| S4428 |
Tenofovir alafenamide fumarate |
Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
Selective |
|
| S5068 |
Adefovir |
Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
Selective |
|
| S8055 |
Lersivirine (UK-453061) |
Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM. |
Selective |
|
| S5959 |
Tenofovir Disoproxil |
Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain. |
Selective |
|
| S4427 |
Tenofovir alafenamide hemifumarate |
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
Selective |
|
| S4685 |
Efavirenz |
Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
Selective |
|
| S5215 |
Abacavir (1592U89) |
Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
Selective |
|
| S1702 |
Didanosine |
Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
Selective |
Reverse transcriptase, IC50: 490 nM |
| S1398 |
Stavudine (d4T) |
Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. |
Selective |
|
| S3080 |
Etravirine |
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
Selective |
|
| S1742 |
Nevirapine (NSC 641530) |
Nevirapine (NSC 641530,NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
Selective |
|
| S1401 |
Tenofovir |
Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
Selective |
|
| S7856 |
Tenofovir Alafenamide (GS-7340) |
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
|
Selective |
|
| S3273 |
Hypericin |
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
Selective |
|
| S1252 |
Entecavir Hydrate |
Entecavir Hydrate (ETV, Baraclude,BMS200475 Hydrate,SQ34676 Hydrate), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
Selective |
|
| S1706 |
Lamivudine |
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. |
Selective |
|
| S2579 |
Zidovudine |
Zidovudine (ZDV, Azidothymidine, NSC 602670,Retrovir) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency. |
Selective |
|
| S7303 |
Rilpivirine |
Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection. |
Selective |
|
| S6848 |
3'-Fluoro-3'-deoxythymidine (Alovudine) |
3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
Selective |
|
| S4187 |
Salicylanilide |
Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
Selective |
|
| S1704 |
Emtricitabine (BW 1592) |
Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h. |
Selective |
|
| S3076 |
Foscarnet Sodium |
Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. |
Selective |
|
