免疫

抗肿瘤免疫应答

TLR激动剂 ^[1]: Lipopolysaccharides; Imiquimod; Resiquimod; FSL-1; Motolimod; Vesatolimod

NF-KB抑制剂 ^[2]: PDTC; Caffeic Acid Phenethyl Ester; Triptolide; Withaferin A; BAY 11-7082; DHA; Mesalazine; Bardoxolone Methyl

NLRP3抑制剂 ^[3]: Procyanidin B2; MCC950; Licochalcone B; Dimethyl itaconate; CY-09; Dapansutrile; NLRP3 Inflammasome Inhibitor I

STING激动剂 ^[4]: 3',3'-cGAMP; 2',3'-cGAMP Sodium Salt; Alpha-Mangostin; Vadimezan; MSA-2

RIG-I激动剂 ^[5]: Inarigivir soproxil

免疫检查点阻断

Anti-PD-1/PD-L1: Pembrolizumab; Nivolumab; Cemiplimab; Sintilimab; Spartalizumab; Atezolizumab; Durvalumab; Avelumab

Anti-CTLA-4: Ipilimumab; Tremelimumab; Zalifrelimab; Quavonlimab

Anti-LAG-3: Relatlimab

Anti-VISTA: CA-170; NSC622608

Anti-CD47: Magrolimab; Anti-CD47

Anti-TIM-3: Sabatolimab; Cobolimab

Anti-TIGIT: Tiragolumab; Vibostolimab

Anti-B7-H3 (CD276): Enoblituzumab; Omburtamab

Anti-BTLA (CD272): Icatolimab

肿瘤免疫逃逸

TGF-β抑制剂 ^[7]: Sulfasalazine; SB431542; Galunisertib; Pirfenidone; Fresolimumab

PI3K/AKT/mTOR抑制剂 ^[8]: Rapamycin; Everolimus; Temsirolimus; Torin 1; LY294002; 3-MA; Miltefosine; MK-2206 2HCl

JAK/STAT抑制剂 ^[9]: Napabucasin; Curcumin; Itacitinib; Ruxolitinib; Tofacitinib; Resveratrol; Baricitinib; Bosutinib

CCR/CXCR抑制剂: Reparixin; SB225002; Plerixafor; BX471; Cenicriviroc; RS102895

COX2/PGE2抑制剂 ^[10]: Vitamin E; Dexamethasone; Aspirin; Resveratrol

靶向新生血管 ^[6]

Sorafenib

Sunitinib malate

Lenalidomide

Cabozantinib

Lenvatinib

Regorafenib

Axitinib

Nintedanib

Apatinib

Ponatinib

Anlotinib dihydrochloride

Erdafitinib

免疫共刺激分子

Anti-ICOS (CD278) ^[11]: Vopratelimab; Anti-ICOS / CD278; Feladilimab; Alomfilimab

Anti-4-1BB (CD137) ^[11]: Urelumab; Utomilumab

Anti-OX40 (CD134) ^[11]: Anti-TNFRSF4 / OX40 / CD134; Ivuxolimab; Vonlerizumab; Telazorlimab; Tavolixizumab; Cudarolimab; Revdofilimab

Anti-TNFRSF5 (CD40) ^[12]: Dacetuzumab; Lucatumumab; Selicrelumab; Sotigalimab; Mitazalimab

免疫抑制剂

细胞毒性分子 ^[13]: Cyclophosphamide; Busulfan; Cisplatin; Ifosfamide; Thiotepa

抗代谢分子: Mycophenolate mofetil; Azathioprine

钙调素抑制剂: Cyclosporine; Cyclosporin A; Tacrolimus; Pimecrolimus

免疫蛋白酶体抑制剂: Bortezomib; Carfilzomib; Sotrastaurin

免疫抑制抗体: Tocilizumab; Rituximab; Belimumab; Eculizumab; Obinutuzumab; Sutimlimab; Siplizumab

免疫增强剂

多糖类: Lipopolysaccharides; Lentinan; Chondroitin sulfate; Sodium Hyaluronate; Hyaluronic acid; Chitin; Chitosan

维生素类 ^[14]: Vitamin A Acetate; Vitamin B12; Folic acid; Thiamine HCl; Pyridoxine; Biotin; Riboflavin; Calcium D-Panthotenate; Vitamin C; cholecalciferol; Trolox; Menadione; Vitamin K2; Calcitriol; Vitamin E

疫苗佐剂 ^[15]: 1V209; Squalene; KIN1148; Larazotide; Cholesterol; Dioscin; Sapogenins Glycosides; Levamisole hydrochloride; Isoprinosine; Imiquimod; Resiquimod

免疫调节剂

小分子: Avadomide; Iberdomide; Teriflunomide; Thalidomide; Amlexanox; Fingolimod; Prednisolone; Ossirene; Methylprednisolone; Laquinimod

生物大分子: LL37; Polzastobart; Bexmarilimab; Mupadolimab; Tesnatilimab; Imalumab; Narsoplimab; Falbikitug; Lacutamab; Enokizumab; Tildrakizumab; Carotuximab

抗体免疫疗法

单抗: Cetuximab; Trastuzumab; Bevacizumab; Rituximab; Tocilizumab; Magrolimab; Sacituzumab; Adalimumab; Tiragolumab; Daratumumab

双抗: Tidutamab; Rolinsatamab; Talquetamab; Emicizumab; Navicixizumab; Tepoditamab; Anti-ROBO1

ADC: Trastuzumab-deruxtecan; Sacituzumab-govitecan; Trastuzumab-Emtansine; Loncastuximab tesirine; Enfortumab vedotin-ejfv; Datopotamab deruxtecan; Polatuzumab vedotin-piiq; Anetumab ravtansine; Tisotumab vedotin; Patritumab deruxtecan

相关化合物库

Immunology/Inflammation Compound Library

Cytokine Inhibitor Library

Angiogenesis Related compound Library

JAK/STAT compound library

NF-κB Signaling Compound Library

PI3K/Akt Inhibitor Library

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Small Molecule Immuno-Oncology Compound Library

参考文献