卵巢癌

造模剂

7,12-Dimethylbenz[a]anthracene

N-Nitroso-N-methylurea

4-Vinylcyclohexene dioxide

卵巢癌类器官 ^[1] ^[2]

Hydrocortisone

Forskolin

Nicotinamide

Sodium Pyruvate

Vitamin C

Y-27632

Doxycycline

获批药物

Melphalan

Bevacizumab

Carboplatin

Cisplatin

Cyclophosphamide

Doxorubicin HCl

Gemcitabine HCl

Topotecan HCl

Olaparib

Niraparib tosylate

Paclitaxel

Rucaparib Camsylate

Thiotepa

化疗方案

BEP/PEB: Bleomycin sulfate; Etoposide; Cisplatin

CARBOPLATIN-TAXOL: Carboplatin; Paclitaxel

GEMCITABINE-CISPLATIN: Gemcitabine HCl; Cisplatin

JEB: Carboplatin; Etoposide; Bleomycin sulfate

VAC: Vincristine; Actinomycin D; Cyclophosphamide

VeIP: Vinblastine sulfate; Ifosfamide; Cisplatin

免疫检查点抑制剂

PD-1: Pembrolizumab; Dostarlimab; Cemiplimab; Camrelizumab; Sintilimab; Nivolumab; Serplulimab

PD-L1: Atezolizumab; Durvalumab; Avelumab; Adebrelimab; Sugemalimab

CTLA-4: Nurulimab; Zalifrelimab; Quavonlimab; Ipilimumab; Tremelimumab

抗血管生成 ^[3]

VEGFR: Bevacizumab; Pazopanib; Cediranib; Lenvatinib; Regorafenib

FGFR: Sorafenib; Ponatinib; Nintedanib

Angiotensin: Angiotensin II human Acetate; Angiotensin; Olmesartan

Endothelin: Zibotentan; BQ-123; Ambrisentan

IL-6: Tocilizumab; Sarilumab; Methylprednisolone

IL-8: SB225002; Aprepitant

PDGFR: Crenolanib; Ripretinib

DNA修复相关 ^[3]

PARP: Olaparib; Veliparib; Rucaparib; Niraparib

DNA Alkylator: Melphalan; Trabectedin; Oxaliplatin; Carboplatin; Cyclophosphamide Monohydrate

RAD51: Amuvatinib; RI-1; RS-1

BRCA1: Bractoppin

ATM: AZD0156; AZD1390; AZ32; KU-60019; KU-55933

铂类相关 ^[3]

铂类敏感: Carboplatin; Paclitaxel; Gemcitabine HCl; Bevacizumab; Cediranib; Niraparib; Doxorubicin HCl; Trabectedin; Olaparib

铂类耐药: Paclitaxel; Bevacizumab; Doxorubicin HCl; Topotecan HCl; Cediranib

靶向疗法 (A) ^[3] ^[4]

TP53: Pifithrin-α HBr; Pifithrin-μ; PRIMA-1

HER2: Trastuzumab; Pertuzumab; Margetuximab; Trastuzumab deruxtecan; Trastuzumab Emtansine; Disitamab vedotin; Trastuzumab MMAE

PI3K: LY294002; Wortmannin; Alpelisib; Copanlisib; Idelalisib

mTOR: Everolimus; Temsirolimus; OSI-027

MYC: 10058-F4; 10074-G5

KRAS G12D: MRTX1133; KRpep-2d; BI-2865

KRAS G12C: Adagrasib; Sotorasib; ARS-1620

靶向疗法 (B) ^[3]

PTEN: VO-Ohpic trihydrate; bpV

MDM2: Nutlin-3; Nutlin-3a; Triptolide; -Parthenolide

CA-125/MUC16: Oregovomab; Abagovomab; Sofituzumab; Sofituzumab vedotin

Notch: Crenigacestat; Limantrafin

BRAF: Sorafenib; Vemurafenib; Dabrafenib

CDK2: SNS-032; CVT-313; Milciclib

HSP90: Ganetespib; Apoptozole; NMS-E973

靶向疗法 (C) ^[3]

ERBB3/HER3: Patritumab; Seribantumab; Lumretuzumab; Patritumab deruxtecan

FRalpha: Mirvetuximab; Farletuzumab; Mirvetuximab-MMAE

FOXM1: RCM-1; FDI-6

BRD4: ABBV-744; dBET6

AURKA: Alisertib; Tozasertib; MLN8054

SMARCA4: PFI-3; ACBI1; AU-15330

KLF5: ML264; SR18662

mAb & ADC

HER2: Trastuzumab; Pertuzumab; Margetuximab; Trastuzumab deruxtecan; Trastuzumab Emtansine; Disitamab vedotin; Trastuzumab MMAE

CA-125/MUC16: Oregovomab; Abagovomab; Sofituzumab; Sofituzumab vedotin

ERBB3/HER3: Patritumab; Seribantumab; Barecetamab; Lumretuzumab; Patritumab deruxtecan

FRalpha: Mirvetuximab; Farletuzumab; Mirvetuximab-MMAE

相关化合物库

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

DNA Damage/DNA Repair compound Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

Stem Cell Differentiation Compound Library