Vorinostat (SAHA)
别名: MK0683, Suberoylanilide hydroxamic acid 中文名称：伏立诺他
Vorinostat (SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。
Vorinostat (SAHA) Chemical Structure
CAS: 149647-78-9
产品质控
批次：
纯度：
99.96%
99.96
Vorinostat (SAHA)相关产品
相关信号通路图
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| HCT116 | Apoptosis Assay | 3 μM | 24 h | does not induce apoptosis assessed as increase in p53 protein level | 24766560 |
| Jurkat | Cytotoxic Assay | 20 μM | 72 h | no cytotoxicity assessed as growth inhibition | 24304348 |
| MDA-MB-231 | Kinase Assay | 1 μM | 24 h | does not inhibit HDAC6 assessed as acetylation levels of tubulin | 23493449 |
| MDA-MB-231 | Kinase Assay | 10 μM | 5 min | does not inhibit HDAC2a | 23493449 |
| GM11272 | Function Assay | 0.1 μM | 72 h | does not reactivate MeCp2 mutant expression | 21840716 |
| HepG2 | Function Assay | 10 μM | 24 h | does not induce apoptosis assessed as hyperacetylation of p53 | 21548582 |
| HCT116 | Kinase Assay | 0.3 μM | 30 h | does not inhibit HDAC1 assessed as induction of histone H3K9 acetylation | 21080647 |
| A549 | Function Assay | 5 μM | 3 h | does not induce autophagy assessed as increase in LC3II | 20855208 |
| SCC4 | Function Assay | 1 μM | 10 min | has no agonist activity at VDR assessed as induction of CYP24 gene expression | 20452225 |
| Caco-2 | Function Assay | 5 μM | 24 h | does not induce P21WAF1 gene expression | 20143840 |
| PANC1 | Function Assay | 1 μM | 48 h | does not increase in p27kip1 gene expression | 17588744 |
| PANC1 | Function Assay | 1 μM | 24 h | does not increase in p27kip1 gene expression | 17588744 |
| U937 | Kinase Assay | 1 μM | 24 h | has no effect on alpha tubulin acetylation | 17447750 |
| U937 | Kinase Assay | 5 μM | 24 h | has no effect on alpha tubulin acetylation | 17447750 |
| GM15850 | Function Assay | 5 μM | 12 h | has no effect on FXN mRNA expression | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | does not inhibit HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene | 16921367 |
| Jurkat | Cytotoxic Assay | 100 μM | 72 h | GI50=0.9 μM | 24900743 |
| AsPC1 | Growth Inhibition Assay | 30 μM | 48 h | IC50=3.66 μM | 24185378 |
| HL60 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC | 23707260 |
| HGC27 | Growth Inhibition Assay | 5 μM | 72 h | IC50=5.4 μM | 23707260 |
| GBC-SD | Growth Inhibition Assay | 5 μM | 72 h | IC50=14.8 μM | 23707260 |
| MEF | Cytotoxic Assay | 10 μM | 72 h | IC50=4.4 μM | 23570542 |
| HS68 | Cytotoxic Assay | 10 μM | 72 h | IC50=4.6 μM | 23570542 |
| MDA-MB-231 | Kinase Assay | 1 μM | 24 h | Inhibition of HDAC6 assessed as acetylation levels of tubulin | 23493449 |
| MDA-MB-231 | Kinase Assay | 10 μM | 30 min | Inhibition of HDAC2a | 23493449 |
| UO31 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| UACC62 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.4 μM | 22435669 |
| UACC257 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| TK10 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.63 μM | 22435669 |
| T47D | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| SR | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.4 μM | 22435669 |
| SNB75 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.79 μM | 22435669 |
| SNB19 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.63 μM | 22435669 |
| SN12C | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=2 μM | 22435669 |
| SKOV3 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1 μM | 22435669 |
| SK-MEL-5 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.63 μM | 22435669 |
| SK-MEL-28 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1 μM | 22435669 |
| SK-MEL-2 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| SF539 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=2 μM | 22435669 |
| SF295 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.6 μM | 22435669 |
| SF268 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.6 μM | 22435669 |
| RXF393 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| OVCAR8 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| OVCAR5 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.79 μM | 22435669 |
| OVCAR4 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=4 μM | 22435669 |
| OVCAR3 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| NCI-H522 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| NCI-H460 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.79 μM | 22435669 |
| NCI-H322M | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.79 μM | 22435669 |
| NCI-H23 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1 μM | 22435669 |
| NCI-ADR-RES | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.16 μM | 22435669 |
| MOLT4 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.4 μM | 22435669 |
| MDA-MB-468 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.63 μM | 22435669 |
| MDA-MB-435 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.5 μM | 22435669 |
| MCF10A | Growth Inhibition Assay | 6.2 μM | 48 h | GI50=9.6 μM | 22435669 |
| MALME-3M | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=0.32 μM | 22435669 |
| M14 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| LOXIMVI | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1 μM | 22435669 |
| IGROV1 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| HOP92 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=4 μM | 22435669 |
| HCT15 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=2.5 μM | 22435669 |
| EKVX | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| BT549 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| ACHN | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.3 μM | 22435669 |
| A549/ATCC | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.6 μM | 22435669 |
| A498 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=1.6 μM | 22435669 |
| 786-0 | Growth Inhibition Assay | 6.2 μM | 72 h | GI50=3.2 μM | 22435669 |
| DU145 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as histone H3 hyperacetylation | 22260166 |
| DU145 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as histone H4 acetylation | 22260166 |
| DU145 | Kinase Assay | 2.5 μM | 24 h | Inhibition of HDAC assessed as upregulation of p21waf1 protein expression | 22260166 |
| CFBE41o | Function Assay | 1 μM | 24 h | Restoration of CFTR deltaF508 mutant trafficking to cell surface as glycoforms | 21984958 |
| GM11272 | Function Assay | 100 nM | 72 h | Reactivation of MeCp2 mutant expression at 10 to 100 nM | 21840716 |
| U937 | Kinase Assay | 5 μM | 15 min | Inhibition of histone acetyltransferase assessed as increase of histone H3 acetylation level | 21292492 |
| U937 | Kinase Assay | 5 μM | 24 h | Inhibition of histone acetyltransferase assessed as increase of pan-acetylated histone H4 level | 21292492 |
| U937 | Kinase Assay | 5 μM | 24 h | Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K18 | 21292492 |
| U937 | Kinase Assay | 5 μM | 24 h | Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K9 | 21292492 |
| HCT116 | Kinase Assay | 30 μM | 30 h | Inhibition of HDAC1 assessed as induction of histone H3K9 acetylation | 21080647 |
| HCT116 | Kinase Assay | 30 μM | 30 h | Inhibition of HDAC6 assessed as induction of alpha-tubulin acetylation | 21080647 |
| MCR5-SV2 | Growth Inhibition Assay | 10 μM | 72 h | GI50=2.1 μM | 21080647 |
| LoVo | Growth Inhibition Assay | 10 μM | 72 h | GI50=1.7 μM | 21080647 |
| DU145 | Growth Inhibition Assay | 10 μM | 72 h | GI50=1.05 μM | 21080647 |
| COR-L23 | Growth Inhibition Assay | 10 μM | 72 h | GI50=1.1 μM | 21080647 |
| A549 | Function Assay | 5 μM | 3 h | Induction of autophagy in human A549 cells assessed as increase in LC3II | 20855208 |
| NB4 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as increase in histone H3 acetylation | 20491440 |
| NB4 | Function Assay | 5 μM | 24 h | Induction of p21WAF1/CIP1 expression | 20491440 |
| NB4 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as increase in acetylate tubulin level | 20491440 |
| NB4 | Function Assay | 5 μM | 24 h | Cell cycle arrest assessed as increase in accumulation at pre-G1 phase | 20491440 |
| SCC4 | Function Assay | 1 μM | 5 min | Agonist activity at VDR assessed as induction of CYP24 gene expression | 20452225 |
| SCC4 | Kinase Assay | 1 μM | 24h | Inhibition of HDAC assessed as increase in histone acetylation | 20452225 |
| SCC4 | Kinase Assay | 1 μM | 24h | Inhibition of HDAC assessed as increase in tubulin acetylation | 20452225 |
| COLO205 | Kinase Assay | 10 μM | 24 h | Inhibition of HDAC1 assessed as induction of histone H3 acetylation with IC50 of 2.2 μM | 20451378 |
| HepG2 | Kinase Assay | 5 μM | 6h | Induction of HDAC-mediated H3/H4 histone acetylation | 20143840 |
| HepG2 | Kinase Assay | 5 μM | 6h | Induction of HDAC-mediated alpha-tubulin acetylation | 20143840 |
| HepG2 | Kinase Assay | 5 μM | 6h | Induction of HDAC-mediated histone hyperacetylation | 20143840 |
| HepG2 | Kinase Assay | 5 μM | 6h | Induction of HDAC-mediated histone acetylation | 20143840 |
| Caco-2 | Kinase Assay | 0.316 nM to 31.6 μM | 4 h | Ex vivo inhibition of human HDAC6 | 20143840 |
| Caco-2 | Kinase Assay | 6.32 nM to 632 μM | 4 h | Ex vivo inhibition of human HDAC7 with IC50 of 41 μM | 20143840 |
| Caco-2 | Kinase Assay | 6.32 nM to 632 μM | 4 h | Ex vivo inhibition of human HDAC5 with IC50 of 12.6 μM | 20143840 |
| Caco-2 | Kinase Assay | 0.316 nM to 31.6 μM | 4 h | Ex vivo inhibition of human HDAC3 with IC50 of 0.147 μM | 20143840 |
| Caco-2 | Kinase Assay | 0.316 nM to 31.6 μM | 4 h | Ex vivo inhibition of human HDAC1 with IC50 of 0.119 μM | 20143840 |
| Caco-2 | Kinase Assay | 5 μM | 4 h | Induction of HDAC-mediated histone acetylation IC50 of 0.037 μM | 20143840 |
| Caco-2 | Growth Inhibition Assay | 100 μM | 48h | IC50=8.1 μM | 20143840 |
| MUF | Growth Inhibition Assay | 100 μM | 48 h | Growth inhibition at 0.05 to 100 uM | 20143840 |
| BJ | Growth Inhibition Assay | 100 μM | 48 h | Growth inhibition at 0.05 to 100 uM | 20143840 |
| Primary bronchial epithelial cell | Kinase Assay | 1 μM | 96 h | Inhibition of HDAC7 assessed as increase in short circuit currents | 19966789 |
| Primary bronchial epithelial cell | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as induction of mutant Fdelta508 CFTR protein apical surface localization | 19966789 |
| CFBE41o- | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC7 assessed as correction of mutant Fdelta508 CFTR trafficking to cell surface as glycoform | 19966789 |
| CFBE41o- | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC7 assessed as increase in stability of Fdelta508 CFTR protein | 19966789 |
| CFBE41o- | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC7 assessed as increase in rate of maturation of CFTR protein to its glycoform | 19966789 |
| CFBE41o- | Kinase Assay | 1 μM | 24 h | Inhibition of HDAC7 assessed as increase in Fdelta508 CFTR protein trafficking | 19966789 |
| CFBE41o- | Kinase Assay | 1 μM | 5 days | Inhibition of HDAC7 assessed as increase in stabilization of Fdelta508 CFTR protein | 19966789 |
| Primary bronchial epithelial cell | Kinase Assay | 1 μM | 24 h | Inhibition of HDAC7 assessed as induction of mutant Fdelta508 CFTR protein apical surface localization | 19966789 |
| CFBE41o- | Kinase Assay | 1 μM | 1 h | Inhibition of HDAC assessed as increase in CFTR protein level | 19966789 |
| CFBE41o- | Kinase Assay | 5 μM | 4 h | Inhibition of HDAC assessed as increase in mutant Fdelta508 CFTR protein level | 19966789 |
| CFBE41o- | Kinase Assay | 5 μM | 8 h | Inhibition of HDAC assessed as hyperacetylation of histone H3 | 19966789 |
| BHK | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC7 expressed assessed as increase in plasma membrane Fdelta508 CFTR protein | 19966789 |
| SHSY5Y | Cytotoxic Assay | 10 μM | 48 h | IC50=2 μM | 19344175 |
| SHSY5Y | Kinase Assay | 10 μM | 48 h | Inhibition of HDAC with IC50 of 0.5 μM | 19344175 |
| S2 | Kinase Assay | 0.1-10 μM | 1 h | Inhibition of Plasmodium falciparum HDAC1 expressed with IC50 of 0.059 μM | 19317450 |
| IGROV1 | Kinase Assay | 10 μM | 4 h | Inhibition of HDAC6 assessed as alpha-tubulin acetylation | 19084294 |
| IGROV1 | Kinase Assay | 10 μM | 4 h | Inhibition of HDAC assessed as histone-H4 acetylation | 19084294 |
| IGROV1 | Kinase Assay | 5 μM | 24 h | Inhibition of HDAC assessed as p53 acetylation | 19084294 |
| HeLa | Kinase Assay | 2 μM | 30 min | Inhibition of HDAC2 in human HeLa cells with IC50 of 0.1 μM | 19084294 |
| HEK293 | Function Assay | 10 μM | 24 h | Activation of mouse Wnt3a signaling expressed | 19022675 |
| RAW264.7 | Function Assay | 2 μM | 3.5 h | Antimalarial activity against Plasmodium falciparum infected with IC50 of 0.11 μM | 18644969 |
| SU 86.86 | Cytotoxic Assay | 50 μM | 72h | IC50=1.3 μM | 18494463 |
| Panc 04.03 | Cytotoxic Assay | 50 μM | 72h | IC50=1.2 μM | 18494463 |
| Mia Paca2 | Cytotoxic Assay | 50 μM | 72h | IC50=1.1 μM | 18494463 |
| Hup T3 | Cytotoxic Assay | 50 μM | 72h | IC50=0.8 μM | 18494463 |
| Human microvascular epithelial cell | Cytotoxic Assay | 50 μM | 72 h | IC50=1.3 μM | 18494463 |
| HPDE6c7 | Cytotoxic Assay | 50 μM | 72 h | IC50=1.3 μM | 18494463 |
| HEK-TE | Function Assay | 5 μM | 6h | Increase in histone H3 acetylation | 18434144 |
| U937 | Kinase Assay | 5 μM | 24 h | Inhibition of human HDAC4 | 18381238 |
| U937 | Kinase Assay | 5 μM | 24 h | Inhibition of human HDAC1 | 18381238 |
| U937 | Function Assay | 5 μM | 24 h | Induction of granulocytic differentiation | 18381238 |
| U937 | Function Assay | 5 μM | 24 h | Induction of apoptosis | 18381238 |
| U937 | Function Assay | 5 μM | 24 h | Induction of p21 expression | 18381238 |
| U937 | Function Assay | 5 μM | 24 h | Induction of alpha tubulin hyperacetylation | 18381238 |
| U937 | Function Assay | 5 μM | 24 h | Induction of histone H4 hyperacetylation | 18381238 |
| MCF7 | Function Assay | 10 μM | 8 h | Induction of tubulin hyperacetylation | 18269226 |
| NUGC3 | Growth Inhibition Assay | 5 μM | 24 h | GI50=2.79 μM | 17904843 |
| HeLa | Kinase Assay | 10 μM | 30 min | Inhibition of recombinant HDAC1 with IC50 of 0.02 μM | 17691763 |
| PANC1 | Function Assay | 1 μM | 24 h | Increase in p27kip1 gene expression | 17588744 |
| PANC1 | Function Assay | 1 μM | 24 h | Increase in p21WAF1/CIP1 gene expression | 17588744 |
| ST14A | Function Assay | 5 nM | 72 h | Increase in E2F1 mRNA expression | 17565993 |
| ST14A | Function Assay | 5 nM | 72 h | Increase in REST/NRSF mRNA expression | 17565993 |
| RAW264.7 | Function Assay | 10 μM | 24h | Inhibition of LPS-stimulated NO production with IC50 of 1.88 μM | 17477518 |
| RAW264.7 | Function Assay | 10 μM | 24h | Inhibition of LPS-stimulated TNFalpha production with IC50 of 0.76 μM | 17477518 |
| U937 | Function Assay | 1 μM | 24 h | Effect on alpha tubulin acetylation | 17447750 |
| U937 | Function Assay | 5 μM | 24 h | Increase in histone H3 acetylation | 17447750 |
| U937 | Function Assay | 5 μM | 24 h | Cell cycle arrest by accumulation at S/G2/M phase | 17004718 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene | 16921367 |
| GM15850 | Kinase Assay | 2.5 μM | 96 h | Inhibition of HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene | 16921367 |
| ARP1 | Function Assay | 2 μM | 6 h | Induction of P21WAF1 gene expression | 14734806 |
| Friend leukemic cell | Growth Inhibition Assay | 50 μM | 72 h | IC50=0.99 μM | 12109913 |
| NUGC3 | Growth Inhibition Assay | 10 μM | GI=2.94 μM | 23163332 | |
| CFBE41o | Kinase Assay | 5 μM | Down regulation of HDAC7 at 0.2 to 5 uM | 21984958 | |
| PANC1 | Growth Inhibition Assay | 1 μM | IC50=0.45 μM | 17588744 | |
| HEK293 | Growth Inhibition Assay | 72 h | GI50=13 μM | 24900500 | |
| HL60 | Growth Inhibition Assay | 72 h | GI50=0.93 μM | 24900500 | |
| TSGH | Cytotoxic Assay | 12 h | IC50=2.09 μM | 24766560 | |
| MKN45 | Cytotoxic Assay | 12 h | IC50=1.25 μM | 24766560 | |
| MONE1 | Cytotoxic Assay | 12 h | IC50=1.18 μM | 24766560 | |
| H460 | Cytotoxic Assay | 12 h | IC50=0.82 μM | 24766560 | |
| KB | Cytotoxic Assay | 12 h | IC50=0.75 μM | 24766560 | |
| HT-29 | Cytotoxic Assay | 12 h | IC50=0.72 μM | 24766560 | |
| HSC3 | Cytotoxic Assay | 12 h | IC50=0.71 μM | 24766560 | |
| HEL | Growth Inhibition Assay | 48 h | IC50=0.49 μM | 24694055 | |
| KG1 | Growth Inhibition Assay | 48 h | IC50=1.15 μM | 24525003 | |
| Jurkat E6.1 | Kinase Assay | 2 h | Inhibition of HDAC4 with IC50 of 0.04 μM | 24261862 | |
| MDA-MB-435 | Growth Inhibition Assay | 48 h | GI=0.88 μM | 24119555 | |
| MCF7 | Growth Inhibition Assay | 48 h | GI=0.45 μM | 24119555 | |
| MDA-MB-231 | Growth Inhibition Assay | 48 h | IC50=0.16 μM | 24095016 | |
| Hs578T | Cytotoxic Assay | 48 h | GI=4.83 μM | 24015327 | |
| KM12 | Cytotoxic Assay | 48 h | GI=1.88 μM | 24015327 | |
| U251 | Cytotoxic Assay | 48 h | GI=1.53 μM | 24015327 | |
| SW620 | Cytotoxic Assay | 48 h | GI=0.54 μM | 24015327 | |
| NCI60 | Cytotoxic Assay | 48 h | GI=0.53 μM | 24015327 | |
| Vero | Growth Inhibition Assay | 72 h | IC50=0.9 μM | 23786452 | |
| High5 | Kinase Assay | 24 h | Inhibition of human recombinant HDAC3 with IC50 of 0.17 μM | 23602523 | |
| High5 | Kinase Assay | 24 h | Inhibition of human recombinant HDAC1 with IC50 of 0.12 μM | 23602523 | |
| High5 | Kinase Assay | 24 h | Inhibition of human recombinant HDAC6 with IC50 of 0.09 μM | 23602523 | |
| ES2 | Growth Inhibition Assay | 48 h | IC50=12.7 μM | 23493449 | |
| MDA-MB-231 CisR | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.61 μM | 23252603 | |
| MDA-MB-231 sens | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.61 μM | 23252603 | |
| KYSE-510 sens | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.7 μM | 23252603 | |
| KYSE-510 CisR | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.59 μM | 23252603 | |
| CAL27 CisR | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.61 μM | 23252603 | |
| CAL27 sens | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.36 μM | 23252603 | |
| A2780 CisR | Kinase Assay | 18 h | Inhibition of HDAC with IC50 of 0.44 μM | 23252603 | |
| SMMC7721 | Growth Inhibition Assay | 72 h | GI90=20 μM | 23061376 | |
| SKHEP1 | Growth Inhibition Assay | 72 h | GI90=17 μM | 23061376 | |
| SGC7901 | Growth Inhibition Assay | 72 h | GI90=9.4 μM | 23061376 | |
| MGC803 | Growth Inhibition Assay | 72 h | GI90=10.8 μM | 23061376 | |
| BGC823 | Growth Inhibition Assay | 72 h | GI90=7.5 μM | 23061376 | |
| Bel7404 | Growth Inhibition Assay | 72 h | GI90=18 μM | 23061376 | |
| Bel7402 | Growth Inhibition Assay | 72 h | GI90=17 μM | 23061376 | |
| BE(2)-C | Growth Inhibition Assay | 72 h | IC70=2 μM | 22932316 | |
| Hep3B | Growth Inhibition Assay | 48 h | GI50=0.69 μM | 22439863 | |
| Hep3B | Growth Inhibition Assay | 48 h | GI50=1.21 μM | 21712146 | |
| COLO205 | Growth Inhibition Assay | 96 h | IC50=2.12 μM | 21634430 | |
| A2780 | Growth Inhibition Assay | 96 h | IC50=1.62 μM | 21634430 | |
| SKOV3 | Cytotoxic Assay | 72 h | Cytotoxicity against human SKOV3 cells overexpressing HER2 with IC50 of 2.2 μM | 21080629 | |
| SKBR3 | Cytotoxic Assay | 72 h | Cytotoxicity against human SKBR3 cells overexpressing HER2 with IC50 of 2.6 μM | 21080629 | |
| Sf21 | Kinase Assay | 3 h | Inhibition of Flag tagged human recombinant HDAC8 expressed with IC50 of 1.2 μM | 21080629 | |
| HeLa | Cytotoxic Assay | 72 h | Cytotoxicity against human HeLa cells overexpressing HDAC with IC50 of 1.5 μM | 21080629 | |
| CAL27 | Cytotoxic Assay | 72 h | Cytotoxicity against human CAL27 cells overexpressing EGFR with IC50 of 3.2 μM | 21080629 | |
| A549 | Cytotoxic Assay | 72 h | Cytotoxicity against human A549 cells overexpressing HDAC with IC50 of 1.8 μM | 21080629 | |
| A431 | Cytotoxic Assay | 72 h | Cytotoxicity against human A431 cells overexpressing EGFR with IC50 of 4.2 μM | 21080629 | |
| U937 | Growth Inhibition Assay | 72 h | GI50=0.39 μM | 20884208 | |
| HUT78 | Growth Inhibition Assay | 72 h | GI50=0.3 μM | 20884208 | |
| SKHEP1 | Growth Inhibition Assay | 72 h | IC50=3.46 μM | 20143778 | |
| SCC25 | Growth Inhibition Assay | 72 h | IC50=1.93 μM | 20143778 | |
| SCC15 | Growth Inhibition Assay | 72 h | IC50=2.49 μM | 20143778 | |
| NCI-H358 | Growth Inhibition Assay | 72 h | IC50=2.5 μM | 20143778 | |
| NCI-H2122 | Growth Inhibition Assay | 72 h | IC50=7.5 μM | 20143778 | |
| LNCAP | Growth Inhibition Assay | 72 h | IC50=0.58 μM | 20143778 | |
| HCC827 | Growth Inhibition Assay | 72 h | IC50=1.8 μM | 20143778 | |
| Capan1 | Growth Inhibition Assay | 72 h | IC50=7.3 μM | 20143778 | |
| CAL27 | Growth Inhibition Assay | 72 h | IC50=3.72 μM | 20143778 | |
| BxPC3 | Growth Inhibition Assay | 72 h | IC50=2.7 μM | 20143778 | |
| HeLa | Growth Inhibition Assay | 72 h | IC50=0.46 μM | 19441846 | |
| SNB78 | Growth Inhibition Assay | 48 h | GI50=16 μM | 19419205 | |
| HBC5 | Growth Inhibition Assay | 48 h | GI50=17 μM | 19419205 | |
| DMS114 | Growth Inhibition Assay | 48 h | GI50=2.9 μM | 19419205 | |
| SKMES1 | Cytotoxic Assay | 72 h | IC50=2.42 μM | 19093884 | |
| NCI-H69 | Cytotoxic Assay | 72 h | IC50=2.06 μM | 19093884 | |
| HeLa | Kinase Assay | 15 min | Inhibition of HDAC8 from nuclear extract with IC50 of 1.86 μM | 19093884 | |
| HeLa | Kinase Assay | 15 min | Inhibition of HDAC6 from nuclear extract with IC50 of 0.0855 μM | 19093884 | |
| T24 | Kinase Assay | 3 h | Induction of alpha tubulin acetylation with EC50 of 0.25 μM | 19084395 | |
| T24 | Kinase Assay | 3 h | Induction of histone H3 acetylation with EC50 of 0.12 μM | 19084395 | |
| IGROV1 | Growth Inhibition Assay | 72 h | IC50=2.2 μM | 19084294 | |
| HCT116 | Growth Inhibition Assay | 72h | IC50=0.31 μM | 19084294 | |
| NB4 | 48h | IC50=0.6 μM | 18723349 | ||
| HeLa | Kinase Assay | 2 h | Inhibition of nuclear HDAC with IC50 of 0.083 μM | 18558669 | |
| HEK293 | Kinase Assay | 3 h | Inhibition of recombinant HDAC6 expression with IC50 of 0.019 μM | 18558669 | |
| Human renal epithelial cell | Growth Inhibition Assay | 72 h | IC50=14 μM | 18370373 | |
| HeLa | Growth Inhibition Assay | 72 h | IC50=0.46 μM | 18370373 | |
| G401 | Growth Inhibition Assay | 72 h | IC50=1 μM | 18370373 | |
| HEK293 | Kinase Assay | 1 h | Inhibition of HDAC3 with IC50 of 0.057 μM | 18308563 | |
| HEK293 | Kinase Assay | 1 h | Inhibition of HDAC1 with IC50 of 0.03 μM | 18308563 | |
| U87MG | Cytotoxic Assay | 72 h | IC50=11 μM | 17691763 | |
| SK-OV-3 | Cytotoxic Assay | 72 h | IC50=2.2 μM | 17691763 | |
| Saos2 | Cytotoxic Assay | 72 h | IC50=2.3 μM | 17691763 | |
| RKOp21 | Cytotoxic Assay | 72 h | IC50=1.76 μM | 17691763 | |
| Hec-1-A | Cytotoxic Assay | 72 h | IC50=1 μM | 17691763 | |
| EOL1 | Cytotoxic Assay | 72 h | IC50=1 μM | 17691763 | |
| CCRF-CEM | Cytotoxic Assay | 72 h | IC50=0.8 μM | 17691763 | |
| Cal27 | Cytotoxic Assay | 72 h | IC50=3.2 μM | 17691763 | |
| A431 | Cytotoxic Assay | 72 h | IC50=4.2 μM | 17691763 | |
| PC3 | Growth Inhibition Assay | 21 h | GI50=0.71 μM | 17662606 | |
| ACHN | Growth Inhibition Assay | 21 h | GI50=0.65 μM | 17662606 | |
| SC9 | Growth Inhibition Assay | 48 h | IC50=0.606 μM | 17507219 | |
| H661 | Growth Inhibition Assay | 48 h | IC50=1 μM | 17157009 | |
| NCI-H23 | Growth Inhibition Assay | 48 h | GI50=0.92 μM | 16723227 | |
| HCT15 | Growth Inhibition Assay | 48 h | GI50=0.82 μM | 16723227 | |
| CEM | Kinase Assay | 1 h | Inhibition of HDAC with IC50 of 0.33 μM | 16420064 | |
| St-4 | Growth Inhibition Assay | 48 h | IC50=5.2 μM | 15715470 | |
| SNB-78 | Growth Inhibition Assay | 48 h | IC50=16 μM | 15715470 | |
| RXF-631L | Growth Inhibition Assay | 48 h | IC50=2 μM | 15715470 | |
| NCI-H226 | Growth Inhibition Assay | 48 h | IC50=2.6 μM | 15715470 | |
| LOX-IMVI | Growth Inhibition Assay | 48 h | IC50=1.3 μM | 15715470 | |
| HeLa | Kinase Assay | 30 min | Inhibitory concentration against histone deacetylase with IC50 of 0.28 μM | 15603949 | |
| H1299 | Growth Inhibition Assay | 72 h | IC50=7.24 μM | 14521422 | |
| A20 | Kinase Assay | 1 h | anti-HDAC1 activity with IC50 of 0.112 μM | 11960489 | |
| K562 | Kinase Assay | 6 h | Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) with IC50 of 0.01 μM | 12419380 | |
| HT1080 | Growth Inhibition Assay | 72 h | IC50=2.4 μM | 12270175 | |
| H1299 | Kinase Assay | 20 min | Inhibitory activity against HDAC enzyme with IC50 of 0.194 μM | 14521422 | |
| ECC10 | Growth Inhibition Assay | IC50=945.87 nM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=920.84 nM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=910.49 nM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=900.43 nM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=894.62 nM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=894.12 nM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=872.34 nM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=863.16 nM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=862.03 nM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=846.51 nM | SANGER | ||
| D-566MG | Growth Inhibition Assay | IC50=838.62 nM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=835.7 nM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=832.96 nM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=832.45 nM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=822.86 nM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=814.66 nM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=813.67 nM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=813.1 nM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=809.44 nM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=806.08 nM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=793.84 nM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=791.1 nM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=787.46 nM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=775.45 nM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=751.92 nM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=751.91 nM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=740.28 nM | SANGER | ||
| MOLT-13 | Growth Inhibition Assay | IC50=738.98 nM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=729.9 nM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=729.12 nM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=724.4 nM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=714.14 nM | SANGER | ||
| D-423MG | Growth Inhibition Assay | IC50=706.89 nM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=706.68 nM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=696.95 nM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=678.18 nM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=659.1 nM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=644.91 nM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=642.08 nM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=598.57 nM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=596.51 nM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=581.56 nM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=576.11 nM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=563.25 nM | SANGER | ||
| NCI-H720 | Growth Inhibition Assay | IC50=560.18 nM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=544.27 nM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=538.13 nM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=537.92 nM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=526.96 nM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=523.53 nM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=503.1 nM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=501.42 nM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=473.41 nM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=472.19 nM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=457.53 nM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=45425 nM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=411.71 nM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=400.59 nM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=345.74 nM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=294.53 nM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=289.38 nM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=286.26 nM | SANGER | ||
| H9 | Growth Inhibition Assay | IC50=255.04 nM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=244.18 nM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=173.89 nM | SANGER | ||
| KASUMI-1 | Growth Inhibition Assay | IC50=99.17 nM | SANGER | ||
| K562 | Kinase Assay | does not inhibit HDAC | 23591111 | ||
| K562 | Growth Inhibition Assay | IC50=0.645 μM | 23644210 | ||
| HCT116 | Growth Inhibition Assay | IC50=0.757 μM | 23644210 | ||
| A549 | Growth Inhibition Assay | IC50=1.079 μM | 23644210 | ||
| BGC823 | Growth Inhibition Assay | GI50=3.09 μM | 23601706 | ||
| NUGC3 | Growth Inhibition Assay | GI50=2.94 μM | 20850971 | ||
| St4 | Growth Inhibition Assay | EC50=5.2 μM | 18247554 | ||
| SQ20B | Growth Inhibition Assay | IC50=3 μM | 18247554 | ||
| SNB78 | Growth Inhibition Assay | EC50=16 μM | 18247554 | ||
| SKBR3 | Growth Inhibition Assay | IC50=0.8 μM | 18247554 | ||
| HT1080 | Growth Inhibition Assay | IC50=0.0024 μM | 18247554 | ||
| HepG2 | Growth Inhibition Assay | IC50=0.0006 μM | 18247554 | ||
| CCD1059SK | Growth Inhibition Assay | IC50=43.5 μM | 18247554 | ||
| PT45 | Growth Inhibition Assay | IC50=4 μM | 17588744 | ||
| EW-1 | Growth Inhibition Assay | IC50=947.26 nM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=949.12 nM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=958.48 nM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=968.04 nM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=974.45 nM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=988.1 nM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=1.00407 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=1.00582 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=1.00617 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=1.02331 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=1.02331 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=1.0268 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=1.04081 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=1.04879 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=1.05107 μM | SANGER | ||
| NBsusSR | Growth Inhibition Assay | IC50=1.05166 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=1.05501 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=1.06624 μM | SANGER | ||
| U-2-OS | Growth Inhibition Assay | IC50=1.07911 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=1.08291 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=1.09422 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=1.12102 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=1.13621 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=1.15406 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=1.17212 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=1.1775 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=1.17881 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=1.18312 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=1.19108 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=1.19856 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=1.23464 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=1.23835 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=1.25043 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=1.28329 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=1.29018 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=1.29797 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=1.31761 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=1.32477 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=1.34027 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=1.34112 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=1.35162 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=1.3524 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=1.36026 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=1.37085 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=1.41194 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.41693 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=1.43945 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=1.443 μM | SANGER | ||
| HuO9 | Growth Inhibition Assay | IC50=1.45362 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=1.46118 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=1.46531 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=1.47291 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=1.48536 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=1.493 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=1.49851 μM | SANGER | ||
| YH-13 | Growth Inhibition Assay | IC50=1.49894 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=1.50912 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=1.54477 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=1.54645 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=1.54773 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=1.56424 μM | SANGER | ||
| TI-73 | Growth Inhibition Assay | IC50=1.5906 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=1.59284 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=1.59385 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=1.59866 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=1.65131 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=1.69278 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=1.70014 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=1.70435 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=1.70621 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=1.71179 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=1.715 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=1.71971 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=1.7211 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=1.72691 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=1.72829 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=1.73157 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=1.74107 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=1.75827 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=1.76319 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=1.78741 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=1.8037 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=1.82681 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=1.82897 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=1.85451 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=1.87151 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=1.88197 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=1.88725 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=1.88947 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=1.8981 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=1.89946 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=1.91298 μM | SANGER | ||
| EW-22 | Growth Inhibition Assay | IC50=1.92887 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=1.93631 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=1.93819 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=1.93902 μM | SANGER | ||
| human HOP-92 | Growth Inhibition Assay | IC50=1.94065 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=1.94899 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=1.9536 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=1.98231 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=1.99493 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=2.20303 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=2.04599 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=2.06147 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=2.07653 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=2.07811 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=2.08529 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=2.12898 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=2.14583 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=2.14837 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=2.15765 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=2.16398 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=2.16699 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=2.16844 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=2.1777 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=2.18456 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=2.19317 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=2.21334 μM | SANGER | ||
| OC-314 | Growth Inhibition Assay | IC50=2.23259 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=2.23626 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.24275 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=2.25862 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=2.2685 μM | SANGER | ||
| NCI-H1666 | Growth Inhibition Assay | IC50=2.28111 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=2.28913 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=2.30543 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=2.30637 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=2.31987 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=2.32129 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=2.32335 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=2.32615 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=2.33416 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=2.33906 μM | SANGER | ||
| RH-18 | Growth Inhibition Assay | IC50=2.35022 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=2.36725 μM | SANGER | ||
| NB17 | Growth Inhibition Assay | IC50=2.38243 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=2.41873 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=2.43214 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=2.44509 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=2.44561 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=2.44864 μM | SANGER | ||
| A549 | Growth Inhibition Assay | IC50=2.44893 μM | SANGER | ||
| KNS-62 | Growth Inhibition Assay | IC50=2.45061 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=2.45437 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=2.47008 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=2.47162 μM | SANGER | ||
| TGBC11TKB | Growth Inhibition Assay | IC50=2.47177 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=2.49535 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=2.50549 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=2.50927 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.53043 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=2.53513 μM | SANGER | ||
| NCI-H1048 | Growth Inhibition Assay | IC50=2.55025 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=2.56076 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=2.56335 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=2.58566 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=2.59037 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=2.59274 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=2.6046 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=2.60984 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=2.62185 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=2.63012 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=2.64085 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=2.64143 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=2.64426 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=2.6585 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=2.66993 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=2.70451 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=2.7117 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=2.7171 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=2.74391 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=2.77121 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=2.77355 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=2.8051 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=2.81743 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=2.8233 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=2.85523 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=2.86 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=2.86596 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=2.86645 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=2.89182 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=2.90438 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=2.96082 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=2.96717 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=3.00796 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=3.02592 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=3.03314 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=3.03874 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=3.04523 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=3.04823 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=3.06164 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=3.07847 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=3.10278 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=3.11283 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=3.13724 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=3.1507 μM | SANGER | ||
| A498 | Growth Inhibition Assay | IC50=3.20871 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=3.22139 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=3.22398 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=3.23627 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=3.24644 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=3.26153 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=3.26614 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=3.29511 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=3.29629 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=3.30757 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=3.33018 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=3.37674 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=3.40045 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=3.41312 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=3.4543 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=3.46057 μM | SANGER | ||
| SW1116 | Growth Inhibition Assay | IC50=3.46269 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=3.47066 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=3.47681 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=3.50073 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=3.5057 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=3.5251 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=3.53294 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=3.54514 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=3.54665 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=3.6331 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=3.63372 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=3.64287 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=3.65022 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=3.65657 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=3.68582 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=3.72181 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=3.7295 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=3.74723 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=3.75012 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=3.78195 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=3.79085 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=3.79602 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=3.80551 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=3.82051 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=3.82624 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=3.82841 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=3.84488 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=3.87909 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=3.89052 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=3.89153 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=3.91663 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=3.9201 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=3.92889 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=3.94635 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=4.05966 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=4.07633 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=4.12495 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=4.13051 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=4.13103 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=4.15743 μM | SANGER | ||
| CW-2 | Growth Inhibition Assay | IC50=4.19001 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=4.20312 μM | SANGER | ||
| KP-N-YN | Growth Inhibition Assay | IC50=4.20927 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=4.22157 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=4.22381 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=4.23064 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=4.24769 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=4.25505 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=4.26593 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=4.26859 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=4.2934 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=4.35803 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=4.35819 μM | SANGER | ||
| EPLC-272H | Growth Inhibition Assay | IC50=4.3895 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=4.38992 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=4.42198 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=4.42382 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=4.42724 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=4.42819 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=4.50868 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=4.5173 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=4.55994 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=4.57732 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=4.58398 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=4.65238 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=4.70243 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=4.72273 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=4.76107 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=4.77424 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=4.77655 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=4.78011 μM | SANGER | ||
| NCI-H630 | Growth Inhibition Assay | IC50=4.78081 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=4.78773 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=4.79263 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=4.79429 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=4.81747 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=4.85766 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=4.87713 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=4.88458 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=4.93977 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=4.94421 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=4.99962 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=5.00738 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=5.02845 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=5.02944 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=5.0306 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=5.05908 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=5.06452 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=5.06903 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=5.09702 μM | SANGER | ||
| DMS-79 | Growth Inhibition Assay | IC50=5.13883 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=5.18438 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=5.23856 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=5.24987 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=5.2576 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=5.26356 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=5.26632 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=5.27751 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=5.35826 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=5.37878 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=5.39096 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=5.41554 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=5.46335 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=5.49908 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=5.62651 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=5.64041 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=5.66031 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=5.7132 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=5.73085 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=5.78052 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=5.86718 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=5.88677 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=5.92139 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=5.988 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=5.98836 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=5.99148 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=6.00255 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=6.03441 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=6.13034 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=6.24099 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=6.26152 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=6.30645 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=6.3548 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=6.49631 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=6.55989 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=6.56347 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=6.72233 μM | SANGER | ||
| SW900 | Growth Inhibition Assay | IC50=6.76221 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=6.80403 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=6.85402 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=6.89669 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=6.89847 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=6.91226 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=7.00641 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=7.02159 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=7.02881 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=7.05427 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=7.13952 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=7.14072 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=7.15184 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=7.19267 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=7.21133 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=7.3452 μM | SANGER | ||
| CFPAC-1 | Growth Inhibition Assay | IC50=7.36222 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=7.41849 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=7.44061 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=7.59729 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=7.72863 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=7.83707 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=7.85347 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=7.86172 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=7.9173 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=8.05452 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=8.05963 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=8.21937 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=8.25353 μM | SANGER | ||
| NCI-H1838 | Growth Inhibition Assay | IC50=8.25781 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=8.37047 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=8.50928 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=8.57437 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=8.73535 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=8.76262 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=8.76994 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=8.78618 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=8.87565 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=9.06725 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=9.10532 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=9.13681 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=9.24975 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=9.25715 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=9.26028 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=9.32232 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=9.37528 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=9.45171 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=9.46116 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=9.49364 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=9.51644 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=9.52195 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=9.67352 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=9.71816 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=9.72785 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=9.82159 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=9.92432 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=10.0193 μM | SANGER | ||
| NCI-H2452 | Growth Inhibition Assay | IC50=10.16 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=10.178 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=10.1882 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=10.2452 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=10.322 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=10.4208 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=10.4727 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=10.7838 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=10.8679 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=10.8711 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=10.8746 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=11.0387 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=11.1009 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=11.3747 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=11.4079 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=11.4109 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=12.1217 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=12.2036 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=12.2901 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=12.3956 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=12.5816 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=13.0649 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=13.4399 μM | SANGER | ||
| H-EMC-SS | Growth Inhibition Assay | IC50=13.9104 μM | SANGER | ||
| SW1783 | Growth Inhibition Assay | IC50=14.2391 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=14.419 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=14.4233 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=14.7045 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=14.927 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=14.9539 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=15.0729 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=15.2218 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=15.8028 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=15.8359 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=16.0039 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=16.1873 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=16.573 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=16.6589 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=17.4201 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=17.9345 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=18.6317 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=19.0303 μM | SANGER | ||
| ZR-75-30 | Growth Inhibition Assay | IC50=19.0968 μM | SANGER | ||
| LU-135 | Growth Inhibition Assay | IC50=19.2636 μM | SANGER | ||
| NCI-H2029 | Growth Inhibition Assay | IC50=19.6021 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=19.9227 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=20.3117 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=20.6413 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=20.7501 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=21.2829 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=22.7611 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=23.0718 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=23.1038 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=23.2674 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=23.7217 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=23.9055 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=24.6759 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=25.2498 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=26.4288 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=27.4919 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=28.126 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=30.1924 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=31.3666 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=32.2616 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=33.7648 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=34.3605 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=36.3022 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=37.0529 μM | SANGER | ||
| D-336MG | Growth Inhibition Assay | IC50=41.8442 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=42.5505 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=45.3256 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=47.1958 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=47.2287 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=47.2451 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=49.3908 μM | SANGER | ||
| NCI-H2291 | Growth Inhibition Assay | IC50=49.8301 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Vorinostat (SAHA)是一种HDAC抑制剂，无细胞试验中IC50为~10 nM。Vorinostat 会抑制高效的HPV-18 DNA扩增。 | ||
|---|---|---|---|
| 特性 | Vorinostat是广谱HDAC活性抑制剂，抑制I和II类酶 。 | ||
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Vorinostat是小分子量（<300）线性肟酸，抑制HDAC活性，包括乙酰化组蛋白和非组蛋白的积累，抑制培养细胞的增殖，且抑制肿瘤生长。Vorinostat通过结合到酶的活性位点而抑制 HDAC活性。Vorinostat 抑制多种转化细胞增殖（包括 淋巴瘤，多发性骨髓瘤，白血病，和非小细胞肺癌），与对照组相比抑制生长达50% 时的浓度为0.5 到10μM。Vorinostat作用于淋巴瘤和白血病细胞，包括 Burkitt, B-细胞急性淋巴细胞白血病 (B-ALL), MCL, DLBCL, ATL和T-细胞，不同程度抑制细胞增殖。除了抑制转化细胞增殖, Vorinostat 也抑制正常细胞增殖，通过比较Vorinostat 作用于一组细胞系–正常人非纤维细胞(WI-38)和 SV40巨大T抗原转化WI-38(VA-13细胞)而得到证明。Vorinostat 抑制两种类型细胞增殖，这种作用存在剂量依赖性。但发现Vorinostat 对转化细胞具有选择毒性，包括使肿瘤细胞死亡，而对正常细胞只起抑制作用，不会使其死亡。[1] Genistein 和Vorinostat 联用效果比5-aza和Vorinostat 联用作用于诱导细胞死亡有效很多。Genistein和Vorinostat联用作用于ARCaP-E使增殖降低 80 %，作用于ARCaP-M细胞，增殖降低60 %以上。Genistein和Vorinostat 联用抑制细胞增殖具有协同效应。作用于ARCaP-E 细胞(820个基因 诱导和1046个基因抑制) ARCaP-M 细胞，Vorinostat比Genistein 影响更多基因。[2] Vorinostat作用于肿瘤细胞表面，提高Fas蛋白水平，这种作用存在剂量依赖性，且按0.75 μM剂量处理，提高达到一个稳定水平。[3] Vorinostat 抑制肿瘤细胞生长，包括NB4, H460 和HCT-116，IC50分别为0.7μM, 3.4μM和1.2 μM。[4] |
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|---|---|---|---|---|
| 激酶实验 | 组蛋白去乙酰化酶活性测定 | |||
| 为了进行 HDAC 实验24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸钠盐标记的组蛋白H4等份样, 加到每个试管中，试管中含悬浮在25 µL实验buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 µg全部HeLa细胞裂解液进行免疫沉淀获得的HDAC。加入不同浓度Vorinostat，在30oC下温育90分钟。加入20 µL 终止缓冲液(0.5 N HCl, 0.08 M AcOH)终止反应。加入0.8 mL TBME提取释放放入氚醋酸盐。在8,000 × g 转速下离心5分钟，600 µL 有机相(上相) 转移到包含3 mL闪烁液的闪烁瓶中。 | ||||
| 细胞实验 | 细胞系 | NB4, NCI-H460和HCT-116肿瘤细胞系 | ||
| 浓度 | 0 μM - 0.1 μM | |||
| 孵育时间 | 48小时 | |||
| 方法 | NB4, NCI-H460和HCT-116肿瘤细胞系生长在200 µL 96孔板中，约10%汇合，生长24小时后，覆盖孔中。使用多种浓度 Vorinostat或溶剂处理肿瘤细胞24小时。处理后，冲洗实验板，移除Vorinostat，温育48小时。使用sulphorodamine B 实验测定Vorinostat处理后存活细胞的分数。 |
|||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | Ac-Histone H4 / Ac-Histone H3 phospho-CDK1 phospho-Cdc25c / Cdc25c Cyclin B1 c-Myc / c-Raf / Akt / Cyclin D1 / CDK4 p-eIF2α / ATF4 / CHOP p21 |
|
21598070 | |
| Immunofluorescence | HDAC1 / CK19 Nrf2 α-SMA Ac-STAT3 / IGF2 |
|
29917299 | |
| Growth inhibition assay | Cell apoptosis Cell viability |
|
19440035 | |
| ELISA | IGF2 IL-13 / IL-10 / IL-5 M-CSF MMP-9 |
|
27086926 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | Decitabine和Vorinostat都具有使肿瘤衰退的功能。然而, Decitabine 和 Vorinostat 联用使肿瘤衰退的效果更强。没有任何处理时,在野生型和Fasgld 小鼠中在肺肿瘤负担方面观察不到明显的区别。然而, Decitabine 和Vorinostat联用处理野生型小鼠，使肿瘤衰退比处理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使结肠癌细胞对FasL调节的肿瘤衰退敏感。低剂量Decitabine和Vorinostat处理，没有明显的肝脏毒性。[3] |
|
|---|---|---|
| 动物实验 | Animal Models | 植入CWR22肿瘤细胞的雄性BALB/c裸鼠 |
| Dosages | 25, 50, and 100 mg/kg/day | |
| Administration | 腹腔注射 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05700630 | Withdrawn | HIV-1-infection|ART|Cd4+ Lymphocyte Deficiency|Lymphoid Tissue; Infection|Interleukin |
Masonic Cancer Center University of Minnesota |
July 15 2024 | Phase 1 |
| NCT03022565 | Withdrawn | Uveal Melanoma |
University of Miami|University of Miami Sylvester Comprehensive Cancer Center |
January 2020 | Early Phase 1 |
| NCT03167437 | Recruiting | Crohn''s Disease |
National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) |
October 30 2017 | Phase 1|Phase 2 |
| NCT03056495 | Terminated | Alzheimer Disease |
German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen |
September 28 2017 | Phase 1 |
化学信息&溶解度
| 分子量 | 264.3 | 分子式 | C14H20N2O3 |
| CAS号 | 149647-78-9 | SDF | Download Vorinostat (SAHA) SDF |
| Smiles | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 52 mg/mL ( (196.74 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 6.5 mg/mL (24.59 mM) Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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常见问题及建议解决方法
问题 1:
What’s the recommendation about reconstitution of the compound for in vivo animal study?
回答：
We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.
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