黑色素瘤

造模剂

PMA

DMBA

获批药物

Binimetinib

Encorafenib

Cobimetinib

Dabrafenib Mesylate

Dacarbazine

Melphalan

Ipilimumab

Pembrolizumab

Trametinib DMSO solvate

Nivolumab

Relatlimab

Vemurafenib

化疗 ^[1]

TMZ

Cisplatin

Carboplatin

Dacarbazine

Paclitaxel

Nab-Paclitaxel

免疫检查点抑制剂

PD-1: Retifanlimab; Zimberelimab; Penpulimab; Prolgolimab; Tislelizumab; Camrelizumab; Sintilimab; Pembrolizumab; Nivolumab; Cetrelimab; Sasanlimab; Spartalizumab; Ezabenlimab; Pidilizumab

PD-L1: Sugemalimab; Durvalumab; Atezolizumab; INCB086550; Cosibelimab; Lodapolimab; Manelimab

CALT-4: Tremelimumab; Ipilimumab; Quavonlimab; Nurulimab

抗血管生成 ^[2]

VEGF: Bevacizumab

VEGFR: Lenvatinib; Nintedanib; Cabozantinib malate; Axitinib; Sunitinib malate; Sorafenib tosylate; Apatinib (YN968D1) mesylate; Vorolanib

FGFR: Lenvatinib; Golvatinib

PDGFR: Nintedanib; Imatinib (STI571) Mesylate; Vorolanib

MMPs: Marimastat; Doxycycline

靶向疗法 (A)

IL-2R: Daclizumab; Basiliximab; Camidanlumab

BRAF: Encorafenib; Exarafenib

Tubulin: Nab-Paclitaxel; Paclitaxel; Vindesine sulfate; Vincristine sulfate; Verubulin hydrochloride; Patupilone

DNA: TMZ; Dacarbazine; Cyclophosphamide; Evofosfamide

JAK1/2: Ruxolitinib

靶向疗法 (B)

MEK1/2: Selumetinib; Binimetinib; Cobimetinib; Trametinib DMSO solvate; PD0325901; Pimasertib; TAK-733; GDC-0623

ERK1/2: ASN007; Temuterkib; Ulixertinib; Ravoxertinib

4-1BB/CD137: Urelumab; Utomilumab

HDAC: Panobinostat; Tucidinostat; Romidepsin; Vorinostat; Entinostat; PCI-34051

干细胞标志物 ^[2]

ABCG2: Ko143; RG14620; YHO-13177; KS176; 5,7-Dimethoxyflavone

ALDH: Disulfiram; Daidzin; NCT-501; Alda 1; CM10; 3-Hydroxybenzaldehyde; CVT-10216

KLF4: APTO-253

激酶抑制剂 ^[3]

KIT: Imatinib; Nilotinib; Dasatinib; Sunitinib malate

BRAF: Encorafenib; Dabrafenib Mesylate; Vemurafenib

MEK: Binimetinib; Cobimetinib; Trametinib DMSO solvate

免疫增强

L-Fucose

FICZ

相关化合物库

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library