Pentoxifylline
中文名称：己酮可可碱
Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
Pentoxifylline Chemical Structure
CAS: 6493-05-6
产品质控
Pentoxifylline相关产品
相关信号通路图
生物活性
| 产品描述 | Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. |
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| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06344390 | Recruiting | Cognitive Impairment |
The First Hospital of Hebei Medical University |
April 10 2024 | Phase 1|Phase 2 |
| NCT06041932 | Not yet recruiting | Liver Cirrhosis |
Institute of Liver and Biliary Sciences India |
November 1 2023 | Not Applicable |
| NCT05490953 | Recruiting | Hodgkin Lymphoma |
University of Guadalajara|Hospital Civil de Guadalajara |
July 11 2022 | Phase 4 |
| NCT05189535 | Completed | Breast Cancer Female|Peripheral Neuropathy |
Ain Shams University |
October 3 2021 | Phase 2|Phase 3 |
| NCT04152980 | Recruiting | Neonatal Late Onset Sepsis |
Erasmus Medical Center |
January 12 2020 | Phase 3 |
| NCT05660694 | Completed | Triamcinolone|Pentoxifylline|Vitamin E|Oral Submucosa Fibrosis|Tumor |
Altamash Institute of Dental Medicine |
January 1 2020 | Phase 4 |
化学信息&溶解度
| 分子量 | 278.31 | 分子式 | C13H18N4O3 |
| CAS号 | 6493-05-6 | SDF | Download Pentoxifylline SDF |
| Smiles | CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C | ||
| 储存条件(自收到货起) | |||
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体外溶解度 |
DMSO : 55 mg/mL ( (197.62 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : 55 mg/mL (197.62 mM) Ethanol : 55 mg/mL (197.62 mM) |
摩尔浓度计算器 |
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体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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