LNCaP |
Function Assay |
5 μM |
0-24 h |
induces AKTS473 and AKTT308 phosphorylation in a time dependent manner |
23966621 |
C4-2 |
Function Assay |
5 μM |
0-24 h |
induces AKTS473 and AKTT308 phosphorylation in a time dependent manner |
23966621 |
LNCaP |
Function Assay |
5 μM |
0-24 h |
inhibits phosphorylation of the distal AKT-pathway biomarkers including PRAS40, eIF4E, 4E-BP1, mTOR, and P70 S6 kinase in a time-dependent manner |
23966621 |
C4-2 |
Function Assay |
5 μM |
0-24 h |
inhibits phosphorylation of the distal AKT-pathway biomarkers including PRAS40, eIF4E, 4E-BP1, mTOR, and P70 S6 kinase in a time-dependent manner |
23966621 |
LNCaP |
Growth Inhibition Assay |
1-10000 nM |
0-3 d |
inhibits cell viability dose dependently |
23966621 |
C4-2 |
Growth Inhibition Assay |
1-10000 nM |
0-3 d |
inhibits cell viability dose dependently |
23966621 |
LNCaP |
Growth Inhibition Assay |
100-5000 nM |
72 h |
increases the fraction of cells undergoing cell death |
23966621 |
C4-2 |
Growth Inhibition Assay |
100-5000 nM |
72 h |
increases the fraction of cells undergoing cell death |
23966621 |
PC-3 |
Function Assay |
0.5/1/10 μM |
48 h |
downregulates the phosphorylation of downstream pathway proteins in a dose-dependent manner |
23258740 |
DU145 |
Function Assay |
0.5/1/10 μM |
48 h |
downregulates the phosphorylation of downstream pathway proteins in a dose-dependent manner |
23258740 |
LNCaP |
Cell Viability Assay |
0-1000 nM |
0-4 d |
reduced LNCaP cell viability in a dose- and time-dependent manner |
23258740 |
PC-3 |
Function Assay |
10 μM |
12 h |
induces autophagy |
23258740 |
PC-9 |
Function Assay |
1/5/10 μM |
4/24 h |
increases AKT phosphorylation |
24957682 |
NCI-H522 |
Function Assay |
1/5/10 μM |
4/24 h |
increases AKT phosphorylation |
24957682 |
MR49F |
Growth Inhibition Assay |
0-5 μM |
48 h |
inhibits cell growth in a dose dependent manner |
25151012 |
MR49C |
Growth Inhibition Assay |
0-5 μM |
48 h |
inhibits cell growth in a dose dependent manner |
25151012 |
SKBR3 |
Growth Inhibition Assay |
0-1.35 μM |
5 d |
enhances the growth inhibition of AZD8931 |
26095475 |
KPL4 |
Growth Inhibition Assay |
0-1.35 μM |
5 d |
enhances the growth inhibition of AZD8931 |
26095475 |
BT474c |
Growth Inhibition Assay |
0-1.35 μM |
5 d |
enhances the growth inhibition of AZD8931 |
26095475 |
HCC1954 |
Growth Inhibition Assay |
0-1.35 μM |
5 d |
enhances the growth inhibition of AZD8931 |
26095475 |
TamR |
Growth Inhibition Assay |
400 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
T74D LTED |
Growth Inhibition Assay |
100 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
ZR75 LTED |
Growth Inhibition Assay |
100 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
MCF7 LTED |
Growth Inhibition Assay |
200 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
1%MCF7 |
Growth Inhibition Assay |
400 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
T74D |
Growth Inhibition Assay |
100 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
ZR75 |
Growth Inhibition Assay |
100 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
MCF7 |
Growth Inhibition Assay |
200 nM |
6 d |
increased drug sensitivity of 4-OHT and fulvestrant |
26351323 |
MDA-MB-468 |
Function assay |
|
2 hrs |
Inhibition of Akt in human MDA-MB-468 cells assessed as inhibition of GSK3beta phosphorylation after 2 hrs by laser scanning cytometry, IC50 = 0.089 μM. |
23394218 |
PTEN-null LNCAP |
Function assay |
|
1 hr |
Inhibition of Akt in human PTEN-null LNCAP cells assessed as suppression in PRAS40 phosphorylation after 1 hr by ELISA analysis, IC50 = 0.3368 μM. |
27089211 |
HCT116 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay, IC50 = 5.2 μM. |
27089211 |
OVCAR8 |
Antiproliferative assay |
|
72 hrs |
Antiproliferative activity against human OVCAR8 cells after 72 hrs by SRB assay, IC50 = 7.27 μM. |
27089211 |
SNU-638 |
Growth Inhibition Assay |
|
|
IC50=4.523 μM |
24088382 |
SNU-1 |
Growth Inhibition Assay |
|
|
IC50=5.258 μM |
24088382 |
SNU-601 |
Growth Inhibition Assay |
|
|
IC50=5.938 μM |
24088382 |
SNU-668 |
Growth Inhibition Assay |
|
|
IC50=6.003 μM |
24088382 |
HS746T |
Growth Inhibition Assay |
|
|
IC50=6.084 μM |
24088382 |
KATO III |
Growth Inhibition Assay |
|
|
IC50=7.267 μM |
24088382 |
SNU-484 |
Growth Inhibition Assay |
|
|
IC50=7.392 μM |
24088382 |
OCUM-1 |
Growth Inhibition Assay |
|
|
IC50=14.515 μM |
24088382 |
SNU-16 |
Growth Inhibition Assay |
|
|
IC50=11.097 μM |
24088382 |
NUGC-3 |
Growth Inhibition Assay |
|
|
IC50=21.873 μM |
24088382 |
AZ521 |
Growth Inhibition Assay |
|
|
IC50=25.448 μM |
24088382 |
SNU-216 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
NUGC-4 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
SNU-5 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
GTL-16 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
MKN74 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
PAMC82 |
Growth Inhibition Assay |
|
|
IC50=30 μM |
24088382 |
SNU-620 |
Growth Inhibition Assay |
|
|
IC50=3.384 μM |
24088382 |
MKN1 |
Growth Inhibition Assay |
|
|
IC50=2.421 μM |
24088382 |
23132/87 |
Growth Inhibition Assay |
|
|
IC50=1.671 μM |
24088382 |
NCI-N87 |
Growth Inhibition Assay |
|
|
IC50=1.037 μM |
24088382 |
AGS |
Growth Inhibition Assay |
|
|
IC50=0.552 μM |
24088382 |
IM95m |
Growth Inhibition Assay |
|
|
IC50=0.51 μM |
24088382 |
HGC27 |
Growth Inhibition Assay |
|
|
IC50=0.445 μM |
24088382 |
PC-9 |
Growth Inhibition Assay |
|
|
IC50=9.3 (±1.2) μM |
24957682 |
NCI-H522 |
Growth Inhibition Assay |
|
|
IC50=11.3 (±2.7) μM |
24957682 |
LNCaP |
Function assay |
|
|
Inhibition of Akt in PTEN-deficient human LNCaP cells assessed as phosphorylation of GSK3beta, IC50 = 0.06 μM. |
23394218 |
LNCaP |
Function assay |
|
|
Inhibition of Akt in PTEN-deficient human LNCaP cells assessed as phosphorylation of PRAS40, IC50 = 0.22 μM. |
23394218 |
BT474c |
Function assay |
|
|
Inhibition of Akt in human BT474c cells harboring HER2+/PIK3CA double mutant assessed as phosphorylation of PRAS40, IC50 = 0.31 μM. |
23394218 |
MDA-MB-468 |
Function assay |
|
|
Inhibition of Akt in PTEN-deficient human MDA-MB-468 cells assessed as phosphorylation of GSK3beta, IC50 = 0.38 μM. |
23394218 |
MDA-MB-468 |
Function assay |
|
|
Inhibition of Akt in PTEN-deficient human MDA-MB-468 cells assessed as phosphorylation of PRAS40, IC50 = 0.39 μM. |
23394218 |
BT474c |
Function assay |
|
|
Inhibition of Akt in human BT474c cells harboring HER2+/PIK3CA double mutant assessed as phosphorylation of GSK3beta, IC50 = 0.76 μM. |
23394218 |
RT4 |
Function assay |
|
|
Inhibition of PKA in TSC1 deficient human RT4 cells assessed as S6 phosphorylation, IC50 = 1 μM. |
23394218 |
RT4 |
Function assay |
|
|
Inhibition of P70S6K in TSC1 deficient human RT4 cells assessed as S6 phosphorylation, IC50 = 5 μM. |
23394218 |
A673 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells |
29435139 |
DAOY |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells |
29435139 |
Saos-2 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells |
29435139 |
SK-N-SH |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells |
29435139 |
NB1643 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells |
29435139 |
MG 63 (6-TG R) |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells |
29435139 |
Rh41 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells |
29435139 |
SK-N-MC |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells |
29435139 |
NB-EBc1 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells |
29435139 |
LAN-5 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells |
29435139 |
Rh18 |
qHTS assay |
|
|
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells |
29435139 |