
48 h |
disperses the exogenous CSGalNAcT2 protein |
25807054 |
COS |
Function Assay |
1 μg/ml |
3 h |
completely disperses the AP-1 signal |
25915900 |
HeLa |
Function Assay |
200 ng/ml |
3 h |
induces the artificial break-up of the Golgi complex |
25948586 |
NRK |
Function Assay |
200 ng/ml |
4 h |
rescues mitotic progression |
25948586 |
Caco-2 |
Function Assay |
2.5 μM |
30 min |
attenuates the TGF-β1-mediated increase in SERT function |
25954931 |
HUVEC |
Function Assay |
10 μM |
1 h |
increases the number and intensity of fluorescent areas especially in perinuclear space |
25956988 |
HUVEC |
Function Assay |
10 μM |
1 h |
abolishes hypoxia-induced release of ATP from apical and basolateral surfaces |
25956988 |
HEMC-1 |
Function Assay |
0.1 µg/ml |
24 h |
causes a higher inhibitory effect on exocytosis than nocodazole |
25972759 |
SMCs |
Function Assay |
10 µg/ml |
0-12 h |
causes a transient Ca2+ release from the ER/SR |
26172080 |
SMCs |
Function Assay |
10 µg/ml |
0-12 h |
shows a trend towards a higher concentration of the ER/SR network in the perinuclear area |
26172080 |
MEFs VAMP7 KO |
Function Assay |
5 μM |
20 min |
causes resident enzymes such as NAGT-GFP, to diffuse back to the ER |
26196023 |
MEFs WT |
Function Assay |
5 μM |
20 min |
causes resident enzymes such as NAGT-GFP, to diffuse back to the ER |
26196023 |
C2C12 |
Function Assay |
1 μg/ml |
1 h |
abolishes cytokine release from C2C12 myotubes |
26291279 |
PC12 |
Function Assay |
2 μM |
1 h |
inhibits the L-DOPA (20 μM)-induced transient ERK1/2 phosphorylation |
26363191 |
HEK293 |
Function Assay |
5 μg/ml |
12 h |
abolishes CMA-induced CRELD2 secretion |
24687431 |
COS-1 |
Function Assay |
5 µg/ml |
24 h |
restricts localization of NB in the perinuclear region |
24671751 |
RAW264.7 |
Apoptosis Assay |
4 μM |
48 h |
attenuates the inhibition of ox-LDL-induced apoptosis and the facilitation of cholesterol efflux by Ac-hE-18A-NH2 |
24639032 |
MDMs |
Apoptosis Assay |
10 μg/ml |
12/15 h |
induces apoptosis |
24556695 |
PMHs |
Function Assay |
10–20 μg/ml |
24 h |
induced ER stress |
24407242 |
PMHs |
Apoptosis Assay |
10–20 μg/ml |
24 h |
increases cell death |
24407242 |
HEK293/tau |
Function Assay |
5 μM |
1/2/4 h |
induces Golgi fragmentation |
24368089 |
HEK293/tau |
Function Assay |
5 μM |
3 h |
induces tau hyperphosphorylation |
24368089 |
ADF |
Function Assay |
10 μM |
16 h |
inhibits the ZnCl2-induced translocation of CRT |
24228232 |
U373 |
Function Assay |
10 μM |
16 h |
inhibits the ZnCl2-induced translocation of CRT |
24228232 |
RKO-HIPK2i |
Function Assay |
10 μM |
16 h |
inhibits the ZnCl2-induced translocation of CRT |
24228232 |
ADF |
Function Assay |
10 μM |
6 h |
impairs the DC activation |
24228232 |
Huh7 |
Function Assay |
5 μg/ml |
4 h |
abolishes the secretion of intracellular ApoB |
24100140 |
Huh7 |
Function Assay |
5 μg/ml |
1 h |
causes a significant increase in ApoB-crescents |
24100140 |
Huh7 |
Function Assay |
5–10 ng/ml |
12 h |
increases ApoB-crescents without inhibiting secretion |
24100140 |
BAECs |
Function Assay |
5 μg/ml |
0-4 h |
induces the rapid dephosphorylation of eNOS at Ser1179 |
24085225 |
Macrophages |
Function Assay |
71 µM |
6 h |
inhibits lunasin internalization |
24039740 |
Colo 205 |
Growth Inhibition Assay |
0-5 μg/mL |
48 h |
inhibits cell growth in suspension cultures with an estimated IC50 of ~15 ng/mL |
23973996 |
Colo 205 |
Function Assay |
0.012-0.025 μg/mL |
14 d |
reduces the clonogenicity of Colo 205 CSCs |
23973996 |
Colo 205 |
Apoptosis Assay |
0.1 μg/mL |
0-24 h |
induces apoptosis of Colo 205 cells in suspension cultures |
23973996 |
Colo 205 |
Function Assay |
0.015 μg/mL |
24 h |
induces the expression of ER stress-related genes |
23973996 |
Colo 205 |
Function Assay |
0.015 μg/mL |
24 h |
inhibits the activity of MMPs |
23973996 |
IBRS2 |
Function Assay |
5 μg/ml |
0.5 h |
disrupts the ERGIC and Golgi |
23963534 |
IBRS2 |
Function Assay |
5 μg/ml |
0.5 h |
enhances FMDV infection |
23963534 |
HeLa |
Function Assay |
2 μM |
2 h |
attenuates the TNF-induced secretion of IL-15 |
23950892 |
HFS |
Function Assay |
0-1 μg/ml |
24 h |
GLTP expression reaches a plateau at concentrations as low as 0.01 µg/ml |
23894633 |
HFS |
Function Assay |
0.01 µg/ml |
24 h |
increases the expression of glycosphingolipid synthase genes at 6 h |
23894633 |
OVCAR-3 |
Growth Inhibition Assay |
1–15 μM |
24 h |
induces a loss of cell viability dose dependently |
23826964 |
OVCAR-3 |
Function Assay |
1–15 μM |
24 h |
induces nuclear damage |
23826964 |
OVCAR-3 |
Apoptosis Assay |
1-10 μM |
4 h |
induces the activation of apoptosis-related proteins |
23826964 |
OVCAR-3 |
Apoptosis Assay |
10 μM |
24 h |
induces activation of caspases |
23826964 |
OVCAR-3 |
Function Assay |
1–10 μM |
24 h |
induces disruption of the mitochondrial transmembrane potential |
23826964 |
OVCAR-3 |
Function Assay |
1–10 μM |
24 h |
induces formation of reactive oxygen species |
23826964 |
OVCAR-3 |
Function Assay |
1–10 μM |
24 h |
inhibits cell adhesion and migration |
23826964 |
HeLa |
Function assay |
100 uM |
2 hrs |
Dispersion of cis golgi marker betaCoP in human HeLa cells at 100 uM for 2 hrs |
17563369 |
HeLa |
Function assay |
100 uM |
2 hrs |
Dispersion of cis golgi marker KDEL in human HeLa cells at 100 uM for 2 hrs |
17563369 |
Vero |
Function assay |
10 ug/ml |
5 mins |
Inhibition of Arf1 in african green monkey Vero cells assessed as rapid AP-1 dispersal from golgi membranes at 10 ug/ml after 5 mins by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
5 mins |
Inhibition of Arf1 in african green monkey Vero cells assessed as rapid GGA3 dispersal from trans golgi network at 10 ug/ml after 5 mins by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 uM |
1 hr |
Inhibition of GBF1 QNV deleted mutant in african green monkey Vero cells assessed as effect on change in golgi morphology at 10 uM after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 uM |
1 hr |
Inhibition of GBF1 QNV to AAA mutant in african green monkey Vero cells assessed as effect on change in golgi morphology at 10 uM after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
1 hr |
Inhibition of Arf1 in african green monkey Vero cells assessed as decrease in Arf1-GTP levels at 10 ug/ml after 1 hr |
19182783 |
Vero |
Function assay |
10 uM |
1 hr |
Inhibition of GBF1 in african green monkey Vero cells assessed as punctate and diffuse distribution of medial-Golgi marker giantin from TGN at 10 uM after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
1 hr |
Inhibition of Arf1 in african green monkey Vero cells assessed as punctate and diffuse distribution of medial-Golgi marker giantin at 10 ug/ml after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
5 mins |
Inhibition of Arf1 in african green monkey Vero cells assessed as rapid COPI redistribution from golgi at 10 ug/ml after 5 mins by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
1 hr |
Inhibition of Arf1 in african green monkey Vero cells assessed as tubule formation from trans golgi network and endosomes before its dispersal at 10 ug/ml after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
1 hr |
Inhibition of Arf1 in african green monkey Vero cells assessed as giantin positive punctate structures in contact with Sec31-positive ER exit site at 10 ug/ml after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 uM |
1 hr |
Induction of GBF1 in african green monkey Vero cells assessed as punctate and diffuse distribution of cis-Golgi marker GM130 from TGN at 10 uM after 1 hr by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
1 hr |
Inhibition of Arf1 in african green monkey Vero cells assessed as punctate and diffuse distribution of cis-Golgi marker GM130 at 10 ug/ml after 1 hr by immunofluorescence method |
19182783 |
NRK |
Function assay |
7 uM |
60 mins |
Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as fusion of golgi membrane fusion with endoplasmic reticulum at 7 uM after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy |
20189813 |
HeLa R19 |
Antiviral assay |
0.5 uM |
7 hrs |
Antiviral activity against Coxsackievirus B3 infected in human HeLa R19 cells assessed as inhibition of viral replication at 0.5 uM after 7 hrs by luciferase reporter gene assay |
23805957 |
HeLa |
Function assay |
5 uM |
30 to 60 mins |
Induction of golgi apparatus disassembly in human HeLa cells at 5 uM after 30 to 60 mins by confocal microscopic analysis |
23805957 |
Arabidopsis thaliana root cells |
Function assay |
90 uM |
30 mins |
Induction of morphological changes of golgi apparatus in Arabidopsis thaliana root cells expressing ST-YFP/VHAa1-RFP at 90 uM after 30 mins by confocal laser scanning microscopic analysis |
23805957 |
HeLa R19 |
Antiviral assay |
5 to 50 uM |
7 hrs |
Antiviral activity against Coxsackievirus B3 infected in human HeLa R19 cells assessed as inhibition of viral replication at 5 to 50 uM after 7 hrs by luciferase reporter gene assay |
23805957 |
PC3 |
Function assay |
50 nM |
72 hrs |
Potentiation of 3 nM docetaxel-induced cytotoxicity against human PC3 cells assessed as decrease in cell viability at 50 nM after 72 hrs by trypan blue exclusion assay |
28462831 |
HeLa |
Function assay |
18 uM |
3 hrs |
Inhibition of alkaline phosphatase secretion in human HeLa cells at 18 uM incubated for 3 hrs |
31421965 |
PRP |
Function Assay |
10 μM |
|
abrogates SDF-1α-mediated CXCR7 externalization |
24668750 |
Vero |
Function assay |
10 uM |
|
Inhibition of GBF1 in african green monkey Vero cells assessed as inhibition of StxB-SS retrogade transport from endosomes to TGN at 10 uM by immunofluorescence method |
19182783 |
Vero |
Function assay |
10 ug/ml |
|
Inhibition of Arf1 in african green monkey Vero cells assessed as inhibition of StxB-SS retrogade transport from endosomes to TGN at 10 ug/ml by immunofluorescence method |
19182783 |
L02 |
Cytotoxicity assay |
|
72 hrs |
Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay, IC50<0.0004μM. |
28494251 |
PC3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50=0.068μM. |
28494251 |
HT-29 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50=0.16μM. |
28494251 |
HepG2 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay, IC50=0.35μM. |
28494251 |
LO2 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay, IC50<0.001μM. |
29524728 |
Bel7402 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay, IC50=0.024μM. |
29524728 |
HL60 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay, IC50=0.025μM. |
29524728 |
PC3 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay, IC50=0.068μM. |
29524728 |
Bel7402/5-FU |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by MTT assay, IC50=0.82μM. |
29524728 |
VERO-E6 |
Function assay |
|
48 hrs |
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging, IC50=0.02μM. |
ChEMBL |
VERO-E6 |
Function assay |
|
48 hrs |
Toxicity CC50 against VERO-E6 cells determined at 48 hours by high content imaging (same conditions as 2_LEY without exposure to 0.01 MOI SARS CoV-2 virus), CC50=0.06μM. |
ChEMBL |
MKN45 |
Growth Inhibition Assay |
|
|
IC50<0.001 μg/ml |
23793342 |
LOVO |
Growth Inhibition Assay |
|
|
IC50=0.12 μg/ml |
23793342 |
A549 |
Growth Inhibition Assay |
|
|
IC50=0.04 μg/ml |
23793342 |
MDA-MB-435 |
Growth Inhibition Assay |
|
|
IC50<0.001 μg/ml |
23793342 |
HepG2 |
Growth Inhibition Assay |
|
|
IC50<0.001 μg/ml |
23793342 |
HL-60 |
Growth Inhibition Assay |
|
|
IC50<0.001 μg/ml |
23793342 |
neural precursor cells |
Function assay |
|
|
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay |
17417631 |
NCI60 |
Cytostatic assay |
|
|
Cytostatic activity against human NCI60 cells by SRB assay, GI50=0.0206μM. |
23805957 |
NCI60 |
Cytostatic assay |
|
|
Cytostatic activity against human NCI60 cells by SRB assay, TGI=3.48μM. |
23805957 |