Thymidine
别名: NSC 21548, Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd 中文名称：胸苷
Thymidine是嘧啶核苷，由连接至糖脱氧核糖的嘧啶碱基胸腺嘧啶组成。作为DNA的组成部分，胸腺嘧啶核苷与DNA双螺旋中的腺嘌呤配对。
Thymidine Chemical Structure
CAS: 50-89-5
产品质控
批次：
纯度：
99.98%
99.98
Thymidine相关产品
相关信号通路图
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| ONS | Function assay | 10 uM | 24 hrs | Induction of phenotypic perturbation in human ONS cells assessed as decrease in EEA1-associated early endosomes level in at 10 uM after 24 hrs by EEA1 staining based assay relative to control | 26883470 |
| ONS | Function assay | 10 uM | 24 hrs | Induction of phenotypic perturbation in human ONS cells assessed as decrease in autophagy markers level in at 10 uM after 24 hrs relative to control | 26883470 |
| HEL | Antiviral assay | 3 days | Antiviral activity against Human adenovirus 2 infected in human HEL cells assessed as inhibition of virus-induced cytopathic effect after 3 days by microscopic method, EC50 = 22 μM. | 30286952 | |
| Vero | Antiviral assay | Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay, IC50 = 0.0003 μM. | 10464017 | ||
| HepG2.2.15 | Antiviral assay | Antiviral activity against HBV in HepG2.2.15 cells assessed as decrease in extracellular viral DNA level by RT-PCR, EC50 = 0.3 μM. | 17404006 | ||
| HL-60 | Function assay | The compound was tested for [3H]TdR incorporation into DNA in HL-60 cells, ID50 = 0.61 μM. | 2840503 | ||
| Vero | Function assay | Compound was evaluated for Kinetic constant for cellular thymidine kinase in Vero cells, Km = 0.81 μM. | 3033244 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Thymidine是嘧啶核苷，由连接至糖脱氧核糖的嘧啶碱基胸腺嘧啶组成。作为DNA的组成部分，胸腺嘧啶核苷与DNA双螺旋中的腺嘌呤配对。 |
|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT01199250 | Not yet recruiting | Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer |
Gynecologic Oncology Group|National Cancer Institute (NCI)|GOG Foundation |
January 2100 | -- |
| NCT04598516 | Withdrawn | Acute Kidney Injury (Nontraumatic)|Contrast-induced Nephropathy|Renal Insufficiency |
Maastricht University Medical Center |
November 1 2097 | -- |
| NCT05454306 | Suspended | Clavicle Fracture |
University of Minnesota |
January 9 2028 | Not Applicable |
| NCT04795856 | Not yet recruiting | Mitral Valve Regurgitation |
University of Alabama at Birmingham |
June 18 2027 | Early Phase 1 |
| NCT06359262 | Not yet recruiting | Mental Health Wellness 1 |
Karolinska Institutet |
January 1 2027 | Not Applicable |
化学信息&溶解度
| 分子量 | 242.23 | 分子式 | C10H14N2O5 |
| CAS号 | 50-89-5 | SDF | Download Thymidine SDF |
| Smiles | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 48 mg/mL ( (198.15 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : 48 mg/mL (198.15 mM) Ethanol : 9 mg/mL (37.15 mM) |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
技术支持
在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。
如果有其他问题，请给我们留言。
* 必填项
Tags: buy Thymidine | Thymidine supplier | purchase Thymidine | Thymidine cost | Thymidine manufacturer | order Thymidine | Thymidine distributor
