胃癌

工具分子

造模剂: 1-Methyl-3-nitro-1-nitrosoguanidine; N-Nitroso-N-methylurea

染料: Indocyanine green; Toluidine Blue O; Isosulfan Blue

抗感染

抗幽门螺杆菌: Clarithromycin; Amoxicillin; Vonoprazan Fumarate; Auranofin; Auraptene; Fucoidan

抗EBV: NIBR189; Paederoside

获批药物

Capecitabine

Ramucirumab

Docetaxel

Doxorubicin HCl

Trastuzumab deruxtecan

5-FU

Trastuzumab

Pembrolizumab

Trifluridine

Tipiracil hydrochloride

Mitomycin C

Nivolumab

化疗

单药: Tegafur

FP: 5-FU; Cisplatin

XP: Capecitabine; Cisplatin

FOLFOX: 5-FU; Oxaliplatin

XELOX: Capecitabine; Oxaliplatin

SOX: Tegafur; Oxaliplatin

DCF: Docetaxel; Cisplatin; 5-FU

DOS: Tegafur; Oxaliplatin; Docetaxel

CSCO指南推荐 ^[1]

一线治疗: Trastuzumab; Pembrolizumab; Oxaliplatin; Capecitabine; Cisplatin; 5-FU; Tegafur; Leucovorin Calcium Pentahydrate; Calcium Folinate; Nivolumab; Sintilimab; Tislelizumab; Docetaxel

二线治疗: Docetaxel; Paclitaxel; Irinotecan; Nab-Paclitaxel; Ramucirumab; Pembrolizumab; Nivolumab; Disitamab; Apatinib mesylate

免疫检查抑制剂

PD-1: Nivolumab; Pembrolizumab; Camrelizumab; Spartalizumab; Cemiplimab; Sintilimab; Zimberelimab; Retifanlimab; Sasanlimab; Tislelizumab; Balstilimab

PD-L1: Avelumab; Atezolizumab; Durvalumab; Adebrelimab; Sugemalimab; Cosibelimab

CTLA-4: Ipilimumab; Tremelimumab

近期活跃药物

Lirafugratinib

Zolbetuximab

Tislelizumab

Balstilimab

Fruquintinib

胃癌干细胞 ^[2]

靶向GC干性: Apatinib; Retinoic acid; Trastuzumab; Cisplatin; Amlodipine; Verapamil HCl; Verteporfin; Ibuprofen; Metformin; Pantoprazole; Quercetin; Sulforaphane; Evodiamine; DAPT; Atractylenolide I; Genistein

靶向CSCs: Vantictumab; MK-0752; Vismodegib; Amcasertib

靶向-HER2

抑制剂: Lapatinib; Afatinib; Neratinib; Sapitinib; Poziotinib; Tucatinib

抗体: Trastuzumab; Pertuzumab

ADC: Trastuzumab deruxtecan; Trastuzumab Emtansine; Disitamab vedotin; Trastuzumab MMAE

靶向治疗(A) ^[3]

Claudin18.2: Zolbetuximab

TYMS: 5-FU; Trifluridine; TAS-102; Folinic acid

Tubulin: Combretastatin A4; Ixabepilone; Vincristine sulfate

c-Met: Savolitinib; AMG 337; Onartuzumab; Tivantinib

DNA: Lurbinectedin; Oxaliplatin; Nimustine Hydrochloride; Cisplatin; Lomustine; Thiotepa; Proflavine

Topoisomerase: Irinotecan HCl Trihydrate; Doxorubicin; Topotecan HCl; Epirubicin HCl; Dxd

VEGFR: Apatinib mesylate; Ramucirumab; Foretinib; Pazopanib; Sorafenib; Regorafenib; Fruquintinib

靶向治疗(B)

EGFR: Nimotuzumab; Pimurutamab; Matuzumab; Tomuzotuximab

FGFR: Pemigatinib; Derazantinib; Bemarituzumab; Lirafugratinib

PARP1/2: Pamiparib; Niraparib tosylate; Veliparib; Venadaparib

NF-kB ^[4]: Bortezomib; Curcumin; DHA; Shikonin; Sulfasalazine; Zeaxanthin

WNT ^[5]: Laduviglusib; XAV-939; RCM-1; SKL2001

NOTCH ^[5]: DAPT; Crenigacestat

Hedgehog ^[5]: Itraconazole

PAK4 ^[6]: LCH-7749944; KPT 9274; PF-3758309; FRAX486; FRAX1036

靶向治疗(C)

HIPPO ^[7]: Verteporfin; Simvastatin; Metformin; Defactinib; PF-573228; Dasatinib

mTOR ^[8]: Everolimus; Vistusertib; GSK1059615; Rapamycin

AKT ^[8]: MK-2206 2HCl; Capivasertib; Ipatasertib; Osthole

PI3K ^[8]: Alpelisib; GSK2636771

PI3K/AKT/mTOR ^[8]: Pectolinarigenin; Thymoquinone; ABBV-744; Dactolisib; GSK1059615; Calycosin

HSP90 ^[8]: Luminespib

MMP ^[8]: Astaxanthin

相关化合物库

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

PI3K/Akt Inhibitor Library

参考文献