前列腺癌

造模剂

N-Nitroso-N-methylurea

获批药物

Olaparib

Enzalutamide

Talazoparib

Docetaxel

Niraparib tosylate

Darolutamide

Apalutamide

Abiraterone Acetate

Mitoxantrone 2HCl

Cabazitaxel

Bicalutamide

Flutamide

Relugolix

Rucaparib Camsylate

Degarelix acetate

Nilutamide

内分泌疗法 ^[1]

AR: Enzalutamide; Darolutamide; Apalutamide; Bavdegalutamide

GnRHR: Relugolix; Degarelix acetate; Abarelix

CYP17A1

Abiraterone

Galeterone

Orteronel

靶向骨微环境

Bisphosphonates: Zoledronic acid; Risedronate; Alendronic Acid; Clodronate disodium tetrahydrate

RANKL: Denosumab

Calcium Channels ^[2]: Thapsigargin; GSK1016790A; Suramin sodium salt; ML-9 HCl; SKF96365; CarboxyaMidotriazole orotate; Diethylstilbestrol; 5-BDBD

化疗

Docetaxel

Carboplatin

Mitoxantrone 2HCl

Cabazitaxel

Estramustine phosphate sodium

免疫检查点抑制剂

PD-1: Pembrolizumab; Nivolumab

PD-L1: Atezolizumab; Durvalumab; Avelumab

CTLA4: Ipilimumab

抗血管生成 ^[3]

Bevacizumab

Sorafenib

Sunitinib

Thalidomide

Cabozantinib

Cediranib

Lenalidomide

Tasquinimod

Carotuximab

靶向PSMA ^[1]

mAbs: Rosopatamab; Pelgifatamab

ADC: Vipivotide tetraxetan

靶向DNA修复 ^[1]

PARP: Olaparib; Talazoparib; Niraparib; Veliparib; Rucaparib; Pamiparib

靶向细胞周期 ^[1]

CDK4/6: Abemaciclib; Ribociclib; Palbociclib

Mutant p53: Eprenetapopt

靶向PI3K/AKT/mTOR ^[1]

PI3K: Dactolisib; Samotolisib; AZD8186; GSK2636771

AKT: Perifosine; MK-2206 2HCl; Ipatasertib; Capivasertib

mTOR: Rapamycin; Ridaforolimus; Temsirolimus; Everolimus; Sapanisertib; Vistusertib; CC-115

PI3K/mTOR: Apitolisib

靶向表观遗传标志物 ^[1]

EZH2: Lirametostat; PF-06821497; Tazemetostat; Valemetostat

LSD1: Pulrodemstat (CC-90011) besylate

p300/CBP: Inobrodib

BET bromodomain: Birabresib; Mivebresib; Molibresib; ZEN-3694

HDACs: Entinostat; Panobinostat; Pracinostat; Vorinostat

DNMT: Azacitidine; Decitabine

靶向WNT通路 ^[1]

WNT-5A: Foxy-5

VEGF-A: Bevacizumab

ETAR: Zibotentan

FGFR: Erdafitinib; Masitinib

EGFR: Cetuximab; Gefitinib

VEGFR: Sunitinib; Cabozantinib

TGFβR1: Galunisertib; Anti-TGFb1

SRC: Dasatinib; Saracatinib

MEK: Trametinib

相关化合物库

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

PI3K/Akt Inhibitor Library