抗衰老

工具分子

造模剂: D-Galactose; DL-Homocysteine

检测试剂: Thiobarbituric acid; 2,6-Dihydroxypurine; 2,2-Diphenyl-1-picrylhydrazyl; ABTS

抗氧化

GSH

Quercetin

Curcumin

Oleanolic Acid

Hesperidin

Phlorizin

Baicalein

Astaxanthin

Ferulic Acid

Proanthocyanidins

Inulin

Vitamin C

Acetylcysteine

EGCG

Naringenin

Vitamin E

抗炎

Metformin HCl

TFAP

Columbin

Curcumin

Ferulic Acid

Proanthocyanidins

H-151

Dexamethasone Acetate

Glucosamine hydrochloride

Gallic acid

-Catechin

Epicatechin

Verbascoside

Ginsenoside Rg1

Flavanone

蛋白质内稳态调节 ^[1]

自噬诱导剂&蛋白酶体激活剂: LY294002; Wortmannin; TSA; Spermidine; Rapamycin; Everolimus; Metformin; Resveratrol; Acetylcorynoline

抗糖基化试剂: Ferulic Acid; Rosmarinic acid; Carnosic acid; Piceatannol; Ethylenediaminetetraacetic acid; -α-Lipoic acid

胞外基质转换刺激物: Minoxidil

自噬激活 (A)

激活线粒体自噬: Rapamycin; Melatonin; Resveratrol; Doxorubicin HCl; Urolithin A; Rotenone; Quercetin; Metformin

AMPK激活剂 ^[2]: Metformin; Resveratrol; Aspirin; MOTS-c; AICAR; Nilotinib

抵抗NAD+耗竭: Nicotinamide Riboside Chloride; β-Nicotinamide Mononucleotide; Nicotinic Acid; Luteolin

自噬激活 (B)

长寿蛋白SIRTs激活剂: SRT1720 HCl; Fisetin; Resveratrol; Quercetin; SRT2104; SRT2183; SRT3025 HCl

mTOR抑制剂: Rapamycin; Everolimus; Dactolisib; AZD8055; Torkinib; Temsirolimus; Vistusertib; KU-0063794

ULK1激活剂: LYN-1604; BL-918; Ginkgolide K

衰老细胞清除药 ^[3]

BCL-2抑制剂: Dasatinib; Quercetin; ABT-737; Navitoclax; A-1331852; A-1155463

HSP90抑制剂: Alvespimycin HCl; Geldanamycin; Tanespimycin; Ganetespib

靶向p53: RG-7112; P5091; P22077

天然产物: Fisetin; Curcumin

强心苷: Ouabain; Digoxin; Bufalin

PROTACs: ARV-825

其余: Fenofibrate; Azithromycin; Roxithromycin; R406; Panobinostat; Xevinapant

Senomorphics ^[3]

NF-κB抑制剂: Rapamycin; Metformin

p38MAPK抑制剂: Adezmapimod; Doramapimod; PF-3644022

JAK/STAT抑制剂: Ruxolitinib

ATM抑制剂: KU-55933; KU-60019

Statins: Atorvastatin; Pravastatin; Pitavastatin calcium; Simvastatin

天然产物: Apigenin; Kaempferol; Quercetin; EGCG; Genistein; Oleuropein; Hydroxytyrosol

血糖调节控制

AMPK激活剂: Metformin; Resveratrol; Aspirin; MOTS-c; AICAR; Nilotinib

Alpha-Glucosidase抑制剂 ^[4]: Acarbose; 1-Deoxynojirimycin; 4',7-Dimethoxy-5-Hydroxyflavone; N-Caffeoyl O-methyltyramine

Alpha-Amylase抑制剂 ^[4]: 4',7-Dimethoxy-5-Hydroxyflavone; trans-Chalcone; Andrographis Herba Extract

GLP-1R激动剂 ^[5]: Exenatide Acetate; Liraglutide; Lixisenatide; Semaglutide Sodium; Dulaglutide

免疫衰老调控

免疫调节小分子: Avadomide; Iberdomide; Teriflunomide; Thalidomide; Amlexanox; Fingolimod; Prednisolone; Ossirene; Methylprednisolone; Laquinimod

免疫调节大分子: LL37; Polzastobart; Bexmarilimab; Mupadolimab; Tesnatilimab; Imalumab; Narsoplimab; Falbikitug; Lacutamab; Enokizumab; Tildrakizumab; Carotuximab

抑制基因组不稳定 ^[1]

反转录转座抑制剂: Lamivudine; Abacavir; Zidovudine; Emtricitabine; Tenofovir

端粒稳定剂: Nicotinamide Riboside Chloride; β-Nicotinamide Mononucleotide; Nicotinic Acid

Hormetins ^[1]

Spermidine

Berberine

Curcumin

Sulforaphane

L-Sulforaphane

cis-Resveratrol

肠道微生物相关

益生元: Inulin; Lactulose; 1-Kestose; 1F-Fructofuranosylnystose; 1,1,1,1-Kestohexaose

代谢物: Urolithin A; Spermidine; Vitamin K2; Sodium propionate; Sodium butyrate; 2-Methylpentanoic acid

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