蛋白降解

分子胶 & PROTAC

分子胶: Avadomide; Iberdomide; BI-3802; Pomalidomide; Mezigdomide; Indisulam; E7820; CC-99282; Thalidomide; Tasisulam; (R)-CR8 trihydrochloride; Sodium 2-(1H-indol-3-yl)acetate; Lenalidomide; Cyclosporin A; dCeMM1

PROTAC: Gefitinib-based PROTAC 3; MS4078; dBET57; MT-802; dBET1; ARV-825; ARV-771; dBET6; A1874; GMB-475; DT2216; THAL-SNS-032; UNC6852; PROTAC SGK3 degrader-1; GSK215

ADC

Trastuzumab deruxtecan

Sacituzumab govitecan

Trastuzumab Emtansine（T-DM1）

Patritumab deruxtecan

Vorsetuzumab mafodotin

Anetumab-MMAE

Clivatuzumab-MMAE

Indusatumab vedotin

Lifastuzumab vedotin

Anetumab ravtansine

Polatuzumab vedotin-piiq

Zilovertamab vedotin

Farletuzumab-MMAE

Iladatuzumab vedotin

Pinatuzumab vedotin

Sirtratumab vedotin

Codrituzumab-MMAE

Cetuximab-MMAE

Tusamitamab ravtansine

Serclutamab talirine

Cantuzumab ravtansine

Ozuriftamab vedotin

Sofituzumab vedotin

Laprituximab emtansine

Enapotamab vedotin

Praluzatamab ravtansine

Depatuxizumab mafodotin

多泛素化修饰

泛素连接酶E3: Lenalidomide; Pomalidomide; Thalidomide; Nutlin-3; Serdemetan

泛素结合酶 E2: NSC697923; NAcM-OPT

泛素活化酶 E1: Pevonedistat; TAK-243; PYR-41; ML792; COH000

去泛素化酶: BAY 11-7082; PR-619; P5091; Degrasyn; Spautin-1; P22077

类泛素化修饰: 2-D08; Subasumstat; Ginkgolic Acid; momordin-Ic; NSC 632839

含缬酪肽蛋白: NMS-873; CB-5083; DBeQ; MNS; CB-5339; NPD8733

蛋白酶体降解

26S蛋白酶体: MG132; (±)-Shikonin

20S蛋白酶体: Isoginkgetin; Bortezomib; Ixazomib Citrate; Ixazomib Citrate (MLN9708) Analogue; Marizomib; Delanzomib; ONX-0914; Oprozomib; Celastrol; Epoxomicin; Carfilzomib; VR23

线粒体自噬调控 ^[1]

NAD: Nicotinamide Riboside Chloride; β-Nicotinamide Mononucleotide; Nicotinic Acid; Luteolin

SIRT1/3: Resveratrol; Honokiol; Selisistat; SRT1720 HCl; 3-TYP; SRT2104; SRT2183

USP30: MF-094

p53: Pifithrin-α (PFTα) HBr; (-)-Parthenolide; Metformin HCl; Doxorubicin; Harpagoside

Nrf2: Sulforaphane; Tomatidine Hydrochloride

PINK1: Gemcitabine; 1400W 2HCl

MCL-1: UMI-77; VU661013; AZD5991; S63845; MIK665; A-1210477

溶酶体途径

蛋白转运: Brefeldin A; Sodium Monensin; Exo1

溶酶体降解: Bafilomycin A1; EN6; KM91104; Hydroxychloroquine (HCQ) Sulfate; DC661

内吞调控

Dansylcadaverine

Pitstop 2

Methyl-β-cyclodextrin

Chlorpromazine

相关化合物库

Protease Inhibitor Library

Protein-protein Interaction Inhibitor Library

Ubiquitination Compound Library

Autophagy Compound Library

参考文献