S4009 |
Mirabegron
|
Mirabegron (YM 178)是一种选择性的beta3-adrenoceptor(β3肾上腺素受体)激动剂,EC50为22.4 nM。 |
-
J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
|
|
S4076 |
Propranolol HCl
|
Propranolol HCl (AY-64043, ICI-45520, NCS-91523) 是一种竞争性和非选择性β-肾上腺素受体抑制剂。 |
-
Cell Res, 2024, 10.1038/s41422-024-00946-z
-
J Immunother Cancer, 2024, 12(11)e009805
-
Sci Rep, 2024, 14(1):4178
|
|
S2521 |
Epinephrine bitartrate
|
Epinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。 |
-
Sci Adv, 2024, 10(33):eado1533
-
Int J Biol Sci, 2023, 19(7):2006-2019
-
Int J Biol Sci, 2023, 19(7):2006-2019
|
|
S2569 |
Phenylephrine HCl
|
Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。 |
-
NPJ Regen Med, 2023, 8(1):9
-
Front Immunol, 2022, 13:1090773
-
Front Immunol, 2022, 10.3389/fimmu.2022.1090773
|
|
S2516 |
Xylazine HCl
|
Xylazine HCl(BAY 1470 hydrochloride)是一种α2肾上腺素能受体激动剂,用作镇定剂和肌肉松弛剂。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Cell Death Dis, 2023, 14(5):318
-
Eur J Pharmacol, 2021, 911:174522
|
|
S2507 |
Salbutamol (Albuterol) Sulfate
|
Salbutamol (Albuterol) Sulfate是一种短效的β2-肾上腺素能受体激动剂,IC50为8.93 µM。 |
-
Front Physiol, 2022, 13:800055
-
cell, 2020, 180(1):64-78.e16
-
Sci Signal, 2020, 13(659)eaax0273
|
|
S1831 |
Carvedilol
|
Carvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂,用于治疗充血性心力衰竭和高血压。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Antioxidants (Basel), 2023, 12(8)1585
-
Antioxidants (Basel), 2023, 12(8)1585
|
|
S8114 |
Zenidolol (ICI-118551) Hydrochloride
|
Zenidolol (ICI-118551) Hydrochloride是高选择性的β2肾上腺素受体拮抗剂,其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。 |
-
Biomedicines, 2022, 10(2)487
-
iScience, 2021, 24(12):103362
-
Toxicol In Vitro, 2021, 77:105251
|
|
S2566 |
Isoprenaline (Isoproterenol) HCl
|
Isoprenaline (Isoproterenol) HCl是一种非选择性β-肾上腺素能受体激动剂,用于治疗心动过缓和心传导阻滞。 |
-
Stem Cell Res Ther, 2022, 13(1):287
-
BMC Cancer, 2022, 22(1):213
-
J Dairy Sci, 2022, 105-10:8426-8438
|
|
S1206 |
Bisoprolol fumarate
|
Bisoprolol fumarate (EMD33512) 是一种选择性β1型肾上腺素能受体抑制剂。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
J Pathol, 2022, 10.1002/path.6020
-
Front Nutr, 2022, 9:907986
|
|
S1324 |
Doxazosin Mesylate
|
Doxazosin Mesylate是一种α-1肾上腺素能受体抑制剂。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
J Exp Clin Cancer Res, 2023, 10.1186/s13046-023-02866-z
-
J Ocul Pharmacol Ther, 2017, 33(1):50-56
|
|
S9507 |
(−)-Norepinephrine
|
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂,对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。 |
-
iScience, 2023, 26(3):106241
-
Commun Biol, 2022, 5(1):339
-
Eur J Pharmacol, 2022, 926:175040
|
|
S2373 |
Yohimbine HCl
|
Yohimbine (Antagonil) 是一种瞳孔放大剂,用于治疗阳痿,也是一种春药。 |
-
Anesth Analg, 2023, 137(2):426-39
-
Mol Pain, 2022, 18:17448069221107810
-
J Med Chem, 2021, 64(18):13510-13523
|
|
S1283 |
Asenapine maleate
|
Asenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂,用于治疗神经分裂症以及抑郁狂躁型忧郁症。 |
-
J Adv Res, 2024, S2090-1232(24)00079-1
-
Cell Commun Signal, 2024, 22(1):266
-
Mol Cancer, 2023, 22(1):136
|
|
S1549 |
Nebivolol hydrochloride (R-65824)
|
在兔肺β1-肾上腺素受体结合实验中,Nebivolol HCl (R-65824 hydrochloride)选择性阻断β1受体,IC50为0.8 nM。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Oncogenesis, 2022, 11(1):24
-
Nat Commun, 2021, 12(1):5919
|
|
S2509 |
Sotalol HCl
|
Sotalol(MJ-1999)是一种非选择性β受体抑制剂,是钾离子通道抑制剂,IC50为43 μM。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
EBioMedicine, 2023, 95:104741
-
Toxicol Appl Pharmacol, 2021, 431:115731
|
|
S2090 |
Dexmedetomidine HCl
|
Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) 是一种有效的,高度选择性α-2肾上腺素受体激动剂,具有显著的镇静效果,从而降低患者的麻醉量。 |
-
Oral Dis, 2022, 10.1111/odi.14286
-
JHEP Rep, 2021, 3(4):100296
-
Sci Rep, 2021, 11(1):13345
|
|
S7974 |
L755507
|
L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂,EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。 |
-
Front Cell Dev Biol, 2023, 11:1276890
-
bioRxiv, 2023, 10.1101/2023.10.03.560773
-
Genesis, 2022, 60(1-2):e23465
|
|
S5739 |
Nebivolol
|
Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure. |
-
Int J Mol Sci, 2023, 24(11)9708
-
Front Pharmacol, 2022, 13:1049640
-
Front Pharmacol, 2021, 12:691998
|
|
S5527 |
Salmeterol
|
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
-
Front Pharmacol, 2022, 13:865715
-
Mol Syst Biol, 2021, 17(8):e10239
-
Drug Test Anal, 2020, 10.1002/dta.2917
|
|
S5564 |
Xylazine
|
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
-
Cell Death Dis, 2023, 14(5):318
-
Cell Death Differ, 2020, 10.1038
-
Mol Med Rep, 2017, 16(2):1911-1919
|
|
S5683 |
Isoproterenol sulfate dihydrate
|
Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
-
Stem Cell Res Ther, 2022, 13(1):287
-
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
-
Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080
|
|
S4650 |
Atipamezole
|
Atipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。 |
-
Exp Mol Med, 2020, 10.1038/s12276-020-0461-6
-
Nitric Oxide, 2019, 85:1-9
-
Front Neurol, 2019, 10:1041
|
|
S4065 |
Guanabenz Acetate
|
Guanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体, α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂,pEC50分别为8.25, 7.01和5左右。 |
-
Cell Stem Cell, 2020, 27(6):876-889.e12
-
Thyroid, 2019, 29(6):809-823
|
|
S3061 |
Epinephrine HCl
|
Epinephrine HCl (Adrenaline) 是一种激素和神经递质。 |
-
Cell Rep Methods, 2023, 3(10):100599
-
J Immunother Cancer, 2021, 9(1)e001466
|
|
S4296 |
Salmeterol Xinafoate
|
Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur)是一种长效的β2-adrenergic receptor激动剂,具有抗炎作用,用于哮喘症状和慢性阻塞性肺疾病(COPD)症状的治疗。
|
-
ACS Pharmacol Transl Sci, 2019, 2(3):148-154
-
Commun Biol, 2018, 1:106
|
|
S3960 |
Higenamine hydrochloride
|
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
-
Mol Cell Biochem, 2021, 10.1007/s11010-021-04197-z
-
Oncol Rep, 2021, 46(3)202
|
|
S4127 |
Terbutaline Sulfate
|
Terbutaline Sulfate(Terbutaline hemisulfate)是一种选择性的β2-肾上腺素能受体激动剂,IC50为53 nM。 |
-
BMC Pharmacol Toxicol, 2020, 21(1):61
-
Hum Reprod, 2016, 31(11):2506-2519
|
|
S5703 |
Carvedilol Phosphate
|
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. |
-
Res Pharm Sci, 2016, 11(5):419-427
-
Res Pharm Sci, 2015, 10(5):388-96
|
|
S3727 |
Vilanterol Trifenate
|
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
-
Toxicol In Vitro, 2021, 77:105251
-
J Neuroimmunol, 2019, 332:37-48
|
|
S5654 |
Indacaterol
|
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
-
Drug Test Anal, 2020, 10.1002/dta.2917
-
J Neuroimmunol, 2019, 332:37-48
|
|
S4358 |
Pimozide
|
Pimozide (Orap, R6238) 是一种 Dopamine Receptors 的拮抗剂,对dopamine D3,D2和D1受体的Ki值分别为0.83 nM,3.0 nM和6600 nM。Pimozide 在5-HT1A和α1-adrenoceptor 处也表现出结合亲和力,对应的Ki值分别为310 nM、39 nM。Pimozide 是一种具有抗肿瘤活性的抗精神病药物,可抑制 STAT3 和 STAT5 活性。 |
-
Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101286
-
Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
|
|
S2086 |
Ivabradine HCl
|
Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride)是一种新型If抑制剂,IC50为2.9 μM,特定有效作用于窦房结心脏起搏器活性,是一种纯粹的心跳速率降低剂。 |
-
Cell Rep, 2022, 38(10):110468
-
J Pain, 2018, 19(6):626-634
|
|
S2091 |
Betaxolol
|
Betaxolol (SL 75212,Dextrobetaxolol) 是一种选择性的β1肾上腺素能受体抑制剂,用于治疗高血压和青光眼。 |
-
Nat Commun, 2020, 24;11(1):1990
-
Chirality, 2018, 30(11):1195-1205
|
|
S5430 |
Metoprolol
|
Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
BMC Pharmacol Toxicol, 2024, 25(1):25
-
Cell Rep, 2022, 38(10):110468
|
|
S4817 |
Atenolol
|
Atenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂,对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。 |
-
Int J Mol Sci, 2022, 23(21)12948
-
Oncol Rep, 2021, 46(3)202
|
|
S5494 |
Salbutamol
|
Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
-
Front Physiol, 2022, 13:800055
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S1409 |
Alfuzosin HCl
|
Alfuzosin HCl(SL 77499 HCl) 是一种α1受体拮抗剂,用于治疗良性前列腺增生(BPH)。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Prostate, 2016, 76(8):757-66
|
|
S3083 |
Indacaterol Maleate
|
Indacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂,对β1-adrenoceptor的pKi为 7.36,对 β2-adrenoceptor 的pKi为5.48。 |
-
J Allergy Clin Immunol, 2021, S0091-6749(21)00979-9
|
|
S2458 |
Clonidine HCl
|
Clonidine HCl(Kapvay) 是一种直接起作用的α2肾上腺素能受体激动剂,ED50为0.02±0.01 mg/kg。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Mol Pain, 2022, 18:17448069221107810
|
|
S1424 |
Prazosin HCl
|
Prazosin HCl (cp-12299-1) 是Quinazoline 衍生物,是一种新型的化学类抗高血压药物。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S2038 |
Phentolamine Mesylate
|
Phentolamine Mesylate(Phentolamine methanesulfonate)是一种非选择性α-肾上腺素能拮抗剂,IC50为0.1 μM。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Int J Mol Sci, 2024, 25(18)10162
-
Sci Rep, 2024, 14(1):4178
|
|
S2059 |
Terazosin HCl Dihydrate
|
Terazosin HCl 是α-肾上腺素能受体抑制剂,用于治疗高血压和前列腺肥大。 |
-
J Biomed Sci, 2021, 28(1):8
|
|
S2517 |
Maprotiline HCl
|
Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂,也是一种四环类抗抑郁药。 |
-
Front Pharmacol, 2021, 12:689767
|
|
S4113 |
Desvenlafaxine
|
Desvenlafaxine (WY 45233 Succinate)是一种5-羟色胺(5-HT)和去甲肾上腺素(NE)重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM。 |
-
Am J Cancer Res, 2024, 14(3):1087-1100
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S2126 |
Naftopidil
|
Naftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂,或α受体抑制剂,Ki为58.3 nM。 |
-
Cell Syst, 2019, 8(2):97-108
|
|
S4123 |
Timolol Maleate
|
Timolol Maleate (MK-950,(S)-Timolol Maleate)是一种非选择性的β-肾上腺素能受体拮抗剂,作用于β1/β2,Ki为1.97 nM/2.0 nM。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
J Dermatolog Treat, 2020, 24:1-7
|
|
S4010 |
Acebutolol HCl
|
Acebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。 |
-
Front Pharmacol, 2021, 12:740529
|
|
S3060 |
Medetomidine HCl
|
Medetomidine HCl是一种选择性的α2-adrenoceptor(α2-肾上腺素受体)激动剂,Ki为1.08 nM,比作用于α1-adrenoceptor选择性高1620倍。 |
-
Micromachines, 2018, 9(6)
|
|
S1437 |
Tizanidine HCl
|
Tizanidine HCl (DS 103-282) 是一种 α2-肾上腺素能受体激动剂,可抑制中枢神经系统去甲肾上腺素能神经元释放神经递质。 |
-
Drug Metab Dispos, 2021, 49(8):638-647
|
|
S1827 |
Betaxolol HCl
|
Betaxolol (SL 75212)是一种β1肾上腺素受体阻断剂,IC50是6 Μm。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Chirality, 2018, 30(11):1195-1205
|
|
S2092 |
Detomidine HCl
|
Detomidine HCl(MPV 253AII) 可产生镇静和镇痛作用,这种作用具有剂量依赖性,通过激活α2儿茶酚胺受体来调节。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Nature, 2018, 560(7718):372-376
|
|
S5537 |
Tizanidine
|
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
-
Drug Metab Dispos, 2021, 49(8):638-647
|
|
S5768 |
Fenoterol hydrobromide
|
Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
-
Toxicol In Vitro, 2021, 77:105251
|
|
S4124 |
Tolazoline HCl
|
Tolazoline HCl(Imidaline hydrochloride,NSC35110 hydrochloride)是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
Insect Biochem Mol Biol, 2017, 90:61-70
|
|
S5942 |
Bisoprolol
|
Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂,用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。 |
-
J Pathol, 2022, 10.1002/path.6020
|
|
S5337 |
Rauwolscine hydrochloride
|
Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
-
J Pharm Biomed Anal, 2020, 180:113019
|
|
S3656 |
Piribedil
|
Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
-
Cell Rep Methods, 2023, 3(1):100381
-
Cell Rep Methods, 2023, 3(1):100381
|
|
E2901 |
(-)-Isoproterenol hydrochloride
|
(-)-Isoproterenol hydrochloride 是 β-adrenergic受体 的激动剂。(-)-Isoproterenol hydrochloride也用于治疗心动过缓; 支气管扩张剂。 |
-
Stem Cell Res Ther, 2022, 13(1):287
|
|
S4679 |
Terazosin HCl
|
Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂,用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。 |
-
J Immunother Cancer, 2024, 12(11)e009805
-
J Biomed Sci, 2021, 28(1):8
|
|
S5780 |
Prazosin
|
Prazosin是α1阻断剂,是alpha-1肾上腺素能受体的反向激动剂。 |
-
BMC Pharmacol Toxicol, 2020, 21(1):61
|
|
S5787 |
Dronedarone
|
Dronedarone (SR33589)是amiodarone的衍生物,是III类抗心律失常药。它能抑制与心率相关的快速Na+流、抑制α和β肾上腺素能受体、阻断K+外向离子流和Ca2+慢速内流。 |
-
Korean Circ J, 2024, 54(4):172-186
-
Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127
|
|
S4112 |
Desvenlafaxine Succinate hydrate
|
Desvenlafaxine Succinate hydrate (WY 45233) 是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM |
-
Drug Metab Dispos, 2020, 48(10):1044-1052
|
|
S5023 |
Nadolol
|
Nadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂,具有抗高血压和抗心律失常活性。 |
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J Chromatogr A, 2024, 1734:465286
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Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
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S4243 |
Deoxycorticosterone acetate
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Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone)是一种类固醇激素,用于肌肉注射,是肾上腺皮质类固醇的代替疗法。 |
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Nat Cancer, 2020, 1(2):235-248
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S2113 |
Cisatracurium Besylate
|
Cisatracurium Besylate(51W89)是一种非去极化神经肌肉阻断剂,通过抑制神经肌肉的传导而对乙酰胆碱起拮抗作用。 |
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Biosci Trends, 2021, 15(1):50-54
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S2020 |
Formoterol Hemifumarate
|
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate)是一种有效的,选择性的,长效β2-adrenoceptor 激动剂,用于治疗哮喘以及慢性阻塞性肺病。 |
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S1613 |
Silodosin
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Silodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂,具有高泌尿选择性。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S2691 |
BMY 7378 Dihydrochloride
|
BMY 7378是一种多靶点抑制剂,作用于α2C-adrenoceptor和α1D-adrenoceptor,pKi分别为6.54和8.2,且为混合型5-HT1A受体激动剂和拮抗剂,pKi为8.3。 |
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S3041 |
Droxidopa
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Droxidopa (L-DOPS)是一种精神药物,是合成的氨基酸前体,它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。 |
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bioRxiv, 2024, 2024.07.30.605812
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S2522 |
L-Adrenaline
|
L-Adrenaline (Epinephrine) 属于儿茶酚胺类。此产品为危化品(急性毒性/易燃/皮肤腐蚀),请在穿戴防护面罩、防护手套和防护服后使用。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S1856 |
Metoprolol Tartrate
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Metoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂,IC50为42 ng/mL。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S1387 |
Naftopidil DiHCl
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Naftopidil DiHCl (Flivas, KT-611, Avishot,BM-15275)是一种选择性5-HT1A和α1-adrenergic receptor(α1-肾上腺素受体)拮抗剂,IC50分别为0.1 μM和0.2 μM。 |
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S2499 |
Phenoxybenzamine HCl
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Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。 |
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S2519 |
Naphazoline HCl
|
Naphazoline HCl 是一种眼部血管收缩剂,是咪唑啉衍生的拟交感胺类。 |
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S2533 |
Ritodrine HCl
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Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) 是Ritodrine的盐酸盐,是β-2肾上腺素能受体激动剂。 |
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S2438 |
Synephrine HCl
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Synephrine HCl是一种交感神经α-adrenergic receptor (AR)(肾上腺素受体)激动剂。 |
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S3153 |
Levalbuterol tartrate
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Levalbuterol tartrate(Levosalbutamol tartrate)是一种相对选择性的β2-肾上腺素受体激动剂,用于治疗哮喘。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S3294 |
Demethyl-Coclaurine
|
Demethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分,是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化,需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。 |
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Signal Transduct Target Ther, 2024, 9(1):243
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S2545 |
Scopine
|
Scopine(6,7-Epoxytropine)是Anisodine的代谢产物,是一种α1-肾上腺素能受体激动剂,用于治疗急性循环性休克。 |
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S2607 |
Buflomedil HCl
|
Buflomedil HCl(NSC 759291)是一种血管扩张剂,用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S5088 |
Labetalone hydrochloride
|
Labetalone hydrochloride (Benzoic amide)是labetalone的盐酸盐形式,labetalone是alpha- 和 beta-adrenergic receptors的阻滞剂,被用作一种降压药。 |
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S2523 |
DL-Adrenaline
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DL-Adrenaline(dl-Epinephrine)是一种激素,是由肾上腺髓质分泌的一种神经递质。 |
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S4266 |
Brimonidine Tartrate
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Brimonidine Tartrate(UK 1434 Tartrate)是一种高选择性的α-肾上腺素能受体激动剂,EC50为0.45 nM,用于治疗开角型青光眼或高眼压症。 |
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S5540 |
Landiolol hydrochloride
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Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
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S2615 |
Noradrenaline bitartrate monohydrate
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Noradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。 |
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S0032 |
Batefenterol
|
Batefenterol (GSK961081, TD-5959) 既是 muscarinic receptor 的拮抗剂又是 β2-adrenoceptor 的激动剂,hM2、hM3 muscarinic receptors 和 hβ2-adrenoceptor 的Ki值分别为1.4 nM、1.3 nM和3.7 nM。 |
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E4888New |
Guanabenz hydrochloride
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Guanabenz hydrochloride(NE56490)是一种小分子抗高血压α2-肾上腺素能受体激动剂。它还能抑制eIF2α和GADD34,具有治疗心脏肥大、心力衰竭、动脉粥样硬化和缺血性心脏病的潜力。 |
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E4825New |
Naphazoline (nitrate)
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Naphazoline (nitrate)是外周α2-adrenergic receptor的激动剂,作为血管收缩剂,有效地减少术中出血,增强术后镇痛。当与鼻内利多卡因联合使用时,可显著减少术中和术后疼痛,从而减少鼻中隔成形术后对抢救性镇痛药物的需求。 |
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F2415New |
Adrenergic α 1A Receptor/ADRA1A Rabbit mAb
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S5802 |
Alprenolol hydrochloride
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Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂,被用作抗高血压、减轻心绞痛和抗心律失常的试剂。 |
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S5769 |
Fenoterol
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Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S7538 |
RS-102895 Hydrochloride
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RS-102895 hydrochloride (HCl) 是一种有效的 Chemokine (C-C motif) receptor 2 (CCR2) 的拮抗剂,其IC50值为360 nM,对CCR1无影响。RS-102895 hydrochloride 还可抑制细胞中的 human α1a 和 α1d receptors,大鼠脑皮质 5-HT1a receptor,其IC50值分别为130 nM、320 nM和470 nM。 |
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S4135 |
Clorprenaline HCl
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Clorprenaline HCl (NSC 334693) 是β2-受体激动剂,具有显著的扩张支气管作用。 |
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S5666 |
Moxisylyte hydrochloride
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Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
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J Immunother Cancer, 2024, 12(11)e009805
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S6345 |
3-Nitro-L-tyrosine
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3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT) 是由过氧化亚硝酸盐从L-酪氨酸合成的,是一氧化氮和超氧化物的产物。3-Nitro-L-tyrosine 可通过抑制 alpha 1-adrenoceptor 介导的反应来抑制血管紧张素II引起的血液动力学反应。 |
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S5766 |
Alfuzosin
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Alfuzosin(SL 77499)是具有选择性的、竞争性α1肾上腺素能受体(α1-adrenoceptor)拮抗剂。 |
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S4043 |
Tetrahydrozoline HCl
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Tetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物,具有α受体激动剂活性。 |
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S0862 |
L-765314
|
L-765314是一种选择性和有效的α1b-adrenoceptor (α1b adrenergic receptor)拮抗剂,IC50为1.90 nM,对于大鼠和人α1b肾上腺素能受体的Ki分别为5.4和2.0。 |
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E4865New |
Noradrenaline bitartrate
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Noradrenaline bitartrate (Norepinephrine Bitartrate)是一种中枢神经系统(CNS)神经递质和β1 adrenergic receptors和α-adrenergic receptors的刺激剂,引起收缩性和心率增加,以及血管收缩。 |
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E2875New |
Levobunolol hydrochloride
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Levobunolol (l-Bunolol) hydrochloride是一种强效和非选择性的β-肾上腺素受体拮抗剂,IC50为48μM。 |
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S9285 |
Fargesin
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Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
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S5789 |
Propafenone
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Propafenone (SA-79) 是一种口服活性 sodium channel 的阻断剂和 beta-adrenoceptor (β-adrenergic receptor) 的拮抗剂。Propafenone 在治疗心律不齐方面具有广泛的活性。 |
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S5965 |
Urapidil
|
Urapidil 是一种降压药,可作为 α1 adrenoreceptor 的拮抗剂和 5-HT1A 激动剂。 |
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E4963New |
Clonidine
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Clonidine(Clonidin) 是一种直接作用的α2-肾上腺素激动剂。它可用于治疗儿童和青少年的注意力缺陷多动障碍 (ADHD)。 |
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S5217 |
Arformoterol Tartrate
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Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
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S5281 |
Dapiprazole Hydrochloride
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Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
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S5734 |
Midodrine hydrochloride
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Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
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S5735 |
Midodrine
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Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
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S9470 |
Penbutolol Sulfate
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Penbutolol sulfate ((-)-Terbuclomine)是一种有效的β-肾上腺素受体阻滞剂和利尿剂,可用作抗高血压药。 |
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S5727 |
Tetryzoline
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Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
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S5954 |
L-(-)-α-Methyldopa hydrate
|
L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate 是一种有效的降压药,是 α2-adrenergic receptors 的选择性激动剂。 |
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F0220New |
Androgen Receptor Rabbit mAb
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Androgen Receptor Rabbit mAb recognizes endogenous levels of total Androgen Receptor protein. |
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S1642 |
Methyldopa
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Methyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。 |
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J Immunother Cancer, 2024, 12(11)e009805
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E4842New |
Vilanterol
|
Vilanterol (GW642444) 是 β2-肾上腺素能受体 (β2-AR) 的强效选择性激动剂,在 cAMP 检测试验中,Vilanterol 对β2-AR、β1-AR 和 β3-AR 的 pEC50 分别为 10.37、6.98 和 7.36。 |
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S2576 |
Xylometazoline HCl
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Xylometazoline HCl 是α-adrenoceptor激动剂,常用作鼻血管收缩药,高效作用于α2B肾上腺素受体亚型,EC50为4 μM。 |
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S3913 |
Pimethixene maleate
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Pimethixene (Pimetixene) maleate 是一种抗组胺药、抗焦虑药和抗血清素的化合物,是多种monoamine receptors,包括多种 serotonin receptors 的高效拮抗剂。Pimethixene maleate 可抑制5-HT2A、5-HT2B、5-HT2C、5-HT1A、5-HT1B、5-HT6、5-HT7、Adrenergic α-1A、Dopamine D1 Receptor、Dopamine D2 Receptor、Dopamine D4.4 Receptor、Histamine H1 Receptor、Muscarinic M1 和 Muscarinic M2,对应的pKi值分别为10.22、10.44、8.42、7.63、<5、7.30、7.28、7.61、6.37、8.19、7.54、10.14、8.61和9.38。 |
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S3640 |
Methoxyphenamine Hydrochloride
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Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
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S4649 |
Atipamezole hydrochloride
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Atipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。 |
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S3643 |
Amitraz
|
Amitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。 |
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S2304 |
Gramine
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Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱,是一种活性脂联素受体(AdipoR)激动剂,对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。 |
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S0116 |
Piperoxan hydrochloride
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Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。 |
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S5981 |
S(-)-Propranolol hydrochloride
|
(S)-(-)-Propranolol hydrochloride 是 propranolol的活性对映体,是 β-Adrenoceptor (β-Adrenergic Receptor) 的拮抗剂,对β1、β2和β3的Kd值分别为-8.16、-9.08和-6.93。 |
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Heliyon, 2024, 10(11):e31865
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S0812 |
SR59230A
|
SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂,对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。 |
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S1423 |
Dobutamine HCl
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Dobutamine(Dobutrex) Hydrochloride 是一种选择性强效β1-AR(β-1 肾上腺素受体)激动剂,对 α1-AR 和 β2-AR 表现出弱活性。 多巴酚丁胺是一种拟交感神经化合物,可通过改善心肌收缩力和增加心输出量 (CO) 来有效恢复低血压狗和人类患者的血压。 |
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S6583 |
Apraclonidine HCl
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Apraclonidine (Iopidine,ALO 2145)是一种拟交感神经要,用于治疗青光眼。它是α2-肾上腺素能受体激动剂。 |
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S3764 |
Isoferulic Acid
|
Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. |
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S4485 |
Olodaterol
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Olodaterol是一种长效的 β2-adrenergic receptor 的激动剂,可作为吸入剂(Tiotropium/Olodaterol)的成分之一,用于治疗慢性阻塞性肺疾病(COPD)患者。 |
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S9050 |
Boldine
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Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
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S4693 |
Guanfacine Hydrochloride
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Guanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂,具有降压效果。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S1435 |
Tamsulosin hydrochloride
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Tamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。 |
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S5669 |
Isoxsuprine hydrochloride
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Isoxsuprine hydrochloride是β-肾上腺素能受体(beta-adrenergic)激动剂,具有血管扩张活性。 |
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S4085 |
Levobetaxolol HCl
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Levobetaxolol (AL 1577A,(S)-Betaxolol hydrochloride)高亲和力作用于克隆的人β1和β2受体,Ki分别为0.76 nM和32.6 nM。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S5042 |
Bevantolol hydrochloride
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Bevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂,没有β内源性拟交感活性,膜稳定性较弱,具有局部麻醉作用。 |
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S5925 |
Olodaterol hydrochloride
|
Olodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式,Olodaterol是一种长效的β2肾上腺素能受体(beta2-adrenergic)激动剂。 |
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E0949 |
Mebicar
|
Mebicar是双环双脲的衍生物,可抑制白化病小鼠的定向反应,增强麻醉催眠药的作用,消除回避的条件反射反应,显示中枢肾上腺素溶解活性,干扰脑干中的去甲肾上腺素代谢。 |
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E1049New |
CL316243
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CL316243 是一种高效、选择性的β3-肾上腺素能受体激动剂,EC50 值为 3 nM,但对 β1/2-受体的作用极差。它能有效刺激脂肪细胞脂肪分解,增加棕色脂肪组织的产热和代谢率。 |
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S5778 |
Esmolol
|
Esmolol是心脏选择性β1阻断剂,能迅速发挥作用、持续时间短,在治疗剂量下,对内在拟交感活性或膜稳定性没有显著影响。 |
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S6407 |
Tulobuterol hydrochloride
|
Tulobuterol是长效的β2-adrenergic receptor激动剂,具有支气管扩张、消炎和抗病毒活性。 |
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E0408 |
JP1302
|
JP-1302(MMV006172)是一种新型的高选择性α2C-肾上腺素受体(α2C-adrenoceptor)拮抗剂,对α2C-肾上腺素受体亚型的Kb为16 nM,同时能产生抗抑郁和抗精神病样作用。 |
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E4880New |
Labetalol
|
Labetalol (AH5158, Sch-15719W free base)是一种口服活性的选择性竞争性拮抗剂,可拮抗 α1-肾上腺素受体 和非选择性 β-肾上腺素受体。Labetalol 是一种抗高血压药物,用于心血管疾病的研究。 |
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S4100 |
Esmolol HCl
|
Esmolol (ASL8052) 是一种心脏选择性B受体阻滞剂,用于控制心跳急或异常心率节律。
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-
J Immunother Cancer, 2024, 12(11)e009805
|
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S5496 |
Guanethidine Monosulfate
|
Guanethidine monosulfate is an antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. |
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S5782 |
Doxazosin
|
Doxazosin(UK 33274)是一种喹唑啉衍生物,可选择性拮抗突触后α1肾上腺素能受体(α1-adrenergic receptors)。 |
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E4892New |
Formoterol
|
Formoterol是一种高选择性、强效的长效β2-肾上腺素受体激动剂,通过结合并激活气道平滑肌细胞上的β2-肾上腺素受体发挥作用。它用于治疗慢性阻塞性肺病 (COPD) 患者。 |
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S2174 |
Hydroxyflutamide (Hydroxyniphtholide)
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Hydroxyflutamide (SCH-16423,Hydroxyniphtholide)是一种雄激素受体androgen receptor (AR)拮抗剂,IC50为0.7 μM。 |
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S5923 |
Celiprolol hydrochloride
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Celiprolol是β1-adrenoceptor拮抗剂,具有部分β2受体激动剂活性。 |
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S6447 |
Carazolol
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Carazolol是一种非特异性β肾上腺素能阻滞剂。 |
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E2944 |
Norepinephrine hydrochloride
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Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride是一种有效的肾上腺素受体(AR)激动剂。 Norepinephrine hydrochloride激活α1、α2、β1受体。 |
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E4849New |
Terbutaline
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Terbutaline(Brican, Brethine)是bambuterol的活性代谢物,是一种口服的 β2-肾上腺素受体 激动剂,可增加 MKP-1 表达。Terbutaline可作为支气管扩张剂用于治疗阻塞性肺病。它还具有抗炎作用。 |
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S5341 |
Metroprolol succinate
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Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
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S2083 |
Procaterol HCl
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Procaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂,Kp为8 nM,用于治疗哮喘。 |
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S5432 |
Dibenamine Hydrochloride
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Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
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E2964 |
Norepinephrine tartrate
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Norepinephrine tartrate 是一种有效的肾上腺素受体(AR)激动剂。 Norepinephrine tartrate激活α1、α2、β1受体。 |
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S4277 |
Bambuterol HCl
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Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride)是强效β-adrenoceptor拮抗剂,用于治疗哮喘。
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S4278 |
Carteolol HCl
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Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
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J Immunother Cancer, 2024, 12(11)e009805
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E1746New |
Protokylol hydrochloride
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Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) 是 Protokylol 的盐形式,是 β-肾上腺素能受体 的激动剂。 Protokylol hydrochloride也用作支气管扩张剂。 |
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S5750 |
DL-Norepinephrine hydrochloride
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Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
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S9560 |
Anisodamine Hydrobromide
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Anisodamine (6-Hydroxyhyoscyamine)是天然存在的阿托品(atropine)衍生物,具有消炎活性。它能抑制α1-adrenergic receptors和mAChRs。 |
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S2362 |
Synephrine
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Synephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇,常用于减肥。 |
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S9508 |
Brimonidine
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Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
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E0529 |
Metipranolol
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Metipranolol (Betamann) 是一种β-肾上腺素能受体(β-adrenergic receptor)的强效拮抗剂,对豚鼠心房β1-肾上腺素受体及大鼠子宫的β2-肾上腺素受体展示出乙型阻断效能(the beta-blocking potencies,pA2)分别为8.3和8.4,它也是3H-DHA结合试验中的强效置换剂,配体浓度0.7 nM时,Ki为39±24 nM。 |
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S0896 |
DSP-4 HCl
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DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride))可用于中央和外周去甲肾上腺素能神经元的暂时选择性降解,只影响蓝斑(locus coeruleus, LC)的去甲肾上腺素能纤维。 |
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E0785 |
YS-49
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YS-49是一种PI3K/Akt (RhoA的下游靶点)激活剂,可减少3-甲基胆蒽处理的细胞中RhoA/PTEN的活化,YS-49通过诱导血红素加氧酶(HO)-1抑制血管紧张素II (angiotensin II,AngII)刺激的血管平滑肌细胞(vascular smooth muscle cells,VSMCs)增殖,YS-49也是一种异喹啉类化合物生物碱,通过激活心脏β-肾上腺素受体(cardiac β-adrenoceptors),具有很强的正性肌力作用。 |
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Signal Transduct Target Ther, 2024, 9(1):243
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S4291 |
Labetalol HCl
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Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W)是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂,用于高血压的治疗。
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J Immunother Cancer, 2024, 12(11)e009805
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S5267 |
Nylidrin Hydrochloride
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Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
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S5723 |
Carvedilol EP IMpurity E
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Carvedilol EP IMpurity E (Carvedilol USP E, Carvedilol Impurity E) is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). |
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S6487 |
fluticasone furoate
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Fluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。 |
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S3185 |
Adrenalone HCl
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Adrenalone HCl是一种肾上腺素激动剂,作为外用的血管收缩剂和止血剂,主要作用于α-1肾上腺素受体。 |
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J Immunother Cancer, 2024, 12(11)e009805
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S4481 |
Guanabenz
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Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) 是一种具有抗高血压作用的中枢 alpha 2-adrenoceptor (α2 adrenergic receptor) 的口服活性激动剂。 |
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S4797 |
Nicergoline
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Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
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S1831 |
Carvedilol
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Carvedilol (BM-14190, SKF 105517)是一种非选择性β/α-1受体抑制剂,用于治疗充血性心力衰竭和高血压。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Antioxidants (Basel), 2023, 12(8)1585
- Antioxidants (Basel), 2023, 12(8)1585
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S8114 |
Zenidolol (ICI-118551) Hydrochloride
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Zenidolol (ICI-118551) Hydrochloride是高选择性的β2肾上腺素受体拮抗剂,其对β2,β1和β3 受体的Ki值分别为0.7, 49.5和611 nM。 |
- Biomedicines, 2022, 10(2)487
- iScience, 2021, 24(12):103362
- Toxicol In Vitro, 2021, 77:105251
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S2373 |
Yohimbine HCl
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Yohimbine (Antagonil) 是一种瞳孔放大剂,用于治疗阳痿,也是一种春药。 |
- Anesth Analg, 2023, 137(2):426-39
- Mol Pain, 2022, 18:17448069221107810
- J Med Chem, 2021, 64(18):13510-13523
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S1283 |
Asenapine maleate
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Asenapine maleate (Org 5222)是一种高亲和性的包括 serotonin, norepinephrine, dopamine 和 histamine receptors在内的多种受体的拮抗剂,用于治疗神经分裂症以及抑郁狂躁型忧郁症。 |
- J Adv Res, 2024, S2090-1232(24)00079-1
- Cell Commun Signal, 2024, 22(1):266
- Mol Cancer, 2023, 22(1):136
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S1549 |
Nebivolol hydrochloride (R-65824)
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在兔肺β1-肾上腺素受体结合实验中,Nebivolol HCl (R-65824 hydrochloride)选择性阻断β1受体,IC50为0.8 nM。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Oncogenesis, 2022, 11(1):24
- Nat Commun, 2021, 12(1):5919
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S2509 |
Sotalol HCl
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Sotalol(MJ-1999)是一种非选择性β受体抑制剂,是钾离子通道抑制剂,IC50为43 μM。 |
- J Immunother Cancer, 2024, 12(11)e009805
- EBioMedicine, 2023, 95:104741
- Toxicol Appl Pharmacol, 2021, 431:115731
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S4650 |
Atipamezole
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Atipamezole (MPV-1248, MPV1248, Antisedan)是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。 |
- Exp Mol Med, 2020, 10.1038/s12276-020-0461-6
- Nitric Oxide, 2019, 85:1-9
- Front Neurol, 2019, 10:1041
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S4358 |
Pimozide
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Pimozide (Orap, R6238) 是一种 Dopamine Receptors 的拮抗剂,对dopamine D3,D2和D1受体的Ki值分别为0.83 nM,3.0 nM和6600 nM。Pimozide 在5-HT1A和α1-adrenoceptor 处也表现出结合亲和力,对应的Ki值分别为310 nM、39 nM。Pimozide 是一种具有抗肿瘤活性的抗精神病药物,可抑制 STAT3 和 STAT5 活性。 |
- Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101286
- Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
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S2091 |
Betaxolol
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Betaxolol (SL 75212,Dextrobetaxolol) 是一种选择性的β1肾上腺素能受体抑制剂,用于治疗高血压和青光眼。 |
- Nat Commun, 2020, 24;11(1):1990
- Chirality, 2018, 30(11):1195-1205
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S5430 |
Metoprolol
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Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension. |
- BMC Pharmacol Toxicol, 2024, 25(1):25
- BMC Pharmacol Toxicol, 2024, 25(1):25
- Cell Rep, 2022, 38(10):110468
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S4817 |
Atenolol
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Atenolol (Tenormin, Normiten, Blokium)是一种选择性的β1 receptor拮抗剂,对人源β1-, β2- 和β3-肾上腺受体的log Kd值分别为−6.66±0.05, −5.99±0.14, −4.11±0.07。 |
- Int J Mol Sci, 2022, 23(21)12948
- Oncol Rep, 2021, 46(3)202
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S1409 |
Alfuzosin HCl
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Alfuzosin HCl(SL 77499 HCl) 是一种α1受体拮抗剂,用于治疗良性前列腺增生(BPH)。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Prostate, 2016, 76(8):757-66
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S1424 |
Prazosin HCl
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Prazosin HCl (cp-12299-1) 是Quinazoline 衍生物,是一种新型的化学类抗高血压药物。 |
- J Immunother Cancer, 2024, 12(11)e009805
- BMC Pharmacol Toxicol, 2020, 21(1):61
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S2038 |
Phentolamine Mesylate
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Phentolamine Mesylate(Phentolamine methanesulfonate)是一种非选择性α-肾上腺素能拮抗剂,IC50为0.1 μM。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Int J Mol Sci, 2024, 25(18)10162
- Sci Rep, 2024, 14(1):4178
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S2059 |
Terazosin HCl Dihydrate
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Terazosin HCl 是α-肾上腺素能受体抑制剂,用于治疗高血压和前列腺肥大。 |
- J Biomed Sci, 2021, 28(1):8
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S2517 |
Maprotiline HCl
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Maprotiline HCl是一种选择性去甲肾上腺素再摄取抑制剂,也是一种四环类抗抑郁药。 |
- Front Pharmacol, 2021, 12:689767
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S2126 |
Naftopidil
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Naftopidil (KT-611) 是选择性α1-肾上腺素能受体拮抗剂,或α受体抑制剂,Ki为58.3 nM。 |
- Cell Syst, 2019, 8(2):97-108
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S4123 |
Timolol Maleate
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Timolol Maleate (MK-950,(S)-Timolol Maleate)是一种非选择性的β-肾上腺素能受体拮抗剂,作用于β1/β2,Ki为1.97 nM/2.0 nM。 |
- J Immunother Cancer, 2024, 12(11)e009805
- J Dermatolog Treat, 2020, 24:1-7
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S4010 |
Acebutolol HCl
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Acebutolol HCl是beta-adrenergic receptors(β-肾上腺素能受体)拮抗剂,用于治疗高血压,心绞痛,和心律失常。 |
- Front Pharmacol, 2021, 12:740529
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S1827 |
Betaxolol HCl
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Betaxolol (SL 75212)是一种β1肾上腺素受体阻断剂,IC50是6 Μm。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Chirality, 2018, 30(11):1195-1205
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S4124 |
Tolazoline HCl
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Tolazoline HCl(Imidaline hydrochloride,NSC35110 hydrochloride)是一种非选择性和竞争性的α-肾上腺素能受体拮抗剂。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Insect Biochem Mol Biol, 2017, 90:61-70
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S5942 |
Bisoprolol
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Bisoprolol是心脏选择性β1-adrenergic receptor阻滞剂,用于阻止心肌梗死、心力衰竭、心绞痛和轻中度高血压。 |
- J Pathol, 2022, 10.1002/path.6020
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S5337 |
Rauwolscine hydrochloride
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Rauwolscine hydrochloride (Isoyohimbine, α-Yohimbine, corynanthidine) is the hydrochloride salt form of Rauwolscine, a specific and potent α2 antagonist with Ki of 12 nM. |
- J Pharm Biomed Anal, 2020, 180:113019
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S3656 |
Piribedil
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Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
- Cell Rep Methods, 2023, 3(1):100381
- Cell Rep Methods, 2023, 3(1):100381
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E2901 |
(-)-Isoproterenol hydrochloride
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(-)-Isoproterenol hydrochloride 是 β-adrenergic受体 的激动剂。(-)-Isoproterenol hydrochloride也用于治疗心动过缓; 支气管扩张剂。 |
- Stem Cell Res Ther, 2022, 13(1):287
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S4679 |
Terazosin HCl
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Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin)是一种选择性的alpha-1拮抗剂,用于治疗前列腺肿大症状。它通过抑制膀胱平滑肌和血管壁上的肾上腺素的作用发挥效应。 |
- J Immunother Cancer, 2024, 12(11)e009805
- J Biomed Sci, 2021, 28(1):8
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S5780 |
Prazosin
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Prazosin是α1阻断剂,是alpha-1肾上腺素能受体的反向激动剂。 |
- BMC Pharmacol Toxicol, 2020, 21(1):61
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S5023 |
Nadolol
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Nadolol (Corgard, Solgol, Anabet, SQ11725) 是一种非选择性的β-肾上腺素能受体拮抗剂,具有抗高血压和抗心律失常活性。 |
- J Chromatogr A, 2024, 1734:465286
- Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
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S1613 |
Silodosin
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Silodosin (KAD 3213, KMD 3213)是一种α1-肾上腺素受体拮抗剂,具有高泌尿选择性。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S2691 |
BMY 7378 Dihydrochloride
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BMY 7378是一种多靶点抑制剂,作用于α2C-adrenoceptor和α1D-adrenoceptor,pKi分别为6.54和8.2,且为混合型5-HT1A受体激动剂和拮抗剂,pKi为8.3。 |
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S1856 |
Metoprolol Tartrate
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Metoprolol Tartrate (CGP 2175E) 是一种心脏选择性的β-肾上腺素能受体抑制剂,IC50为42 ng/mL。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S1387 |
Naftopidil DiHCl
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Naftopidil DiHCl (Flivas, KT-611, Avishot,BM-15275)是一种选择性5-HT1A和α1-adrenergic receptor(α1-肾上腺素受体)拮抗剂,IC50分别为0.1 μM和0.2 μM。 |
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S2499 |
Phenoxybenzamine HCl
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Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。 |
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S2607 |
Buflomedil HCl
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Buflomedil HCl(NSC 759291)是一种血管扩张剂,用于治疗跛行或外周动脉疾病的症状。是一种非选择性alpha adrenergic receptor抑制剂。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S5540 |
Landiolol hydrochloride
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Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist. |
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S5802 |
Alprenolol hydrochloride
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Alprenolol hydrochloride是alprenolol的盐酸盐形式。Alprenolol是beta adrenergic receptor拮抗剂,被用作抗高血压、减轻心绞痛和抗心律失常的试剂。 |
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S7538 |
RS-102895 Hydrochloride
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RS-102895 hydrochloride (HCl) 是一种有效的 Chemokine (C-C motif) receptor 2 (CCR2) 的拮抗剂,其IC50值为360 nM,对CCR1无影响。RS-102895 hydrochloride 还可抑制细胞中的 human α1a 和 α1d receptors,大鼠脑皮质 5-HT1a receptor,其IC50值分别为130 nM、320 nM和470 nM。 |
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S5666 |
Moxisylyte hydrochloride
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Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. |
- J Immunother Cancer, 2024, 12(11)e009805
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S5766 |
Alfuzosin
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Alfuzosin(SL 77499)是具有选择性的、竞争性α1肾上腺素能受体(α1-adrenoceptor)拮抗剂。 |
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S0862 |
L-765314
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L-765314是一种选择性和有效的α1b-adrenoceptor (α1b adrenergic receptor)拮抗剂,IC50为1.90 nM,对于大鼠和人α1b肾上腺素能受体的Ki分别为5.4和2.0。 |
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E2875New |
Levobunolol hydrochloride
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Levobunolol (l-Bunolol) hydrochloride是一种强效和非选择性的β-肾上腺素受体拮抗剂,IC50为48μM。 |
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S9285 |
Fargesin
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Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway. |
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S5789 |
Propafenone
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Propafenone (SA-79) 是一种口服活性 sodium channel 的阻断剂和 beta-adrenoceptor (β-adrenergic receptor) 的拮抗剂。Propafenone 在治疗心律不齐方面具有广泛的活性。 |
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S5965 |
Urapidil
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Urapidil 是一种降压药,可作为 α1 adrenoreceptor 的拮抗剂和 5-HT1A 激动剂。 |
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S5281 |
Dapiprazole Hydrochloride
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Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination. |
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S4649 |
Atipamezole hydrochloride
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Atipamezole (Antisedan, MPV1248) 是一种合成的α2肾上腺素能受体拮抗剂。作为潜在抗帕金森病的药物在人类中被研究。Atipamezole hydrochloride是atipamezole的盐酸盐形式。 |
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S0116 |
Piperoxan hydrochloride
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Piperoxan hydrochloride (Benodaine, Fourneau 933, F933, DL-Piperoxan) 是 α2 (alpha 2) adrenoceptor 的拮抗剂。 |
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S5981 |
S(-)-Propranolol hydrochloride
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(S)-(-)-Propranolol hydrochloride 是 propranolol的活性对映体,是 β-Adrenoceptor (β-Adrenergic Receptor) 的拮抗剂,对β1、β2和β3的Kd值分别为-8.16、-9.08和-6.93。 |
- Heliyon, 2024, 10(11):e31865
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S0812 |
SR59230A
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SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂,对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。 |
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S9050 |
Boldine
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Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects. |
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S1435 |
Tamsulosin hydrochloride
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Tamsulosin (Flomax) hydrochloride是一种作用于前列腺的α1A肾上腺素拮抗剂。 |
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S4085 |
Levobetaxolol HCl
|
Levobetaxolol (AL 1577A,(S)-Betaxolol hydrochloride)高亲和力作用于克隆的人β1和β2受体,Ki分别为0.76 nM和32.6 nM。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S5042 |
Bevantolol hydrochloride
|
Bevantolol hydrochloride (NC-1400) 选择性β肾上腺素受体拮抗剂,没有β内源性拟交感活性,膜稳定性较弱,具有局部麻醉作用。 |
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S5778 |
Esmolol
|
Esmolol是心脏选择性β1阻断剂,能迅速发挥作用、持续时间短,在治疗剂量下,对内在拟交感活性或膜稳定性没有显著影响。 |
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E0408 |
JP1302
|
JP-1302(MMV006172)是一种新型的高选择性α2C-肾上腺素受体(α2C-adrenoceptor)拮抗剂,对α2C-肾上腺素受体亚型的Kb为16 nM,同时能产生抗抑郁和抗精神病样作用。 |
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E4880New |
Labetalol
|
Labetalol (AH5158, Sch-15719W free base)是一种口服活性的选择性竞争性拮抗剂,可拮抗 α1-肾上腺素受体 和非选择性 β-肾上腺素受体。Labetalol 是一种抗高血压药物,用于心血管疾病的研究。 |
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S4100 |
Esmolol HCl
|
Esmolol (ASL8052) 是一种心脏选择性B受体阻滞剂,用于控制心跳急或异常心率节律。
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- J Immunother Cancer, 2024, 12(11)e009805
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S5782 |
Doxazosin
|
Doxazosin(UK 33274)是一种喹唑啉衍生物,可选择性拮抗突触后α1肾上腺素能受体(α1-adrenergic receptors)。 |
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S2174 |
Hydroxyflutamide (Hydroxyniphtholide)
|
Hydroxyflutamide (SCH-16423,Hydroxyniphtholide)是一种雄激素受体androgen receptor (AR)拮抗剂,IC50为0.7 μM。 |
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S5923 |
Celiprolol hydrochloride
|
Celiprolol是β1-adrenoceptor拮抗剂,具有部分β2受体激动剂活性。 |
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S6447 |
Carazolol
|
Carazolol是一种非特异性β肾上腺素能阻滞剂。 |
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S5341 |
Metroprolol succinate
|
Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. |
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S5432 |
Dibenamine Hydrochloride
|
Dibenamine (N-(2-Chloroethyl)dibenzylamine, Sympatholytin, Dibenzylchlorethamine) is an irreversible blocker of α1 adrenoceptors. |
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S4278 |
Carteolol HCl
|
Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) 是一种β-adrenoceptor拮抗剂,用于治疗青光眼。
|
- J Immunother Cancer, 2024, 12(11)e009805
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E0529 |
Metipranolol
|
Metipranolol (Betamann) 是一种β-肾上腺素能受体(β-adrenergic receptor)的强效拮抗剂,对豚鼠心房β1-肾上腺素受体及大鼠子宫的β2-肾上腺素受体展示出乙型阻断效能(the beta-blocking potencies,pA2)分别为8.3和8.4,它也是3H-DHA结合试验中的强效置换剂,配体浓度0.7 nM时,Ki为39±24 nM。 |
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S4291 |
Labetalol HCl
|
Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W)是一种选择性alpha1-adrenergic 和非选择性beta-adrenergic receptors的双重拮抗剂,用于高血压的治疗。
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- J Immunother Cancer, 2024, 12(11)e009805
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S4797 |
Nicergoline
|
Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions. |
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S4009 |
Mirabegron
|
Mirabegron (YM 178)是一种选择性的beta3-adrenoceptor(β3肾上腺素受体)激动剂,EC50为22.4 nM。 |
- J Pers Med, 2022, 12(2)258
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 10.1007/s13577-021-00639-4
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S2521 |
Epinephrine bitartrate
|
Epinephrine bitartrate (Adrenalinium)是一种α和β-肾上腺素能受体激动剂。 |
- Sci Adv, 2024, 10(33):eado1533
- Int J Biol Sci, 2023, 19(7):2006-2019
- Int J Biol Sci, 2023, 19(7):2006-2019
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S2569 |
Phenylephrine HCl
|
Phenylephrine HCl是一种选择性的α1-肾上腺素能受体激动剂。 |
- NPJ Regen Med, 2023, 8(1):9
- Front Immunol, 2022, 13:1090773
- Front Immunol, 2022, 10.3389/fimmu.2022.1090773
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S2516 |
Xylazine HCl
|
Xylazine HCl(BAY 1470 hydrochloride)是一种α2肾上腺素能受体激动剂,用作镇定剂和肌肉松弛剂。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Cell Death Dis, 2023, 14(5):318
- Eur J Pharmacol, 2021, 911:174522
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S2507 |
Salbutamol (Albuterol) Sulfate
|
Salbutamol (Albuterol) Sulfate是一种短效的β2-肾上腺素能受体激动剂,IC50为8.93 µM。 |
- Front Physiol, 2022, 13:800055
- cell, 2020, 180(1):64-78.e16
- Sci Signal, 2020, 13(659)eaax0273
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S2566 |
Isoprenaline (Isoproterenol) HCl
|
Isoprenaline (Isoproterenol) HCl是一种非选择性β-肾上腺素能受体激动剂,用于治疗心动过缓和心传导阻滞。 |
- Stem Cell Res Ther, 2022, 13(1):287
- BMC Cancer, 2022, 22(1):213
- J Dairy Sci, 2022, 105-10:8426-8438
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S9507 |
(−)-Norepinephrine
|
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline)是一种天然存在的神经递质和激素。它是adrenergic receptors的激动剂,对α1, α2A和β1肾上腺素受体的Ki值分别为330 nM、56 nM和740 nM。 |
- iScience, 2023, 26(3):106241
- Commun Biol, 2022, 5(1):339
- Eur J Pharmacol, 2022, 926:175040
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S2090 |
Dexmedetomidine HCl
|
Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) 是一种有效的,高度选择性α-2肾上腺素受体激动剂,具有显著的镇静效果,从而降低患者的麻醉量。 |
- Oral Dis, 2022, 10.1111/odi.14286
- JHEP Rep, 2021, 3(4):100296
- Sci Rep, 2021, 11(1):13345
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S7974 |
L755507
|
L-755,507是一种有效的、选择性的β3肾上腺素能受体部分激动剂,EC50为0.43 nM。它能在iPSCs和其他细胞类型中增强CRISPR介导的同源重组修复效率。 |
- Front Cell Dev Biol, 2023, 11:1276890
- bioRxiv, 2023, 10.1101/2023.10.03.560773
- Genesis, 2022, 60(1-2):e23465
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S5527 |
Salmeterol
|
Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500). |
- Front Pharmacol, 2022, 13:865715
- Mol Syst Biol, 2021, 17(8):e10239
- Drug Test Anal, 2020, 10.1002/dta.2917
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S5564 |
Xylazine
|
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
- Cell Death Dis, 2023, 14(5):318
- Cell Death Differ, 2020, 10.1038
- Mol Med Rep, 2017, 16(2):1911-1919
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S5683 |
Isoproterenol sulfate dihydrate
|
Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. |
- Stem Cell Res Ther, 2022, 13(1):287
- Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
- Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080
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S4065 |
Guanabenz Acetate
|
Guanabenz Acetate (WY-8678) 是一种选择性的α2a-肾上腺素能受体, α2b-肾上腺素能受体和α2c-肾上腺素能受体激动剂,pEC50分别为8.25, 7.01和5左右。 |
- Cell Stem Cell, 2020, 27(6):876-889.e12
- Thyroid, 2019, 29(6):809-823
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S3061 |
Epinephrine HCl
|
Epinephrine HCl (Adrenaline) 是一种激素和神经递质。 |
- Cell Rep Methods, 2023, 3(10):100599
- J Immunother Cancer, 2021, 9(1)e001466
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S4296 |
Salmeterol Xinafoate
|
Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur)是一种长效的β2-adrenergic receptor激动剂,具有抗炎作用,用于哮喘症状和慢性阻塞性肺疾病(COPD)症状的治疗。
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- ACS Pharmacol Transl Sci, 2019, 2(3):148-154
- Commun Biol, 2018, 1:106
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S3960 |
Higenamine hydrochloride
|
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants. |
- Mol Cell Biochem, 2021, 10.1007/s11010-021-04197-z
- Oncol Rep, 2021, 46(3)202
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S4127 |
Terbutaline Sulfate
|
Terbutaline Sulfate(Terbutaline hemisulfate)是一种选择性的β2-肾上腺素能受体激动剂,IC50为53 nM。 |
- BMC Pharmacol Toxicol, 2020, 21(1):61
- Hum Reprod, 2016, 31(11):2506-2519
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S3727 |
Vilanterol Trifenate
|
Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma. |
- Toxicol In Vitro, 2021, 77:105251
- J Neuroimmunol, 2019, 332:37-48
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S5654 |
Indacaterol
|
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor. |
- Drug Test Anal, 2020, 10.1002/dta.2917
- J Neuroimmunol, 2019, 332:37-48
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S5494 |
Salbutamol
|
Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. |
- Front Physiol, 2022, 13:800055
- BMC Pharmacol Toxicol, 2020, 21(1):61
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S3083 |
Indacaterol Maleate
|
Indacaterol (QAB149)是一种超长效的β-adrenoceptor激动剂,对β1-adrenoceptor的pKi为 7.36,对 β2-adrenoceptor 的pKi为5.48。 |
- J Allergy Clin Immunol, 2021, S0091-6749(21)00979-9
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S2458 |
Clonidine HCl
|
Clonidine HCl(Kapvay) 是一种直接起作用的α2肾上腺素能受体激动剂,ED50为0.02±0.01 mg/kg。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Mol Pain, 2022, 18:17448069221107810
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S3060 |
Medetomidine HCl
|
Medetomidine HCl是一种选择性的α2-adrenoceptor(α2-肾上腺素受体)激动剂,Ki为1.08 nM,比作用于α1-adrenoceptor选择性高1620倍。 |
- Micromachines, 2018, 9(6)
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S1437 |
Tizanidine HCl
|
Tizanidine HCl (DS 103-282) 是一种 α2-肾上腺素能受体激动剂,可抑制中枢神经系统去甲肾上腺素能神经元释放神经递质。 |
- Drug Metab Dispos, 2021, 49(8):638-647
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S2092 |
Detomidine HCl
|
Detomidine HCl(MPV 253AII) 可产生镇静和镇痛作用,这种作用具有剂量依赖性,通过激活α2儿茶酚胺受体来调节。 |
- J Immunother Cancer, 2024, 12(11)e009805
- Nature, 2018, 560(7718):372-376
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S5537 |
Tizanidine
|
Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity. |
- Drug Metab Dispos, 2021, 49(8):638-647
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S5768 |
Fenoterol hydrobromide
|
Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
- Toxicol In Vitro, 2021, 77:105251
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S2020 |
Formoterol Hemifumarate
|
Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate)是一种有效的,选择性的,长效β2-adrenoceptor 激动剂,用于治疗哮喘以及慢性阻塞性肺病。 |
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S3041 |
Droxidopa
|
Droxidopa (L-DOPS)是一种精神药物,是合成的氨基酸前体,它作为神经传导物质去甲肾上腺素和肾上腺素的前药来发挥作用。 |
- bioRxiv, 2024, 2024.07.30.605812
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S2522 |
L-Adrenaline
|
L-Adrenaline (Epinephrine) 属于儿茶酚胺类。此产品为危化品(急性毒性/易燃/皮肤腐蚀),请在穿戴防护面罩、防护手套和防护服后使用。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S2519 |
Naphazoline HCl
|
Naphazoline HCl 是一种眼部血管收缩剂,是咪唑啉衍生的拟交感胺类。 |
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S2533 |
Ritodrine HCl
|
Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) 是Ritodrine的盐酸盐,是β-2肾上腺素能受体激动剂。 |
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S2438 |
Synephrine HCl
|
Synephrine HCl是一种交感神经α-adrenergic receptor (AR)(肾上腺素受体)激动剂。 |
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S3294 |
Demethyl-Coclaurine
|
Demethyl-Coclaurine (Higenamine, Norcoclaurine) 是中草药乌头根的关键成分,是一种 beta-2 adrenergic receptor (β2-AR) 的激动剂。Demethyl-Coclaurine 可刺激 AKT 的磷酸化,需要 PI3K 的激活才能使心肌细胞产生抗凋亡的作用。 |
- Signal Transduct Target Ther, 2024, 9(1):243
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S2545 |
Scopine
|
Scopine(6,7-Epoxytropine)是Anisodine的代谢产物,是一种α1-肾上腺素能受体激动剂,用于治疗急性循环性休克。 |
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S2523 |
DL-Adrenaline
|
DL-Adrenaline(dl-Epinephrine)是一种激素,是由肾上腺髓质分泌的一种神经递质。 |
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S4266 |
Brimonidine Tartrate
|
Brimonidine Tartrate(UK 1434 Tartrate)是一种高选择性的α-肾上腺素能受体激动剂,EC50为0.45 nM,用于治疗开角型青光眼或高眼压症。 |
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S2615 |
Noradrenaline bitartrate monohydrate
|
Noradrenaline bitartrate monohydrate (Levophed)是一种直接的α-肾上腺素能受体激动剂。 |
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S0032 |
Batefenterol
|
Batefenterol (GSK961081, TD-5959) 既是 muscarinic receptor 的拮抗剂又是 β2-adrenoceptor 的激动剂,hM2、hM3 muscarinic receptors 和 hβ2-adrenoceptor 的Ki值分别为1.4 nM、1.3 nM和3.7 nM。 |
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E4888New |
Guanabenz hydrochloride
|
Guanabenz hydrochloride(NE56490)是一种小分子抗高血压α2-肾上腺素能受体激动剂。它还能抑制eIF2α和GADD34,具有治疗心脏肥大、心力衰竭、动脉粥样硬化和缺血性心脏病的潜力。 |
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E4825New |
Naphazoline (nitrate)
|
Naphazoline (nitrate)是外周α2-adrenergic receptor的激动剂,作为血管收缩剂,有效地减少术中出血,增强术后镇痛。当与鼻内利多卡因联合使用时,可显著减少术中和术后疼痛,从而减少鼻中隔成形术后对抢救性镇痛药物的需求。 |
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S5769 |
Fenoterol
|
Fenoterol (Phenoterol) 是β2 adrenoreceptor激动剂,具有支气管扩张活性。 |
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S4135 |
Clorprenaline HCl
|
Clorprenaline HCl (NSC 334693) 是β2-受体激动剂,具有显著的扩张支气管作用。 |
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S4043 |
Tetrahydrozoline HCl
|
Tetrahydrozoline (Tetryzoline) HCl是一种咪唑啉衍生物,具有α受体激动剂活性。 |
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E4963New |
Clonidine
|
Clonidine(Clonidin) 是一种直接作用的α2-肾上腺素激动剂。它可用于治疗儿童和青少年的注意力缺陷多动障碍 (ADHD)。 |
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S5217 |
Arformoterol Tartrate
|
Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity. |
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S5734 |
Midodrine hydrochloride
|
Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor. |
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S5735 |
Midodrine
|
Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist. |
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S5727 |
Tetryzoline
|
Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays. |
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S5954 |
L-(-)-α-Methyldopa hydrate
|
L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate 是一种有效的降压药,是 α2-adrenergic receptors 的选择性激动剂。 |
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E4842New |
Vilanterol
|
Vilanterol (GW642444) 是 β2-肾上腺素能受体 (β2-AR) 的强效选择性激动剂,在 cAMP 检测试验中,Vilanterol 对β2-AR、β1-AR 和 β3-AR 的 pEC50 分别为 10.37、6.98 和 7.36。 |
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S2576 |
Xylometazoline HCl
|
Xylometazoline HCl 是α-adrenoceptor激动剂,常用作鼻血管收缩药,高效作用于α2B肾上腺素受体亚型,EC50为4 μM。 |
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S3640 |
Methoxyphenamine Hydrochloride
|
Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. |
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S3643 |
Amitraz
|
Amitraz (NSC 324552) 是一种α2 肾上腺素能受体激动剂。它是非系统性杀螨剂和杀虫剂。 |
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S2304 |
Gramine
|
Gramine (Donaxine) 是一种从巨型芦苇中分离出的天然吲哚生物碱,是一种活性脂联素受体(AdipoR)激动剂,对AdipoR2和AdipoR1的IC50分别为3.2 µM和4.2 µM。 禾胺也是人和小鼠 β2-Adrenergic receptor (β2-AR) 激动剂。 |
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S1423 |
Dobutamine HCl
|
Dobutamine(Dobutrex) Hydrochloride 是一种选择性强效β1-AR(β-1 肾上腺素受体)激动剂,对 α1-AR 和 β2-AR 表现出弱活性。 多巴酚丁胺是一种拟交感神经化合物,可通过改善心肌收缩力和增加心输出量 (CO) 来有效恢复低血压狗和人类患者的血压。 |
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S6583 |
Apraclonidine HCl
|
Apraclonidine (Iopidine,ALO 2145)是一种拟交感神经要,用于治疗青光眼。它是α2-肾上腺素能受体激动剂。 |
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S4485 |
Olodaterol
|
Olodaterol是一种长效的 β2-adrenergic receptor 的激动剂,可作为吸入剂(Tiotropium/Olodaterol)的成分之一,用于治疗慢性阻塞性肺疾病(COPD)患者。 |
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S4693 |
Guanfacine Hydrochloride
|
Guanfacine Hydrochloride (Tenex, Intuniv)是一种选择性的α2A-肾上腺素受体激动剂,具有降压效果。 |
- J Immunother Cancer, 2024, 12(11)e009805
|
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S5669 |
Isoxsuprine hydrochloride
|
Isoxsuprine hydrochloride是β-肾上腺素能受体(beta-adrenergic)激动剂,具有血管扩张活性。 |
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S5925 |
Olodaterol hydrochloride
|
Olodaterol hydrochloride (BI-1744)是Olodaterol的盐酸盐形式,Olodaterol是一种长效的β2肾上腺素能受体(beta2-adrenergic)激动剂。 |
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E1049New |
CL316243
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CL316243 是一种高效、选择性的β3-肾上腺素能受体激动剂,EC50 值为 3 nM,但对 β1/2-受体的作用极差。它能有效刺激脂肪细胞脂肪分解,增加棕色脂肪组织的产热和代谢率。 |
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S6407 |
Tulobuterol hydrochloride
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Tulobuterol是长效的β2-adrenergic receptor激动剂,具有支气管扩张、消炎和抗病毒活性。 |
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E4892New |
Formoterol
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Formoterol是一种高选择性、强效的长效β2-肾上腺素受体激动剂,通过结合并激活气道平滑肌细胞上的β2-肾上腺素受体发挥作用。它用于治疗慢性阻塞性肺病 (COPD) 患者。 |
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E2944 |
Norepinephrine hydrochloride
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Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride是一种有效的肾上腺素受体(AR)激动剂。 Norepinephrine hydrochloride激活α1、α2、β1受体。 |
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E4849New |
Terbutaline
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Terbutaline(Brican, Brethine)是bambuterol的活性代谢物,是一种口服的 β2-肾上腺素受体 激动剂,可增加 MKP-1 表达。Terbutaline可作为支气管扩张剂用于治疗阻塞性肺病。它还具有抗炎作用。 |
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S2083 |
Procaterol HCl
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Procaterol HCl (OPC-2009) 是短效的β2-肾上腺素能受体激动剂,Kp为8 nM,用于治疗哮喘。 |
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E2964 |
Norepinephrine tartrate
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Norepinephrine tartrate 是一种有效的肾上腺素受体(AR)激动剂。 Norepinephrine tartrate激活α1、α2、β1受体。 |
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S4277 |
Bambuterol HCl
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Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride)是强效β-adrenoceptor拮抗剂,用于治疗哮喘。
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E1746New |
Protokylol hydrochloride
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Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) 是 Protokylol 的盐形式,是 β-肾上腺素能受体 的激动剂。 Protokylol hydrochloride也用作支气管扩张剂。 |
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S5750 |
DL-Norepinephrine hydrochloride
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Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. |
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S2362 |
Synephrine
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Synephrine (Oxedrine)是从苦橘及其他柑橘属植物中提取的一种不饱和的植物甾醇,常用于减肥。 |
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S9508 |
Brimonidine
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Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. |
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S5267 |
Nylidrin Hydrochloride
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Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well. |
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S6487 |
fluticasone furoate
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Fluticasone furoate (GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。 |
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S3185 |
Adrenalone HCl
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Adrenalone HCl是一种肾上腺素激动剂,作为外用的血管收缩剂和止血剂,主要作用于α-1肾上腺素受体。 |
- J Immunother Cancer, 2024, 12(11)e009805
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S4481 |
Guanabenz
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Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) 是一种具有抗高血压作用的中枢 alpha 2-adrenoceptor (α2 adrenergic receptor) 的口服活性激动剂。 |
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