| S5267 |
Nylidrin Hydrochloride |
Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
Selective |
|
| S3294 |
Demethyl-Coclaurine |
Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes. |
Selective |
|
| S3727 |
Vilanterol Trifenate |
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
Selective |
|
| S5430 |
Metoprolol |
Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
Selective |
|
| S5769 |
Fenoterol |
Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity. |
Selective |
|
| S5540 |
Landiolol hydrochloride |
Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
Selective |
|
| S5341 |
Metroprolol succinate |
Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
Selective |
|
| S5023 |
Nadolol |
Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. |
Selective |
|
| S4485 |
Olodaterol (BI 1744) |
Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD). |
Selective |
|
| S5768 |
Fenoterol hydrobromide |
Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. |
Selective |
|
| S5494 |
Salbutamol |
Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
Selective |
|
| S7974 |
L755507 |
L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types. |
Selective |
β3 adrenergic receptor, EC50: 0.43 nM |
| S8114 |
Zenidolol (ICI-118551) Hydrochloride |
Zenidolol (ICI-118551) Hydrochloride is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. |
Selective |
β2-adrenergic receptor, Ki: 0.7nM; β1-adrenergic receptor, Ki: 49.5nM; β3-adrenoceptor, Ki: 611nM |
| S4085 |
Levobetaxolol HCl |
Levobetaxolol (AL 1577A,(S)-Betaxolol hydrochloride) exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. |
Selective |
β1-adrenergic receptor, Ki: 0.76 nM; β2-adrenergic receptor, Ki: 32.6 nM |
| S1549 |
Nebivolol hydrochloride (R-65824) |
Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM. |
Selective |
β1-adrenoceptor, IC50: 0.8 nM |
| S5527 |
Salmeterol |
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
Selective |
β2-adrenergic receptor, Ki: 1.5 nM |
| S4123 |
Timolol Maleate |
Timolol Maleate (MK-950,(S)-Timolol Maleate) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM. |
Selective |
β1-adrenergic receptor, Ki: 1.97 nM; β2-adrenergic receptor, Ki: 2.0 nM |
| S0032 |
Batefenterol |
Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively. |
Selective |
hβ2-adrenoceptor, Ki: 3.7 nM |
| S4076 |
Propranolol HCl |
Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor. |
Selective |
β-adrenergic receptor, IC50: 12 nM |
| S4009 |
Mirabegron |
Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
Selective |
β3-adrenoceptor, EC50: 22.4 nM |
| S0812 |
SR59230A |
SR59230A is a blood-brain barrier penetrating, potent and selective antagonist of β3-adrenergic receptor with IC50 of 40 nM, 408 nM, and 648 nM for β3, β1, and β2 receptors, respectively. |
Selective |
β3-adrenergic receptor, IC50: 40 nM; β1-adrenergic receptor, IC50: 408 nM; β2-adrenergic receptor, IC50: 648 nM |
| S3083 |
Indacaterol Maleate |
Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
Selective |
β1-adrenoceptor, pKi: 7.36; β2-adrenoceptor, pKi: 5.48 |
| S5654 |
Indacaterol |
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
Selective |
β1-adrenoceptor, pKi: 7.36; β2-adrenoceptor, pKi: 5.48 |
| S4127 |
Terbutaline Sulfate |
Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM. |
Selective |
β2-adrenergic receptor, IC50: 53 nM |
| S5778 |
Esmolol |
Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. |
Selective |
Human β1-Receptor, Ki: 194 nM; Human β2-Receptor, Ki: 5.8 μM |
| S4817 |
Atenolol |
Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors. |
Selective |
β1 receptor, Kd: 0.25 μM; β2 receptor, Kd: 1 μM |
| S1827 |
Betaxolol HCl |
Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM. |
Selective |
β1-adrenergic receptor, IC50: 6 μM |
| S2507 |
Salbutamol Sulfate |
Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. |
Selective |
β2-adrenergic receptor, IC50: 8930 nM |
| S5925 |
Olodaterol hydrochloride |
Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. |
Selective |
|
| S4010 |
Acebutolol HCl |
Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias. |
Selective |
|
| S4278 |
Carteolol HCl |
Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) is a β-adrenoceptor antagonist, used for the treatment of glaucoma.
|
Selective |
|
| S1856 |
Metoprolol Tartrate |
Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure. |
Selective |
|
| S5789 |
Propafenone |
Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias. |
Selective |
|
| S4135 |
Clorprenaline HCl |
Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect. |
Selective |
|
| S2566 |
Isoprenaline (NCI-C55630) HCl |
Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. |
Selective |
|
| S1206 |
Bisoprolol fumarate |
Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker. |
Selective |
|
| S2533 |
Ritodrine HCl |
Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist. |
Selective |
|
| S4277 |
Bambuterol HCl |
Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride) is a potent β-adrenoceptor agonist, used in the treatment of asthma.
|
Selective |
|
| S4296 |
Salmeterol Xinafoate |
Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
|
Selective |
|
| S2509 |
Sotalol HCl |
Sotalol(MJ-1999) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. |
Selective |
|
| S2091 |
Betaxolol |
Betaxolol (SL 75212,Dextrobetaxolol) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma. |
Selective |
|
| S2020 |
Formoterol Hemifumarate |
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). |
Selective |
|
| S3960 |
Higenamine hydrochloride |
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
Pan |
|
| S9470 |
Penbutolol Sulfate |
Penbutolol sulfate ((-)-Terbuclomine) is an effective beta-adrenergic receptor blocker and diuretic that is used as an antihypertensive agent. |
Pan |
|
| S9507 |
(−)-Norepinephrine |
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. |
Pan |
β1 adrenoceptor, Ki: 740 nM |
| S2691 |
BMY 7378 Dihydrochloride |
BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
Pan |
β1-adrenoceptor, pIC50: 5.1 |
| S1831 |
Carvedilol |
Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure. |
Pan |
|
| S4100 |
Esmolol HCl |
Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms. |
Pan |
|
| S4291 |
Labetalol HCl |
Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W) is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
|
Pan |
|
| S2521 |
Epinephrine bitartrate |
Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator. |
Pan |
|
