S7418 |
Cycloheximide
|
Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80),一种抗真菌抗生素,是一种真核生物蛋白质合成(protein synthesis)抑制剂,对体内蛋白质合(protein synthesis)和 RNA 合成(RNA synthesis)的 IC50 分别为 532.5 nM 和 2880 nM。Cycloheximide抑制铁死亡并抑制自噬。在溶液中不稳定,请现配现用!此产品为危化品(急性毒性/易燃/皮肤腐蚀),请在穿戴防护面罩、防护手套和防护服后使用。 |
-
Signal Transduct Target Ther, 2024, 9(1):65
-
Mol Cancer, 2024, 23(1):143
-
Mol Cancer, 2024, 23(1):240
|
|
S2476 |
Itraconazole
|
Itraconazole是一种三唑类抗真菌药物,是CYP3A4的有效抑制剂,IC50为6.1 nM。Itraconazole 是一个有效的Hedgehog (Hh)信号通路的拮抗剂。Itraconazole 可通过诱导自噬来抑制恶性胶质瘤的生长。 |
-
Front Cell Infect Microbiol, 2023, 13:1128000
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Front Cell Infect Microbiol, 2022, 12:864912
|
|
S1442 |
Voriconazole
|
Voriconazole是类似于氟康唑和伊曲康唑的新型三唑衍生物,其作用是通过抑制真菌 cytochrome P-450 依赖性的,14-alpha-sterol demethylase 介导的 麦角固醇的合成。 |
-
Pharmaceutics, 2024, 16(7)897
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Front Cell Infect Microbiol, 2022, 12:864912
|
|
S1331 |
Fluconazole
|
Fluconazole是一种羊毛甾醇14 alpha去甲基化酶 抑制剂,抑制了麦角固醇的形成,用于治疗和预防浅表性和全身性真菌感染。 |
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Front Cell Infect Microbiol, 2024, 14:1296151
-
Front Cell Infect Microbiol, 2023, 13:1131641
-
Nat Commun, 2022, 13(1):1658
|
|
S1353 |
Ketoconazole
|
Ketoconazole能抑制cyclosporine oxidase(环孢素氧化酶)和testosterone 6 beta-hydroxylase(睾丸素6β-羟化酶),IC50分别为0.19 mM和0.22 mM。Ketoconazole 是一种雄性激素 androgen 生物合成抑制剂。 |
-
J Med Virol, 2023, 95(6):e28856
-
J Med Virol, 2023, 95(6):e28856
-
Cell Death Dis, 2023, 14(1):64
|
|
S3073 |
Caspofungin (MK-0991) Acetate
|
Caspofungin Acetate (MK-0991, L-743872)是一种脂肽类抗真菌β-1,3-glucan synthase抑制剂。 |
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PLoS Pathog, 2024, 20(9):e1012521
-
Sci Rep, 2024, 14(1):27500
-
J Vis Exp, 2024, (206).
|
|
S1934 |
Nystatin
|
Nystatin (Fungicidin) 是一种多烯类抗真菌剂,常常被用作oropharyngeal candidosis的局部治疗剂。 |
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Microbiol Spectr, 2023, 10.1128/spectrum.02553-23
-
Nature, 2022, 603(7899):159-165
-
Nat Metab, 2022, 4-10:1369-1401
|
|
S4286 |
Anidulafungin
|
Anidulafungin, 一种echinocandin的衍生物, 抑制glucan synthase的活性, 用作抗真菌药。
|
-
Viruses, 2023, 15(2)452
-
BMC Med, 2022, 20(1):359
-
Antiviral Res, 2021, S0166-3542(21)00178-9
|
|
S4287 |
Micafungin Sodium
|
Micafungin Sodium是1,3-β-D-葡聚糖合成抑制剂,用作抗真菌的药物。
|
-
Microbiol Spectr, 2024, e0352623.
-
BMC Med, 2022, 20(1):359
-
Antiviral Res, 2021, S0166-3542(21)00178-9
|
|
S3019 |
Ciclopirox ethanolamine
|
Ciclopirox ethanolamine(Ciclopirox olamine, HOE 296,Ciclopiroxolamine)作为一种铁离子螯合剂,具有广谱抗真菌作用。 |
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Commun Biol, 2023, 6(1):402
-
Commun Biol, 2023, 6(1):402
-
J Clin Invest, 2022, 132(9)e152345
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|
S2058 |
Tolnaftate
|
Tolnaftate 是一种合成的硫代氨基甲酸酯,用作抗真菌剂。 |
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J Pers Med, 2022, 12(2)258
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S2321 |
Magnolol
|
Magnolol (NSC 293099) 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-κB的激活。 |
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Mol Oncol, 2022, 16(15):2823-2842
-
Int Immunopharmacol, 2022, 112:109242
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Reprod Biol, 2021, 21(4):100567
|
|
S1725 |
Terbinafine
|
Terbinafine (SF 86-327,TDT 067) 用于治疗真菌感染,可以杀死真菌或防止其生长。 |
-
Front Oncol, 2023, 13:1111570
-
Neurooncol Adv, 2022, 4(1):vdac018
-
J Cell Mol Med, 2020, 25
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S1956 |
Miconazole Nitrate
|
Miconazole (NSC 169434) Nitrate是一种咪唑类抗真菌剂,外用或静脉输液。 |
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Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
-
Chem Biol Interact, 2021, 343:109498
-
Biomol Ther (Seoul), 2020, 25
|
|
S2528 |
Ciclopirox
|
Ciclopirox(HOE 296b, Penlac) 是一种合成的抗真菌药物。 |
-
Cell Death Dis, 2021, 12(12):1141
-
J Transl Med, 2021, 19(1):347
-
Int J Mol Sci, 2021, 22(15)8299
|
|
S3079 |
Atovaquone
|
Atovaquone (Atavaquone)用于治疗或预防肺孢子菌肺炎,弓形虫病, 疟疾和巴贝西虫。 |
-
Cells, 2024, 13(12)1025
-
iScience, 2024, 27(3):109172
-
J Cell Biochem, 2022, 10.1002/jcb.30213
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|
S1606 |
Clotrimazole
|
Clotrimazole (BAY b 5097, FB 5097)是一种合成的抗真菌药物,是imidazole的广谱衍生物。 |
-
PLoS Pathog, 2024, 20(10):e1012601
-
iScience, 2022, 25(11):105342
-
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
|
|
S2557 |
Terbinafine HCl
|
Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride)通过抑制角鲨烯环氧酶抑制了麦角固醇的合成,用作抗真菌药物。 |
-
Cell Rep Med, 2023, S2666-3791(22)00494-3
-
Oncogene, 2021, 10.1038/s41388-021-01934-y
-
J Cell Mol Med, 2020, 25
|
|
S2536 |
Miconazole
|
Miconazole(Monistat,R18134) 是一种咪唑类抗真菌药物。 |
-
Nat Commun, 2024, 15(1):3068
-
Int J Mol Sci, 2022, 23(22)13809
-
Chem Biol Interact, 2021, 343:109498
|
|
S1676 |
Amorolfine HCl
|
Amorolfine HCl(Ro 14-4767 HCl)是一种抗真菌药物。 |
-
Nat Commun, 2021, 12(1):652
-
Cell Chem Biol, 2019, 26(4):593-599
-
Nature, 2018, 560(7718):372-376
|
|
S4075 |
Zinc Pyrithione
|
Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物,可以通过阻断质子泵破坏膜转运。 |
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Cell Chem Biol, 2021, S2451-9456(21)00213-0
-
Biol Reprod, 2019, 100(2):468-478
-
Cell Syst, 2017, 4(6-:600-610
|
|
S5080 |
Neticonazole
|
Neticonazole (SS717) 是一种选择性的针对 exosome 形成和分泌的抑制剂。 Neticonazole具有Neticonazole的抗真菌和抗肿瘤活性。 |
-
Nat Commun, 2023, 14(1):6692
-
Nat Commun, 2023, 14(1):6692
-
Clin Transl Med, 2022, 12(9):e1037
|
|
S1517 |
Natamycin
|
Natamycin (Pimaricin) 是一种天然存在的三唑类抗真菌药物。具有极少或无味道干扰。 |
-
Expert Opin Drug Deliv, 2020, 17(3):407-421
-
BMC Microbiol, 2020, 20(1):275
|
|
S2535 |
Econazole nitrate
|
Econazole Nitrate (NSC 243115,Spectazole) 是一种咪唑类抗真菌药物。 |
-
Nat Commun, 2024, 15(1):8708
-
Cell Rep Med, 2023, 4(12):101309
-
Int J Mol Sci, 2022, 23(22)13809
|
|
S1910 |
Tioconazole
|
Tioconazole (UK-20349) 是一种抗真菌药物,IC50为1.7 μM。 |
-
J Mol Cell Biol, 2021, mjab059
-
Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
|
|
S4120 |
Sulconazole Nitrate
|
Sulconazole Nitrate(Exelderm,RS 44872) 是一种咪唑衍生物,具有广谱抗真菌活性。 |
-
Int J Mol Sci, 2022, 23(22)13809
-
Sci Adv, 2021, 7(36):eabf6033
|
|
S4601 |
Clioquinol
|
Clioquinol (Iodochlorhydroxyquin, Chinoform) 是一种具有口服活性的、亲油性的、铜离子结合的卤代8-羟基喹啉(8-hydroxyquinoline),具有抗真菌、抗寄生物以及潜在的抗肿瘤活性。 |
-
Cancer Lett, 2024, 588:216797
-
Mol Oncol, 2021, 10.1002/1878-0261.13079
-
FASEB J, 2019, 10.1096/fj.201802603RR
|
|
S5373 |
Pseudolaric Acid B
|
Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties. |
-
Toxicology, 2023, 493:153556
-
Eur J Pharmacol, 2020, 876:173064
|
|
S1666 |
Flucytosine (5-Fluorocytosine)
|
Flucytosine (5-Fluorocytosine)是氟嘧啶类似物, 是抗菌药,作用于人白色念珠菌(C. albicans)时 IC50 为0.12 μg/mL。 |
-
Sci Adv, 2021, 7(27)eabh3032
|
|
S1854 |
Bifonazole
|
Bifonazole (Bay h 4502,(±)-bifonazole) 是一种抗真菌剂和前列腺芳香化酶抑制剂,IC50为1.6 μM。 |
-
Nature, 2018, 560(7718):372-376
|
|
S3161 |
Sertaconazole nitrate
|
Sertaconazole nitrate (FI-7045,FI7056)是一种外用广谱抗真菌药,是用来治疗表面皮肤和粘膜感染的辅助用药 |
-
Int J Mol Sci, 2022, 23(22)13809
|
|
S5359 |
Butoconazole
|
Ethyl chrysanthemate is an allelochemical compound used as an attractant. |
-
Arch Biochem Biophys, 2024, 754:109958
-
Nature, 2018, 560(7718):372-376
|
|
S8095 |
Tubercidin
|
Tubercidin (7-deaza-adenosine),腺苷类似物,是一种核苷抗生素。它可掺入到DNA中,抑制聚合酶,因此抑制DNA复制和RNA、蛋白合成。Tubercidin还具有抗真菌和抗病毒活性。 |
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Mol Cell, 2020, 80(6):1104-1122.e9
|
|
S4584 |
Butylparaben
|
Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) 是一种常在化妆品中被用作抗菌防腐剂的化合物。 |
-
Environ Toxicol, 2018, 33(4):436-445
|
|
S4178 |
Climbazole
|
Climbazole(BAY-e 6975)是一种广谱的咪唑类抗真菌药剂,具有抗头皮屑的效果。 |
-
Sci Adv, 2022, 8(49):eadd2191
|
|
S3646 |
Thimerosal
|
Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
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EMBO J, 2024, 10.1038/s44318-024-00217-y
-
J Invest Dermatol, 2024, S0022-202X(23)03210-4
-
Cell Chem Biol, 2021, S2451-9456(21)00442-6
|
|
S4187 |
Salicylanilide
|
Salicylanilides (WR10019,2-Hydroxybenzanilide)是一组具有广泛的生物活性的化合物,具有抗病毒效力,抗菌(包括抗分枝杆菌),和抗真菌活性。 |
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Hum Mol Genet, 2020, ddaa244
|
|
S9057 |
Sinigrin
|
Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. |
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J Invest Dermatol, 2018, 138(12):2644-2652
|
|
S5033 |
Terconazole
|
Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470)是一种新型的、广谱的、三唑抗真菌试剂,主要用于治疗阴道真菌感染。 |
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bioRxiv, 2020, 2020/9/20.4.7.30734
|
|
S5174 |
Kojic acid
|
Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives. |
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Int J Mol Sci, 2017, 18(9)
|
|
S3722 |
Isavuconazole
|
Isavuconazole (BAL-4815, RO-0094815) 是新型超广谱三唑类化合物,对酵母、霉菌和双态性真菌具有活性,抑制cytochrome P450 (CYP)依赖性的14α-lanosterol脱甲基作用,以此抑制真菌细胞膜麦角固醇的合成。 |
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Sci Rep, 2024, 14(1):27500
-
J Pharm Sci, 2023, 10.1016/j.xphs.2023.11.005
|
|
S5083 |
Lentinan
|
Lentinan (A823605, Bromoduline),分离纯化自香菇子实体水煮提取物,是一种真菌多糖免疫调制剂,具有抗肿瘤活性。 |
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Cell Commun Signal, 2024, 22(1):376
-
Iran J Basic Med Sci, 2023, 26(7):836-842
|
|
S4878 |
Neticonazole Hydrochloride
|
Neticonazole是咪唑类抗真菌剂,用于治疗皮肤真菌感染。 |
-
Toxins (Basel), 2024, 16(9)380
-
Clin Transl Med, 2022, 12(9):e1037
|
|
S5512 |
Juglone
|
Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone)是一种天然萘醌,存在于黑核桃等植物中,对多种植物具有中等的抗真菌活性和促生长作用。它有时可以用作除草剂,作为布料和油墨的染料,以及作为食品和化妆品的着色剂。在溶液中不稳定,请现配现用! |
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Chin Med, 2024, 19(1):52
-
Nat Commun, 2019, 10(1):4013
|
|
S1997 |
Liranaftate
|
Liranaftate(M-732,Piritetrate) 是一种角鲨烯环氧酶抑制剂具有抗真菌活性。 |
-
Cell Rep, 2024, 43(4):114094
|
|
S2031 |
Fenticonazole Nitrate
|
Fenticonazole Nitrate(Lomexin,REC 15-1476,Falvin) 是一种唑类抗真菌药物。 |
|
|
S3154 |
Butenafine HCl
|
Butenafine HCl (KP-363)是一种合成的苄胺类抗真菌药物,通过抑制甾醇合成,通过抑制角鲨烯环氧酶,而发挥作用。 |
|
|
S3156 |
Naftifine HCl
|
Naftifine HCl(AW 105-843)是一种烯丙基胺类抗真菌药,外用治疗足癣,股癣,体癣,通过抑制角鲨烯2,3-环氧酶选择性抑制甾醇的生物合成。 |
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Clin Transl Med, 2024, 14(2):e1586
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Arch Biochem Biophys, 2024, 754:109958
|
|
S1833 |
Butoconazole nitrate
|
Butoconazole nitrate (RS-35887)是一种抗真菌剂,抑制PHA刺激下人外周血淋巴细胞中细胞因子(如IL-2, TNFα, IFN 和 GM-CSF)的分泌,IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。 |
|
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S4806 |
Potassium 1-Naphthaleneacetate
|
Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens. |
|
|
E3040 |
Stemonae Extract
|
Stemonae Extract从百部Radix Stemonae的根茎中提取,作为一种口服镇咳药,在中医中已有几千年的历史,具有镇咳、抗结核、抗菌、抗真菌、抗寄生虫等药理作用。 |
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|
S9200 |
Pneumocandin B0
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
|
|
S0917 |
Allosecurinin
|
Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。 |
|
|
S6254 |
Hydrocinnamic acid
|
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid)是苯丙氨酸代谢途径中氧化还原酶的底物。它是一种抗真菌剂和代谢物。 |
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|
S4581 |
Triacetin
|
Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) 是一种甘油三酸酯,具有杀真菌作用。 |
|
|
S5213 |
Piroctone Olamine
|
Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections. |
|
|
S5553 |
Kasugamycin hydrochloride
|
Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species. |
|
|
S0938 |
Sakuranetin
|
Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. |
|
|
E3071 |
Malaytea Scurfpea Extract
|
Malaytea Scurfpea Extract是从补骨脂Psoralea corylifolia L.中提取的,具有抗真菌活性,对病原体具有防御作用。 |
|
|
S5944 |
Butenafine
|
Butenafine是合成的苄胺抗真菌剂。 |
|
|
S3966 |
Nifuratel
|
Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action. |
|
|
S3307 |
Galangin 3-methyl ether
|
Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分,具有很强的抗细菌和抗真菌作用。 |
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|
S4970 |
Nerol
|
Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。 |
|
|
S4862 |
Squalene
|
Squalene (Spinacene, Supraene, trans-Squalene),自然存在于植物、动物和人体中,是一种添加在疫苗中佐剂,用于增强免疫反应。 |
-
Nature, 2024, 626(7998):411-418.
|
|
S3829 |
Isoalantolactone
|
Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. |
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|
S0770 |
Camalexin
|
Camalexin 是从亚麻荠和拟南芥(十字花科)中分离得到的一种植物抗毒素,能诱导活性氧(ROS)产生。Camalexin具有抗菌、抗真菌、抗增殖和抗癌活性。 |
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|
S6118 |
Terpinen-4-ol
|
Terpinen-4-ol是一种天然存在的单萜,是茶树油的主要活性成分,具有多种生物活性如抗真菌活性。 |
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S4996 |
Tavaborole (AN-2690)
|
Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity. |
|
|
S5271 |
Suloctidil
|
Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent. |
|
|
E3725 |
Sapindus saponaria Linnaeus nutshell Extract (40%)
|
Sapindus Saponaria Linnaeus Nutshell Extract (40%)提取自无患子Sapindus saponaria L.,具有抗真菌活性。 |
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E3726 |
Sapindus saponaria Linnaeus nutshell Extract (70%)
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Sapindus Saponaria Linnaeus Nutshell Extract (70%)提取自无患子Sapindus saponaria L.,具有抗真菌活性。 |
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S4755 |
lanosterol
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Lanosterol是一种四环三萜,它可由所有的动物、真菌类固醇衍生而来。 |
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Commun Biol, 2023, 6(1):1108
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S3532 |
AN-2718
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AN-2718是一种真菌生长(fungal growth)抑制剂,通过oxaborole tRNA捕获(OBORT)机制阻断蛋白合成。 |
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S3778 |
Patchouli alcohol
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Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis. |
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S4963 |
Purpurin
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Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin)是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。Purpurin 可有效地抑制CYP1A1、CYP1A2 和 CYP1B1。 |
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S6270 |
2-Aminoisobutyric acid
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2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH)是一种稀有的、非蛋白氨基酸,是嘧啶代谢的终产物,随着尿液排出,在一些真菌来源的抗生素中有发现。 |
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S3676 |
Carbendazim
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Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi. |
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S4258 |
Luliconazole
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Luliconazole(NND 502)是一种广谱抗真菌药物。 |
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Arch Biochem Biophys, 2024, 754:109958
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S9350 |
Ethyl 4-Methoxycinnamate
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Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. |
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S2534 |
Isoconazole nitrate
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Isoconazole nitrate(Travogen,Adestan G 100, R 15454) 是一种唑类抗真菌药物。 |
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S5704 |
Myclobutanil
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Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
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S3705 |
Chlorobutanol
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Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol)是一种防腐剂、镇静剂、催眠剂和弱的局部麻醉剂,具有抗菌抑菌作用。 |
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S1991 |
iKIX1
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iKIX1是一种抗真菌药物,可在体外使耐药的光念珠菌对唑类抗真菌药物重新敏感;iKIX1抑制CgGal11A的KIX结构域与CgPdr1的活化结构域相互作用,IC50和Ki值分别为190.2 μM和18 μM。 |
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S3860 |
Allicin
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Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
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S9072 |
Sweroside
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Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
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S6408 |
Hexetidine
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Hexetidine是一种抗细菌和抗真菌剂,具有局部麻醉、止血、除臭、预防牙菌斑作用。 |
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S5025 |
Efinaconazole
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Efinaconazole (KP-103) 是14 alpha-demethylase的抑制剂。14 alpha-demethylase参与ergosterol的生物合成,ergosterol是真菌细胞膜的成分之一。 |
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S3588 |
Hexylene glycol
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Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂,已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。 |
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S3595 |
D-Gluconic acid
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D-Gluconic acid 是一种抗真菌 antifungal 药。 |
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S9413 |
Yangonin
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Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. |
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E3706 |
Cortex pseudolaricis Extract
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Cortex Pseudolaricis Extract来自Pseudolarix amabilis Rehder的根皮,其中部分成分具有抗真菌活性、抗癌活性和过氧化物酶体增殖物激活受体活性等生物活性。 |
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S5724 |
Dichlorophen
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Dichlorophen (Dichlorophene, Bis(5-chloro-2-hydroxyphenyl)methane) is an anticestodal agent, fungicide, germicide, and antimicrobial agent. |
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Nat Commun, 2024, 15(1):8708
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S5829 |
Monomyristin
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Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate)具有抗细菌和抗真菌活性。 |
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S6451 |
Salifungin
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Salifungin (Multifungin, Bromosalicylchloranilide)是一种抗真菌剂,在某些个体中可能导致过敏性接触性皮炎。 |
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S5541 |
Dimetridazole
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Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds. |
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S3979 |
Zinc Undecylenate
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Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. |
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S5086 |
p-Anisaldehyde
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p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde),茴芹种子提取物,具有抗真菌活性,对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。 |
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S6467 |
Fosfluconazole
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Fosfluconazole是一种水溶性的fluconazole盐酸盐前体药物。Fluconazole是三唑抗真菌药物,用于治疗和组织表面的和系统性真菌感染。 |
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S9444 |
Tomatine
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Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties. |
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S4525 |
Ethylparaben
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Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate)是对羟基苯甲酸(p-hydroxybenzoic acid)的乙酯形式,被用作抗真菌防腐剂和食品添加剂。它还是一种化学过敏原,其生理效应是通过增加组胺释放和细胞所介导的免疫反应所实现。 |
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S4781 |
Xanthoxyline
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Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin. |
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S5845 |
Chalcone
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Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone)是一种芳族酮,是很多重要的生物化合物(chalcones)的中心,具有抗菌、抗肿瘤和消炎活性。 |
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S4793 |
Cedryl acetate
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Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
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E3772 |
Eyebright Extract
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Eyebright Extract是从玄参科的小米草Herba Euphrasiae中提取的,具有抗炎、抗氧化、抗菌、抗癌、抗真菌、抗病毒、降压、保护皮肤、抗癫痫、抗卡他等活性。 |
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E3488 |
Fucus vesiculosis Extract
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Fucus Vesiculosis Extract是从具有抗真菌特性的墨角藻Fucus vesiculosus中提取的。 |
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S4516 |
(+)-Camphor
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Camphor是一种蜡质的、易燃的、白色或透明的固体,有强烈的香味,通常用于缓解疼痛、减少瘙痒以及治疗真菌感染。它能够激活TRPV1和TRPV3。 |
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S4843 |
Potassium acetate
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Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties. |
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E4002 |
Potassium D-gluconate
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Potassium D-gluconate(Potassium Gluconate)是一种具有口服活性的氧化羧酸,具有防腐和螯合特性。 |
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S3910 |
4',7-Dimethoxyisoflavone
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4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
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S4559 |
Cloxiquine
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Cloxiquine (5-Chloro-8-quinolinol, Dermofungin)是一种抗细菌、抗真菌、抗衰老和抗痨药物。 |
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S3985 |
Methyl 4-hydroxybenzoate
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Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) 是一种抗真菌剂,应用于多种化妆品、个人护理用品和食品防腐剂。 |
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S0491 |
Manogepix (E1210)
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Manogepix (E1210, MGX, APX001A) 是一种广谱的、口服活性的抗真菌剂,可抑制 Gwt1/Gwt1p (GPI锚定壁转移蛋白1),该蛋白在真菌细胞壁完整性中起重要作用。 |
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Nat Commun, 2024, 15(1):9194
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Antimicrob Agents Chemother, 2024, 68(11):e0080324
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S3990 |
Trans-Anethole
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Trans-anethole (4-Propenylanisole)是苯丙烯衍生物,存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。 |
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S7418 |
Cycloheximide
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Cycloheximide (NSC-185, Actidione, Naramycin A, CHX, FT 3422-2, NM-MCD 80),一种抗真菌抗生素,是一种真核生物蛋白质合成(protein synthesis)抑制剂,对体内蛋白质合(protein synthesis)和 RNA 合成(RNA synthesis)的 IC50 分别为 532.5 nM 和 2880 nM。Cycloheximide抑制铁死亡并抑制自噬。在溶液中不稳定,请现配现用!此产品为危化品(急性毒性/易燃/皮肤腐蚀),请在穿戴防护面罩、防护手套和防护服后使用。 |
- Signal Transduct Target Ther, 2024, 9(1):65
- Mol Cancer, 2024, 23(1):143
- Mol Cancer, 2024, 23(1):240
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S2476 |
Itraconazole
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Itraconazole是一种三唑类抗真菌药物,是CYP3A4的有效抑制剂,IC50为6.1 nM。Itraconazole 是一个有效的Hedgehog (Hh)信号通路的拮抗剂。Itraconazole 可通过诱导自噬来抑制恶性胶质瘤的生长。 |
- Front Cell Infect Microbiol, 2023, 13:1128000
- Front Cell Infect Microbiol, 2023, 13:1131641
- Front Cell Infect Microbiol, 2022, 12:864912
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S1331 |
Fluconazole
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Fluconazole是一种羊毛甾醇14 alpha去甲基化酶 抑制剂,抑制了麦角固醇的形成,用于治疗和预防浅表性和全身性真菌感染。 |
- Front Cell Infect Microbiol, 2024, 14:1296151
- Front Cell Infect Microbiol, 2023, 13:1131641
- Nat Commun, 2022, 13(1):1658
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S1353 |
Ketoconazole
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Ketoconazole能抑制cyclosporine oxidase(环孢素氧化酶)和testosterone 6 beta-hydroxylase(睾丸素6β-羟化酶),IC50分别为0.19 mM和0.22 mM。Ketoconazole 是一种雄性激素 androgen 生物合成抑制剂。 |
- J Med Virol, 2023, 95(6):e28856
- J Med Virol, 2023, 95(6):e28856
- Cell Death Dis, 2023, 14(1):64
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S3073 |
Caspofungin (MK-0991) Acetate
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Caspofungin Acetate (MK-0991, L-743872)是一种脂肽类抗真菌β-1,3-glucan synthase抑制剂。 |
- PLoS Pathog, 2024, 20(9):e1012521
- Sci Rep, 2024, 14(1):27500
- J Vis Exp, 2024, (206).
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S1934 |
Nystatin
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Nystatin (Fungicidin) 是一种多烯类抗真菌剂,常常被用作oropharyngeal candidosis的局部治疗剂。 |
- Microbiol Spectr, 2023, 10.1128/spectrum.02553-23
- Nature, 2022, 603(7899):159-165
- Nat Metab, 2022, 4-10:1369-1401
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S4286 |
Anidulafungin
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Anidulafungin, 一种echinocandin的衍生物, 抑制glucan synthase的活性, 用作抗真菌药。
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- Viruses, 2023, 15(2)452
- BMC Med, 2022, 20(1):359
- Antiviral Res, 2021, S0166-3542(21)00178-9
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S4287 |
Micafungin Sodium
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Micafungin Sodium是1,3-β-D-葡聚糖合成抑制剂,用作抗真菌的药物。
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- Microbiol Spectr, 2024, e0352623.
- BMC Med, 2022, 20(1):359
- Antiviral Res, 2021, S0166-3542(21)00178-9
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S3019 |
Ciclopirox ethanolamine
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Ciclopirox ethanolamine(Ciclopirox olamine, HOE 296,Ciclopiroxolamine)作为一种铁离子螯合剂,具有广谱抗真菌作用。 |
- Commun Biol, 2023, 6(1):402
- Commun Biol, 2023, 6(1):402
- J Clin Invest, 2022, 132(9)e152345
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S2058 |
Tolnaftate
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Tolnaftate 是一种合成的硫代氨基甲酸酯,用作抗真菌剂。 |
- J Pers Med, 2022, 12(2)258
- Hum Cell, 2022, 10.1007/s13577-022-00671-y
- Hum Cell, 2021, 34(6):1911-1918
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S2321 |
Magnolol
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Magnolol (NSC 293099) 是一种在Houpu magnolia (Magnolia officinalis) 树皮中发现的生物活性化合物。它能抑制TNFα诱导的NF-κB的激活。 |
- Mol Oncol, 2022, 16(15):2823-2842
- Int Immunopharmacol, 2022, 112:109242
- Reprod Biol, 2021, 21(4):100567
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S1725 |
Terbinafine
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Terbinafine (SF 86-327,TDT 067) 用于治疗真菌感染,可以杀死真菌或防止其生长。 |
- Front Oncol, 2023, 13:1111570
- Neurooncol Adv, 2022, 4(1):vdac018
- J Cell Mol Med, 2020, 25
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S1956 |
Miconazole Nitrate
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Miconazole (NSC 169434) Nitrate是一种咪唑类抗真菌剂,外用或静脉输液。 |
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
- Chem Biol Interact, 2021, 343:109498
- Biomol Ther (Seoul), 2020, 25
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S2528 |
Ciclopirox
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Ciclopirox(HOE 296b, Penlac) 是一种合成的抗真菌药物。 |
- Cell Death Dis, 2021, 12(12):1141
- J Transl Med, 2021, 19(1):347
- Int J Mol Sci, 2021, 22(15)8299
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S3079 |
Atovaquone
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Atovaquone (Atavaquone)用于治疗或预防肺孢子菌肺炎,弓形虫病, 疟疾和巴贝西虫。 |
- Cells, 2024, 13(12)1025
- iScience, 2024, 27(3):109172
- J Cell Biochem, 2022, 10.1002/jcb.30213
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S1606 |
Clotrimazole
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Clotrimazole (BAY b 5097, FB 5097)是一种合成的抗真菌药物,是imidazole的广谱衍生物。 |
- PLoS Pathog, 2024, 20(10):e1012601
- iScience, 2022, 25(11):105342
- Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
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S2557 |
Terbinafine HCl
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Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride)通过抑制角鲨烯环氧酶抑制了麦角固醇的合成,用作抗真菌药物。 |
- Cell Rep Med, 2023, S2666-3791(22)00494-3
- Oncogene, 2021, 10.1038/s41388-021-01934-y
- J Cell Mol Med, 2020, 25
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S2536 |
Miconazole
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Miconazole(Monistat,R18134) 是一种咪唑类抗真菌药物。 |
- Nat Commun, 2024, 15(1):3068
- Int J Mol Sci, 2022, 23(22)13809
- Chem Biol Interact, 2021, 343:109498
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S1676 |
Amorolfine HCl
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Amorolfine HCl(Ro 14-4767 HCl)是一种抗真菌药物。 |
- Nat Commun, 2021, 12(1):652
- Cell Chem Biol, 2019, 26(4):593-599
- Nature, 2018, 560(7718):372-376
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S4075 |
Zinc Pyrithione
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Zinc pyrithione (OM-1563)是一种抗真菌和抗细菌药物,可以通过阻断质子泵破坏膜转运。 |
- Cell Chem Biol, 2021, S2451-9456(21)00213-0
- Biol Reprod, 2019, 100(2):468-478
- Cell Syst, 2017, 4(6-:600-610
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S5080 |
Neticonazole
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Neticonazole (SS717) 是一种选择性的针对 exosome 形成和分泌的抑制剂。 Neticonazole具有Neticonazole的抗真菌和抗肿瘤活性。 |
- Nat Commun, 2023, 14(1):6692
- Nat Commun, 2023, 14(1):6692
- Clin Transl Med, 2022, 12(9):e1037
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S1517 |
Natamycin
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Natamycin (Pimaricin) 是一种天然存在的三唑类抗真菌药物。具有极少或无味道干扰。 |
- Expert Opin Drug Deliv, 2020, 17(3):407-421
- BMC Microbiol, 2020, 20(1):275
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S2535 |
Econazole nitrate
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Econazole Nitrate (NSC 243115,Spectazole) 是一种咪唑类抗真菌药物。 |
- Nat Commun, 2024, 15(1):8708
- Cell Rep Med, 2023, 4(12):101309
- Int J Mol Sci, 2022, 23(22)13809
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S1910 |
Tioconazole
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Tioconazole (UK-20349) 是一种抗真菌药物,IC50为1.7 μM。 |
- J Mol Cell Biol, 2021, mjab059
- Chem Biol Drug Des, 2016, 10.1111/cbdd.12872
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S4120 |
Sulconazole Nitrate
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Sulconazole Nitrate(Exelderm,RS 44872) 是一种咪唑衍生物,具有广谱抗真菌活性。 |
- Int J Mol Sci, 2022, 23(22)13809
- Sci Adv, 2021, 7(36):eabf6033
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S4601 |
Clioquinol
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Clioquinol (Iodochlorhydroxyquin, Chinoform) 是一种具有口服活性的、亲油性的、铜离子结合的卤代8-羟基喹啉(8-hydroxyquinoline),具有抗真菌、抗寄生物以及潜在的抗肿瘤活性。 |
- Cancer Lett, 2024, 588:216797
- Mol Oncol, 2021, 10.1002/1878-0261.13079
- FASEB J, 2019, 10.1096/fj.201802603RR
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S5373 |
Pseudolaric Acid B
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Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties. |
- Toxicology, 2023, 493:153556
- Eur J Pharmacol, 2020, 876:173064
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S1666 |
Flucytosine (5-Fluorocytosine)
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Flucytosine (5-Fluorocytosine)是氟嘧啶类似物, 是抗菌药,作用于人白色念珠菌(C. albicans)时 IC50 为0.12 μg/mL。 |
- Sci Adv, 2021, 7(27)eabh3032
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S1854 |
Bifonazole
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Bifonazole (Bay h 4502,(±)-bifonazole) 是一种抗真菌剂和前列腺芳香化酶抑制剂,IC50为1.6 μM。 |
- Nature, 2018, 560(7718):372-376
|
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S3161 |
Sertaconazole nitrate
|
Sertaconazole nitrate (FI-7045,FI7056)是一种外用广谱抗真菌药,是用来治疗表面皮肤和粘膜感染的辅助用药 |
- Int J Mol Sci, 2022, 23(22)13809
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S5359 |
Butoconazole
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Ethyl chrysanthemate is an allelochemical compound used as an attractant. |
- Arch Biochem Biophys, 2024, 754:109958
- Nature, 2018, 560(7718):372-376
|
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S8095 |
Tubercidin
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Tubercidin (7-deaza-adenosine),腺苷类似物,是一种核苷抗生素。它可掺入到DNA中,抑制聚合酶,因此抑制DNA复制和RNA、蛋白合成。Tubercidin还具有抗真菌和抗病毒活性。 |
- Mol Cell, 2020, 80(6):1104-1122.e9
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S4584 |
Butylparaben
|
Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) 是一种常在化妆品中被用作抗菌防腐剂的化合物。 |
- Environ Toxicol, 2018, 33(4):436-445
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S4178 |
Climbazole
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Climbazole(BAY-e 6975)是一种广谱的咪唑类抗真菌药剂,具有抗头皮屑的效果。 |
- Sci Adv, 2022, 8(49):eadd2191
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S3646 |
Thimerosal
|
Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing. |
- EMBO J, 2024, 10.1038/s44318-024-00217-y
- J Invest Dermatol, 2024, S0022-202X(23)03210-4
- Cell Chem Biol, 2021, S2451-9456(21)00442-6
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S4187 |
Salicylanilide
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Salicylanilides (WR10019,2-Hydroxybenzanilide)是一组具有广泛的生物活性的化合物,具有抗病毒效力,抗菌(包括抗分枝杆菌),和抗真菌活性。 |
- Hum Mol Genet, 2020, ddaa244
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S9057 |
Sinigrin
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Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. |
- J Invest Dermatol, 2018, 138(12):2644-2652
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S5033 |
Terconazole
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Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470)是一种新型的、广谱的、三唑抗真菌试剂,主要用于治疗阴道真菌感染。 |
- bioRxiv, 2020, 2020/9/20.4.7.30734
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S3722 |
Isavuconazole
|
Isavuconazole (BAL-4815, RO-0094815) 是新型超广谱三唑类化合物,对酵母、霉菌和双态性真菌具有活性,抑制cytochrome P450 (CYP)依赖性的14α-lanosterol脱甲基作用,以此抑制真菌细胞膜麦角固醇的合成。 |
- Sci Rep, 2024, 14(1):27500
- J Pharm Sci, 2023, 10.1016/j.xphs.2023.11.005
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S4878 |
Neticonazole Hydrochloride
|
Neticonazole是咪唑类抗真菌剂,用于治疗皮肤真菌感染。 |
- Toxins (Basel), 2024, 16(9)380
- Clin Transl Med, 2022, 12(9):e1037
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S5512 |
Juglone
|
Juglone (Regianin, 5-Hydroxy-1,4-naphthoquinone)是一种天然萘醌,存在于黑核桃等植物中,对多种植物具有中等的抗真菌活性和促生长作用。它有时可以用作除草剂,作为布料和油墨的染料,以及作为食品和化妆品的着色剂。在溶液中不稳定,请现配现用! |
- Chin Med, 2024, 19(1):52
- Nat Commun, 2019, 10(1):4013
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S1997 |
Liranaftate
|
Liranaftate(M-732,Piritetrate) 是一种角鲨烯环氧酶抑制剂具有抗真菌活性。 |
- Cell Rep, 2024, 43(4):114094
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S2031 |
Fenticonazole Nitrate
|
Fenticonazole Nitrate(Lomexin,REC 15-1476,Falvin) 是一种唑类抗真菌药物。 |
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S3154 |
Butenafine HCl
|
Butenafine HCl (KP-363)是一种合成的苄胺类抗真菌药物,通过抑制甾醇合成,通过抑制角鲨烯环氧酶,而发挥作用。 |
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S3156 |
Naftifine HCl
|
Naftifine HCl(AW 105-843)是一种烯丙基胺类抗真菌药,外用治疗足癣,股癣,体癣,通过抑制角鲨烯2,3-环氧酶选择性抑制甾醇的生物合成。 |
- Clin Transl Med, 2024, 14(2):e1586
- Arch Biochem Biophys, 2024, 754:109958
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S1833 |
Butoconazole nitrate
|
Butoconazole nitrate (RS-35887)是一种抗真菌剂,抑制PHA刺激下人外周血淋巴细胞中细胞因子(如IL-2, TNFα, IFN 和 GM-CSF)的分泌,IC50分别为7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL 和 7.6 μg/mL。 |
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S4806 |
Potassium 1-Naphthaleneacetate
|
Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens. |
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E3040 |
Stemonae Extract
|
Stemonae Extract从百部Radix Stemonae的根茎中提取,作为一种口服镇咳药,在中医中已有几千年的历史,具有镇咳、抗结核、抗菌、抗真菌、抗寄生虫等药理作用。 |
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S9200 |
Pneumocandin B0
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
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S0917 |
Allosecurinin
|
Allosecurinine (Phyllochrysine) 是一种从 M.indica 和 M.discoidea 分离的具有抗真菌活性的Securinega生物碱。 |
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S6254 |
Hydrocinnamic acid
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Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid)是苯丙氨酸代谢途径中氧化还原酶的底物。它是一种抗真菌剂和代谢物。 |
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S4581 |
Triacetin
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Triacetin (Glycerol triacetate, Glyceryl triacetate, Glycerin triacetate, 1,2,3-Triacetoxypropane) 是一种甘油三酸酯,具有杀真菌作用。 |
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S5213 |
Piroctone Olamine
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Piroctone Olamine (piroctone ethanolamine) is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections. |
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S5553 |
Kasugamycin hydrochloride
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Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species. |
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S0938 |
Sakuranetin
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Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. |
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E3071 |
Malaytea Scurfpea Extract
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Malaytea Scurfpea Extract是从补骨脂Psoralea corylifolia L.中提取的,具有抗真菌活性,对病原体具有防御作用。 |
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S5944 |
Butenafine
|
Butenafine是合成的苄胺抗真菌剂。 |
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S3966 |
Nifuratel
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Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action. |
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S3307 |
Galangin 3-methyl ether
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Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin) 分离自 Lychnophora markgravii 的地上部分,具有很强的抗细菌和抗真菌作用。 |
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S4970 |
Nerol
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Nerol (Cis-Geraniol, Neryl alcohol)是存在于多种香精油如柠檬草和槐花中的单萜化合物。 |
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S3829 |
Isoalantolactone
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Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. |
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S0770 |
Camalexin
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Camalexin 是从亚麻荠和拟南芥(十字花科)中分离得到的一种植物抗毒素,能诱导活性氧(ROS)产生。Camalexin具有抗菌、抗真菌、抗增殖和抗癌活性。 |
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S6118 |
Terpinen-4-ol
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Terpinen-4-ol是一种天然存在的单萜,是茶树油的主要活性成分,具有多种生物活性如抗真菌活性。 |
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S4996 |
Tavaborole (AN-2690)
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Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity. |
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S5271 |
Suloctidil
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Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent. |
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E3725 |
Sapindus saponaria Linnaeus nutshell Extract (40%)
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Sapindus Saponaria Linnaeus Nutshell Extract (40%)提取自无患子Sapindus saponaria L.,具有抗真菌活性。 |
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E3726 |
Sapindus saponaria Linnaeus nutshell Extract (70%)
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Sapindus Saponaria Linnaeus Nutshell Extract (70%)提取自无患子Sapindus saponaria L.,具有抗真菌活性。 |
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S4755 |
lanosterol
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Lanosterol是一种四环三萜,它可由所有的动物、真菌类固醇衍生而来。 |
- Commun Biol, 2023, 6(1):1108
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S3532 |
AN-2718
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AN-2718是一种真菌生长(fungal growth)抑制剂,通过oxaborole tRNA捕获(OBORT)机制阻断蛋白合成。 |
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S3778 |
Patchouli alcohol
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Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis. |
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S4963 |
Purpurin
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Purpurin (1,2,4-Trihydroxyanthraquinone, Hydroxylizaric acid, Verantin)是从茜草根和其他茜草科植物家族中分离出的天然色素。它具有抗血管生成、抗菌、抗氧化活性。Purpurin 可有效地抑制CYP1A1、CYP1A2 和 CYP1B1。 |
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S6270 |
2-Aminoisobutyric acid
|
2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH)是一种稀有的、非蛋白氨基酸,是嘧啶代谢的终产物,随着尿液排出,在一些真菌来源的抗生素中有发现。 |
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S3676 |
Carbendazim
|
Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi. |
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S4258 |
Luliconazole
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Luliconazole(NND 502)是一种广谱抗真菌药物。 |
- Arch Biochem Biophys, 2024, 754:109958
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S9350 |
Ethyl 4-Methoxycinnamate
|
Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. |
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S2534 |
Isoconazole nitrate
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Isoconazole nitrate(Travogen,Adestan G 100, R 15454) 是一种唑类抗真菌药物。 |
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S5704 |
Myclobutanil
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Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. |
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S3705 |
Chlorobutanol
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Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol)是一种防腐剂、镇静剂、催眠剂和弱的局部麻醉剂,具有抗菌抑菌作用。 |
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S1991 |
iKIX1
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iKIX1是一种抗真菌药物,可在体外使耐药的光念珠菌对唑类抗真菌药物重新敏感;iKIX1抑制CgGal11A的KIX结构域与CgPdr1的活化结构域相互作用,IC50和Ki值分别为190.2 μM和18 μM。 |
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S3860 |
Allicin
|
Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects. |
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S9072 |
Sweroside
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Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects. |
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S6408 |
Hexetidine
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Hexetidine是一种抗细菌和抗真菌剂,具有局部麻醉、止血、除臭、预防牙菌斑作用。 |
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S5025 |
Efinaconazole
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Efinaconazole (KP-103) 是14 alpha-demethylase的抑制剂。14 alpha-demethylase参与ergosterol的生物合成,ergosterol是真菌细胞膜的成分之一。 |
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S3588 |
Hexylene glycol
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Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) 是一种衍生自丙酮的氧化溶剂,已广泛用于工业化学品和化妆品中。Hexylene glycol 具有抗菌 antibacterial 和抗真菌 antifungal 的特性。 |
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S3595 |
D-Gluconic acid
|
D-Gluconic acid 是一种抗真菌 antifungal 药。 |
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S9413 |
Yangonin
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Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. |
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E3706 |
Cortex pseudolaricis Extract
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Cortex Pseudolaricis Extract来自Pseudolarix amabilis Rehder的根皮,其中部分成分具有抗真菌活性、抗癌活性和过氧化物酶体增殖物激活受体活性等生物活性。 |
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S5724 |
Dichlorophen
|
Dichlorophen (Dichlorophene, Bis(5-chloro-2-hydroxyphenyl)methane) is an anticestodal agent, fungicide, germicide, and antimicrobial agent. |
- Nat Commun, 2024, 15(1):8708
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S5829 |
Monomyristin
|
Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate)具有抗细菌和抗真菌活性。 |
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S6451 |
Salifungin
|
Salifungin (Multifungin, Bromosalicylchloranilide)是一种抗真菌剂,在某些个体中可能导致过敏性接触性皮炎。 |
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S5541 |
Dimetridazole
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Dimetridazole is an anti-fungal and anti-protozoal used for the control of infection in pigs, poultry, turkeys, game birds, pigeons and other caged birds. |
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S3979 |
Zinc Undecylenate
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Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. |
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S5086 |
p-Anisaldehyde
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p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde),茴芹种子提取物,具有抗真菌活性,对很多酵母和实验室培养基、果泥和果汁中的霉菌菌株具有活性。 |
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S6467 |
Fosfluconazole
|
Fosfluconazole是一种水溶性的fluconazole盐酸盐前体药物。Fluconazole是三唑抗真菌药物,用于治疗和组织表面的和系统性真菌感染。 |
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S9444 |
Tomatine
|
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties. |
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S4525 |
Ethylparaben
|
Ethylparaben (Ethyl parahydroxybenzoate, Ethyl 4-hydroxybenzoate)是对羟基苯甲酸(p-hydroxybenzoic acid)的乙酯形式,被用作抗真菌防腐剂和食品添加剂。它还是一种化学过敏原,其生理效应是通过增加组胺释放和细胞所介导的免疫反应所实现。 |
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S5845 |
Chalcone
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Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone)是一种芳族酮,是很多重要的生物化合物(chalcones)的中心,具有抗菌、抗肿瘤和消炎活性。 |
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S4793 |
Cedryl acetate
|
Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
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E3772 |
Eyebright Extract
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Eyebright Extract是从玄参科的小米草Herba Euphrasiae中提取的,具有抗炎、抗氧化、抗菌、抗癌、抗真菌、抗病毒、降压、保护皮肤、抗癫痫、抗卡他等活性。 |
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E3488 |
Fucus vesiculosis Extract
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Fucus Vesiculosis Extract是从具有抗真菌特性的墨角藻Fucus vesiculosus中提取的。 |
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S4516 |
(+)-Camphor
|
Camphor是一种蜡质的、易燃的、白色或透明的固体,有强烈的香味,通常用于缓解疼痛、减少瘙痒以及治疗真菌感染。它能够激活TRPV1和TRPV3。 |
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S4843 |
Potassium acetate
|
Potassium acetate (Diuretic salt, Potassium ethanoate) is the potassium salt of acetic acid, which is a synthetic carboxylic acid with antibacterial and antifungal properties. |
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S3910 |
4',7-Dimethoxyisoflavone
|
4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro. |
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S4559 |
Cloxiquine
|
Cloxiquine (5-Chloro-8-quinolinol, Dermofungin)是一种抗细菌、抗真菌、抗衰老和抗痨药物。 |
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S3985 |
Methyl 4-hydroxybenzoate
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Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) 是一种抗真菌剂,应用于多种化妆品、个人护理用品和食品防腐剂。 |
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S0491 |
Manogepix (E1210)
|
Manogepix (E1210, MGX, APX001A) 是一种广谱的、口服活性的抗真菌剂,可抑制 Gwt1/Gwt1p (GPI锚定壁转移蛋白1),该蛋白在真菌细胞壁完整性中起重要作用。 |
- Nat Commun, 2024, 15(1):9194
- Antimicrob Agents Chemother, 2024, 68(11):e0080324
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S3990 |
Trans-Anethole
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Trans-anethole (4-Propenylanisole)是苯丙烯衍生物,存在于多种香精油、包括茴香油中。它具有神经调节、抗焦虑、抗氧化、抗真菌、抗炎症和免疫调节活性。 |
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