胰腺癌

造模剂

7,12-Dimethylbenz[a]anthracene

获批药物

Nab-Paclitaxel

Everolimus

Capecitabine

Erlotinib HCl

5-FU

Gemcitabine HCl

Irinotecan hydrochloride

Olaparib

Mitomycin C

Sunitinib malate

化疗方案

FOLFIRINOX: Calcium Folinate; 5-FU; Irinotecan hydrochloride; Oxaliplatin

GEMCITABINE-CISPLATIN: Gemcitabine HCl; Cisplatin

GEMCITABINE-OXALIPLATIN: Gemcitabine HCl; Oxaliplatin

OFF: Oxaliplatin; 5-FU; Calcium Folinate

GN: Gemcitabine; Nab-Paclitaxel

NALIRIFOX: Irinotecan; 5-FU; Folinic acid; Oxaliplatin

S-1: Tegafur; Gimeracil; Potassium oxonate

mFOLFOX6: Folinic acid; 5-FU; Oxaliplatin

ESMO指南推荐 ^[1]

一线治疗: 5-FU; Irinotecan hydrochloride; Oxaliplatin; Nab-Paclitaxel; Folinic acid

二线治疗: 5-FU; Gimeracil; Larotrectinib; Folinic acid; Calcium Folinate; Potassium oxonate; Oxaliplatin; Entrectinib

免疫检查点抑制剂

PD-1: Pembrolizumab; Dostarlimab; Cemiplimab; Camrelizumab; Sintilimab; Nivolumab; Serplulimab; Balstilimab

PD-L1: Atezolizumab; Durvalumab; Avelumab; Adebrelimab; Sugemalimab

CALT-4: Nurulimab; Zalifrelimab; Quavonlimab; Ipilimumab; Tremelimumab

抗血管生成

VEGF: Bevacizumab; Everolimus; Axitinib; Sorafenib

EGFR: Panitumumab; Nimotuzumab; Demupitamab

PDGFR: Crenolanib; Ripretinib

c-kit: Masitinib

TKIs: Sunitinib; Sorafenib; Pazopanib

靶向疗法 (A) ^[2]

CLDN18.2: Zolbetuximab

MSLN: Anetumab; Anetumab-MMAE

DNA: Lurbinectedin; Oxaliplatin; STZ; Evofosfamide

KRAS G12D: MRTX1133; KRpep-2d

Tubulin: Nab-Paclitaxel; Paclitaxel; Docetaxel

MUC1: Clivatuzumab; Cantuzumab; Gatipotuzumab; Clivatuzumab-MMAE; Cantuzumab mertansine

TOP1: Irinotecan hydrochloride; Rubitecan

TYMS: Leucovorin Calcium Pentahydrate; Gimeracil; Capecitabine; Tegafur

靶向疗法 (B) ^[2]

EGFR: Panitumumab; Nimotuzumab; Demupitamab

CD40: Giloralimab; Sotigalimab; Selicrelumab

FAK: Defactinib; GSK2256098; Narmafotinib; PF-562271; VS-4718

KRAS G12C: Adagrasib; LY3537982; ARS-853; K-Ras inhibitor 12

STAT3: Napabucasin

CD73: Mupadolimab; Oleclumab; Uliledlimab; AB680; LY-3475070

CEACAM5: Tusamitamab; Labetuzumab; Cergutuzumab; Tusamitamab ravtansine; Labetuzumab govitecan

干细胞标志物 ^[3]

CD44+CD24+ESA+: Curcumin

CD133: Metformin

CD44: Metformin; Angstrom6

EPCAM: Metformin

ALDH1: Metformin; Triptolide; Sulforaphane; Disulfiram; NCT-501

DCLK1: Licofelone; DCLK1-IN-1

相关化合物库

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

PI3K/Akt Inhibitor Library