| S9229 |
Linderane |
Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache. |
Selective |
|
| S5806 |
Cilostamide |
Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively. |
Selective |
PDE3A, IC50: 27 nM; PDE3B, IC50: 50 nM |
| S1294 |
Cilostazol (OPC-13013) |
Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. |
Selective |
PDE3, IC50: 0.2 μM |
| S1550 |
Pimobendan |
Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
Selective |
PDE3, IC50: 0.32 μM |
| S5539 |
Olprinone |
Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively. |
Selective |
PDE3, IC50: 0.35 mM |
| S6433 |
Udenafil |
Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. |
Pan |
PDE3, IC50: 52 nM |
| S2484 |
Milrinone |
Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. |
Pan |
PDE3, IC50: 2.1 μM |
| S5836 |
IBMX |
IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist. |
Pan |
PDE3, IC50: 6.5 μM |
| S2320 |
Luteolin |
Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. |
Pan |
PDE3, Ki: 13.9 μM |
| S4090 |
Fenspiride HCl |
Fenspiride(Decaspiride) is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi. |
Pan |
PDE3, pIC50: 3.44 |
