MK-2206 2HCl

MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂,在无细胞试验中IC50分别为8 nM/12 nM/65 nM;对250种其他蛋白激酶没有抑制活性。MK-2206 2HCl 在肿瘤细胞中可诱导自噬凋亡。Phase 2。

MK-2206 2HCl Chemical Structure

MK-2206 2HCl Chemical Structure

CAS: 1032350-13-2

规格 价格 库存 购买数量
10mM (1mL in DMSO) 1789.01 现货
5mg 895.01 现货
25mg 3032.85 现货
100mg 6470.1 现货
1g 16134.3 现货
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MK-2206 2HCl相关产品

相关信号通路图

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
Rh30 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells 29435139
OHS-50 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells 29435139
MG 63 (6-TG R) Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells 29435139
SK-N-SH Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells 29435139
BT-37 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells 29435139
DAOY Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells 29435139
NCI-H292 Cytotoxic Assay 3 μM 72 h Inhibition of cell proliferation 20571069
A431 Kinase Assay 5 μM 5 h Suppresses the signaling of Akt and Erk 20571069
HepG2 Cytotoxic Assay 10 μM 24 h Sensitizes resistant cells to the cytotoxic effect of 21205925
Sk-Hep1 Cytotoxic Assay 10 μM 24 h Sensitizes resistant cells to the cytotoxic effect of 21205925
OCUT1 cells harbored PIK3CA (H1047R+/+) Growth Inhibition Assay 3 μM 5 d IC50=0.14 μM 21289267
FTC133 cells harbored PTEN (allele deletion and R130+) Growth Inhibition Assay 3 μM 5 d IC50=0.18 μM 21289267
C643 cells harbored HRAS (G13R+/−) Growth Inhibition Assay 3 μM 5 d IC50=0.27 μM 21289267
Hth7 cells harbored NRAS (Q61R+/−) Growth Inhibition Assay 3 μM 5 d IC50=4.5 μM 21289267
HC11 Function Assay 10 μM 24 h Inhibits β-casein and ADRP synthesis 22426621
CEM-S Cytotoxic Assay 10 μM 48 h IC50=5.1 μM 22614243
MOLT-4 Function Assay 10 μM 24 h Blocks cells in the G0/G1 phase of the cell cycle 22614243
CEM-R Function Assay 4 μM 4 h Increases the amount of cleaved LC4A/B, a well-established autophagy marker 22614243
CEM-S Function Assay 4 μM 4 h Increases the amount of cleaved LC5A/B, a well-established autophagy marker 22614243
LoVo Growth Inhibition Assay IC50=1.32534 μM SANGER
SJ-GBM2 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
C2BBe1 Growth Inhibition Assay IC50=231.905 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=36.67 μM SANGER
Daoy Growth Inhibition Assay IC50=36.6538 μM SANGER
SW48 Growth Inhibition Assay IC50=36.2474 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=36.1198 μM SANGER
NB14 Growth Inhibition Assay IC50=34.4684 μM SANGER
COLO-800 Growth Inhibition Assay IC50=34.3647 μM SANGER
OE33 Growth Inhibition Assay IC50=34.2855 μM SANGER
769-P Growth Inhibition Assay IC50=32.3641 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=32.2897 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=31.8516 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=31.069 μM SANGER
HT-1197 Growth Inhibition Assay IC50=30.0598 μM SANGER
ES6 Growth Inhibition Assay IC50=29.8157 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=29.444 μM SANGER
ES7 Growth Inhibition Assay IC50=29.1465 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=28.5417 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=28.2964 μM SANGER
YAPC Growth Inhibition Assay IC50=28.2564 μM SANGER
CAL-12T Growth Inhibition Assay IC50=28.1112 μM SANGER
EW-13 Growth Inhibition Assay IC50=26.0274 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=25.9945 μM SANGER
BT-549 Growth Inhibition Assay IC50=25.9011 μM SANGER
HT-1376 Growth Inhibition Assay IC50=25.6465 μM SANGER
U-2-OS Growth Inhibition Assay IC50=25.6888 μM SANGER
RH-18 Growth Inhibition Assay IC50=25.5918 μM SANGER
TE-1 Growth Inhibition Assay IC50=25.3563 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=25.1953 μM SANGER
ALL-PO Growth Inhibition Assay IC50=24.619 μM SANGER
HCC2998 Growth Inhibition Assay IC50=24.4885 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=24.3302 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=24.4874 μM SANGER
DK-MG Growth Inhibition Assay IC50=24.294 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=24.2226 μM SANGER
HCC1806 Growth Inhibition Assay IC50=23.8709 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=23.7759 μM SANGER
S-117 Growth Inhibition Assay IC50=23.7651 μM SANGER
DJM-1 Growth Inhibition Assay IC50=23.5234 μM SANGER
M14 Growth Inhibition Assay IC50=23.4088 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=23.2533 μM SANGER
AM-38 Growth Inhibition Assay IC50=22.8689 μM SANGER
Rh41 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells 29435139
NB1643 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells 29435139
BT-12 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells 29435139
RD Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells 29435139
Saos-2 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells 29435139
A673 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells 29435139
HCT116 Growth inhibition assay 72 h IC50 = 7.5 μM 24900862
NCI-H460 Growth inhibition assay 72 h IC50 = 5.4 μM 24900862
HeLa Function assay 1 h IC50 = 0.0228 μM 29100733
K1 cells harbored PIK3CA (E542K+/+) Growth Inhibition Assay 3 μM 5 d IC50=0.52 μM 21289267
TPC1 cells harbored RET/PTC1 rearrangement Growth Inhibition Assay 3 μM 5 d IC50=0.59 μM 21289267
Hth74 Growth Inhibition Assay 3 μM 5 d IC50=2.19 μM 21289267
KAT18 Growth Inhibition Assay 3 μM 5 d IC50=4.62 μM 21289267
SW1736 Growth Inhibition Assay 100 μM 5 d IC50=47.56 μM 21289267
WRO Growth Inhibition Assay 1000 μM 5 d IC50>1000 μM 21289267
LN229 Apoptosis Assay 0.5 μM 60 h Augments apoptogenic effects of 22057914
TAD2 Growth Inhibition Assay 1000 μM 5 d IC50>1000 μM 21289267
T98G Apoptosis Assay 0.5 μM 60 h Augments apoptogenic effects of 22057914
MOLT-4 Cytotoxic Assay 10 μM 48 h IC50=1.7 μM 22614243
CEM-R Cytotoxic Assay 10 μM 48 h IC50=3.3 μM 22614243
MOLT-4 Function Assay 4 μM 4 h Increases the amount of cleaved LC3A/B, a well-established autophagy marker 22614243
HepG2 cell Kinase Assay 20 μM 24 h Downregulates the phosphorylation of AKT 23797319
HepG2 cell Growth Inhibition Assay 30 μM 24 h Inhibits cell growth 23797319
HepG2 cell Apoptosis Assay 20 μM 24 h Induces cell apoptosis 23797319
GEO Growth Inhibition Assay 500 nM 72 h Inhibits cell growth 24581231
CNE-1 Growth Inhibition Assay 10 μM 96 h IC50=2.96 μM 25336925
CNE-2 Growth Inhibition Assay 10 μM 96 h IC50=4.53 μM 25336925
SUNE-1 Growth Inhibition Assay 10 μM 96 h IC50=0.52 μM 25336925
HONE-1 Growth Inhibition Assay 10 μM 96 h IC50=3.37 μM 25336925
CNE-2 Function Assay 10 μM 48 h Induces cell cycle arrest at G1 25336925
HONE-1 Function Assay 10 μM 48 h Induces cell cycle arrest at G1 25336925
NEC8 Growth Inhibition Assay IC50=0.09651 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.1162 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.13738 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.22122 μM SANGER
T47D Growth Inhibition Assay IC50=0.2825 μM SANGER
HH Growth Inhibition Assay IC50=0.30283 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.3032 μM SANGER
ES5 Growth Inhibition Assay IC50=0.34455 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.3461 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.37321 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.37679 μM SANGER
H9 Growth Inhibition Assay IC50=0.38883 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.4401 μM SANGER
SBC-1 Growth Inhibition Assay IC50=0.44035 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.46868 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.48189 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.48892 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=0.49939 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.52961 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.55249 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.56783 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.57761 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.5826 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.59827 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.61048 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.6213 μM SANGER
HT Growth Inhibition Assay IC50=0.63239 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=0.63626 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.63723 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.64745 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.70966 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.73025 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.74403 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.80582 μM SANGER
NB7 Growth Inhibition Assay IC50=0.82411 μM SANGER
L-363 Growth Inhibition Assay IC50=0.83442 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.86253 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.87223 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.8872 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.92751 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.96465 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.97939 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.98592 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.99734 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=1.14485 μM SANGER
LXF-289 Growth Inhibition Assay IC50=1.17156 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=1.17256 μM SANGER
COLO-684 Growth Inhibition Assay IC50=1.23725 μM SANGER
ES1 Growth Inhibition Assay IC50=1.24065 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=1.28203 μM SANGER
CTB-1 Growth Inhibition Assay IC50=1.2899 μM SANGER
G-401 Growth Inhibition Assay IC50=1.29795 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=1.33701 μM SANGER
MFM-223 Growth Inhibition Assay IC50=1.34461 μM SANGER
PA-1 Growth Inhibition Assay IC50=1.35265 μM SANGER
697 Growth Inhibition Assay IC50=1.37616 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=1.49116 μM SANGER
HOS Growth Inhibition Assay IC50=1.49558 μM SANGER
DMS-273 Growth Inhibition Assay IC50=1.51959 μM SANGER
ME-180 Growth Inhibition Assay IC50=1.56891 μM SANGER
HCC2218 Growth Inhibition Assay IC50=1.68225 μM SANGER
CAL-54 Growth Inhibition Assay IC50=1.71242 μM SANGER
OMC-1 Growth Inhibition Assay IC50=1.74677 μM SANGER
COR-L105 Growth Inhibition Assay IC50=1.79737 μM SANGER
BV-173 Growth Inhibition Assay IC50=1.81074 μM SANGER
RKO Growth Inhibition Assay IC50=1.87101 μM SANGER
SNU-387 Growth Inhibition Assay IC50=1.88406 μM SANGER
SW1088 Growth Inhibition Assay IC50=1.94606 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=2.11433 μM SANGER
OC-314 Growth Inhibition Assay IC50=2.15086 μM SANGER
RMG-I Growth Inhibition Assay IC50=2.16398 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=2.18091 μM SANGER
GAMG Growth Inhibition Assay IC50=2.23845 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=2.24317 μM SANGER
MN-60 Growth Inhibition Assay IC50=2.29923 μM SANGER
OAW-28 Growth Inhibition Assay IC50=2.29951 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=2.31552 μM SANGER
ABC-1 Growth Inhibition Assay IC50=2.33253 μM SANGER
LS-513 Growth Inhibition Assay IC50=2.33484 μM SANGER
KS-1 Growth Inhibition Assay IC50=2.38191 μM SANGER
NB69 Growth Inhibition Assay IC50=2.38983 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=2.39083 μM SANGER
D-423MG Growth Inhibition Assay IC50=2.41044 μM SANGER
EW-18 Growth Inhibition Assay IC50=2.41939 μM SANGER
YH-13 Growth Inhibition Assay IC50=2.46153 μM SANGER
T-24 Growth Inhibition Assay IC50=2.47881 μM SANGER
ES8 Growth Inhibition Assay IC50=2.49287 μM SANGER
ES3 Growth Inhibition Assay IC50=2.49759 μM SANGER
RXF393 Growth Inhibition Assay IC50=2.60487 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=2.62953 μM SANGER
AGS Growth Inhibition Assay IC50=2.72137 μM SANGER
HCC1395 Growth Inhibition Assay IC50=2.75187 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=2.75266 μM SANGER
A204 Growth Inhibition Assay IC50=2.83872 μM SANGER
MCF7 Growth Inhibition Assay IC50=2.86117 μM SANGER
SNU-423 Growth Inhibition Assay IC50=2.89242 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=2.96865 μM SANGER
GR-ST Growth Inhibition Assay IC50=3.04611 μM SANGER
EoL-1- Growth Inhibition Assay IC50=3.07058 μM SANGER
HuH-7 Growth Inhibition Assay IC50=3.09464 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=3.1119 μM SANGER
EW-3 Growth Inhibition Assay IC50=3.19529 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=3.20694 μM SANGER
EW-16 Growth Inhibition Assay IC50=3.21879 μM SANGER
DOK Growth Inhibition Assay IC50=3.22859 μM SANGER
HCC2157 Growth Inhibition Assay IC50=3.38179 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=3.40786 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=3.41224 μM SANGER
H4 Growth Inhibition Assay IC50=3.45626 μM SANGER
SW1710 Growth Inhibition Assay IC50=3.46678 μM SANGER
RT-112 Growth Inhibition Assay IC50=3.52388 μM SANGER
DMS-114 Growth Inhibition Assay IC50=3.62278 μM SANGER
AN3-CA Growth Inhibition Assay IC50=3.62456 μM SANGER
KNS-62 Growth Inhibition Assay IC50=3.63338 μM SANGER
SJRH30 Growth Inhibition Assay IC50=3.69122 μM SANGER
G-402 Growth Inhibition Assay IC50=3.70711 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=3.72038 μM SANGER
P30-OHK Growth Inhibition Assay IC50=3.80976 μM SANGER
RVH-421 Growth Inhibition Assay IC50=3.81788 μM SANGER
LU-134-A Growth Inhibition Assay IC50=3.88428 μM SANGER
ECC10 Growth Inhibition Assay IC50=3.93622 μM SANGER
TGW Growth Inhibition Assay IC50=4.02305 μM SANGER
MLMA Growth Inhibition Assay IC50=4.02966 μM SANGER
SCC-25 Growth Inhibition Assay IC50=4.06566 μM SANGER
TYK-nu Growth Inhibition Assay IC50=4.09534 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=4.14191 μM SANGER
Calu-3 Growth Inhibition Assay IC50=4.24416 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=4.26443 μM SANGER
EGI-1 Growth Inhibition Assay IC50=4.37778 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=4.38146 μM SANGER
HCE-T Growth Inhibition Assay IC50=4.41579 μM SANGER
EW-11 Growth Inhibition Assay IC50=4.41838 μM SANGER
ATN-1 Growth Inhibition Assay IC50=4.44304 μM SANGER
NB5 Growth Inhibition Assay IC50=4.53697 μM SANGER
KLE Growth Inhibition Assay IC50=4.70198 μM SANGER
CAL-39 Growth Inhibition Assay IC50=4.72146 μM SANGER
TI-73 Growth Inhibition Assay IC50=4.80609 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=4.942 μM SANGER
786-0 Growth Inhibition Assay IC50=4.94673 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=4.96142 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=5.20009 μM SANGER
ETK-1 Growth Inhibition Assay IC50=5.21165 μM SANGER
BT-20 Growth Inhibition Assay IC50=5.21353 μM SANGER
MEL-HO Growth Inhibition Assay IC50=5.37336 μM SANGER
CAL-27 Growth Inhibition Assay IC50=5.46339 μM SANGER
SW872 Growth Inhibition Assay IC50=5.59428 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=5.66199 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=5.72732 μM SANGER
SF295 Growth Inhibition Assay IC50=5.80633 μM SANGER
Becker Growth Inhibition Assay IC50=5.86472 μM SANGER
Saos-2 Growth Inhibition Assay IC50=5.8653 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=5.99816 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=6.08773 μM SANGER
EW-22 Growth Inhibition Assay IC50=6.19649 μM SANGER
BT-474 Growth Inhibition Assay IC50=6.233 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=6.30345 μM SANGER
NB12 Growth Inhibition Assay IC50=6.39071 μM SANGER
D-263MG Growth Inhibition Assay IC50=6.45169 μM SANGER
SNB75 Growth Inhibition Assay IC50=6.60143 μM SANGER
A704 Growth Inhibition Assay IC50=6.6306 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=6.63604 μM SANGER
LN-405 Growth Inhibition Assay IC50=6.79672 μM SANGER
CHL-1 Growth Inhibition Assay IC50=6.80079 μM SANGER
A498 Growth Inhibition Assay IC50=6.81961 μM SANGER
TE-12 Growth Inhibition Assay IC50=6.83817 μM SANGER
TE-6 Growth Inhibition Assay IC50=6.93038 μM SANGER
AU565 Growth Inhibition Assay IC50=6.96957 μM SANGER
RD Growth Inhibition Assay IC50=6.98284 μM SANGER
SW1463 Growth Inhibition Assay IC50=7.11168 μM SANGER
LU-99A Growth Inhibition Assay IC50=7.14322 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=7.2924 μM SANGER
MC-IXC Growth Inhibition Assay IC50=7.48576 μM SANGER
GP5d Growth Inhibition Assay IC50=7.48764 μM SANGER
GB-1 Growth Inhibition Assay IC50=7.54804 μM SANGER
CAL-33 Growth Inhibition Assay IC50=7.66233 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=7.67336 μM SANGER
TE-5 Growth Inhibition Assay IC50=7.79334 μM SANGER
D-566MG Growth Inhibition Assay IC50=8.04429 μM SANGER
JVM-3 Growth Inhibition Assay IC50=8.15268 μM SANGER
T98G Growth Inhibition Assay IC50=8.18067 μM SANGER
HCC1954 Growth Inhibition Assay IC50=8.45104 μM SANGER
SF126 Growth Inhibition Assay IC50=8.45936 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=8.53257 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=8.63069 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=8.64643 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=8.64696 μM SANGER
SCC-4 Growth Inhibition Assay IC50=8.68219 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=8.77146 μM SANGER
D-502MG Growth Inhibition Assay IC50=8.78629 μM SANGER
ESS-1 Growth Inhibition Assay IC50=8.88704 μM SANGER
HEC-1 Growth Inhibition Assay IC50=8.89866 μM SANGER
NB10 Growth Inhibition Assay IC50=9.02224 μM SANGER
8505C Growth Inhibition Assay IC50=9.04232 μM SANGER
EFO-27 Growth Inhibition Assay IC50=9.16412 μM SANGER
HN Growth Inhibition Assay IC50=9.16628 μM SANGER
DSH1 Growth Inhibition Assay IC50=9.2087 μM SANGER
NBsusSR Growth Inhibition Assay IC50=9.27402 μM SANGER
LS-123 Growth Inhibition Assay IC50=9.31761 μM SANGER
SHP-77 Growth Inhibition Assay IC50=9.39935 μM SANGER
ACN Growth Inhibition Assay IC50=9.53277 μM SANGER
U251 Growth Inhibition Assay IC50=9.65544 μM SANGER
A431 Growth Inhibition Assay IC50=9.80238 μM SANGER
5637 Growth Inhibition Assay IC50=9.84984 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=9.92878 μM SANGER
A101D Growth Inhibition Assay IC50=9.99974 μM SANGER
YKG-1 Growth Inhibition Assay IC50=10.2006 μM SANGER
LAN-6 Growth Inhibition Assay IC50=10.2164 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=10.2433 μM SANGER
A549 Growth Inhibition Assay IC50=10.3973 μM SANGER
no-11 Growth Inhibition Assay IC50=10.4353 μM SANGER
SF539 Growth Inhibition Assay IC50=10.9041 μM SANGER
A388 Growth Inhibition Assay IC50=11.3897 μM SANGER
DEL Growth Inhibition Assay IC50=11.424 μM SANGER
SW954 Growth Inhibition Assay IC50=11.4668 μM SANGER
TK10 Growth Inhibition Assay IC50=11.5271 μM SANGER
SW756 Growth Inhibition Assay IC50=11.5294 μM SANGER
PC-3 Growth Inhibition Assay IC50=11.5764 μM SANGER
ONS-76 Growth Inhibition Assay IC50=11.636 μM SANGER
A427 Growth Inhibition Assay IC50=11.7093 μM SANGER
MEG-01 Growth Inhibition Assay IC50=11.7509 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=11.7982 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=11.8093 μM SANGER
GCT Growth Inhibition Assay IC50=11.8228 μM SANGER
D-247MG Growth Inhibition Assay IC50=11.9663 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=11.9782 μM SANGER
EKVX Growth Inhibition Assay IC50=12.0313 μM SANGER
CAL-51 Growth Inhibition Assay IC50=12.0716 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=12.1177 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=12.1854 μM SANGER
RH-1 Growth Inhibition Assay IC50=12.2184 μM SANGER
BCPAP Growth Inhibition Assay IC50=12.4749 μM SANGER
GCIY Growth Inhibition Assay IC50=12.5209 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=12.5869 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=12.8595 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=12.9041 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=12.9115 μM SANGER
HCC1187 Growth Inhibition Assay IC50=13.1912 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=13.2327 μM SANGER
CTV-1 Growth Inhibition Assay IC50=13.345 μM SANGER
WM-115 Growth Inhibition Assay IC50=13.6483 μM SANGER
CHP-212 Growth Inhibition Assay IC50=13.9739 μM SANGER
SCC-15 Growth Inhibition Assay IC50=13.9775 μM SANGER
BPH-1 Growth Inhibition Assay IC50=14.1664 μM SANGER
SW780 Growth Inhibition Assay IC50=14.5025 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=14.5878 μM SANGER
JEG-3 Growth Inhibition Assay IC50=14.6326 μM SANGER
CAL-120 Growth Inhibition Assay IC50=14.7027 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=14.7997 μM SANGER
MS-1 Growth Inhibition Assay IC50=14.9611 μM SANGER
PC-14 Growth Inhibition Assay IC50=14.9654 μM SANGER
D-283MED Growth Inhibition Assay IC50=15.0111 μM SANGER
OE19 Growth Inhibition Assay IC50=15.1541 μM SANGER
CAS-1 Growth Inhibition Assay IC50=15.4184 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=15.4221 μM SANGER
SiHa Growth Inhibition Assay IC50=15.7594 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=15.7694 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=16.1642 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=16.6373 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=16.6956 μM SANGER
Detroit562 Growth Inhibition Assay IC50=16.7318 μM SANGER
HCC1569 Growth Inhibition Assay IC50=16.8337 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=16.8419 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=17.0479 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=17.0707 μM SANGER
SW1783 Growth Inhibition Assay IC50=17.128 μM SANGER
NH-12 Growth Inhibition Assay IC50=17.3303 μM SANGER
UACC-257 Growth Inhibition Assay IC50=17.5512 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=17.6757 μM SANGER
KG-1 Growth Inhibition Assay IC50=17.6937 μM SANGER
M059J Growth Inhibition Assay IC50=17.703 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=17.9673 μM SANGER
EW-1 Growth Inhibition Assay IC50=18.1382 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=18.2357 μM SANGER
639-V Growth Inhibition Assay IC50=18.3354 μM SANGER
C32 Growth Inhibition Assay IC50=18.4727 μM SANGER
KM-H2 Growth Inhibition Assay IC50=18.5232 μM SANGER
A253 Growth Inhibition Assay IC50=18.7286 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=18.9008 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=19.0646 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=19.1546 μM SANGER
8305C Growth Inhibition Assay IC50=19.2286 μM SANGER
TE-8 Growth Inhibition Assay IC50=19.3024 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=20.0217 μM SANGER
HL-60 Growth Inhibition Assay IC50=20.0941 μM SANGER
Mo-T Growth Inhibition Assay IC50=20.1665 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=20.3374 μM SANGER
HT-1080 Growth Inhibition Assay IC50=20.5497 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=20.6883 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=20.7379 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=20.8134 μM SANGER
HT-3 Growth Inhibition Assay IC50=21.5631 μM SANGER
22RV1 Growth Inhibition Assay IC50=21.5685 μM SANGER
LK-2 Growth Inhibition Assay IC50=21.5953 μM SANGER
CW-2 Growth Inhibition Assay IC50=21.6069 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=21.6095 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=21.7166 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=22.034 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=22.1697 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=22.2432 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=22.3895 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=441.083 μM SANGER
HCC38 Growth Inhibition Assay IC50=401.593 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=398.472 μM SANGER
NB17 Growth Inhibition Assay IC50=392.596 μM SANGER
SBC-5 Growth Inhibition Assay IC50=386.985 μM SANGER
K-562 Growth Inhibition Assay IC50=383.36 μM SANGER
T84 Growth Inhibition Assay IC50=374.712 μM SANGER
LU-135 Growth Inhibition Assay IC50=367.035 μM SANGER
TE-9 Growth Inhibition Assay IC50=363.589 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=347.401 μM SANGER
BE-13 Growth Inhibition Assay IC50=344.167 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=342.365 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=342.326 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=332.294 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=341.123 μM SANGER
C3A Growth Inhibition Assay IC50=311.802 μM SANGER
HEL Growth Inhibition Assay IC50=309.983 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=310.57 μM SANGER
LU-65 Growth Inhibition Assay IC50=304.32 μM SANGER
L-428 Growth Inhibition Assay IC50=297.616 μM SANGER
FADU Growth Inhibition Assay IC50=297.51 μM SANGER
IGR-1 Growth Inhibition Assay IC50=295.659 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=294.409 μM SANGER
C8166 Growth Inhibition Assay IC50=278.506 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=278.178 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=276.007 μM SANGER
COLO-680N Growth Inhibition Assay IC50=272.527 μM SANGER
NB6 Growth Inhibition Assay IC50=270.1 μM SANGER
GAK Growth Inhibition Assay IC50=253.002 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=249.27 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=247.713 μM SANGER
LS-1034 Growth Inhibition Assay IC50=246.266 μM SANGER
SH-4 Growth Inhibition Assay IC50=246.09 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=243.795 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=216.125 μM SANGER
KNS-42 Growth Inhibition Assay IC50=216.574 μM SANGER
RCM-1 Growth Inhibition Assay IC50=214.762 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=207.909 μM SANGER
SW982 Growth Inhibition Assay IC50=207.948 μM SANGER
SW1116 Growth Inhibition Assay IC50=207.077 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=204.208 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=202.103 μM SANGER
COLO-678 Growth Inhibition Assay IC50=201.45 μM SANGER
HT-29 Growth Inhibition Assay IC50=201.212 μM SANGER
SCC-9 Growth Inhibition Assay IC50=191 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=191.888 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=188.333 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=186.84 μM SANGER
CAL-72 Growth Inhibition Assay IC50=185.054 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=180.165 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=178.467 μM SANGER
no-10 Growth Inhibition Assay IC50=178.134 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=177.503 μM SANGER
HCE-4 Growth Inhibition Assay IC50=166.845 μM SANGER
NY Growth Inhibition Assay IC50=165.314 μM SANGER
A673 Growth Inhibition Assay IC50=161.705 μM SANGER
SAS Growth Inhibition Assay IC50=162.678 μM SANGER
Capan-2 Growth Inhibition Assay IC50=160.553 μM SANGER
KU812 Growth Inhibition Assay IC50=158.674 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=154.694 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=153.064 μM SANGER
BEN Growth Inhibition Assay IC50=153.928 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=151.539 μM SANGER
GT3TKB Growth Inhibition Assay IC50=149.928 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=147.878 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=145.636 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=144.501 μM SANGER
COR-L88 Growth Inhibition Assay IC50=142.14 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=139.833 μM SANGER
HCT-116 Growth Inhibition Assay IC50=137.217 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=135.993 μM SANGER
U-87-MG Growth Inhibition Assay IC50=133.604 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=131.483 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=131.243 μM SANGER
A2780 Growth Inhibition Assay IC50=128.988 μM SANGER
BALL-1 Growth Inhibition Assay IC50=126.23 μM SANGER
COLO-679 Growth Inhibition Assay IC50=126.753 μM SANGER
SF268 Growth Inhibition Assay IC50=126.158 μM SANGER
SN12C Growth Inhibition Assay IC50=124.176 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=125.514 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=122.21 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=123.244 μM SANGER
ML-2 Growth Inhibition Assay IC50=121.676 μM SANGER
SW1990 Growth Inhibition Assay IC50=120.951 μM SANGER
D-392MG Growth Inhibition Assay IC50=117.398 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=109.28 μM SANGER
GOTO Growth Inhibition Assay IC50=107.777 μM SANGER
HLE Growth Inhibition Assay IC50=105.282 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=100.121 μM SANGER
SW684 Growth Inhibition Assay IC50=98.6654 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=96.9566 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=96.8992 μM SANGER
SCH Growth Inhibition Assay IC50=96.3877 μM SANGER
COLO-792 Growth Inhibition Assay IC50=95.2564 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=92.9106 μM SANGER
TE-10 Growth Inhibition Assay IC50=91.5611 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=91.4042 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=89.9028 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=86.8872 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=86.1977 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=85.4641 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=84.2185 μM SANGER
KY821 Growth Inhibition Assay IC50=84.0892 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=83.4702 μM SANGER
HSC-3 Growth Inhibition Assay IC50=83.3071 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=81.1768 μM SANGER
A3-KAW Growth Inhibition Assay IC50=80.2154 μM SANGER
CAL-62 Growth Inhibition Assay IC50=80.095 μM SANGER
JAR Growth Inhibition Assay IC50=79.0546 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=77.5454 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=77.4243 μM SANGER
MC116 Growth Inhibition Assay IC50=75.5708 μM SANGER
U-266 Growth Inhibition Assay IC50=75.4516 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=74.4048 μM SANGER
NCI-H522 Growth Inhibition Assay IC50=72.3413 μM SANGER
COLO-668 Growth Inhibition Assay IC50=71.8451 μM SANGER
Mewo Growth Inhibition Assay IC50=71.505 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=70.7835 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=70.6705 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=69.9486 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=68.3238 μM SANGER
SW620 Growth Inhibition Assay IC50=66.2039 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=65.8481 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=65.5649 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=65.0095 μM SANGER
KGN Growth Inhibition Assay IC50=64.5514 μM SANGER
BHY Growth Inhibition Assay IC50=64.1245 μM SANGER
C-33-A Growth Inhibition Assay IC50=64.0957 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=62.7496 μM SANGER
LS-411N Growth Inhibition Assay IC50=61.3903 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=60.5294 μM SANGER
647-V Growth Inhibition Assay IC50=60.1347 μM SANGER
COLO-824 Growth Inhibition Assay IC50=60.0719 μM SANGER
TCCSUP Growth Inhibition Assay IC50=59.5279 μM SANGER
JVM-2 Growth Inhibition Assay IC50=58.9506 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=58.4814 μM SANGER
FTC-133 Growth Inhibition Assay IC50=58.0969 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=57.778 μM SANGER
HPAF-II Growth Inhibition Assay IC50=56.4073 μM SANGER
MKN7 Growth Inhibition Assay IC50=56.0285 μM SANGER
UACC-62 Growth Inhibition Assay IC50=55.1046 μM SANGER
IA-LM Growth Inhibition Assay IC50=54.6322 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=49.4793 μM SANGER
HT55 Growth Inhibition Assay IC50=49.1474 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=48.4016 μM SANGER
U-118-MG Growth Inhibition Assay IC50=48.3702 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=48.2845 μM SANGER
SW1573 Growth Inhibition Assay IC50=47.3736 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=46.9822 μM SANGER
KM12 Growth Inhibition Assay IC50=45.9076 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=45.8967 μM SANGER
TE-11 Growth Inhibition Assay IC50=45.4842 μM SANGER
PSN1 Growth Inhibition Assay IC50=45.2548 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=43.6019 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=43.3477 μM SANGER
Calu-6 Growth Inhibition Assay IC50=43.2382 μM SANGER
HCC1937 Growth Inhibition Assay IC50=42.7843 μM SANGER
UMC-11 Growth Inhibition Assay IC50=41.263 μM SANGER
HSC-2 Growth Inhibition Assay IC50=40.9113 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=40.5686 μM SANGER
COLO-741 Growth Inhibition Assay IC50=40.1304 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=39.8274 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=39.5512 μM SANGER
MG-63 Growth Inhibition Assay IC50=39.3424 μM SANGER
EFO-21 Growth Inhibition Assay IC50=38.9349 μM SANGER
SW1417 Growth Inhibition Assay IC50=38.0552 μM SANGER
DU-4475 Growth Inhibition Assay IC50=36.9033 μM SANGER
CaR-1 Growth Inhibition Assay IC50=33.9822 μM SANGER
HT-144 Growth Inhibition Assay IC50=33.863 μM SANGER
LU-139 Growth Inhibition Assay IC50=33.6605 μM SANGER
SW626 Growth Inhibition Assay IC50=33.1776 μM SANGER
COR-L23 Growth Inhibition Assay IC50=32.9073 μM SANGER
DB Growth Inhibition Assay IC50=30.4942 μM SANGER
ZR-75-30 Growth Inhibition Assay IC50=30.2383 μM SANGER
GI-1 Growth Inhibition Assay IC50=27.721 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=27.6012 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=27.4578 μM SANGER
SW948 Growth Inhibition Assay IC50=27.1344 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=27.0879 μM SANGER
SNU-449 Growth Inhibition Assay IC50=27.0803 μM SANGER
SW962 Growth Inhibition Assay IC50=26.5021 μM SANGER
CHP-134 Growth Inhibition Assay IC50=26.3867 μM SANGER
GMS-10 Growth Inhibition Assay IC50=26.2353 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=26.2103 μM SANGER
NB13 Growth Inhibition Assay IC50=26.0949 μM SANGER
MPP-89 Growth Inhibition Assay IC50=25.0458 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=23.8133 μM SANGER
ES4 Growth Inhibition Assay IC50=23.4232 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=22.764 μM SANGER
SK-N-MC Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
NB-EBc1 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells 29435139
LAN-5 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells 29435139
Rh18 Function assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells 29435139
点击查看更多细胞系数据

生物活性

产品描述 MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂,在无细胞试验中IC50分别为8 nM/12 nM/65 nM;对250种其他蛋白激酶没有抑制活性。MK-2206 2HCl 在肿瘤细胞中可诱导自噬凋亡。Phase 2。
特性 MK-2206是第一个进入临床研究阶段的Akt小分子变构抑制剂。
靶点
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
体外研究(In Vitro)
体外研究活性

MK-2206是变构抑制剂,由pleckstrin同源结构域激活。MK-2206抑制Akt的苏氨酸308位点和丝氨酸473位点的自身磷酸化作用。另外,MK-2206阻止Akt调节的下游信号分子(包括TSC2, PRAS40,及核糖体S6蛋白)的磷酸化作用。与抑制Ras 突变型细胞系(如NCI-H358, NCI-H23, NCI-H1299, 和Calu-6)相比,MK-2206 更有效地抑制Ras野生型细胞系(如A431, HCC827, 和NCI-H292)。MK-2206和细胞毒素药剂联用作用于肺部NCI-H460肿瘤细胞或者卵巢A2780肿瘤细胞,MK-2206也显示出协同效应。[1]

激酶实验 Akt激酶实验
通过得到的GSK 生物素肽段基质测定Akt激酶。使用含镧系金属螯合物偶联单抗的均相时间分辨荧光(HTRF)测定肽段磷酸化程度,这种单抗专门作用于与链霉亲和素——藻蓝素(SA-APC)载体相结合的磷酸化作用,SA-APC载体可以结合到肽段的部分生物素上。当镧系金属螯合物与藻蓝素相接触时,无辐射的能量从镧系金属螯合物传递给藻蓝素,然后藻蓝素发射波值为655纳米的光线。工作液:100X 蛋白酶抑制剂混合物(PIC):1mg/ml苯甲脒,0.5 mg/ml 抑肽素, 0.5 mg/ml亮抑肽酶, 0.5 mg/ml 抑肽酶。10X实验 buffer: 500 mM HEPES(pH 为7.5), 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-甘油磷酸。抑制 buffer:50 mM HEPES(pH为7.3), 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM 标记的单抗, 0.0067mg/ml SA-APC。ATP/MgCl2工作液: 1X 实验buffer, 1 mM DTT, 1X PIC, 5% 甘油, 激活的Akt。肽段工作液:1X实验buffer, 1 mM DTT, 1X PIC, 5% 甘油 2 TM GSK生物素肽段。工作液加到合适的孔中,然后加入总负荷为16的 ATP/MgCl2,反应开始。含MK-2206的实验组和对照组加入总负荷为10的肽段工作液。然后加入总负荷为13的酶液,混匀。反应进行50分钟,然后加入总负荷为60的均相时间分辨荧光抑制buffer停止反应。阻断的反应在室温下温育30分钟以上,然后使用仪器读数。
细胞实验 细胞系 A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6,和NCI-H460细胞
浓度 0, 0.3, 1,和3 μM
孵育时间 72或96小时
方法

MK-2206溶解在DMSO中,在实验使用前用培养基稀释。细胞按2~3×103密度接种在96孔板上,温育24小时。MK-2206 (分为0, 0.3, 1,和3 μmol四组)处理细胞,72或者96小时后,测定细胞增殖情况。

实验图片 检测方法 检测指标 实验图片 PMID
Western blot p-AKT(T308) / p-AKT(S473) / pGSK3β(S9) / pFOXO1 / pPRAS(T246) / pBAD / pS6K(T389) / p4E-BP1 22932669
Growth inhibition assay Cell viability 24665203
Immunofluorescence LC3 CFTR/LC3 HMGA2 24490764
ELISA VEGFA 29449553
体内研究(In Vivo)
体内研究活性

MK-2206和这些细胞毒素药剂联用作用于NCI-H292移植瘤,MK-2206显示出非常有效的抗癌活性。卵巢癌A2780移植瘤中,按动物体重,每千克处理240mg MK-2206,则可抑制70%以上的Akt1/2在苏氨酸308位点和丝氨酸473位点的磷酸化,导致肿瘤生长抑制率达到60%。[1]

动物实验 Animal Models 携带SK-OV-3, NCI-H292, HCC70, PC-3,和NCI-H460模型的雄性CD1裸鼠
Dosages 120 mg/kg
Administration 口服处理
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01480154 Active not recruiting
Advanced Malignant Solid Neoplasm|Stage III Cutaneous Melanoma AJCC v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
National Cancer Institute (NCI)
November 23 2011 Phase 1
NCT01466868 Terminated
Diffuse Large B Cell Lymphoma
Centre Leon Berard|National Cancer Institute France
November 2011 Phase 2

化学信息&溶解度

分子量 480.39 分子式

C25H21N5O.2HCl

CAS号 1032350-13-2 SDF Download MK-2206 2HCl SDF
Smiles C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 96 mg/mL ( (199.83 mM) ;DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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操作手册

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常见问题及建议解决方法

问题 1:
What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

回答:
You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

问题 2:
I would want to know if MK-2206 could cross the blood brain barrier?

回答:
MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Tags: buy MK-2206 2HCl | MK-2206 2HCl supplier | purchase MK-2206 2HCl | MK-2206 2HCl cost | MK-2206 2HCl manufacturer | order MK-2206 2HCl | MK-2206 2HCl distributor
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