| HT-p21 |
Function Assay |
50-1250 nM |
24 h |
inhibits phosphorylation of S6 kinase (target of mTORC1) and its downstream target phospho-S6 |
|
| U87vIII |
Function Assay |
0.04-2.5 μM |
24 h |
inhibits mTORC1 and mTORC2 activities |
|
| U87vIII |
Function Assay |
2.5/5 μM |
12 h |
inhibits gap closing in a dose-dependent manner |
|
| 3T3-L1 |
Function Assay |
15 μM |
4 h |
suppresses expression of the Egr1 protein |
|
| Rh30 |
Function Assay |
1 μM |
2 h |
inhibits both mTORC1-mediated phosphorylation of S6K1 and mTORC2-mediated phosphorylation of Akt |
|
| HT29 |
Function Assay |
1 μM |
2 h |
inhibits both mTORC1-mediated phosphorylation of S6K1 and mTORC2-mediated phosphorylation of Akt |
|
| Rh30 |
Function Assay |
1 μM |
2 h |
suppresses the basal or IGF-1-stimulated cell adhesion |
|
| HT29 |
Function Assay |
1 μM |
2 h |
suppresses the basal or IGF-1-stimulated cell adhesion |
|
| U87 |
Growth Inhibition Assay |
25 nM |
24 h |
increases DUSP10 knocked-down induced cell inhibition |
|
| AGS |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| MKN45 |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| MKN28 |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| KATO3 |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| SGC7901 |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| N87 |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| HMEC |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| HUVEC |
Cell Viability Assay |
0-1000 nM |
24/48 h |
decreases cell viability in time and dose dependent manner |
|
| MG63 |
Function Assay |
50-1000 nM |
0.5 h |
dose dependently (50–1000 nM) inhibits phosphorylation of Akt |
|
| U2OS |
Function Assay |
50-1000 nM |
0.5 h |
dose dependently (50–1000 nM) inhibits phosphorylation of Akt |
|
| Saos-2 |
Function Assay |
50-1000 nM |
0.5 h |
dose dependently (50–1000 nM) inhibits phosphorylation of Akt |
|
| Saos-2 |
Function Assay |
100 nM |
0.5 h |
prevents osteosarcoma cell migration |
|
| MG63 |
Apoptosis Assay |
100 nM |
36 h |
promotes apoptosis |
|
| U2OS |
Apoptosis Assay |
100 nM |
36 h |
promotes apoptosis |
|
| Saos-2 |
Apoptosis Assay |
100 nM |
36 h |
promotes apoptosis |
|
| DLD-1 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Caco2 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| HT29 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| H116 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Hct-8 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Colo320 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Sw948 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Colo205 |
Cell Viability Assay |
0-1000 nM |
24 h |
inhibits the growth in a dose-dependent manner |
|
| Colo320 |
Function Assay |
1 μM |
0-24 h |
abolishes the S6S235/236 but partially reduces the 4E-BP1T36/45 |
|
| HT29 |
Function Assay |
1 μM |
0-24 h |
abolishes the S6S235/236 but partially reduces the 4E-BP1T36/45 |
|
| Sw948 |
Function Assay |
1 μM |
0-24 h |
abolishes the S6S235/236 but partially reduces the 4E-BP1T36/45 |
|
| DLD-1 |
Function Assay |
1 μM |
0-24 h |
abolishes the S6S235/236 but partially reduces the 4E-BP1T36/45 |
|
| 786-O |
Function Assay |
0.1/0.5 μM |
24 h |
increases E-cadherin mRNA levels dose dependently |
|
| 786-O |
Function Assay |
0-0.5 μM |
24 h |
results in a dose dependent increase in E-cadherin protein expression |
|
| OCI-AML3 |
Apoptosis Assay |
2.5 μM |
72 h |
induces apoptosis |
|
| Jurkat |
Function Assay |
100/200/400 nM |
18 h |
inhibits mTORC1-dependent S6 S235/236 phosphorylation |
|
| p210 BCR-Abl |
Function Assay |
100/200/400 nM |
18 h |
inhibits mTORC1-dependent S6 S235/236 phosphorylation |
|
| Jurkat |
Growth Inhibition Assay |
400nM |
24/48 h |
synergize with 17-AAG to suppress cell proliferation |
|
| p210 BCR-Abl |
Growth Inhibition Assay |
400nM |
24/48 h |
synergize with 17-AAG to suppress cell proliferation |
|
| 8226 |
Function Assay |
100-1000 nM |
30 min |
activates ERK |
|
| MM1.S |
Function Assay |
100-1000 nM |
30 min |
activates ERK |
|
| 8226 |
Function Assay |
0.5 μM |
30 min |
induces activation of RAF and phosphorylation of MEK |
|
| MM1.S |
Function Assay |
0.5 μM |
30 min |
induces activation of RAF and phosphorylation of MEK |
|
| MCF-7 |
Function Assay |
50/200/500 nM |
30 min |
dose-dependently (50–500 nM) suppresses phosphorylation of Akt |
|
| T47D |
Function Assay |
50/200/500 nM |
30 min |
dose-dependently (50–500 nM) suppresses phosphorylation of Akt |
|
| MDA-MB-231 |
Function Assay |
50/200/500 nM |
30 min |
dose-dependently (50–500 nM) suppresses phosphorylation of Akt |
|
| Bcap-37 |
Function Assay |
50/200/500 nM |
30 min |
dose-dependently (50–500 nM) suppresses phosphorylation of Akt |
|
| MCF-7 |
Apoptosis Assay |
200 nM |
36 h |
induces apoptosis |
|
| MDA-MB-231 |
Apoptosis Assay |
200 nM |
36 h |
induces apoptosis |
|
| Bcap-37 |
Apoptosis Assay |
200 nM |
36 h |
induces apoptosis |
|
| LS174T |
Function Assay |
10/100/1000 nM |
6 h |
inhibits mTORC1 activity by the dephosphorylation of S6 ribosomal protein |
|
| DLD-1 |
Function Assay |
10/100/1000 nM |
6 h |
inhibits mTORC1 activity by the dephosphorylation of S6 ribosomal protein |
|
| SW480 |
Function Assay |
10/100/1000 nM |
6 h |
inhibits mTORC1 activity by the dephosphorylation of S6 ribosomal protein |
|
| NIH 3T3 |
Function Assay |
2 μM |
18 h |
inhibits mTORC2 phosphorylation of Akt on Ser473 and mTORC1 phosphorylation of 4E-BP1 on Thr37/46 |
|
| HCT15 |
Function Assay |
0.5/2 μM |
4 h |
prevents S6K1 phosphorylation of ribosomal protein S6 at Ser240/244 and mTORC2 phosphorylation of Akt at Ser473 |
|
| SW620 |
Function Assay |
0.5/2 μM |
4 h |
blocks all three mTOR outputs |
|
| PC12 |
Function Assay |
40 nM |
|
induces lysosomal biogenesis and alleviated α-SYN accumulation |
|
| DND-1 |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| TMD8 |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| Jurkat |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| KOPT-K1 |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| TMD7 |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| THP-1 |
Growth Inhibition Assay |
0.25/0.5/1 μM |
|
inhibits cell growth dose dependently |
|
| HT1376 |
Growth Inhibition Assay |
|
|
IC50=1.88 ± 1.1 μM |
|
| T24 |
Growth Inhibition Assay |
|
|
IC50=1.37 ± 0.4 μM |
|
| UM-UC-3 |
Growth Inhibition Assay |
|
|
IC50=0.63 ±0.1 μM |
|
| SW620 |
Growth Inhibition Assay |
|
|
IC50=7.8 μM |
|
| SW480 |
Growth Inhibition Assay |
|
|
IC50=4.6 μM |
|
| SK-CO-1 |
Growth Inhibition Assay |
|
|
IC50=4 μM |
|
| LS-513 |
Growth Inhibition Assay |
|
|
IC50=3.9 μM |
|
| SW1116 |
Growth Inhibition Assay |
|
|
IC50=0.84 μM |
|
| LS-174T |
Growth Inhibition Assay |
|
|
IC50=0.84 μM |
|
| HCT 116 |
Growth Inhibition Assay |
|
|
IC50=0.41 μM |
|
| HCT 15 |
Growth Inhibition Assay |
|
|
IC50=0.3 μM |
|
| COLO 205 |
Growth Inhibition Assay |
|
|
IC50=0.24 μM |
|
| HT-29 |
Growth Inhibition Assay |
|
|
IC50=0.23 μM |
|
| COLO 201 |
Growth Inhibition Assay |
|
|
IC50=0.23 μM |
|
| Caco-2 |
Growth Inhibition Assay |
|
|
IC50=0.22 μM |
|
| SW48 |
Growth Inhibition Assay |
|
|
IC50=0.09 μM |
|
| SW-48 |
Growth Inhibition Assay |
|
|
IC50=0.1 μM |
|
| HCT-15 |
Growth Inhibition Assay |
|
|
IC50=0.3 μM |
|
| HCT 116 |
Growth Inhibition Assay |
|
|
IC50=0.6 μM |
|
| SW620-R |
Growth Inhibition Assay |
|
|
IC50=1.3 μM |
|
| SK-CO-1 |
Growth Inhibition Assay |
|
|
IC50=2.1 μM |
|
| SW620 |
Growth Inhibition Assay |
|
|
IC50=11 μM |
|
| BaF3 |
Growth Inhibition Assay |
|
|
GI50=1.449 μM |
|